University of Houston to install nanotech-coated air filters on campus to prevent COVID-19 spread

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UH is investing in a nanotechnology developed on its own campus that can help prevent the spread of COVID-19. Photo courtesy of University of Houston

A nanotechnology developed at the University of Houston is about to make a big difference right on campus.

UH's Facilities/Construction Management Preventive Maintenance team is working on a project that will install air filters that are nanocoated with a material that was first developed at the UH Technology Bridge. UH Professor of Physics Seamus Curran has an extensive background in nanotech, and, as he learned more about COVID-19 and how it spreads, he started nano-coating facemasks to make them more resistant to the small particles that enable the spread of the virus.

Originally developed for the construction business, Curran's coating material could also be used to create hydrophobic facemasks, Curran discovered, and he founded a spin off company, Curran Biotech, to develop his next pandemic-proof innovation: nano-coated air filters.

"The big thing for me when we were shut down was that people couldn't go to work or school. The country can't live that way — but you can't send people back to work in a world that's not safe," Curran said last October in an interview for the Houston Innovators Podcast. "How do you create a safer environment? That's the thing that really got me going in the beginning in the summer. We looked at filters."

Listen to Professor Curran on the Houston Innovators Podcast:

Curran, who says he's learned more about air filters than he ever cared to, realized that even the most expensive air filters can only protect from 10 to 25 percent of viruses. And most buildings' HVAC systems would have to be replaced completely to allow for these pricier, more protective filters. But Curran Biotech's Capture Coating can be used on existing filters and HVAC systems.

Air filters coated with Curran Biotech's sealant were then tested at the New York Family Court Building, by DCAS-Energy Management Division, and now, ahead of the fall semester, UH is implementing the innovation in all buildings that have less than MERV-13 rated filters.

Curran Biotech's sealant can be used on existing air filters and HVAC systems. Photo via UH.edu

This week's innovators to know in Houston includes Tim Neal of GoExpedi, Shay Curran of UH, and Arun Gir of iEducate. Photos courtesy

3 Houston innovators to know this week

Who's who

Editor's note: In today's Monday roundup of Houston innovators, I'm introducing you to three gentlemen representing a diverse set of industries — from nanotech and higher education to industrial e-commerce and education.

Tim Neal, CEO of GoExpedi

Tim Neal, CEO of Houston-based GoExpedi, shares how his company plans to scale following its recent series C closing. Photo by Colt Melrose for GoExpedi

Timing is everything, and Tim Neal says it's been a key factor in his company's success. GoExpedi acts as an Amazon of industrial business, basically. Just as the e-commerce platform has made online ordering easy, trackable, and fast, so has GoExpedi for industrial parts. And, thanks to companies like Amazon and on-demand ordering in general, this type of fast and reliable service is what everyone expects now.

"The labor pool in the oil and gas space in particular — 50 percent of it turn it over. Now you're no longer having these tradesmen who are 60-plus years old and walking encyclopedias. You have a younger workforce that's used to buying on eCommerce and their daily life. So, it's helping them by technical parts in a not technical way," Neal says in a Q&A with InnovationMap. "We just had a pool of clients who were more tech native and who had more familiarity with transacting online." Click here to read more.

Seamus Curran, CEO and founder of Integricote

University of Houston professor and entrepreneur, Seamus Curran, has pivoted amid the pandemic to use his nanotechnology expertise to help reduce the spread of COVID-19. Photo courtesy of Integricote

Seamus Curran's life went from juggling teaching, research, and running his startup from early morning to late at night every day to working and teaching from home when the pandemic hit. He started looking into the virus and realized his nanotechnology actually has a real application in protecting people. First, he started coating masks. Lately he's been working on a new line of protection.

"The big thing for me when we were shut down was that people couldn't go to work or school. The country can't live that way — but you can't send people back to work in a world that's not safe," Curran says in this week's episode of the Houston Innovators Podcast. "How do you create a safer environment? That's the thing that really got me going in the beginning in the summer. We looked at filters." Click here to read more and stream the episode.

