What were the top read stories on Houston energy innovation? These five articles attracted the most attention this year. Photo via Getty Images

Editor's note: As 2022 comes to a close, InnovationMap is looking back at the year's top stories in Houston innovation. In the energy capital of the world, there were dozens of energy tech stories, from most-promising energy tech startups to new cohorts of energy accelerators. Here are five Houston energy tech-focused articles that stood out to readers this year — be sure to click through to read the full story.


Investors name most promising energy tech startups at annual Houston event

The Rice Alliance for Technology and Entrepreneurship handed out awards to the founders of the most promising companies that pitched. Photo courtesy of Slyworks Photography/Rice Alliance

Nearly 100 energy tech startups pitched at the 19th annual Rice Alliance Energy Tech Venture Forum this week — and over a third of those companies are based in the Houston area.

At the conclusion of the event — which took place on Thursday, September 15, at Rice University, and included a day full of company pitches, panels, and thought leadership — 10 startups were deemed the most promising among their peers. The group was voted on by investors attending office hours ahead of the event.

The Rice Alliance for Technology and Entrepreneurship facilitated nearly 700 meetings between 70 investor groups and 90 ventures, according to the organization. The group of presenting companies included participants from Rice's Clean Energy Accelerator's first two cohorts.Read more.

Energy transition innovator shares how Houston could be a biomanufacturing hub​

Moji Karimi joins InnovationMap to discuss how Cemvita Factory has deployed its recent investment funding and what's next for the company and Houston as a whole when it comes to biomanufacturing. Photo courtesy of Cemvita

Moji Karimi and his sister Tara had the idea for a company that could transform carbon emissions and mitigate new damage to the environment. Only, it seems, they were a bit ahead of their time.

Houston-based Cemvita Factory, founded in 2017, uses synthetic biology and take carbon emissions and transform them into industrial chemicals. However, it's only been since recently that the conversation on climate change mitigation has focused on carbon utilization.

"I think people are realizing more about the importance of really focusing on carbon capture and utilization because fossil fuels are gonna be here, whether we like it or not, for a long time, so the best thing we could do is to find ways to decarbonize them," Moji Karimi, co-founder and CEO, tells InnovationMap. "There's been this focus around carbon capture and storage, and I think the next awakening is going to be utilization." Read more.

3 startups join Houston cleantech incubator

Halliburton Labs has announced its next set of clean energy tech companies. Photo courtesy of Halliburton

Three businesses have just joined Halliburton Labs, a Houston-based accelerator for clean energy startups.

The new members of Halliburton Labs are A-W Energy, a Finland-based startup whose technology converts ocean waves into energy; RedShift Energy, a Pennsylvania-based startup whose technology recovers hydrogen; and Renkube, an India-based startup whose technology aims to lower the cost of producing solar power.

Halliburton Labs says its participants enjoy access to technical expertise, mentorships, and other benefits.

“These new companies reflect our view that numerous innovations at scale are important in the evolution of energy systems. … We are eager to collaborate with these companies to help them achieve their strategic, operational, and financial milestones,” Dale Winger, managing director of Halliburton Labs, says in a news release. Read more.

Houston oil and gas company reveals details on $1B carbon capture facility

Oxy is working on a direct air carbon capture facility in the Permian Basin — and is committing to up to a $1 billion price tag for the project. Rendering via 1pointfive.com

Ramping up its investment in clean energy, Houston-based Occidental Petroleum plans to spend up to $1 billion on a facility in the Permian Basin that will pull carbon dioxide from the air.

During a March 23 investor update, executives at Occidental laid out their strategy for developing direct air carbon capture plants and carbon sequestration hubs.

Executives said Occidental’s first direct air capture facility is set to be built in the Permian Basin, a massive oil-producing region in West Texas and southeastern New Mexico. The industrial-scale facility, with an estimated price tag of $800 million to $1 billion, is on track to open in late 2024. Construction is supposed to start later this year. Read more.

How Greentown Houston accelerated the local energy transition in its inaugural year

Greentown Houston's Juliana Garaizar and Emily Reichert look back on the climatetech incubator's first year. Photos via greentownlabs.com

This Thursday, Greentown Houston officially celebrates the completion of its first year in town, as well as the impact its made in just the 365 days since its grand opening.

