Houston engineers develop breakthrough device to advance spinal cord treatment

future of health

The probe or sensor, known as spinalNET, is used to explore how neurons in the spinal cord process sensation and control movement. Photo by Jeff Fitlow/Rice University

A team of Rice University engineers has developed an implantable probe over a hundred times smaller than the width of a hair that aims to help develop better treatments for spinal cord disease and injury.

Detailed in a recent study published in Cell Reports, the probe or sensor, known as spinalNET, is used to explore how neurons in the spinal cord process sensation and control movement, according to a statement from Rice. The research was supported by the National Institutes of Health, Rice, the California-based Salk Institute for Biological Studies, and the philanthropic Mary K. Chapman Foundation based in Oklahoma.

The soft and flexible sensor was used to record neuronal activity in freely moving mice with high resolution for multiple days. Historically, tracking this level of activity has been difficult for researchers because the spinal cord and its neurons move so much during normal activity, according to the team.

“We developed a tiny sensor, spinalNET, that records the electrical activity of spinal neurons as the subject performs normal activity without any restraint,” Yu Wu, a research scientist at Rice and lead author of the study said in a statement. “Being able to extract such knowledge is a first but important step to develop cures for millions of people suffering from spinal cord diseases.”

The team says that before now the spinal cord has been considered a "black box." But the device has already helped the team uncover new findings about the body's rhythmic motor patterns, which drive walking, breathing and chewing.

Lan Luan (from left), Yu Wu, and Chong Xie are working on the breakthrough device. Photo by Jeff Fitlow/Rice University

"Some (spinal neurons) are strongly correlated with leg movement, but surprisingly, a lot of neurons have no obvious correlation with movement,” Wu said in the statement. “This indicates that the spinal circuit controlling rhythmic movement is more complicated than we thought.”

The team said they hope to explore these findings further and aim to use the technology for additional medical purposes.

“In addition to scientific insight, we believe that as the technology evolves, it has great potential as a medical device for people with spinal cord neurological disorders and injury,” Lan Luan, an associate professor of electrical and computer engineering at Rice and a corresponding author on the study, added in the statement.

Rice researchers have developed several implantable, minimally invasive devices to address health and mental health issues.

In the spring, the university announced that the United States Department of Defense had awarded a four-year, $7.8 million grant to the Texas Heart Institute and a Rice team led by co-investigator Yaxin Wang to continue to break ground on a novel left ventricular assist device (LVAD) that could be an alternative to current devices that prevent heart transplantation.

That same month, the university shared news that Professor Jacob Robinson had published findings on minimally invasive bioelectronics for treating psychiatric conditions. The 9-millimeter device can deliver precise and programmable stimulation to the brain to help treat depression, obsessive-compulsive disorder and post-traumatic stress disorder.
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This week's roundup of Houston innovators includes Omair Tariq of Cart.com, Nádia Skorupa Parachin of Cemvita, and Han Xiao of Rice University. Photos courtesy

3 Houston innovators to know this week

who's who

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes an e-commerce startup founder, an industrial biologist, and a cellular scientist.

Omair Tariq, co-founder and CEO of Cart.com

Omair Tariq of Cart.com joins the Houston Innovators Podcast to share his confidence in Houston as the right place to scale his unicorn. Photo via Cart.com

Houston-based Cart.com, which operates a multichannel commerce platform, has secured $105 million in debt refinancing from investment manager BlackRock.

The debt refinancing follows a recent $25 million series C extension round, bringing Cart.com’s series C total to $85 million. The scaleup’s valuation now stands at $1.2 billion, making it one of the few $1 billion-plus “unicorns” in the Houston area.

Cart.com was co-founded by CEO Omair Tariq in October 2020. Read more.

Nádia Skorupa Parachin, vice president of industrial biotechnology at Cemvita

Nádia Skorupa Parachin joined Cemvita as vice president of industrial biotechnology. Photo courtesy of Cemvita

Houston-based biotech company Cemvita recently tapped two executives to help commercialize its sustainable fuel made from carbon waste.