Arun Gir, CEO of iEducate

Houston-based iEducate is connecting local tutors and mentors to students. Photo courtesy of iEducate

Now more than ever, young students need hands-on instruction to keep up in their studies, which for so many still are being conducted virtually. iEducate engages student mentors from the nearby University of Houston education program and graduating Alief ISD high school students to work alongside teachers to ensure that every child has the academic support needed to achieve their full potential.

"We are building on our unique range of educational support services that we have provided over the past to help schools advance student learning in these uncertain times," says Arun Gir, CEO of iEducate.

Gir says the coronavirus pandemic and the subsequent school closings have forced iEducate to adapt, just like many other teachers and educators. For the first time, they are offering a needs assessment to any school that is interested in working with them. Click here to read more.

Houston scientist taps nanotech in masks and air filters to use to prevent COVID-19 spread

HOUSTON INNOVATORS PODCAST EPISODE 52

For over a decade, Seamus Curran, a physics professor at the University of Houston, has worked on his nanotechnology coating substance. He first thought the innovation could be used on fabrics and textile coating, but he realized, once getting acquainted with the industry, he realized there wasn't an interest for a hydrophobic coating that could be used to prevent the spread of germs — at least, not yet.

"Like anything small startup company, one of the things you have to learn is you have to pivot — or you will die," says Curran, who had created his company Integricote (neé C-Voltaics) to take his innovation to market.

So pivot is what he did. Integricote now markets toward coating and sealing materials within the construction industry — wood, concrete, etc. — to protect from water damage and rotting. As Curran shares on this week's episode of the Houston Innovators Podcast, business was growing steadily. That is until COVID-19 hit.

His construction coating business slowed, much like the rest of business across the country, and classes at UH switched to online. Curran used this newfound time at home to dig deeper into the details of the virus, when an idea hit him.

"I learned the virus traveled in a wet medium," Curran says, "(our coating) is hydrophobic, meaning we can stop it from penetrating any fabrics."

Curran worked to create hydrophobic facemasks using his sealant, and the technology was lauded and covered by various news organizations. He created a new company under Integricote, called Curran Biotech, and he started thinking of the next pandemic-proof innovation he could create using his sealant.

"The big thing for me when we were shut down was that people couldn't go to work or school. The country can't live that way — but you can't send people back to work in a world that's not safe," Curran says. "How do you create a safer environment? That's the thing that really got me going in the beginning in the summer. We looked at filters."

Curran, learning more about air filters than he ever cared to, realized that even the most expensive air filters can only protect from 10 to 25 percent of viruses. And most buildings' HVAC systems would have to be replaced completely to allow for these pricier, more protective filters.

"So, you'd have to replace your equipment and your filter prices go up — and you're still not blocking the virus," Curran says.

Curran Biotech's solution is a spray coating that can be used on air filters to make them more protected from COVID-19 spread.

Curran shared more about his nanotechnology innovation — as well as his excitement for being named one of MassChallenge Texas's finalist within the 2020 Houston cohort — in the episode of the podcast. You can listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.

Houston researchers are working to provide COVID-19 solutions amid the pandemic. Getty Images

These 5 Houston-area research institutions have bright minds at work to battle COVID-19

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Since even the early days of COVID-19's existence, researchers all over the world were rallying to find a cure or potential vaccine — which usually take years to make, test, and get approved.

Houston researchers were among this group to put their thinking caps on to come up with solutions to the many problems of the coronavirus. From the testing of existing drugs to tapping into tech to map the disease, here are some research projects that are happening in Houston and are emerging to fight the pandemic.

Baylor College of Medicine evaluating potential COVID-fighting drug

Human Body Organs (Lungs Anatomy)

Baylor College of Medicine has identified a drug that could potentially help heal COVID-19 patients. Photo via bcm.edu

While Baylor College of Medicine has professionals attacking COVID-19 from all angles, one recent discovery at BCM includes a new drug for treating COVID-caused pneumonia.

BCM researchers are looking into Tocilizumab's (TCZ), an immunomodulator drug, effect on patients at Baylor St. Luke's Medical Center and Harris Health System's Ben Taub Hospital.

