Research roundup

These 3 Houston research projects are aiming to fight or prevent cancer

Breakthrough research on metastatic breast cancer, a new way to turn toxic pollutants into valuable chemicals, and an evolved brain tumor chip are three cancer-fighting treatments coming out of Houston. Getty Inages

Cancer remains to be one of the medical research community's huge focuses and challenges, and scientists in Houston are continuing to innovate new treatments and technologies to make an impact on cancer and its ripple effect.

Three research projects coming out of Houston institutions are providing solutions in the fight against cancer — from ways to monitor treatment to eliminating cancer-causing chemicals in the first place.

Baylor College of Medicine's breakthrough in breast cancer

Photo via bcm.edu

Researchers at Baylor College of Medicine and Harvard Medical School have unveiled a mechanism explains how "endocrine-resistant breast cancer acquires metastatic behavior," according to a news release from BCM. This research can be game changing for introducing new therapeutic strategies.

The study was published in the Proceedings of the National Academy of Sciences and shows that hyperactive FOXA1 signaling — previously reported in endocrine-resistant metastatic breast cancer — can trigger genome-wide reprogramming that enhances resistance to treatment.

"Working with breast cancer cell lines in the laboratory, we discovered that FOXA1 reprograms endocrine therapy-resistant breast cancer cells by turning on certain genes that were turned off before and turning off other genes," says Dr. Xiaoyong Fu, assistant professor of molecular and cellular biology and part of the Lester and Sue Smith Breast Center at Baylor, in the release.

"The new gene expression program mimics an early embryonic developmental program that endow cancer cells with new capabilities, such as being able to migrate to other tissues and invade them aggressively, hallmarks of metastatic behavior."

Patients whose cancer is considered metastatic — even ones that initially responded to treatment — tend to relapse and die due to the cancer's resistance to treatment. This research will allow for new conversations around therapeutic treatment that could work to eliminate metastatic cancer.

University of Houston's evolved brain cancer chip

Photo via uh.edu

A biomedical research team at the University of Houston has made improvements on its microfluidic brain cancer chip. The Akay Lab's new chip "allows multiple-simultaneous drug administration, and a massive parallel testing of drug response for patients with glioblastoma," according to a UH news release. GBM is the most common malignant brain tumor and makes up half of all cases. Patients with GBM have a five-year survival rate of only 5.6 percent.

"The new chip generates tumor spheroids, or clusters, and provides large-scale assessments on the response of these GBM tumor cells to various concentrations and combinations of drugs. This platform could optimize the use of rare tumor samples derived from GBM patients to provide valuable insight on the tumor growth and responses to drug therapies," says Metin Akay, John S. Dunn Endowed Chair Professor of Biomedical Engineering and department chair, in the release.

Akay's team published a paper in the inaugural issue of the IEEE Engineering in Medicine & Biology Society's Open Journal of Engineering in Medicine and Biology. The report explains how the technology is able to quickly assess how well a cancer drug is improving its patients' health.

"When we can tell the doctor that the patient needs a combination of drugs and the exact proportion of each, this is precision medicine," Akay explains in the release.

Rice University's pollution transformation technology

Photo via rice.edu

Rice University engineers have developed a way to get rid of cancer-causing pollutants in water and transform them into valuable chemicals. A team lead by Michael Wong and Thomas Senftle has created this new catalyst that turns nitrate into ammonia. The study was published in the journal ACS Catalysis.

"Agricultural fertilizer runoff is contaminating ground and surface water, which causes ecological effects such as algae blooms as well as significant adverse effects for humans, including cancer, hypertension and developmental issues in babies," says Wong, professor and chair of the Department of Chemical and Biomolecular Engineering in Rice's Brown School of Engineering, in a news release. "I've been very curious about nitrogen chemistry, especially if I can design materials that clean water of nitrogen compounds like nitrites and nitrates."

The ability to transform these chemicals into ammonia is crucial because ammonia-based fertilizers are used for global food supplies and the traditional method of creating ammonia is energy intensive. Not only does this process eliminate that energy usage, but it's ridding the contaminated water of toxic chemicals.

"I'm excited about removing nitrite, forming ammonia and hydrazine, as well as the chemistry that we figured out about how all this happens," Wong says in the release. "The most important takeaway is that we learned how to clean water in a simpler way and created chemicals that are more valuable than the waste stream."

Trending News

Building Houston

 
 

Bumble is sponsoring 50 collegiate women athletes in honor of this week’s 50th Anniversary of Title IX. Photo by Kristen Kilpatrick

Bumble is causing a buzz once again, this time for collegiate women athletes. Founded by recent Texas Business Hall of Fame inductee Whitney Wolfe Herd, the Austin-based and female-first dating and social networking app this week announced a new sponsorship for 50 collegiate women athletes with NIL (name, image, and likeness) deals in honor of the 50th anniversary of Title IX.

Established in 1972, the federal law prohibits sex-based discrimination in any school or other education program or activity that receives federal money. According to the Women’s Sports Foundation, the number of women in collegiate athletics has increased significantly since Title IX, from 15 percent to 44 percent.

That said, equity continues to lag in many ways, specifically for BIPOC women who make up only 14 percent of college athletes. The findings also share that men have approximately 60,000 more collegiate sports opportunities than women, despite the fact that women make up a larger portion of the collegiate population.

With this in mind, Bumble’s new sponsorship seeks to support “a wealth of overlooked women athletes around the country,” according to the beehive’s official 50for50 program page.

“We're embarking on a yearlong sponsorship of 50 remarkable women, with equal pay amounts across all 50 NIL (name, image, and likeness) contracts,” says the website. “The inaugural class of athletes are a small representation of the talented women around the country who diligently — and often without recognition — put in the work on a daily basis.”

To celebrate the launch of the program, Bumble partnered with motion graphic artist Marlene “Motion Mami” Marmolejos to create a custom video and digital trading cards that each athlete will post on their personal social media announcing their sponsorship.

“These sponsorships are an exciting step in empowering and spotlighting a diverse range of some of the most remarkable collegiate women athletes from across the country. Athletes who work just as hard as their male counterparts, and should be seen and heard,” says Christina Hardy, Bumble’s director of talent and influencer, in a separate release. “In honor of the 50th anniversary of Title IX, we are so proud to stand alongside these women and are looking forward to celebrating their many achievements throughout the year.”

“Partnering with Bumble and announcing this campaign on the anniversary of Title IX is very special,” said Alexis Ellis, a track and field athlete. “I am grateful for the progress that has been made for women in sports, and am proud to be part of Bumble’s ’50for50’ to help continue moving the needle and striving for more. I look forward to standing alongside so many incredible athletes for this campaign throughout the year.”

“I am so grateful to team up with Bumble and stand alongside these incredible athletes on this monumental anniversary,” said Haleigh Bryant a gymnast. “Many women continue to be overlooked in the world of sports, and I am excited to be part of something that celebrates, and shines a light on, the hard work, tenacity, and accomplishments of so many great athletes.”

Last year, the NCAA announced an interim policy that all current and incoming student athletes could profit off their name, image, and likeness, according to the law of the state where the school is located, for the first time in collegiate history.

The 50for50 initiative adds to Bumble’s previous multi-year investments in sports. In 2019, Bumble also launched a multi-year partnership with global esports organization Gen.G to create Team Bumble, the all-women professional esports team.

To see the 50for50 athletes, visit the official landing page.

------

This article originally ran on CultureMap.

Trending News