4 Houston innovators to know this week

Who's who

This four Houstonians saw a need in their industries and — rather than accepting the status quo — found a solution. Courtesy photos

The crux of innovation is identifying a problem and using your skills to ideate a solution. Each of these four innovators had their "aha" moments that led to their research and development moments, and now to where they are today.

Smriti Agrawal Zaneveld and Jacques Zaneveld, founders of Lazarus 3D

Photo courtesy of Lazarus 3D

It seemed a little antiquated that surgeons were still practicing their techniques on various fruits. Baylor College of Medicine-educated Drs. Jacques Zaneveld and Smriti Agrawal Zaneveld founded Lazarus3D in 2014 to build a better training model — and layer by layer, they created models of abs and ribs and even hearts with a 3D printer.

"We adapted pre-existing 3D printing technology in a novel proprietary way that allows us to, overnight, build soft, silicone or hydrogel models of human anatomy," says Jacques, who serves as CEO. "They can be treated just like real tissue."

Read the full story here.

Guy de Carufel, founder and CEO of Cognitive Space

Photo courtesy of Guy du Carufel

Guy du Carufel knows that in just a matter of years, there will be so many satellites orbiting the early and collecting data, there's not going to be enough people to monitor them. And, frankly, people shouldn't have to. That's why du Carufel created an artificial intelligence-enabled, cloud-based technology that can track and manage each of these satellite clusters on behalf of the cluster's owner.

"We're currently at an inflection point where the satellite industry is expected to grow up to five folds in the next 10 years because of the large companies building up these satellites," du Carufel says. "There are around 2,000 satellites active right now, and that's expected to grow to over 10,000 in the next 10 years."

Read the full story here.

Jim Havelka, founder and CEO of InformAI

Photo courtesy of InformAI

Hospitals and medical centers can be tough places to keep track of data — but that doesn't have to be the case. Jim Havelka founded InformAI to help doctors and health care providers tap into their data to provide better diagnoses and preventative care.

"There were several things missing," says Havelka. "One was access to very large data sets, because it wasn't really until the last five or 10 years that digitalization of data, especially in the health care vertical became more widespread and available in a format that's usable. The second convergence was the technology, the ability to process very large data sets."

Houston celebrated 50 years since the Apollo moon landing on July 20. Here are some startups that are going to be a part of the next 50 years of space tech in Houston. Photo via NASA.gov

5 startups keeping Houston known as the Space City

space tech

This month, for the most part, has been looking back on the history Houston has as the Space City in honor of the 50th anniversary of the moon landing on July 20. While it's great to recognize the men and women who made this city the major player in space exploration that it is, there are still entrepreneurs today with space applications and experience that represent the future of the Space City.

From space tech to former NASA expert-founded companies, here are five companies keeping Houston's rep as the Space City.

Cemvita Factory

Cemvita Factory

Courtesy of Cemvita Factory

Carbon dioxide poses a problem for two major Houston-related industries: Oil and gas and Space. Cemvita Factory, which has a technology that can convert CO2 into other chemicals, has the potential to revolutionize both industries. The Houston startup is growing and Moji Karimi, who founded the company with his sister, Tara Karimi, says 2019 is all about execution.

"We're in Houston, and we have a technology that is from biotech and have applications in the space industry and the energy industry," Karimi says. "There would not have been any better place for us in the country than Houston."

Click here to read more about Cemvita Factory.

Re:3D

Courtesy of re:3D

Two NASA colleagues hung up their metaphorical space space suits to start a 3D-printing company. Six years later, re:3D had grown large enough to warrant a new, swankier space — just down the street from the Johnson Space Center.

The company makes an affordable and customizable 3D printer, called the Gigabot, and has clients across industries in over 50 countries. Recently, re:3D introduced sustainable options, including printing using plastic waste. The 7,000-square-foot space allows for anyone in the community to learn about the 3D printing process, tour the facility, attend social events or workshops, or even buy a printer or some of the company's merchandise.

Click here to read more about re:3D.

Cognitive Space

Pexels

Satellites are getting smaller and easier to launch, which has causing a significant growth in these devices entering earth's atmosphere. Former NASA specialist Guy de Carufel — through his company Cognitive Space — created a much-needed solution to managing satellites using cloud-based AI technology.