"The organ most commonly affected by COVID-19 is the lung, causing pneumonia for some patients and leading to difficulty breathing," says Dr. Ivan O. Rosas, chief of the pulmonary, critical care and sleep medicine section at BCM, in a news release.

TCZ, which has been used to successfully treat hyperimmune responses in cancer patients being treated with immunotherapy, targets the immune response to the coronavirus. It isn't expected to get rid of the virus, but hopefully will reduce the "cytokine storm," which is described as "the hyper-immune response triggered by the viral pneumonia" in the release.

The randomized clinical trial is looking to treat 330 participants and estimates completion of enrollment early next month and is sponsored by Genentech, a biotechnology company.

Texas A&M University leads drug testing

A Texas A&M University researcher is trying to figure out if an existing vaccine has an effect on COVID-19. Screenshot via youtube.com

A researcher from Texas A&M University is working with his colleagues on a short-term response to COVID-19. A vaccine, called BDG, has already been deemed safe and used for treatment for bladder cancer. BDG can work to strengthen the immune system.

"It's not going to prevent people from getting infected," says Dr. Jeffrey D. Cirillo, a Regent's Professor of Microbial Pathogenesis and Immunology at the Texas A&M Health Science Center, in a news release. "This vaccine has the very broad ability to strengthen your immune response. We call it 'trained immunity.'"

A&M leads the study in partnership with the University of Texas MD Anderson Cancer Center and Baylor College of Medicine in Houston, as well as Harvard University's School of Public Health and Cedars Sinai Medical Center in Los Angeles.

Texas A&M Chancellor John Sharp last week set aside $2.5 million from the Chancellor's Research Initiative for the study. This has freed up Cirillo's team's time that was previously being used to apply for grants.

"If there was ever a time to invest in medical research, it is now," Sharp says in the release. "Dr. Cirillo has a head start on a possible coronavirus treatment, and I want to make sure he has what he needs to protect the world from more of the horrible effects of this pandemic."

Currently, the research team is recruiting 1,800 volunteers for the trial that is already underway in College Station and Houston — with the potential for expansion in Los Angeles and Boston. Medical professionals interested in the trial can contact Gabriel Neal, MD at gneal@tamu.edu or Jeffrey Cirillo, PhD at jdcirillo@tamu.edu or George Udeani, PharmD DSc at udeani@tamu.edu.

"This could make a huge difference in the next two to three years while the development of a specific vaccine is developed for COVID-19," Cirillo says in the release.

Rice University is creating a COVID-19 map

Researchers at Rice University's Center for Research Computing's Spatial Studies Lab have mapped out all cases of COVID-19 across Texas by tapping into public health data. The map, which is accessible at coronavirusintexas.org, also identifies the number of people tested across the state, hospital bed utilization rate, and more.

The project is led by Farès el-Dahdah, director of Rice's Humanities Research Center. El-Dahdah used open source code made available by ESRI and data from the Texas Department of State Health Services and Definitive Healthcare.

"Now that the Texas Division of Emergency Management released its own GIS hub, our dashboard will move away from duplicating information in order to correlate other numbers such as those of available beds and the potential for increasing the number of beds in relation to the location of available COVID providers," el-Dahdah says in a press release.

"We're now adding another layer, which is the number of available nurses," el-Dahdah continues. "Because if this explodes, as a doctor friend recently told me, we could be running out of nurses before running out of beds."

Texas Heart Institute is making vaccines more effective

A new compound being developed at Texas Heart Institute could revolutionize the effect of vaccines. Photo via texasheart.org

Molecular technology coming out of the Texas Heart Institute and 7 HIlls Pharma could make vaccines — like a potential coronavirus vaccine — more effective. The oral integrin activator has been licensed to 7 Hills and is slated to a part of a Phase 1 healthy volunteer study to support solid tumor and infectious disease indications in the fall, according to a press release.

The program is led by Dr. Peter Vanderslice, director of biology at the Molecular Cardiology Research Laboratory at Texas Heart Institute. The compound was first envisioned to improve stem cell therapy for potential use as an immunotherapeutic for certain cancers.