Nádia Skorupa Parachin came aboard as vice president of industrial biotechnology, and Phil Garcia was promoted to vice president of commercialization.

Parachin most recently oversaw several projects at Boston-based biotech company Ginkjo Bioworks. She previously co-founded Brazilian biotech startup Integra Bioprocessos. Read more.

Han Xiao, associate professor of chemistry at Rice University

The funds were awarded to Han Xiao, a chemist at Rice University.

A Rice University chemist has landed a $2 million grant from the National Institute of Health for his work that aims to reprogram the genetic code and explore the role certain cells play in causing diseases like cancer and neurological disorders.

The funds were awarded to Han Xiao, the Norman Hackerman-Welch Young Investigator, associate professor of chemistry, from the NIH's Maximizing Investigators’ Research Award (MIRA) program, which supports medically focused laboratories. Xiao will use the five-year grant to advance his work on noncanonical amino acids.

“This innovative approach could revolutionize how we understand and control cellular functions,” Xiao said in the statement. Read more.

The new collaborative hub will foster research into cell therapies, artificial intelligence, nanotechnologies, and more. Photo via tmc.edu

Houston health care leaders announce new hub for cancer-fighting bioengineering

team work

Two Houston organizations recently announced a new hub that will focus on developing cell therapies, nanotechnologies, cancer vaccines, artificial intelligence, and molecular imaging.

Rice University and The University of Texas MD Anderson Cancer Center have teamed up to “drive industry growth and advance life-saving technologies” through the newly established Cancer Bioengineering Collaborative, according to a news release announcing the initiative.

The collaboration between the two institutions includes fundamental and translational cancer research, developing new technologies for cancer detection and therapy, and securing external funding in support of further research and training.

Leading the hub will be Rice researcher and Cancer Prevention and Research Institute of Texas (CPRIT) scholar Gang Bao and MD Anderson’s Dr. Jeffrey Molldrem.

“There is tremendous potential in bringing together experts in engineering and cancer as part of this focused, collaborative framework that is truly unique, not only owing to the complementary nature of the respective strengths but also because this is the first formal joint research initiative of its kind between the two institutions,” says Bao, department chair and Foyt Family Professor of Bioengineering, professor of chemistry, materials science and nanoengineering and mechanical engineering, in the release.

The joint effort will also host monthly seminars focused on cancer bioengineering, annual retreats to highlight research and international leaders in cancer and bioengineering, and also a seed grant program to fund research projects in the early stages of development.

“From fundamental discoveries in cancer science, tumor immunology and patient care to innovative engineering advances in drug delivery systems, nanostructures and synthetic biology, there is great potential for enabling cross-disciplinary collaboration to develop new technologies and approaches for detecting, monitoring and treating cancer,” Molldrem, chair of Hematopoietic Biology & Malignancy at MD Anderson, says in the release. “Our goal is to bridge the gap between bioengineering and cancer research to create transformative solutions that significantly improve patient outcomes.”

Dr. Jeff Molldrem (left) and Gang Bao will lead the new collaborative hub. Photo via MD Anderson

This week's roundup of Houston innovators includes Melanie Johnson of Collaborative for Children, Aditya Mohite of Rice University, Lani Doyle of Cart.com. Photos courtesy

3 Houston innovators to know this week

who's who

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes a nonprofit leader introducing new technologies, a solar tech-focused Rice University professor, and a new hire for a Houston fast-growing startup.

Melanie Johnson, president and CEO of Collaborative for Children

Collaborative for Children is focused on utilizing social-emotional learning robots and coding tech toys. Photo courtesy

Generally, when children are under the age of five, educators believe that they are best suited for and interested in learning, because those are the years in which there is the strongest opportunity to build a broad and solid foundation for lifelong literacy and well-being.

That sentiment is deeply held by Collaborative for Children, the Houston-based nonprofit organization with the mission to meaningfully improve the quality of early childhood education and provide access to cutting-edge technology through its Centers of Excellence to all children, especially those in low-income and marginalized communities.