"By next year we will have major contracts, and growing our team to 15 to 20 people. We'll have a commercial product by then and servicing some commercial players," de Carufel says on his company's growth plan. "Five years from now, we'll probably be in many different verticals, spawning from what we have now to really expand and apply our systems to as many applications as possible."

Click here to learn more about Cognitive Space.

Zibrio

Pexels

Balance is extremely important for humans. Being off balanced can be an indicator of a bigger health issue or a warning sign not to attempt something dangerous. During her postdoctoral work, Katharine Forth and her colleagues at NASA developed a technology to help track balance for astronauts. They designed a compact tool that was a game changer.

"The machines typically used for balance measurement can be as large as a telephone booth, so we invented a new way to measure postural control using a much smaller mechanism that fit inside a moon boot," Forth says.

Forth evolved her technology to create a commercial product that allows for users to track their own balance for her Houston-based company, Zibrio. The startup has grown since its founding in 2015 and just this month worked with the 13,700 athletes at the National Senior Games. Zibrio measured the balance of the seniors aged 50 to 103 in order to make sure they were ready and healthy enough to compete without risking injury.

Click here to read more about Zibrio.

Blue Bear Capital

Courtesy of Tim Kopra

Tim Kopra spent over 244 days in space, and now he's using his tech background to invest in emerging energy companies with his Houston-based investment firm, Blue Bear Capital.

"On face value, it may sound like an odd match, taking someone with a tech and operational background and putting them in venture, but quite frankly it feels very familiar to me because my career has really been focused on working on complex technology and operations with very small teams," Kopra tells InnovationMap in a previous interview. "It's not just a theoretical understanding of the technology, but understanding how to use the technology and how it works."

Blue Bear Capital focuses on cutting-edge technology that has the potential to make waves in the oil and gas industry.

Click here to read more about Blue Bear Capital.

In a decade, there will be five times as many satellites as there is now, and we're going to need a better way of keeping track of them. Cognitive Space, lead by Guy de Carufel, has a solution. Courtesy of Guy de Carufel

Houston entrepreneur using cloud-based AI technology in space and satellite applications

Featured innovator

There are around 2,000 satellites up above our heads, but in the next 10 years, that figure will have surpassed 10,000. As the number of satellites goes up, it'll be harder for companies to manage them.

Houston-based Cognitive Space led by Founder and CEO Guy de Carufel recognizes this as an opportunity to engage artificial intelligence and cloud technology. De Carufel spoke with InnovationMap about his company, how it will grow, and the role Houston plays in the evolving space exploration industry.

InnovationMap: How did you come up with the idea for your company and technology?

Guy de Carufel: From my experience working at [JSC], I understand the traditional way of commanding spacecraft and how you interface with that from the ground station point of view. In the industry, it's changing very quickly in terms of new companies that are launching constellations of satellites. We're currently at an inflection point where the satellite industry is expected to grow up to five folds in the next 10 years because of the large companies building up these satellites. There are around 2,000 satellites active right now, and that's expected to grow to over 10,000 in the next 10 years.

With all these satellites, you're going to need to manage these assets. Having an operator look at each satellite is not going to cut it. It's not going to be enough for all these satellites. I've been investing and researching in AI technology and machine learning, and I came up with a different way of approaching the problem, and it's a cloud-based approach to [managing the satellites.]

IM: What got you interested in space initially?

GC: Just the excitement of the new frontier. It's still one of the only places that we have a lot of exploring to do, and that got me into space in general and then aerospace engineering, which I got my master's degree in.

IM: What are some of the challenges of introducing a new technology in such a rapidly changing industry?

GC: Traditionally, the aerospace industry is very conservative and doesn't adopt change very quickly. Especially from NASA's point of view and large corporations' point of view, it takes a lot of effort to implement changes — and there's reasons behind that. Space crafts are very expensive to launch and mistakes are very costly. The industry doesn't necessarily like to take too many risks, but that's changing quickly. Now, there are a lot of startups in what's called "new space." You have a lot of companies being funded by venture capital. These startups are willing to take a lot more risks.

IM: How is this growth in satellites going to affect things here on earth?