Emily Reichert, CEO of Greentown Labs, officially cut the ribbon on the organization's first location outside of the Boston area last Earth Day. Reichert, along with Juliana Garaizar, head of the Houston incubator and vice president of innovation, joined InnovationMap for a Q&A looking back on this past year — including what surprised them most and where members are moving in from. Read more.

The ultimate who's who of 2022 — favorite Houston Innovators Podcast guests of last year. Photos courtesy

Editor's Picks: 7 favorite Houston interviews of 2022

houston innovators podcast episode 28

Editor's note: In 2022, I recorded over 50 episodes of the Houston Innovators Podcast — a weekly discussion with a Houston innovator, startup founder, investor, and more. I've rounded up seven podcast episodes that stood out for me looking back at the year of recordings. Scroll through to see whom I selected and stream their individual episodes, and tune into the last episode of the year where I explain why I selected each guest.



Veronica Wu, founder of First Bight Ventures — Episode 119

Veronica Wu is the founder of First Bight Ventures, a VC firm focused on funding early-stage synthetic biology companies. Wu relocated from Silicon Valley to Houston to start her firm. She’s held tech positions at Apple, Tesla, and Motorola, and she says she’s not afraid to dive headfirst into a new technology she sees as promising — and that’s exactly what she’s doing in the SynBio space now and she’s betting on Houston to be a hub for it. Read more.

Armand Paradis, founder and CEO of ComboCurve — Episode 132

Houston startups saw some major funding rounds this year, and one startup that was in the midst of deploying new capital into their plans of growing and scaling was ComboCurve. Founder Armand Paradis closed a $50 million series B round earlier this year. The company has built a software platform for various verticals within the energy industry, and Paradis describes how he wants his technology to have an impact the energy transition. Read more.

John "JR" Reale, entrepreneur in residence at the Texas Medical Center — Episode 136 and 137

In June, John Reale was a guest on two episodes. He discussed his role at the Texas Medical Center’s innovation institute as well as his own early-stage venture capital firm. Reale has been a major player within the Houston Innovation ecosystem since its early days, and he has a unique perspective on Houston’s early innovation activity, including the founding of Station Houston and the rejection from Amazon for its second HQ. Read more.


Allie Danziger, founder of Ampersand — Episode 126

In March, Allie Danziger dove into the generational divide within the workforce and the Great Resignation. She founded Ampersand, a professional development tech platform that onboards interns, and upskills them on how to be successful in the workplace. Danziger is so passionate about making sure both companies and the future of the workforce are prepared to be on the same page.Read more.

Benjamin Foster, founder of Nursify — Episode 148

Benjamin Foster founded Nursery, a platform that helps connect nurses with the health care facilities that need them. While he is proud of the tool he created to help nurses find work, he strives to make the platform inclusive, educational, and supportive for these health care professionals who are burnt out from the pandemic. Read more.

Joanna Nathan, CEO of Prana Thoracic — Episode 149

Joanna Nathan is an individual who transitioned from supporting startups at Johnson and Johnson's Center for Device Innovation, to leading a startup of her own. She shares how she came to become CEO of Prana Thoracic, a company tackling early-stage lung cancer diagnostics. She also shared her story of her own personal loss — her young son, Lionel — and how this loss drives her every day. Read more.

Natara Branch, CEO of Houston Exponential — Episode 158

Natara Branch, the new CEO of Houston Exponential, joined HX in November and jumped into the role headfirst. She is passionate about Houston, and took it upon herself to meet the Houston innovation community — and to make sure they know we're all in it together. Read more.

Innovative shoewear, luxury EV charging, and more — all this innovation and more is coming out of Houston startups. Courtesy photos

Top 5 Houston startup feature stories of 2022

year in review

Editor's note: As 2022 comes to a close, InnovationMap is looking back at the year's top stories in Houston innovation. This past year, InnovationMap featured profiles on dozens of these Houston startups — from sportstech apps and health tech companies to startups with solutions in EV tech and more. Here are five Houston startup features that stood out to readers this year — be sure to click through to read the full story.

Houston-based health tech startup is revolutionizing patient selection for clinical trials

Sieve Health is an AI cloud-based SaaS platform designed to automate and accelerate matching patients with clinical trials. Photo via Getty Images

On many occasions in her early career, Dr. Arti Bhosale, co-founder and CEO of Sieve Health, found herself frustrated with having to manually sift through thousands of digital files.

The documents, each containing the medical records of a patient seeking advanced treatment through a clinical trial, were always there to review — and there were always more to read.

