The Ion names new coworking partner for Houston innovation hub

Where to Work

Coworking company Industrious replaces WeWork-owned Common Desk at The Ion. Photo via thecommondesk.com

Rice University subsidiary Rice Real Estate Co. has tapped coworking company Industrious as the new operator of the Ion’s 86,000-square-foot coworking space in Midtown. Industrious replaces WeWork-owned Common Desk in that role.

The Ion, owned by Rice Real Estate and located at 4201 Main St., is a 266,000-square-foot office building and innovation hub in the 16-acre Ion District.

Features of the coworking space include private suites and offices, dedicated desks, phone booths and conference rooms. In 2022, Common Desk said it was expanding the space by 28,000 square feet, bringing it to the current size.

“(Industrious’) unparalleled expertise in delivering quality, hospitality-driven workspaces complements our vision of creating a world-class ecosystem where entrepreneurs, corporations, and academia converge to drive innovation forward,” Ken Jett, president of Rice Real Estate, said in a statement.

Natalie Levine, senior manager of real estate at Industrious, says her company will work with Rice Real Estate “to continue to position the Ion as an invaluable contributor to the growth of Houston’s innovation community.”

Dallas-based commercial real estate services company CBRE said Jan. 14 that it had agreed to acquire Industrious in a deal valued at $400 million.

The Ion is Industrious’ second location in Houston. The company’s other local coworking space is at 1301 McKinney St.

Office tenants at the Ion include Occidental Petroleum, Fathom Fund, Activate, Carbon Clean, Microsoft and Chevron Technology Ventures.

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Sesh Coworking's new space is 10 times as big as its previous location. Photo courtesy of Sesh

Exclusive: Houston coworking company plans to move into larger Midtown location

room to grow

A Houston startup with an inclusive approach to coworking has announced where its new location will be and plans to open in its first phase in the new year.

Sesh Coworking, which bills itself as the first female-centered and LGBTQ+-affirming coworking space, has announced its new 20,000-square-foot space at 2808 Caroline St, Suite 100 and 201. The team is all hands on deck to move over the next few weeks and formally beginning operating in the Midtown location in January 2022.

The two-story space is about ten times the size of its original location, which opened in February of 2020. Current and new tenants will move into the space's second floor in January while the first floor, the larger of the two floors, completes construction.

The new space will open in two phases. Image courtesy of Sesh

"Being able to grow our community at our beautiful original location in Montrose through the pandemic is a testament to the grit and resilience of Houstonians. We are so honored and grateful to be a part of their journey,” says Maggie Segrich, founder of Sesh Coworking. “We are excited that our new location in Midtown, near the Innovation District, will provide more Houstonians with the workspace and support they need."

The new location has hassle-free parking in a walkable part of town. In terms of layout, Sesh plans to have 25 offices, three conference rooms, four phone booths, an amphitheater, library, demo kitchen, pop-up retail shop, locker room with showers, and interactive art installations. A huge new perk of the space: 24/7 access for members.

"We plan to offer a robust calendar of programming featuring community partners such as networking events, lunch and learns, breakfast clubs, cooking classes, book clubs, business development and more," the founders tell InnovationMap.

According to Sesh, membership pricing will remain at the current rate of $199 per month, but individuals will now be able to opt into private offices starting at $789 per month for space that can accommodate teams of up to 15 people.

Sesh worked with real estate developer, The Deal Co, to customize the space in order to best meet the needs of its dynamic female and LGBTQ+ members. The new location was funded in part by a crowdfunding campaign, which raised $40,000, which represented the company’s goal. Sesh also received grant funds from the TWU Center for Women Entrepreneurs, an organization aiming to help women grow into successful business owners.

Founders Maggie Segrich (right) opened Sesh with Meredith Wheeler in 2020. Photo courtesy of Sesh

Houston's moving on up in the worlds of economics and startup activity. Photo by Tim Leviston/Getty Images

Houston ranks high on lists for startup ecosystems and economic growth potential

We're No. 4!

The number four appears to be a sign of good fortune for Houston.

A new ranking from Business Facilities magazine places Bayou City at No. 4 for economic growth potential among large metro areas and at No. 4 for the country's best startup ecosystems.