“The reason the organization was started about 40 years ago is that a group of philanthropists in the greater Houston area suggested that this was so important because 90 percent of the brain develops or grows in the time frame between ages zero to five years of age,” Melanie Johnson, president and CEO of Collaborative for Children, tells InnovationMap. Read more.

Aditya Mohite, director of Rice Engineering Initiative for Energy Transition and Sustainability

The new process developed by Rice University researchers makes solar cells that are about 10 times more durable than traditional methods. Photo courtesy

Presented on the cover of a June issue of Science, a study from Rice University engineer Aditya Mohite's lab uncovered a method to synthesize a high-efficiency perovskite solar cell, known as formamidinium lead iodide (FAPbI3), converting them into ultrastable high-quality photovoltaic films, according to a statement from Rice. Photovoltaic films convert sunlight into electricity.

The new process makes solar cells that are about 10 times more durable than traditional methods.

“Right now, we think that this is state of the art in terms of stability,” Mohite said in a statement. “Perovskite solar cells have the potential to revolutionize energy production, but achieving long-duration stability has been a significant challenge.” Read more.

Lani Doyle, chief people officer at Cart.com

Fast-growing Cart.com has named its new chief people officer. Photo courtesy of Cart.com

Houston-based e-commerce software and services company Cart.com has hired a former Shopify executive as its chief people officer.

Before joining Cart.com, Lani Doyle was chief HR officer at Strategic Solutions Group, a provider of health care software. Previously, she was vice president of HR and people operations at 6 River Systems, a provider of software and robotics for warehouses. Prior to that, Doyle was head of talent development and operations at Shopify, an e-commerce platform for businesses that posted revenue of $7.1 billion in 2023.

“Cart.com is one of the fastest-growing companies in commerce today, and I’m excited to partner with our teams to help drive growth and scalability,” Doyle says in a news release. “I am eager to contribute to shaping our culture and developing programming that supports and elevates high-performing teams, ensuring we achieve our ambitious goals.” Read more.

The Healthcare Navigator is a platform that helps users to learn about not just treatment options, but also the financial bearings thereof. Photo via thehealthcarenav.com

Houston startup designs new platform for better navigating health care

patient portal

Taking control of your health can be a difficult path to walk on your own. A new startup, created by eight female Rice University students, is aimed at wading through the health care system.

The Healthcare Navigator is a platform that helps users to learn about not just treatment options, but also the financial bearings thereof.

“About 88 percent of Americans aren’t health literate,” founder and president Kayla Grimes says in a news release. “It’s very hard for them to navigate health care in the way to get the best benefit for it, so what our platform will do is essentially give them the tools and resources to confidently navigate the health care system. We also help with price transparency specifically.”

The multidisciplinary team includes women majoring in pre-med, computer science, medical humanities, art and business. According to Grimes (a rising senior business major), the seed for the idea’s success was planted two years ago when she was volunteering for the National Patient Advocacy Foundation.

“They told me, ‘If you do this right, this could actually change everything in health care,’” she remembers.

Now she and her team have an app, as well as an accessible website, composed of several features all meant to make it easier to save money — and users’ health. The features are:

  • Cost Compass, which compares procedure costs across local hospitals, enabling users to shop around and save money.
  • Care Genius AI, an AI chatbot that helps users to negotiate medical bills and answers health care system questions.
  • Patient Power Modules, which are interactive educational videos that make understanding the health care system easy and engaging.
  • Pocket Doc, which helps consumers find the best providers for them based on location, ratings and quality metrics.
  • Pulse Check Alert keeps users informed on important health care news and patient insights.
  • Care Manager streamlines users’ health care needs and goals in one convenient place.

Grimes says that she hopes that users will skip Google reviews and go straight to their Pocket Doc, which includes information on hospitals, clinics, urgent care centers and freestanding emergency rooms.