Despite the tediousness of prescreening, which could take years, the idea of missing a patient and not giving them the opportunity to go through a potentially life-altering trial is what kept her going. The one she didn’t read could have slipped through the cracks and potentially not given someone care they needed.

“Those stories have stayed with me,” she says. “That’s why we developed Sieve.” Read more.

Houston startup snags prestigious grant from global health leader

Houston-based medical device and biotech startup Steradian Technologies has been recognized by the Bill and Melinda Gates Foundation. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

A female-founded biotech startup has announced that it has received a grant from the Bill & Melinda Gates Foundation.

Steradian Technologies has developed a breath-based collection device that can be used with diagnostic testing systems. Called RUMI, the device is non-invasive and fully portable and, according to a news release, costs the price of a latte.

“We are extremely honored to receive this award and be recognized by the Bill & Melinda Gates Foundation, a leader in global health. This funding will propel our work in creating deep-tech diagnostics and products to close the equity gap in global public health," says Asma Mirza, CEO and co-founder of Steradian Technologies, in the release. “The RUMI will demonstrate that advanced technology can be delivered to all areas of the world, ensuring the Global South and economically exploited regions receive access to high-fidelity diagnostics instead of solutions that are ill-suited to the environment.” Read more.

Houston sports tech startup is enhancing performance metrics for runners and athletes

Houston-based AiKYNETIX is equipping runners with high-tech tracking tools. Image courtesy of AiKYNETIX

With the Houston Marathon only five months away, a new application using human motion insights could help a runner refine their form to reach peak performance – all from the convenience of their smart phone.

While traditional treadmills are limited in training feedback and wearables are not designed to track elevation, Houston-based AiKYNETIX uses real-time technology to provide a new option for runners on treadmills.

“Runners spend a lot of time, energy and money to run better,” says Denis Akhiyarov, CEO and co-founder. “In my personal life with training for nine marathons, I’ve seen limitations with wearables, they don’t actually track running form while running. Overall, our technology tracks not only your basic parameters but it can also analyze the human running form while in motion.” Read more.

Local startup to upgrade EV charging in Houston and beyond

Houston-based Spark Spaces is looking to build out luxury spots for electric vehicle charging. Rendering courtesy of Spark Spaces

At 3 a.m. one night, just as he had many nights before, Tarun Girish found himself leaving his Houston apartment in search of an EV charger.

Once he located one, he would sit in his car for an hour and a half while his vehicle charged — with not much to do but wait.

But it was on this night he wondered if there was a way to use his previous hospitality experience to build a new kind of experience for EV drivers. He then developed his first iteration of a business plan — all while sitting in his driver’s seat.

His idea became Sparks Spaces, a startup formed in 2021 looking to shake up the EV charging game — the company aims to elevate the experience of charging electric vehicles by focusing on the space between car and charger by creating an airport lounge-type space for drivers. These EV lounges would include luxury waiting areas, clean restrooms, high-end food options, and availability to utilize them 24/7. Read more.

Houston neuroscientist turned startup founder takes steps toward comfier shoes

Steffie Tomson founded a company to prioritize comfort — without sacrificing style — for women on the go. Photo via getawaysticks.com

Two and half years ago, native Houstonian Steffie Tomson ordered $2,000 worth of shoes and sliced them all in half with a bandsaw just to see what was inside.

Tomson, a neuroscientist by trade and the founder and CEO of footwear startup Getaway Sticks, had an idea for a different kind of shoe — one that was redesigned to prioritize women’s comfort.

“I thought, ‘why can’t we start with a sneaker material and then build a heel around it?’” she tells InnovationMap. “I started just slicing everyone else’s shoes and now I’m more convinced than ever that our shoe is different.” Read more.

Impactful tech startups, Houston landing on a list of emerging startup hubs, and more news trended on InnovationMap this year. Photo via Getty Images

Looking back: Top 5 most-read Houston impact stories of 2022

year in review

Editor's note: As 2022 comes to a close, InnovationMap is looking back at the year's top stories in Houston innovation. When it came to impact — from a startup looking to reduce clothing waste and optimize used clothing shopping to Houston being named an emerging startup hub — in Houston, five stories trended among readers.

Houston tech ecosystem ranks as No. 5 in the world for emerging startup hubs

Houston's ranking on this global report improved 14 spots between now and last year. Photo via Getty Images

As a startup hub, Houston is movin’ on up.