"Our research and clinical colleagues are working diligently every day to advance promising discoveries for at risk patients," says Dr. Darren Woodside, co-inventor and vice president for research at the Texas Heart Institute, in the release. "This platform could be an important therapeutic agent for cardiac and cancer patients as well as older individuals at higher risk for infections."

University of Houston's nanotech health monitor

UH researchers have developed a pliable, thin material that can monitor changes in temperature. Photo via uh.edu

While developed prior to the pandemic, nanotechnology out of the University of Houston could be useful in monitoring COVID patients' temperatures. The material, as described in a paper published by ACS Applied Nano Materials, is made up of carbon nanotubes and can indicate slight body temperature changes. It's thin and pliable, making it ideal for a wearable health tech device.

"Your body can tell you something is wrong before it becomes obvious," says Seamus Curran, a physics professor at the University of Houston and co-author on the paper, in a news release.

Curran's nanotechnology research with fellow researchers Kang-Shyang Liao and Alexander J. Wang, which also has applications in making particle-blocking face masks, began almost 10 years ago.

This week's batch of Houston innovators includes Lawson Gow of The Cannon, Tracey Shappro of VISION Production Group, and Seamus Curran of the University of Houston. Photos courtesy

3 Houston innovators to know this week

who's who

Across industries, Houston innovation leaders, entrepreneurs, and innovators are coming up with creative solutions for the coronavirus or its subsequent challenges — from digital resources to reliable face masks.

This week's innovators to know shared their thoughts with InnovationMap on how the pandemic is affecting their industries.

Lawson Gow, founder of The Cannon

Innovation leaders have worked hard to advance its innovation infrastructure, and Lawson Gow doesn't want to see COVID-19 hold Houston back. Photo courtesy of The Cannon

Lawson Gow is confident his coworking and entrepreneurial-focused business will survive the COVID-19 pandemic, but he remarks on this week's episode of the Houston Innovators Podcast that there will be a significant shift in how the city's developing innovation districts present themselves.

"What's interesting is if you read the academic literature on innovation districts, it talks about density, collisions, interactions, and an ecosystem of swirling hustle and bustle of people interacting with each other," Gow says. "It reads like a how-to manual for how to spread disease."

Gow, who is the son of David Gow, owner of InnovationMap's parent company, Gow Media, joins the podcast to explain what he's closely watching throughout the pandemic. Click here to read more and stream the episode.

Tracey Shappro, CEO and founder of VISION Production Group

A Houston company focused on event production is helping its clients navigate a socially distant, increasingly digital time. Photo courtesy of VISION Production Group

Events and conferences across the world have been hit hard by the coronavirus as everyone focuses on staying home and socially distant. But for Tracey Shappro, CEO and founder of Houston-based VISION Production Group, who's worked for over a decade in event production, says she sees an opportunity to advance her clients' digital presences.

"We've got to leverage all of these ways to communicate that are not based on group experiences," she tells InnovationMap. "And I think this position is really going to help our clients make the right decisions and [allow them to] have options on how they want to communicate and engage their audiences."

Shappro sat down with InnovationMap to talk about how to use technology to make events virtual due to the coronavirus pandemic. Click here to continue reading.

Seamus Curran, professor of physics at the University of Houston

A new technology developed by the University of Houston's Seamus Curran is making a mask that's more resistant to viruses. Photo courtesy of the University of Houston

Seamus Curran is well-known for his work commercializing nanotechnologies, and he is pulling from his past to deal with a future demand. The professor is using a hydrophobic coating he developed nearly 10 years ago to improve the ability of surgical masks to protect against transmission of the virus.

The world is in dire need of more face masks, and Curran notes that standard masks are "somewhat porous, and especially if they get wet, they can allow the virus to penetrate." People infected with the virus, he adds, could spread it even through a mask, while people who aren't sick could still become infected, despite wearing a less-protective mask.

Curran is hoping his solution can prove to be much more effective at preventing the spread of the disease. Click here to continue reading.