Regarding the No. 4 ranking for economic potential, Susan Davenport, senior vice president of economic development for the Greater Houston Partnership, says Houston's industrial diversity has helped the region weather downturns in certain economic sectors "and now has us on a solid growth trajectory."

"The region's steady population increases, coupled with our relatively low costs of living and doing business, bode well for our economic growth potential reflected in this ranking," Davenport says.

Houston's status as the one of the top locations for Fortune 1000 headquarters in the U.S. elevates the region's position as a hub where both large and small companies can prosper, she adds.

Houston appeared at No. 1 in Business Facilities' 2018 ranking of the top large metros for economic growth potential. Representatives of Business Facilities couldn't be reached to explain why Houston dropped three places from 2018 to 2019.

Last year, the magazine pointed out that Houston's economy extends far beyond its standing as the Energy Capital of the World.

"The nation's fourth-largest city has a dynamic, diversified economy that is brimming with innovation, technology, and entrepreneurship," said the magazine, citing advantages such as Houston's strong manufacturing base, enormous healthcare presence, and storied aerospace legacy.

The magazine went on to hail Houston's "distinctly favorable business climate."

"The region benefits from a skilled workforce, world-class infrastructure and transportation system, and a pro-business environment that stimulates rather than stifles business growth," Business Facilities noted.

As for the No. 4 ranking in this year's Business Facilities startup category, Davenport says this indicates the recent work of the Houston Exponential initiative to foster the local startup environment is paying off.

Houston Exponential, established in 2017, seeks to make Houston a top 10 innovation ecosystem, generate $2 billion in venture capital annually, and create 10,000 new tech jobs a year by 2022.

Last October, Houston Exponential announced it had collected $25 million for its first venture capital fund. Making financial commitments to the fund were Insperity, Chevron, Shell, Quanta Services, Westlake Chemical, The Plank Cos., PROS, H-E-B, and Camden Property Trust.

"Factor in the demand being satisfied by a number of new incubators and accelerators, plus the four-mile Innovation Corridor running through the heart of the city and anchored by The Ion, and we're seeing momentum on a scale like never before," Davenport says.

In Houston's Midtown, Rice University is transforming the historic Sears building into The Ion, which will serve as an innovation hub designed to cultivate collaboration among startups, corporations, universities, and other elements of the local business community. It's the first development in Houston's evolving innovation district.

"The Midtown innovation district is an embodiment of our shared community vision to give professionals and families a means of seizing opportunity as Houston continues to grow as a leading city in technology," says Matt Thibodeaux, executive director of Midtown Houston.

Here is Business Facilities' 2019 list of the top 10 places for economic growth potential among large U.S. metros:

Atlanta
San Antonio
Phoenix
Houston
Orlando, Florida
Austin
Raleigh-Durham, North Carolina
Las Vegas
Albuquerque, New Mexico
Kansas City, Missouri

Here is Business Facilities' 2019 list of the 10 places with the best startup ecosystems in the country:

Austin
Denver
New York City
Houston
San Jose, California
Orlando, Florida
Nashville, Tennessee
Atlanta
Raleigh-Durham, North Carolina
Salt Lake City

The new two-story wall in Station Houston's space represents Station's promise to its startup members as well as showcases the city's stewards for innovation. Natalie Harms/InnovationMap

Mayor, Station CEO: Houston's innovation ecosystem has arrived

forget up and coming

For Gaby Rowe, Houston's not just an up-and-coming innovation leader.

"Houston's tech ecosystem is here. It exists now. It will continue to grow and gain momentum. It is not a thing of the future; it is here now," Rowe, CEO of Station Houston, tells InnovationMap.

At Station's third anniversary party on January 30, Mayor Sylvester Turner agreed with that sentiment.

"I don't want to say that we're looking to just build this robust, integrated ecosystem," Turner says. "Let me just be bold enough to say that it is done. We've already done it, and we are just expanding on it."

In a week full of announcements — from $2.5 million grants bringing in an international accelerator program to Midtown innovation hub announcing its new name and construction plans — Station, not to be out done, announced its programming expansion plans.