In a new report from Startup Genome and the Global Entrepreneurship Network, Houston ranks fifth among the world’s top 100 emerging ecosystems for startups. Last year, the groups’ report put Houston at No. 19 in the same category.

Ahead of Houston on the list of the top emerging ecosystems for startups are first-ranked Detroit; second-ranked Hong Kong; third-ranked Dublin, Ireland; and fourth-ranked Minneapolis. Read more.

Houston startup seeks to simplify sustainable fashion

A Houston innovator found second-hand shopping time consuming. So, she designed a better experience. Image courtesy of Trendy Seconds

When the coronavirus pandemic started in 2020, people found themselves at home with a surplus of free time. Puzzles covered dining room tables, remnants of new hobbies were strewn across dens, TikTok dances were rehearsed, and television was binged. Maria Burgos found herself watching Netflix’s “Tidying Up with Marie Kondo,” which inspired her to clean out her closet. In practicing Kondo’s dogma of parting with items that don’t “spark joy,” Burgos uncovered a bigger issue to purge: America’s unsustainable fashion industry.

She asked herself why there wasn’t a website where she could find items in one place. “That was the genesis of Trendy Seconds,” she shares. Read more.

International botanical water company plans expansion into Houston

Amid a growing water shortage, this international company has developed an innovative way to harvest a new water source — and it's bringing it to Houston. Image via Getty Images

More than 2 million Americans don’t have access to clean drinking water, according to one study by the U.S. Water Alliance group.

To help close that water gap, international firm, Botanical Water Technologies, has plans to expand its presence in the United States with the Houston region being a strategic area to roll out the implementation of a patented water filtration technology. In addition, the group is launching a blockchain enabled trading platform with Fujitsu to help support the business.

“Water is finite,” says James Rees, chief impact officer at BWT. “Due to global growth and climate conditions, we are going to have between 20 to 30 percent less water available to us by 2025. Communities are facing issues with water infrastructure. Some communities don't have water. This is where BWT plans to come in to help.” Read more.

Q&A: How the Houston tech community can support LGBTQIA+ innovators

Tammi Wallace of the Greater Houston LGBT Chamber of Commerce is a panelist on The Ion's Pride in Tech event. Photo via LinkedIn

It's Pride Month, and the Houston tech community is celebrating its LGBTQIA+ community — as well as addressing some challenges faced within the business arena.

Wallace, who co-founded the Greater Houston LGBT Chamber of Commerce in 2016, joined InnovationMap for a quick Q&A ahead of the event. Read more.

2 Houston organizations announce strategic appointments across finance and research

Here are two of the latest updates on new appointments from two Houston organizations. Photos courtesy

Three Houston innovators have new roles they're excited about this summer. From new academia to bitcoin, here's who's moving and shaking in Houston innovation. Read more.

These five deals were the largest rounds raised by Houston startups, according to InnovationMap. Photo via Getty Images

Big deals: These were the top 5 investment rounds raised by Houston startups in 2022

year in review

Editor's note: As 2022 comes to a close, InnovationMap is looking back at the year's top stories in Houston innovation. When it came to the money raised in Houston, these five startups raised the most, according to reporting done by InnovationMap.

Houston unicorn chemicals company raises $200M series D

Solugen closed its series D funding round at $200 million. Photo via Getty Images

Houston-based Solugen has announced its latest round of investment to the tune of $200 million. The company, which reached unicorn status after its $357 million series C round last year, uses its patented Bioforge processes to produce "green" chemicals from bio-based feedstocks.

"Solugen is reimagining the chemistry of everyday life with enzymes found in nature. We make chemicals better, faster, cheaper, and without fossil fuels from right here in Houston, Texas. Whether you care about the climate, local competitiveness, or just plain old profits, we have good news: it's working," the company states in its news release. Read more.

Houston microgrid tech company announces $150 investment

Houston-based VoltaGrid provides small-scale, self-contained microgrids that can operate independently of major power grids or in tandem with other microgrids. Photo via voltagrid.com

VoltaGrid, a Bellaire-based startup that specializes in distributed power generation via microgrids, has hauled in $150 million in equity funding.

Founded in 2020, VoltaGrid provides small-scale, self-contained microgrids that can operate independently of major power grids or in tandem with other microgrids. VoltaGrid’s product consists of natural gas engines, portable energy storage, natural gas processing and grid power connectivity. Read more.