GC: One of the reasons there's been new interest in space is there are new market forces that are pushing the industry in new directions where you have new uses for space assets. One of them is obviously worldwide connectivity, so internet from space. You have a lot of companies investing billions into that.

The other market force is to have real-time insight into what's going on in the world through imagery. There's a need for tracking transportation and logistics, as well as farming and mining. All of this will have a profound impact on the economy in general.

Industrial IoT, which basically just means everything will be connected, and in order to operate these remote devices, you're going to have to have real-time knowledge of what's going on, and one of the ways to do that is with real-time imagery. It's not something that can be done with today's technology, and we want to be able to position ourselves to be able to enable that market trend.

IM: Has NASA changed with the times? Does it still have the same role in space exploration in "new space"?

GC: The role of NASA has changed over the years. It's changed from initially being a national pride to be the first on the moon and the astronauts were test pilots and the soldier type. When the space station came up and the shuttle program, astronauts became scientists and educators from all sorts of backgrounds. NASA has evolved considerably over the years, and now it is evolving again because of the changes in the industry. NASA will always be relevant, but now it does have to change in how it will play in this new economy. Commercial entities are going to be a large part of exploration, but NASA does have a role to play in setting the roadmap and logistics, as well as sharing the expertise it has from 60 years.

IM: Is Houston a good place for aerospace startups?

There's starting to be a strong startup ecosystem here, but the focus is still medical and oil and gas, much less so aerospace. I do hope that the community realizes that there's a lot of talent here for aerospace. If I were to suggest anything, it would be to have an accelerator program with a focus on space.

IM: Where is Cognitive Space at with its technology and business plan? What are some goals you have for the company?

GC: We're still very early. We're building up our product, and we have a functional prototype. We are in discussion with most major players in the industry and with various government entities.

By next year we will have major contracts, and growing our team to 15 to 20 people. We'll have a commercial product by then and servicing some commercial players. Five years from now, we'll probably be in many different verticals, spawning from what we have now to really expand and apply our systems to as many applications as possible.

IM: Who are Cognitive Space's clients?

GC: Our focus is on earth observation satellite companies — the companies that are developing small satellites with different sensors onboard to take imagery or different spectrum, say hyperspectral or optical. We're focused on that market. What we provide for them is this autonomous tasking solution for their earth observation systems.

We're starting with a niche market but it's growing very quickly. It's expected to grow to $8 billion industry in 5 years. But the technology we develop will be applicable to many different industries.

IM: What's next for Cognitive Space?

GC: We've been focused mostly on developing our prototype and validating the market, but we are looking for investment in a Seed round this year.

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Portions of this interview have been edited.

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Houston Intercontinental Airport's innovative upgrades ready for takeoff

coming soon

After almost five years of construction, passengers heading out of Bush Intercontinental Airport on October 22 will be the very first to experience the expanded, upgraded, and stylish Terminal D-West Pier, an expansion of the existing Terminal D.

The new terminal is part of a broader initiative, the IAH Terminal Redevelopment Program (ITRP), a $1.458 billion project aimed at modernizing the airport's international travel capabilities. ITRP is the single largest capital improvement project developed by Houston Airports and include the refresh of the existing Terminal D, completed in 2023; the expansion of Terminal D with a new D-West Pier, which will be completed this fall 2024; and a new International Central Processor, slated for winter of 2024 and summer of 2025. More than 3,000 people spent more than one million hours on the construction project.

Terminal D-West Pier features six new gates — D1 through D6 — that can simultaneously accommodate wide-body aircraft or converted to accommodate 10 narrow-body airplanes. The expanded terminal with its new capabilities supports increasing demand from passengers and airlines and should enhance the overall travel experience.

The new terminal is part of a broader initiative, the IAH Terminal Redevelopment Program (ITRP), a $1.458 billion project aimed at modernizing the airport's international travel capabilities. Photo courtesy of Houston Airports

In addition to adding 160,000-square-feet, the new wing also boasts eight new, Houston-inspired works by local artists. Those kind of details are why the Houston airport system won Best Airport Art & Entertainment Program in the prestigious Skytrax awards.