Station's Houston VR Lab made its debut at the celebration, which is an AR/VR space where members can use to showcase their technology to potential partners and investors. Station is also a short ways away from finishing up its robotics lab, something that the organization is partnering with TXRX Labs to work on.

When it comes to investors, Station acts as a sort of matchmaker with its member startups. In 2019, the organization will have 15 different investors with weekly, monthly, or quarterly office hours in the Station space — nine of which are already on board, Rowe says.

Station will also be launching a foreign development accelerator aimed at attracting startups from around the world. The program will help educate and transition the companies into business here in the United States over a one- to three-week session.

"Our belief is that there's no better city for an international startup to come to," Rowe says. "It's so easy to assimilate and there's such a global footprint. And, there's such an open community when it comes to the warmth of the people. There's no one here that I've worked with that won't give you one meeting."

Visually, Station Houston's biggest unveiling was the wall that spans two floors of the office. On the wall is four stewards, as Rowe describes them, that have partnered to progress Houston's innovation. On the wall are the logos of Houston Exponential, TMC Innovation Institute, Rice University, and the University of Houston.

"Those four entities have committed through their stewardship tp make sure that this ecosystem a reality, and today we can say it's here," Rowe says.

The historic Sears building in Midtown will transform into The Ion, a Rice University-backed hub for innovation. Courtesy of Rice University

Rice University's Midtown innovation hub dubbed The Ion takes shape

Eye on Ion

Houston's innovation district is one step closer to the Midtown hub it was promised early last year. Rice University announced the construction details of the historic Sears building's transformation into The Ion, as it's now called.

"We chose the name Ion because it's from the Greek ienai, which means 'go'" says Rice University president David Leebron in the release. "We see it as embodying the ever-forward motion of discovery, the spark at the center of a truly original idea. It also represents the last three letters in many of the words that define the building's mission, like inspiration, creation, acceleration and innovation."

Construction on the 270,000-square-foot building will begin in May, according to Rice's release, and is expected to conclude by the end of next year. The cost of the project wasn't disclosed with the announcement. The building will serve as a coworking space, provide resources for entrepreneurs and startups, and host events, the release says, as well as offer retail space for restaurants and entertainment amenities.

"I gleefully applaud this next giant step in the creation of an innovation hub that will take Houston closer to becoming a world leader in data science and digital technologies" says Houston Mayor Sylvester Turner in the release. "As I said last year when the idea was unveiled, we have to leap, not stroll, into the economic frontier. Now the physical transformation of The Ion will help get us there."

Leading the project is the Rice Management Company, and Rice will provide academic programming, along with other educational institutions including the University of Houston, UH-Downtown, the University of St. Thomas, Houston Community College, Texas Southern University, Houston Baptist University, San Jacinto College, and the South Texas College of Law. Station Houston has been named as the programming partner and will have a huge presence in the hub.

"The Ion will inspire open innovation between universities, global corporations and investors," says Gabriela Rowe, CEO of Station Houston, in the release. "Students and faculty members from institutions like Rice University and the University of Houston will coexist and collaborate with scientists from Houston's other great institutions. Investors and corporations will meet face to face with startup entrepreneurs. Together, at The Ion, they will transform Houston into a thriving, connected, high-tech ecosystem."

Houston-based Hines was listed as the developer, and other dealmakers include New York-based SHoP Architects, James Carpenter Design Associates, James Corner Field Operations, and Gensler's Houston office. The Ion's transformation will include removing the '60s-era metal cladding, but the structure will maintain its original art deco façade.

This is the first phase of development for Houston's innovation district — a 16-acre plan for Midtown, according to the release, and the district will also feature housing, public spacing, and important infrastructure.

"We are eager to contribute to an enhanced quality of life for residents and visitors of Midtown Houston," said Matt Thibodeaux, executive director of Midtown Houston. "The Midtown innovation district is an embodiment of our shared community vision to give professionals and families a means of seizing opportunity as Houston continues to grow as a leading city in technology."

Courtesy of Rice University

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10 promising Houston startups that made headlines in 2025

year in review

Editor's note: As we reflect on 2025, we're looking back at the stories and startups that made waves in Houston's innovation scene. These 10 startups reached memorable milestones, won prestigious awards, found creative solutions, and disrupted their industries.