Houston company raises $138M for next-generation geothermal energy

The future of geothermal energy is here — and just got a big payday. Photo via Getty Images

Houston-based startup Fervo Energy has picked up $138 million in funding to propel its creation and operation of carbon-free power plants fueled by geothermal energy.

Fervos says the series C round will help it complete power plants in Nevada and Utah and evaluate new projects in California, Idaho, Oregon, Colorado, and New Mexico, as well as in other countries.

California-based investment firm DCVC led the round, with participation from six new investors. Read more.

Houston company closes $76M series C round to fuel its mission of reducing carbon emissions

Syzygy Plasmonics has raised a series C round of funding. Photo courtesy of Syzygy

A Houston-based company that is electrifying chemical manufacturing has closed its largest round of funding to date.

Syzygy Plasmonics closed a $76 million series C financing round led by New York-based Carbon Direct Capital. The round included participation from Aramco Ventures, Chevron Technology Ventures, LOTTE CHEMICAL, and Toyota Ventures. The company's existing investors joining the round included EVOK Innovations, The Engine, Equinor Ventures, Goose Capital, Horizons Ventures, Pan American Energy, and Sumitomo Corporation of Americas. According to a news release, Carbon Direct Capital will join Syzygy's board and serve as the series C director.Read more.

Fast-growing energy fintech startup raises $50M series B

The series B capital will allow the company to enhance its core product, while also adding on other workflows that focus on emissions and renewable energy. Image via combocurve.com

Houston-based ComboCurve announced today that it has raised $50 million through a series B funding round led by Dragoneer Investment Group and Bessemer Venture Partners.

Founded in 2017, the company is a cloud-based energy analytics and operating platform that uses sophisticated software to forecast and report on a company's energy assets, including renewables.

The series B capital will allow the company to enhance its core product, while also adding on other workflows that focus on emissions and renewable energy. Read more.


The top lifestyle innovation stories of the year included a new surfing spot coming to town. Rendering courtesy of Beach Street Development

These are Houston's top lifestyle tech and innovation articles of 2022

year in review

Editor's note: As 2022 comes to a close, InnovationMap is looking back at the year's top stories in Houston innovation. When it came to the lifestyle innovation — whether it's fit tech companies or space bartenders — in Houston, five stories trended among readers. Be sure to click through to read the full story.

Houston startup seeks to simplify sustainable fashion

A Houston innovator found second-hand shopping time consuming. So, she designed a better experience. Image courtesy of Trendy Seconds

When the coronavirus pandemic started in 2020, people found themselves at home with a surplus of free time. Puzzles covered dining room tables, remnants of new hobbies were strewn across dens, TikTok dances were rehearsed, and television was binged. Maria Burgos found herself watching Netflix’s “Tidying Up with Marie Kondo,” which inspired her to clean out her closet. In practicing Kondo’s dogma of parting with items that don’t “spark joy,” Burgos uncovered a bigger issue to purge: America’s unsustainable fashion industry.

With piles of clothing ready for a new home, Burgos searched for reliable organizations to donate her possessions. Her research led her to learn more about the negative impact the fashion industry has on the environment.

According to Slate, almost 24 billion pounds of clothes and shoes are thrown out each year — more than double what we tossed two decades ago. Americans consume more than 20 billion garments each year, and each garment can be expected to be worn around seven times, according to The Wall Street Journal. We’re buying more clothing than ever when clothing is at its lowest cost. Read more.

New surfing lagoon paradise to bring ocean-perfect waves to Houston

Surf's up soon for Houstonians thanks to this new innovative development. Rendering courtesy of Beach Street Development

Thanks to its relative proximity to the coast, Houston has always enjoyed an underground surf culture (be it shortboarding, longboarding, or even tanker surfing). Now, those who walk the nose and shred can at a new, world-class surf destination coming to Generation Park in north Houston.

HTX Surf will ride into Generation Park in fall of 2024, per an announcement by creators Beach Street Development, the company pushes the barefoot life with its man-made surfing lagoons.

Why the north Houston locale, versus closer to Galveston? Beach Street notes in press materials that the lagoon park is a mere 10 minutes from Bush Intercontinental Airport, making for easy access for visitors from all over. Read more.

Laundry startup unfolds new service in Houston

Hampr Lite will give Houstonians a taste of what it's laundry service is like. Image courtesy of Hampr

As Laurel Hess sat on a video call with a board member for her startup laundry service, a pile of laundry was peeking behind her.