The new technology from University of Houston could make any mask more resistant to viruses. Photo courtesy of Seamus Curran/Integricote

Physics professor at University of Houston puts nanotech to work to fight the spread of COVID-19

making better masks

The start of 2020, though most didn't know it at the time, meant a huge change to society. Though coronavirus didn't yet seem to be an issue for the United States, the world was entering into a new normal where wearing face masks in public is common and necessary to prevent the spread of COVID-19.

"We left normal in December," says Seamus Curran, a professor of physics at the University of Houston, "and, when everyone was planning their New Year's resolutions, little did we know that the old normal of before is gone. None of us saw that life passing away — and it was taken away by a bug 1,000 times smaller than lice. And like lice, it's going to be with us for a long time."

To that end, Curran, who is well-known for his work commercializing nanotechnologies, is pulling from his past to deal with a future demand. The professor is using a hydrophobic coating he developed nearly 10 years ago to improve the ability of surgical masks to protect against transmission of the virus.

It's no secret that good face masks are a dire, worldwide need. But Curran notes that standard masks are "somewhat porous, and especially if they get wet, they can allow the virus to penetrate." People infected with the virus, he adds, could spread it even through a mask, while people who aren't sick could still become infected, despite wearing a less-protective mask.

Curran calls N95 masks, "the gold standard, able to filter very small particles and offering better protection than standard surgical masks." But he notes that they are hard to manufacture, and global demand is for tens of millions of items. His work will make masks impervious to water, thus improving protection, he explains.

That means those who already own masks are in luck: Curran's team is planning to sell spray for the hydrophobic coatings so that people can apply it themselves at home or at work. "However, it's cheaper and far more effective to be able to apply it in large batch quantities that manufacturers can do," Curran adds.

The globally minded Curran has only one local requirement: "We will only sell to U.S. manufacturers that manufacture here in the U.S. It's not a limiting factor and may change in the future, but right now, I have to deal with my community here in Houston, Texas, and the U.S. It has to be my priority."

University of Houston's Dr. Seamus Curran. Photo courtesy of University of Houston

Curran and his team are working though the process to make sure their coatings are compliant with all federal rules. "Sometimes, this is making sure your materials are registered and allowed," he says. "Sometimes it's making sure the products follow relevant EPA and FDA guidelines. However, we are very close, as in weeks, and not some arbitrary academic timeline in the distant future."

He first launched a nanotechnology business in 2013, according to UH. His company, Integricote, based at the UH Technology Bridge, focuses on manufacturing sealers for masonry, wood, and concrete. The professor has developed nanotech coatings for fabrics since 2011, technology that he now is using to demonstrate a way to provide more protection against SARS and COVID-19.

Curran, who often says he hates to "play defense," hopes to get a jump on the virus spread with his new technology and take a proactive approach to a long-term issue. "Remember, H1N1 affected 61 million Americans and 12,500 people died from it between 2009 and 2010," he notes. "Do we think that's it? Did we think Ike was the last big hurricane to hit us, or do we expect more? Yet, we have compensated for this and found a way to be resilient and have a normal life."

Technical and scientific in his work, the passionate professor says he is galvanized by a simple, primal motive. "This is personal, this virus has threatened my family and I'm not sitting back, ideally, just letting this happen," Curran says. "I'm just like any other husband, father, son, brother, and uncle: I will do all I can to protect those dearest to me and I will not have it any other way."

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This article originally ran on CultureMap.

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Houston organizations launch collaborative center to boost cancer outcomes

new to HOU

Rice University's new Synthesis X Center officially launched last month to bring together experts in cancer care and chemistry.

The center was born out of what started about seven years ago as informal meetings between Rice chemist Han Xiao's research group and others from the Baylor College of Medicine’s Dan L Duncan Comprehensive Cancer Center at the Baylor College of Medicine. The level of collaboration between the two teams has grown significantly over the years, and monthly meetings now draw about 100 participants from across disciplines, fields and Houston-based organizations, according to a statement from Rice.

Researchers at the new SynthX Center will aim to turn fundamental research into clinical applications and make precision adjustments to drug properties and molecules. It will focus on improving cancer outcomes by looking at an array of factors, including prevention and detection, immunotherapies, the use of artificial intelligence to speed drug discovery and development, and several other topics.