Persona AI: Houston humanoid robotics startup inks new deal to deploy its rugged robots

A concept design rendering of Persona AI's humanoid robot. The company is expanding at the Ion and plans to deliver prototype humanoids by the end of 2026 for complex shipyard welding tasks. Rendering courtesy Persona AI.

Persona AI is building modularized humanoid robots that aim to deliver continuous, round-the-clock productivity and skilled labor for "dull, dirty, dangerous, and declining" jobs. The company was founded by Houston entrepreneur Nicolaus Radford, who serves as CEO, along with CTO Jerry Pratt and COO Jide Akinyode. It raised $42 million in pre-seed funding this year and is developing its prototype of a robot-welder for Hyundai's shipbuilding division, which it plans to unveil in 2026. The company won in the Deep Tech Business category at this year's Houston Innovation Awards. Continue reading.

Rheom Materials: Houston startup unveils its innovative leather alternative at the rodeo

Rheom Materials presented its bio-based alternative, Shorai, a 93 percent bio-based leather, at the rodeo and plans to scale it up this year. Photos courtesy Rheom Materials

Rheom Materials presented its scalable, bio-based alternative known as Shorai, a 93 percent bio-based leather, through two custom, western-inspired outfits that showed off cowboy flair through a sustainable lens at the Houston Livestock Show and Rodeo earlier this year.

Next up, the company said it aimed to scale production of Shorai, the Japanese word for “future,” at a competitive price point, while also reducing its carbon footprint by 80 percent when compared to synthetic leather. The company also made a large-scale production partnership with a thermoplastic extrusion and lamination company, Bixby International, this year. Continue reading.

Koda Health: Houston digital health platform Koda closes $7 million funding round

Tatiana Fofanova and Dr. Desh Mohan, founders of Koda Health, which recently closed a $7 million series A. Photo courtesy Koda Health.

Houston-based digital advance care planning company Koda Health closed an oversubscribed $7 million series A funding round this year. The round, led by Evidenced, with participation from Mudita Venture Partners, Techstars and Texas Medical Center, will allow the company to scale operations and expand engineering, clinical strategy and customer success. Koda Health, saw major growth this year by integrating its end-of-life care planning platform with Dallas-based Guidehealth in April and with Epic Systems in July. The company won the Health Tech Business category at the 2025 Houston Innovation Awards. Continue reading.

Veloci Running: Student-led startup runs away with prestigious prize at Rice competition

The H. Albert Napier Rice Launch Challenge awarded $100,000 in equity-free funding to student-led startups, including first-place finisher Veloci Running. Photo courtesy of Rice University.

Veloci Running took home the first-place prize and $50,000 at the annual Liu Idea Lab for Innovation and Entrepreneurship's H. Albert Napier Rice Launch Challenge. The company was founded by Tyler Strothman, a former track and field athlete and senior at Rice, majoring in sport management. Inspired by the foot pain he suffered due to the narrow toe boxes in his running shoes, Strothman decided to create a naturally shaped shoe designed to relieve lower leg tightness and absorb impact. Additional prize winners included SteerBio, Kinnections, Labshare and several others. Continue reading.

Square Robot Inc.: Houston robotics co. unveils new robot that can handle extreme temperatures

The new robot eliminates the need for humans to enter dangerous and toxic environments. Photo courtesy of Square Robot

Houston- and Boston-based Square Robot Inc.'s newest tank inspection robot became commercially available and certified to operate at extreme temperatures this fall. The new robot, known as the SR-3HT, can operate from 14°F to 131°F, representing a broader temperature range than previous models in the company's portfolio. According to the company, its previous temperature range reached 32°F to 104°F. The company also announced a partnership with downstream and midstream energy giant Marathon Petroleum Corp. (NYSE: MPC) last month. Continue reading.

Bot Auto: Houston autonomous trucking co. completes first test run without human intervention

Bot Auto completed its first test run without human assistance in Houston. Photo courtesy Bot Auto.