“How can you have clothes piling up while owning a laundry business?” they asked.

Hess coolly replied, “Because laundry just doesn’t stop. It’s literally always there.”

Hampr is a hyper-local laundry and pick-up service that is connected and operated through an online app. The Lafayette-based company, which identified Houston as an early test market, links people who are in need of pick-up and wash laundry services with people in the local communities who are seeking work without leaving home. Read more.

Houston restaurant veteran pops open award-winning and sustainable new bottled water

HOW water comes to you via subscription. Photo by Alex Montoya

Houstonians who are picky about their bottled water but also environmentally minded now have a refreshing local option — one that even comes to them.

A new, “hyperpure” oxygen-enriched water brand has rolled out in Houston in single-serve and subscription options. Dubbed HOW — Hyperpure Oxygenated Water — the award-winning super-filtered water (via a 14-level filtration process that removes impurities down to the nano-level .0001 microns) is now available at 35 specialty retailers around town. Read more.

Celebrity family inks exclusive deal with Houston-based real estate platform ahead of return to HBO

The Hos are back for Season 2 after inking a big deal with Realty.com. Photo by Elizabeth Morris/HBO Max

Houston power fam The Hos are once again back in the house. The docu-reality series stars of House of Ho returned to streaming network HBO Max for a 10-episode second season this week.

Season 2 kicks off with three episodes, with three new episodes to follow on September 1, and the final four episodes debuting September 8, according to HBO.

As fans recall, Season 1 introduced the nation to patriarch Binh and matriarch Hue, who went from Vietnamese immigrants to building a multi-million dollar real estate and banking empire. The Season 1 cast included the Hos’ son Washington and his wife Lesley; their daughter Judy and her fiancé Nate Nguyễn; and Aunt Tina; and Cousin Sammy, who has become an influencer with a propensity for ending posts with “b*tches.”

Aside from flashing their opulent lifestyle and navigating cultural clashes, the Hos are still wheeling and dealing. The Houstonians have inked an exclusive deal with Realty.com to “deliver world-class service to clients in the Houston area,” according to a Realty.com announcement. Read more.

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Houston health tech innovator collaborates on promising medical device funded by DOD

team work

The United States Department of Defense has awarded a grant that will allow the Texas Heart Institute and Rice University to continue to break ground on a novel left ventricular assist device (LVAD) that could be an alternative to current devices that prevent heart transplantation and are a long-term option in end-stage heart failure.

The grant is part of the DOD’s Congressionally Directed Medical Research Programs (CDMRP). It was awarded to Georgia Institute of Technology, one of four collaborators on the project that will be designed and evaluated by the co-investigator Yaxin Wang. Wang is part of O.H. “Bud” Frazier’s team at Texas Heart Institute, where she is director of Innovative Device & Engineering Applications Lab. The other institution working on the new LVAD is North Carolina State University.

The project is funded by a four-year, $7.8 million grant. THI will use about $2.94 million of that to fund its part of the research. As Wang explained to us last year, an LVAD is a minimally invasive device that mechanically pumps a person’s own heart. Frazier claims to have performed more than 900 LVAD implantations, but the devices are far from perfect.

The team working on this new research seeks to minimize near-eventualities like blood clot formation, blood damage, and driveline complications such as infection and limitations in mobility. The four institutions will try to innovate with a device featuring new engineering designs, antithrombotic slippery hydrophilic coatings (SLIC), wireless power transfer systems, and magnetically levitated driving systems.

Wang and her team believe that the non-contact-bearing technology will help to decrease the risk of blood clotting and damage when implanting an LVAD. The IDEA Lab will test the efficacy and safety of the SLIC LVAD developed by the multi-institutional team with a lab-bench-based blood flow loop, but also in preclinical models.

“The Texas Heart Institute continues to be a leading center for innovation in mechanical circulatory support systems,” said Joseph G. Rogers, MD, the president and CEO of THI, in a press release.

“This award will further the development and testing of the SLIC LVAD, a device intended to provide an option for a vulnerable patient population and another tool in the armamentarium of the heart failure teams worldwide.”

If it works as hypothesized, the SLIC LVAD will improve upon current LVAD technology, which will boost quality of life for countless heart patients. But the innovation won’t stop there. Technologies that IDEA Lab is testing include wireless power transfer for medical devices and coatings to reduce blood clotting could find applications in many other technologies that could help patients live longer, healthier lives.