“We have that in the system, so that you can actually see useful metrics instead of just going on Google reviews and reading their readmission rate — we’re going to explain what’s a good readmission rate and what’s a bad readmission rate,” she says. “That’s the whole point: We’re not just going to give you these metrics, we’re also going to give you some benchmarks, so you can make the decision for yourself.”

When dealing with your health, knowledge is certainly power, and Healthcare Navigator is bestowing a new kind of power on its users.

Harry Yan and Weiman Gao have bestowed $1 million on the Baker Institute of Public Policy to establish the interdisciplinary Neuro-Policy Program. Photo via rice.edu

$1M donation to Rice establishes pioneering neuro-policy center in Houston

brainy support

A big donation to Rice University will soon help researchers better understand the workings of the human brain.

Harry Yan and Weiman Gao have bestowed $1 million on the Baker Institute of Public Policy to establish the interdisciplinary Neuro-Policy Program.

Neuro-policy is a newer field that explores how brain health and function can help to fuel economic growth.

“The Neuro-Policy Program is at the forefront of pioneering data analysis, empirical research and policy application,” says Harris Eyre, the lead for the program, as well as a senior fellow in brain health at the Baker Institute, in a news release. “Investing in evidence-based strategies for prevention, diagnosis and treatment can reduce brain and mental health disparities, optimize cognitive development and performance and foster innovation to build more resilient communities.”

Eyre describes the collective value of the human brain as “brain capital.” That’s because brains that are suffering from any number of neurodegenerative or mental health disorders (including depression, anxiety, brain injury and Alzheimer’s disease) have actually taken a toll on the U.S. economy, Eyre explains.

The Neuro-Policy Program seeks to improve brain performance, and consequently enhance economic growth, national security, and our overall standing as a nation of healthy brains. The program’s primary projects include establishing a task force to advise Texas “brain and mind” legislative efforts as well as a Texas Brain Capital Dashboard, collaborating on Texas Forward (Texas Brain Health Plan) with the UT Dallas Center for BrainHealth, thereby working toward U.S. brain capital policy and investment advances. These projects are expected to yield deliverables as early as 2026.

“The Neuro-Policy Program aims to leverage the university’s proximity to the Texas Medical Center and the institute’s strong connections to state and federal policymakers. This is an important yet underrepresented area of research that Houston is poised to lead,” says David Satterfield, the director of the Baker Institute.

Yan and Gao said in a press release that they were inspired to gift the grant funds to Eyre and his research after attending a March 28 Baker Institute event on brain health that featured U.S. Rep. Morgan Luttrell, a co-chair of the Congressional Neuroscience Caucus.

"We are honored to support Dr. Harris Eyre and the Neuro-Policy program he leads. Dr. Eyre’s work has greatly impressed us, highlighting the critical importance of brain health in our society today,” say Yan and Gao. “We hope our contribution can inspire further support and advocacy in the field, helping individuals lead healthier lives through a comprehensive approach to prevention.”

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Houston medical device startup implants artificial heart in first human patient

big win

Heart health tech company BiVACOR and The Texas Heart Institute announced that they successfully implanted the company's first Total Artificial Heart in a human at Baylor St. Luke’s Medical Center in the TMC.

The milestone is part of an FDA-approved early feasibility study that will test the safety and performance of the TAH device, which is based on a magnetically levitated rotor that takes over functions of a failing heart while a patient is awaiting a heart transplant, according to a statement from the organizations.

The "bridge-to-transplant" device could support an active adult male, as well as many women and children suffering from severe biventricular heart failure or univentricular heart failure.

"With heart failure remaining a leading cause of mortality globally, the BiVACOR TAH offers a beacon of hope for countless patients awaiting a heart transplant,” Dr. Joseph Rogers, president and CEO of THI and national principal investigator on the research, says in a statement. “We are proud to be at the forefront of this medical breakthrough, working alongside the dedicated teams at BiVACOR, Baylor College of Medicine, and Baylor St. Luke’s Medical Center to transform the future of heart failure therapy for this vulnerable population.”

BiVACOR received approval from the FDA for the early feasibility study in late 2023 and has four other patients enrolled in the study. At the time the study was approved, 10 hospitals were enrolled as possible sites.