Houston-based Bot Auto, an autonomous trucking company, completed its first test run without human assistance earlier this year. Bot Auto conducted the test in Houston. The transportation-as-a-service startup added that this milestone “serves as a validation benchmark, demonstrating the maturity and safety of Bot Auto’s autonomy stack and test protocols.” This summer, founder Xiaodi Hou told the Front Lines podcast that Bot Auto had raised more than $45 million. Continue reading.

Nomad: Screen-free hiking app developed in Houston earns 'Best of the Best' award

NOMAD aims to help hikers stay in the moment while still utilizing technology. Photo courtesy UH.

An AI-powered, screen-free hiking system developed by Varshini Chouthri, a recent industrial design graduate from the University of Houston, received this year's Red Dot’s “Best of the Best” award, which recognizes the top innovative designs around the world. Known as NOMAD, the system aims to help users stay in the moment while still utilizing technology. Continue reading.

Little Place Labs, Helix Earth, Tempest Droneworx: Houston startups win big at SXSW 2025 pitch competition

Two Houston startups won the SXSW Pitch showcase in their respective categories. Photo via Getty Images

Houston had a strong showing at the SXSW Pitch showcase in Austin this year, with several local startups claiming top prizes in their respective categories.

Little Place Labs, a Houston space data startup, won the Security, GovTech & Space competition. Clean-tech company Helix Earth, which spun out of Rice University and was incubated at Greentown Labs, won in the Smart Cities, Transportation & Sustainability contest. Tempest Droneworx, a Houston-based company that provides real-time intelligence collected through drones, robots and sensors, won the Best Speed Pitch award. Continue reading.

6 Houstonians named to prestigious national group of inventors

top honor

Six Houston scientists and innovation leaders have been named to the National Academy of Inventors’ newest class of fellows. The award is the highest professional distinction awarded to academic inventors by the NAI.

The 2025 class is made up of 169 fellows who hold more than 5,300 U.S. patents, according to the organization. The group hails from 127 institutions across 40 U.S. states.

The Houston-based inventors are leading fields from AI to chemistry to cancer research.

“NAI Fellows are a driving force within the innovation ecosystem, and their contributions across scientific disciplines are shaping the future of our world,” Paul R. Sanberg, president of the National Academy of Inventors, said in a news release. “We are thrilled to welcome this year’s class of Fellows to the Academy. They are truly an impressive cohort, and we look forward to honoring them at our 15th Annual Conference in Los Angeles next year.”

The 2025 list of Houston-based fellows includes:

Vineet Gupta, Vice President for Innovation, Technology Development and Transfer at the University of Texas Medical Branch
Eva Harth, chemistry professor at the University of Houston
Dr. Raghu Kalluri, Professor and Chairman of the Department of Cancer Biology at The University of Texas MD Anderson Cancer Center
Sanjoy Paul, Executive Director of Rice Nexus and AI Houston and Associate Vice President for Technology Development at Rice University
Dr. Jochen Reiser, President of the University of Texas Medical Branch and CEO of UTMB Health System
Todd Rosengart, Professor and Chair of the Department of Surgery at Baylor College of Medicine

"It is a great honor to be named a Fellow of the NAI. It is deeply gratifying to know that the work my students and I do — the daily push, often in small steps — is seen and recognized," Harth added in a news release from UH.

The 2025 fellows will be honored and presented with their medals by a senior official of the United States Patent and Trademark Office at the NAI Annual Conference this summer in Los Angeles.

Money talks: Top Houston innovation grant and gift news of 2025

Year in Review

Editor's note: As 2025 comes to a close, we're looking back at the stories that defined Houston innovation in 2025. Below, we recap the biggest Houston innovation grant funding and gift news of the year:

Houston scores $120M in new cancer research and prevention grants

The Cancer Prevention and Research Institute of Texas has doled out 73 more grants to health care systems and companies in the state. Carter Smith/Courtesy of MD Anderson

In November 2025, the Cancer Prevention and Research Institute of Texas granted more than $120 million to Houston organizations and companies as part of 73 awards issued statewide. The funds were part of nearly $154 million approved by the CPRIT's governing board earlier that month, bringing the organization's total investment in cancer prevention and research to more than $4 billion since its inception.