Houston investor on SaaS investing and cracking product-market fit

Houston innovators podcast episode 230

Aziz Gilani's career in tech dates back to when he'd ride his bike from Clear Lake High School to a local tech organization that was digitizing manuals from mission control. After years working on every side of the equation of software technology, he's in the driver's seat at a local venture capital firm deploying funding into innovative software businesses.

As managing director at Mercury, the firm he's been at since 2008, Gilani looks for promising startups within the software-as-a-service space — everything from cloud computing and data science and beyond.

"Once a year at Mercury, we sit down with our partners and talk about the next investment cycle and the focuses we have for what makes companies stand out," Gilani says on the Houston Innovators Podcast. "The current software investment cycle is very focused on companies that have truly achieved product-market fit and are showing large customer adoption."



An example of this type of company is Houston-based RepeatMD, which raised a $50 million series A round last November. Mercury's Fund V, which closed at an oversubscribed $160 million, contributed to RepeatMD's round.

"While looking at that investment, it really made me re-calibrate a lot of my thoughts in terms what product-market fit meant," Gilani says. "At RepeatMD, we had customers that were so eager for the service that they were literally buying into products while we were still making them."

Gilani says he's focused on finding more of these high-growth companies to add to Mercury's portfolio amidst what, admittedly, has been a tough time for venture capital. But 2024 has been looking better for those fundraising.

"We've some potential for improvement," Gilani says. "But overall, the environment is constrained, interest rates haven't budged, and we've seen some potential for IPO activity."

Gilani shares more insight into his investment thesis, what areas of tech he's been focused on recently, and how Houston has developed as an ecosystem on the podcast.

Houston startup scores $12M grant to support clinical evaluation of cancer-fighting drug

fresh funding

Allterum Therapeutics, a Houston biopharmaceutical company, has been awarded a $12 million product development grant from the Cancer Prevention and Research Institute of Texas (CPRIT).

The funds will support the clinical evaluation of a therapeutic antibody that targets acute lymphoblastic leukemia (ALL), one of the most common childhood cancers.

However, CEO and President Atul Varadhachary, who's also the managing director of Fannin Innovation, tells InnovationMap, “Our mission has grown much beyond ALL.”

The antibody, called 4A10, was invented by Scott Durum PhD and his team at the National Cancer Institute (NCI). Licensed exclusively by Allterum, a company launched by Fannin, 4A10 is a novel immunotherapy that utilizes a patient’s own immune system to locate and kill cancer cells.

Varadhachary explained that while about 80 percent of patients afflicted with ALL have the B-cell version, the other 20 percent suffer from T-cell ALL.

“Because the TLL population is so small, there are really no approved, effective drugs for it. The last drug that was approved was 18 or 19 years ago,” the CEO-scientist said. 4A10 addresses this unmet need, but also goes beyond it.

Because 4A10 targets CD127, also known as the interleukin-7 receptor, it could be useful in the treatment of myriad cancers. In fact, the receptor is expressed not just in hematological cancers like ALL, but also solid tumors like breast, lung, and colorectal cancers. There’s also “robust data,” according to Varadhachary for the antibody’s success against B-cell ALL, as well as many other cancers.

“Now what we're doing in parallel with doing the development for ALL is that we're continuing to do additional preclinical work in these other indications, and then at some point, we will raise a series A financing that will allow us to expand markets into things which are much more commercially attractive,” Varadhachary explains.

Why did they go for the less commercially viable application first? As Varadhachary put it, “The Fannin model is to allow us to go after areas which are major unmet medical needs, even if they are not necessarily as attractive on a commercial basis.”

But betting on a less common malady could have a bigger payoff than the Allterum team originally expected.

Before the new CPRIT grant, Allterum’s funding included a previous seed grant from CPRIT of $3 million. Other funds included an SBIR grant from NCI, as well as another NCI program called NExT, which deals specifically with experimental therapies.

“To get an antibody from research into clinical testing takes about $10 million,” Varadhachary says. “It's an expensive proposition.”

With this, and other nontraditional financing, the company was able to take what Varadhachary called “a huge unmet medical need but a really tiny commercial market” and potentially help combat a raft of other childhood cancers.

“That's our vision. It's not economically hugely attractive, but we think it's important,” says Varadhachary.

Atul Varadhachary is the managing director of Fannin Innovation. Photo via LinkedIn