The airport's 250 newly-hired employees will work among 16 new retail and dining concessions concepts in the Terminal D-West Pier. Passengers can dine at Houston Supply Co., which opened last month. Local restaurants The Kitchen and The Annie, along with popular national brands Popeyes, Einstein Bros. Bagels, Jamba Juice, Be Relax, Jetero Market, Semi-Sweet Confectionary, and a Lego Store will open for business on October 22.

The new wing also boasts eight new, Houston-inspired works by local artists. Photo courtesy of Houston Airports

"We are focused on improving the overall passenger experience at the airport — from parking and traffic to providing modern terminals with the right amenities. This project is a major investment in our city's future," Houston Mayor John Whitmire said in a statement. "The newly expanded international terminal enhances Houston's reputation as a world-class city and provides a boost to our economy, supporting jobs and attracting more visitors from around the globe."

The new terminal offers a host of other amenities designed to make passengers' experiences more comfortable. They include a mother's room, a sensory room, a child's play area, and expanded men's, women's, and family restrooms. The restrooms utilize smart technology sensors that trigger soap and water. Door locks alert to whether a restroom stall is vacant or occupied and soft LED lighting accentuates floor-to-ceiling photography spotlighting Houston's natural beauty.

The new wing has 16 new retail and dining concessions concepts. Photo courtesy of Houston Airports

An International Arrivals corridor provides views of the airfield, the concourse, and large-scale photography inspired by Houston.

More than 500 modern and comfortable seats, including chairs, cushioned benches, and cozy loungers, featuring cup holders and charging capabilities, are present inside the terminal.

"We are excited to share this milestone with the residents of Houston," said Jim Szczesniak, director of aviation for Houston Airports. "The opening of the Terminal D-West Pier is a testament to the hard work and dedication of our team and our partners. This world-class facility will provide a seamless and efficient travel experience for millions of passengers each year. The new pier will provide the necessary capacity so that Houston can continue to attract more nonstop flights to cities around the globe."

New features include a mother's room, a sensory room, a child's play area, and expanded men's, women's, and family restrooms. Photo courtesy of Houston Airports

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This article originally ran on CultureMap.

12 health tech startups named to Houston accelerator's next bootcamp

onboarding

Twelve promising health tech startups have been selected for the annual bootcamp at the Texas Medical Center.

TMC's Accelerator for HealthTech selected 12 companies from around the world and across specialties for the opportunity. Following the bootcamp, TMC will move forward a selection of startups to join its accelerator.

"Houston, a thriving hub for innovation, is rapidly becoming the destination of choice for healthtech companies," reads a statement from TMC. "With the Texas Medical Center at its heart, the city offers unparalleled resources, cutting-edge research facilities, and a collaborative spirit that fosters growth. This environment not only attracts startups but also provides them with the necessary tools to navigate the complex landscape of healthcare commercialization."

Through the bootcamp, the participants will engage with advisors and industry experts, refine their business models, prepare for market entry, and have opportunities for collaboration with the TMC's member organizations.

The selected bootcamp companies, according to TMC, include:

  • Alyf, founded in Newport Beach, California, has developed a personalized cardiac care system that brings patients and providers together with real-time, AI-driven insights, enabling them to monitor, track, and improve cardiac health outcomes collaboratively.
  • Seoul, South Korea-based Deepmetrics leverages artificial intelligence to provide ICU smart care services that optimize medical device settings, such as mechanical ventilators, to reduce mortality and shorten the length of stay for critically ill patients worldwide.
  • EquityQuotient, from New York City, is a healthcare intelligence platform that automates compliance and provides actionable insights by aggregating public, private, and first-party data, using proprietary analytics to help leaders address disparities, improve outcomes, and lower care costs.
  • Also from New York City, Ethermed's AI-powered solution streamlines prior authorizations, eliminating up to 90 percent of auths and 70 percent of the labor involved. Ethermed requires no workflow changes, is fully auditable, and offers aligned incentives from a mission-driven, human-focused company.
  • Fibricheck, based in Hasselt, Belgium, transforms ordinary smartphones into regulated digital heart rhythm monitors, offering unparalleled access to cardiovascular diagnostics for patients and streamlined workflows for physicians.
  • Austin-based NearWave has developed a non-invasive, AI-powered handheld imaging device that can predict breast cancer therapy response within seven days.
  • Pragmaclin, founded in Newfoundland, Canada, developed a cutting-edge PRIMS (Parkinson’s Remote Interactive Management System) that leverages depth cameras and machine learning to monitor and assess Parkinson’s Disease symptoms, offering healthcare professionals remote and in-clinic insights to enhance treatment decisions.
  • Somnair, a Baltimore, Maryland, company, is developing a non-invasive neurostimulation oral appliance for treating obstructive sleep apnea, offering a sleek, retainer-sized device that provides an effective alternative to CPAP or invasive surgery for millions of patients.
  • Vancouver, Canada-headquartered Total Flow Medical is developing solutions to enhance the quality of care and life for patients requiring the use of a heart-lung machine during surgery or life support.
  • Tympulse, hailing from Dublin, Ireland, is commercializing TympanoColl, an innovative and disruptive solution for eardrum (Tympanic Membrane) repair in an outpatient setting through the ear canal.
  • Perth, Australia-based Vital Trace is developing a continuous lactate monitor for real-time, accurate detection of fetal distress.
  • New York City's WorkUp is a healthcare-specific talent pipeline management platform that connects students with tailored resources for their clinical career journey, providing personalized support as their needs evolve.