TMC lands $3M grant to launch cancer device accelerator

Recent funding from CPRIT will help launch the new Accelerator for Cancer Medical Devices. Photo via TMC

In September 2025, a new business accelerator at Houston’s Texas Medical Center received a nearly $3 million grant from the Cancer Prevention and Research Institute of Texas. The CPRIT grant, awarded to the Texas Medical Center Foundation, will help launch the Accelerator for Cancer Medical Devices. The accelerator will support emerging innovators in developing prototypes for cancer-related medical devices and advancing them from prototype to clinical trials.

Houston foundation grants $27M to support Texas chemistry research

Houston's Welch Foundation has awarded more than 80 grants to support chemical research and careers in Texas for 2025. Photo via Getty Images

Houston-based The Welch Foundation doled out $27 million in its June 2025 round of grants for chemical research, equipment and postdoctoral fellowships. $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025.

Houston Methodist receives $25M gift, renames department of medicine

Houston Methodist will rename its department of medicine the Houston Methodist Charles W. Duncan Jr. Department of Medicine. Photo courtesy Houston Methodist.

In August 2025, Houston-based nonprofit The Duncan Fund awarded a $25 million gift to Houston Methodist's department of medicine to establish new endowed fellowships, streamline complex care and bring artificial intelligence into the fold to develop more personalized treatment plans. In turn, the health care system announced that it would rename the department the Houston Methodist Charles W. Duncan Jr. Department of Medicine.

Houston foundation doles out $700K for Texas chemical research

The Welch Foundation has awarded funding through two of its newest grant programs. Photo via Getty Images.

Houston-based The Welch Foundation issued $700,000 in additional funding in August 2025 to support chemical research through two of its newest grant programs. The foundation named the recipients of its Welch eXperimental (WelchX) Collaboration Retreat and Pilot Grants and the Welch Postdoctoral Fellows of the Life Sciences Research Foundation Grants. The WelchX grants were awarded to teams of two Texas researchers who presented "innovative and collaborative ideas" addressing challenges in the clean energy space, according to the foundation.

CPRIT grants $22M to bring top cancer researchers to Houston

CPRIT recently granted $93 million to 61 organizations and scientists, including many in Houston, to advance cancer research. Carter Smith/Courtesy of MD Anderson

In June 2025, it was announced that several prominent cancer researchers would be coming to the Houston area thanks to $22 million in grants awarded by the Cancer Prevention and Research Institute of Texas (CPRIT). The biggest CPRIT recruitment grant — $6 million — went to genetics researcher Jean Gautier. Gautier, a professor of genetics and development at Columbia University’s Institute for Cancer Genetics, joined the University of Texas MD Anderson Cancer Center to continue his research.

Baylor, Rice win $500,000 to launch humanities-driven health AI center

A new center being developed by Baylor College of Medicine and Rice University aims to develop ethically responsible and trustworthy AI for health care. Photo via Getty Images.

In August 2025, Baylor College of Medicine and Rice University announced they had been awarded a $500,000 grant from the National Endowment for the Humanities (NEH) to create the Center for Humanities-based Health AI Innovation (CHHAIN).

Baylor center receives $10M NIH grant to continue rare disease research

BCM's Center for Precision Medicine Models has received funding that will allow it to study more complex diseases. Photo via Getty Images

Baylor College of Medicine’s Center for Precision Medicine Models received a $10 million, five-year grant from the National Institutes of Health in November 2025, which will allow it to continue its work studying rare genetic diseases. The Center for Precision Medicine Models creates customized cell, fly and mouse models that mimic specific genetic variations found in patients, helping scientists to better understand how genetic changes cause disease and explore potential treatments.

Houston billionaire benefactors will donate almost entire fortune to charity

Pictured: Nancy and Richard Kinder. Photo by Michelle Watson/Catchlight Group

Houston billionaires Rich and Nancy Kinder announced plans to donate an astounding 95% of their multi-billion-dollar wealth to charities. The news came as the Kinder Foundation announced an $18.5 million expansion project for Emancipation Park in the heart of Third Ward. That historic park was founded by slaves in 1872.

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