“I’m incredibly proud to witness the successful first-in-human implant of our TAH. This achievement would not have been possible without the courage of our first patient and their family, the dedication of our team, and our expert collaborators at The Texas Heart Institute ... our TAH brings us one step closer to providing a desperately needed option for people with end-stage heart failure who require support while waiting for a heart transplant. I look forward to continuing the next phase of our clinical trial,” Daniel Timms, PhD, founder and CTO of BiVACOR, adds.

About 100,000 patients suffering from severe heart failure could benefit from BiVACOR’s artificial heart, the company says. Globally, only about 6,000 heart transplants are performed each year, while 26 million people worldwide are affected by heart failure.

BiVACOR was founded in 2008 and maintains its headquarters in Houston, along with offices in Huntington Beach, California, and Brisbane, Australia.

To date, the company has raised nearly $50.8 million, according to CB Insights. The company raised $18 million in 2023, and $22 million in 2021.

Earlier this year, BiVACOR named a new CEO in Jim Dillon, a longtime executive in the medical device sector.

Last summer, Rogers joined the Houston Innovators Podcast to share his excitement with THI's innovations.


Here's how much it takes to earn a top 1 percent salary in Texas

wealthy lifestyle

With two Houston-area neighbors cashing in among the most wealthy suburbs in America, Houstonians may be wondering how much money they need to make to secure a place in the top one percent of earners. According to a new study from SmartAsset, the pre-tax salary required to be considered one of the highest earners in Texas amounts to $762,090 in 2024.

Texas has the 14th highest pre-tax salary needed to be considered in the top one percent of earners in the U.S. for the second year in a row. Texas' income threshold is not too far off from the national average, which is $787,712.

The study further revealed 126,128 Texans are within the top one percent of earners. For more context, the U.S. Census Bureau says over 30 million people lived in Texas as of 2022, and Houston's population grew to 2.3 million people in 2023.

Connecticut continues to lead the nation with the highest income threshold required to be in the top one percent, with residents needing to make over $1.15 million pre-tax.

To determine the income needed to be in the top one percent of earners in each state, SmartAsset analyzed 2021 IRS data for individual tax filers, which is the most recent year where data was available. Income data was then adjusted to June 2024 dollars.

Compared to SmartAsset's 2023 report, Texans now need to make $130,241 more in 2024 to maintain their status as one of the highest earners in the state. Last year, the income threshold was $631,849.

If Houstonians aim to be within the top five percent of earners in Texas, the pre-tax income threshold is drastically lower, at $280,676. However, for many Houston residents, achieving even a "middle class" status means making between $40,280 and $120,852 a year.

Meanwhile, the study says the median income in the U.S. comes out to roughly $75,000, and half of Americans are making even less than that. The income disparity is plainly obvious when high-income earners make (at a minimum) 10 times more than the national median income.

The report goes on to say top-earning Americans make up a "disproportionately large part of the tax base," as their income results in paying a 37 percent federal tax bracket rate. (That is, if these high earners are even paying taxes in the first place, considering America's wealthiest are already evading over $150 billion a year in taxes.)

"While state and local level taxes may impact the spread of high earners in those areas, the cost of living can also be drastically different nationwide," the report said. "As a result, what it takes to be considered a top one percent income earner can differ by over $500,000 from state to state."

The top 10 states with the highest thresholds to be considered in the top one percent of earners in the U.S. are:

  • No. 1 – Connecticut ($1,152,254)
  • No. 2 – Massachusetts ($1,113,662)
  • No. 3 – California ($1,035,673)
  • No. 4 – Washington ($989,649)
  • No. 5 – New Jersey ($975,645)
  • No. 6 – New York ($965,645)
  • No. 7 – Colorado ($865,700)
  • No. 8 – Florida ($852,206)
  • No. 9 – Wyoming ($843,121)
  • No. 10 – New Hampshire ($811,098)
The full report can be found on smartasset.com

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This article originally ran on CultureMap.