University of Houston-founded company secures $2.5M in NIH grant funding

all in the timing

You could say that the booming success of Houston biotech company CellChorus owes very much to auspicious TIMING. Those six letters stand for Time-lapse Imaging Microscopy In Nanowell Grids, a platform for dynamic single-cell analysis.

This week, CellChorus announced that the company, along with The University of Houston, has been awarded up to $2.5 million in funding from the National Center for Advancing Translational Sciences (NCATS) at the National Institute of Health. A $350,000 Phase I grant is already underway. Once predetermined milestones are achieved, this will lead to a two-year $2.1 million Phase II grant.

The TIMING platform was created by UH Single Cell Lab researchers Navin Varadarajan and Badri Roysam. TIMING generates high-throughput in-vitro assays that quantitatively profile interactions between cells on a large scale, particularly what happens when immune cells confront target cells. This has been especially useful in the realm of immuno-oncology, where it has demonstrated its power in designing novel therapies, selecting lead candidates for clinical trials and evaluating the potency of manufactured cells.

“By combining AI, microscale manufacturing and advanced microscopy, the TIMING platform yields deep insight into cellular behaviors that directly impact human disease and new classes of therapeutics,” says Rebecca Berdeaux, chief scientific officer at CellChorus. “The generous support of NCATS enables our development of computational tools that will ultimately integrate single-cell dynamic functional analysis of cell behavior with intracellular signaling events.”

Houston’s CellChorus Innovation Lab supports both the further development of TIMING and projects for early-access customers. Those customers include top-25 biopharmaceutical companies, venture-backed biotechnology companies, a leading comprehensive cancer center and a top pediatric hospital, says CEO Daniel Meyer.

CellChorus’s publications include papers written in collaboration with researchers from the Baylor College of Medicine, Houston Methodist, MD Anderson, Texas Children’s Hospital, the University of Texas and UTHealth in journals including Nature Cancer, Journal of Clinical Investigation and The Journal for ImmunoTherapy of Cancer.

The new Small Business Technology Transfer (STTR) award will specifically support the development of a scalable integrated software system conceived with the goal of analyzing cells that are not fluorescently labeled. This label-free analysis will be based on new AI and machine learning (ML) models trained on tens of millions of images of cells.

“This is an opportunity to leverage artificial intelligence methods for advancing the life sciences,” says Roysam. “We are especially excited about its applications to advancing cell-based immunotherapy to treat cancer and other diseases.”

The Houston-born-and-bred company couldn’t have a more appropriate home, says Meyer.

“Houston is a premier location for clinical care and the development of biotechnology and life sciences technologies. In particular, Houston has established itself as a leader in the development and delivery of immune cell-based therapies,” the CEO explains. “As a spin-out from the Single Cell Lab at the University of Houston, we benefit from working with world-class experts at local institutions.”

In May, the company received a similar $2.5 million SBIR grant from NCATS at the NIH. Also this summer, CellChorus's technology was featured in Nature Cancer.

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