"At Rice, we are strong on the fundamental side of research in organic chemistry, chemical biology, bioengineering and nanomaterials,” Xiao says in the statement. “Starting at the laboratory bench, we can synthesize therapeutic molecules and proteins with atom-level precision, offering immense potential for real-world applications at the bedside ... But the clinicians and fundamental researchers don’t have a lot of time to talk and to exchange ideas, so SynthX wants to serve as the bridge and help make these connections.”

SynthX plans to issue its first merit-based seed grants to teams with representatives from Baylor and Rice this month.

With this recognition from Rice, the teams from Xiao's lab and the TMC will also be able to expand and formalize their programs. They will build upon annual retreats, in which investigators can share unpublished findings, and also plan to host a national conference, the first slated for this fall titled "Synthetic Innovations Towards a Cure for Cancer.”

“I am confident that the SynthX Center will be a great resource for both students and faculty who seek to translate discoveries from fundamental chemical research into medical applications that improve people’s lives,” Thomas Killian, dean of the Wiess School of Natural Sciences, says in the release.

Rice announced that it had invested in four other research centers along with SynthX last month. The other centers include the Center for Coastal Futures and Adaptive Resilience, the Center for Environmental Studies, the Center for Latin American and Latinx Studies and the Rice Center for Nanoscale Imaging Sciences.

Earlier this year, Rice also announced its first-ever recipients of its One Small Step Grant program, funded by its Office of Innovation. The program will provide funding to faculty working on "promising projects with commercial potential," according to the website.

Houston physicist scores $15.5M grant for high-energy nuclear physics research

FUTURE OF PHYSICS

A team of Rice University physicists has been awarded a prestigious grant from the Department of Energy's Office of Nuclear Physics for their work in high-energy nuclear physics and research into a new state of matter.

The five-year $15.5 million grant will go towards Rice physics and astronomy professor Wei Li's discoveries focused on the Compact Muon Solenoid (CMS), a large, general-purpose particle physics detector built on the Large Hadron Collider (LHC) at CERN, a European organization for nuclear research in France and Switzerland. The work is "poised to revolutionize our understanding of fundamental physics," according to a statement from Rice.

Li's team will work to develop an ultra-fast silicon timing detector, known as the endcap timing layer (ETL), that will provide upgrades to the CMS detector. The ETl is expected to have a time resolution of 30 picoseconds per particle, which will allow for more precise time-of-flight particle identification.

The Rice team is collaborating with others from MIT, Oak Ridge National Lab, the University of Illinois Chicago and University of Kansas. Photo via Rice.edu

This will also help boost the performance of the High-Luminosity Large Hadron Collider (HL-LHC), which is scheduled to launch at CERN in 2029, allowing it to operate at about 10 times the luminosity than originally planned. The ETL also has applications for other colliders apart from the LHC, including the DOE’s electron-ion collider at the Brookhaven National Laboratory in Long Island, New York.

“The ETL will enable breakthrough science in the area of heavy ion collisions, allowing us to delve into the properties of a remarkable new state of matter called the quark-gluon plasma,” Li explained in a statement. “This, in turn, offers invaluable insights into the strong nuclear force that binds particles at the core of matter.”

The ETL is also expected to aid in other areas of physics, including the search for the Higgs particle and understanding the makeup of dark matter.

Li is joined on this work by co-principal investigator Frank Geurts and researchers Nicole Lewis and Mike Matveev from Rice. The team is collaborating with others from MIT, Oak Ridge National Lab, the University of Illinois Chicago and University of Kansas.

Last year, fellow Rice physicist Qimiao Si, a theoretical quantum physicist, earned the prestigious Vannevar Bush Faculty Fellowship grant. The five-year fellowship, with up to $3 million in funding, will go towards his work to establish an unconventional approach to create and control topological states of matter, which plays an important role in materials research and quantum computing.

Meanwhile, the DOE recently tapped three Houston universities to compete in its annual startup competition focused on "high-potential energy technologies,” including one team from Rice.

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This article originally ran on EnergyCapital.

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University of Houston to install nanotech-coated air filters on campus to prevent COVID-19 spread

who's house

3 Houston innovators to know this week