Houston fintech co. offers new grants, chemist scores funding for cancer treatment, and more top stories

top stories

Editor's note:Let's roundup the most-read Houston innovation news from the week. Trending Houston tech and startup articles from InnovationMap and its daily newsletter included a Rice professor securing support for his cancer treatment, an energy company raising funding, and more.

Houston-based equitable entrepreneurship tech platform expands programs

In partnership with top organizations — like Progressive, Antares Capital, Wells Fargo, and FedEx — Hello Alice has added new offerings for its 2024 Boost Camp programs. Photo via Pexels

Fresh off of celebrating the dismissal of a lawsuit from former Trump Administration officials, Hello Alice is expanding some of its offerings for entrepreneurs.

In partnership with top organizations — like Progressive, Antares Capital, Wells Fargo, and FedEx — Hello Alice has added new offerings for its 2024 Boost Camp programs, a mix of skill-building support and grant opportunities.

“We are fortunate to continue working with great enterprise partners who share our commitment to supporting Main Street through crucial grants and mentorship programs,” Carolyn Rodz, CEO and co-founder of Hello Alice, says in a news release. Continue reading.

Houston chemist lands $2M NIH grant for cancer treatment research

The funds were awarded to Han Xiao, a scientist at Rice University.

A Rice University chemist has landed a $2 million grant from the National Institute of Health for his work that aims to reprogram the genetic code and explore the role certain cells play in causing diseases like cancer and neurological disorders.

The funds were awarded to Han Xiao, the Norman Hackerman-Welch Young Investigator, associate professor of chemistry, from the NIH's Maximizing Investigators’ Research Award (MIRA) program, which supports medically focused laboratories. Continue reading.

Power grid tech co. with Houston HQ raises $25M series B

Heimdall supplies software and sensors for monitoring overhead power lines. Photo via heimdallpower.com

A Norway-based provider of technology for power grids whose U.S. headquarters is in Houston has raised a $25 million series B round of funding.

The venture capital arm of Polish energy giant Orlen, Norwegian cleantech fund NRP Zero, and the Norway-based Steinsvik Family Office co-led Heimdall Energy's round. Existing investors, including Investinor, Ebony, Hafslund, Lyse, and Sarsia Seed, chipped in $8.5 million of the $25 million round.

“This funding gives us fuel to grow internationally, as we continue to build our organization with the best people and industry experts in the world,” Jørgen Festervoll, CEO of Heimdall, says in a news release.Continue reading.

Houston engineers develop breakthrough device to advance spinal cord treatment

The probe or sensor, known as spinalNET, is used to explore how neurons in the spinal cord process sensation and control movement. Photo by Jeff Fitlow/Rice University

A team of Rice University engineers has developed an implantable probe over a hundred times smaller than the width of a hair that aims to help develop better treatments for spinal cord disease and injury.

Detailed in a recent study published in Cell Reports, the probe or sensor, known as spinalNET, is used to explore how neurons in the spinal cord process sensation and control movement, according to a statement from Rice. The research was supported by the National Institutes of Health, Rice, the California-based Salk Institute for Biological Studies, and the philanthropic Mary K. Chapman Foundation based in Oklahoma.Continue reading.

Houston neighbor ranks as one of America's most livable small cities

Missouri City is the No. 4 most livable small city in Texas, and ranked No. 77 nationwide. Photo Courtesy Missouri City

Some Houston suburbs stick out from the rest thanks to their affluent residents, and now Missouri City is getting time in the spotlight, thanks to its new ranking as the No. 77 most livable small city in the country.

The tiny but mighty Houston neighbor, located less than 20 miles southwest of Houston, was among six Texas cities that earned a top-100 ranking in SmartAsset's 2024 " Most Livable Small Cities" report. It compared 281 U.S. cities with populations between 65,000 and 100,000 residents across eight metrics, such as a resident's housing costs as a percentage of household income, the city's average commute times, and the proportions of entertainment, food service, and healthcare establishments.Continue reading.

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