Fast-growing Houston tech firm leads dozens of local companies on Inc. 5000

growth report

Houston-based Action1 landed at No. 29 nationally and No. 1 in the software category in this year's Inc. 5000 ranking. Photo via Getty Images.

Dozens of Houston-area businesses appear in this year’s Inc. 5000 ranking of the 5,000 fastest-growing private companies in the U.S., with a security software provider capturing the region’s No. 1 spot on the list.

Landing at No. 29 nationally and No. 1 in the software category, the top-ranked Houston-area private company is Houston-based Action1. The company recorded median revenue growth of 7,188 percent from 2021 to 2024, according to the Inc. 5000.

It’s the first appearance on the Inc. 5000 list for Action1, founded in 2018.

Action1 produces patch management software. A patch, or fix, quickly repairs software to resolve functionality problems, improve security or add features, according to TechTarget.

“Modern organizations understand that proactive patch management is essential to staying ahead of today’s rapidly evolving threat landscape,” Mike Walters, co-founder and president of Action1, said in a news release. “Our continued hypergrowth reflects the increased demand for enterprise cybersecurity innovation. You can’t be just powerful and secure — you must also be simple to deploy and scale and cost-effective.”

Below are the Houston-area businesses that earned a ranking among the top 1,000 companies, including their industries and their three-year growth rate. To see the other Houston-area companies in the Inc. 5000, visit inc.com/inc5000/2025.

  • No. 29 Houston-based Action1, software (7,188 percent)
  • No. 49 Spring-based Bogey Bros Golf, retail (5,540 percent)
  • No. 84 Houston-based Turtlebox Audio, consumer products (3,818 percent)
  • No. 87 The Woodlands-based Allied Wealth, financial services (3,796 percent)
  • No. 319 Houston-based Strategic Office Support, business products and services (1,228 percent)
  • No. 324 Houston-based Novo Communications, security (1,212 percent)
  • No. 363 Houston-based OptiSigns, software (1,101 percent)
  • No. 385 Houston-based Cart.com, business products and services (1,053 percent)
  • No. 421 Houston-based Sydecar, financial services (962 percent)
  • No. 471 The Woodlands-based Acuity Technology Partners, IT services (869 percent)
  • No. 577 Stafford-based Dahnani Private Equity Group, real estate (718 percent)
  • No. 706 Houston-based Why Not Natural, consumer products (585 percent)
  • No. 709 Stafford-based Signarama Sugar Land, manufacturing (584 percent)
  • No. 744 Houston-based FINBOA, software (557 percent)
  • No. 747 Houston-based Amundson Group, human resources (557 percent)
  • No. 793 Houston-based Field Industries, manufacturing (533 percent)
  • No. 957 Friendswood-based Good Ranchers, food and beverage (448 percent)
  • No. 999 Houston-based ARIA Signs & Design, business products and services (428 percent)
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The Inc. 5000 list is out — here's how Houston faired this year. Photo by Natalie Harms

Houston boasts impressive presence on annual list of fastest-growing businesses

showing off

One hundred businesses in the Houston area — including the top-ranked company in Texas — have been named to the 2024 Inc. 5000 list of the country’s fastest-growing private companies.

The 2024 Inc. 5000 ranks companies based on their percentage growth in revenue from 2020 to 2023.

Topping the list of Houston-area companies on the list is The Woodlands-based Segment HR, which notched revenue growth of 7,353 percent. That growth rate earned Segment HR the No. 32 spot on the national list and the No. 1 ranking in Texas.

Founded in 2018 by former federal HR specialist Robin Scott, Segment HR specializes in providing HR support for federal agencies. The company employs remote HR specialists in 23 states and the District of Columbia.

Here’s the list of the top 25 Houston-area companies in the 2024 edition of the Inc. 5000, including each company’s headquarters city, growth rate, and national ranking:

  • Segment HR, The Woodlands, 7,353 percent, No. 32
  • Dhanani Private Equity Group, Stafford, 3,617 percent, No. 89
  • Realty.com, Houston 3,052 percent, No. 107
  • Turtlebox Audio, Houston, 1,913 percent, No. 209
  • Amundson Group, Houston, 1,306 percent, No. 332
  • Valiant Business Lending, Houston, 1,286 percent, No. 337
  • Strategic Office Support, Houston, 1,192 percent, No. 367
  • 10xTravel, Houston, 1,102 percent, No. 401
  • NOW Insurance, Houston, 797 percent, No. 559
  • Explore Group, Houston, 796 percent, No. 562
  • Specialty1 Partners, Houston, 728 percent, No. 631
  • FINBOA, Houston, 714 percent, No. 650
  • BroCoTec, Houston, 687 percent, No. 690
  • Elite Roofing, Houston, 675 percent, No. 706
  • Patriot Bolt, Humble, 641 percent, No. 757
  • CT Sounds, Houston, 624 percent, No. 789
  • Supreme Jewelers, Friendswood, 525 percent, No. 965
  • Dometik Commercial Construction, Cypress, 477 percent, No. 1,070
  • Vape City, Houston, 459 percent, No. 1,116
  • Highlands Construction, Houston, 451 percent, No. 1,132
  • Houston Tents and Events, Houston, 438 percent, No. 1,171
  • Goebel Fasteners, Houston, 385 percent, No. 1,340
  • Field Industries, Houston, 376 percent, No. 1,366
  • Coverflex Manufacturing, Houston, 365 percent, No. 1,410

“One of the greatest joys of my job is going through the Inc. 5000 list,” says Mike Hofman, editor-in-chief of Inc. magazine. “To see all of the intriguing and surprising ways that companies are transforming sectors, from health care and AI to apparel and pet food, is fascinating for me as a journalist and storyteller.”

Elsewhere in Texas:

  • Austin-based Maev led the Austin-area pack with a growth rate of 6,734 percent, earning the No. 38 spot on the national list.
  • Dallas-based Archer Review led the Dallas-area pack with a growth rate of 5,771 percent, earning the No. 46 spot on the national list.
  • LaVernia-based Begesh led the San Antonio-area pack with a growth rate of 1,111 percent, earning the No. 396 spot on the national list.
The sweaters may be ugly, but the success of Specialty1's team is gorgeous. Specialty1/Facebook

Houston company boasting 18,000-percent growth scores top spot on coveted Inc. 5000 list

winner, winner

Dozens of Houston-based companies have undergone explosive growth in revenue over the last few years, with one such business landing near the top of the prestigious 2023 Inc. 5000 list.

One Houston-based company, Specialty1 Partners, ranked No. 15 nationally, boasting an unimaginable 18,747 percent growth rate from 2019 to 2022. Founded in 2019 by a group of doctors, Specialty1 Partners is a specialty dental services provider focusing on endodontics, oral surgery, and periodontics.

In a press release celebrating their No. 15 spot, the company says it now has more than 350 specialists across 27 states, and over 220 practices.

"We are honored to be recognized by Inc. 5000 for our 3rd consecutive year," stated Daryl Dudum, founder and co-CEO of Specialty1 Partners. "Our tremendous growth reflects our core mission in serving our dental surgical specialists by providing the clinical autonomy they deserve and the business support they need."

While being No. 1 in Houston, Specialty1 Partners is also the fifth highest-ranked Texas business on the list, and No. 1 in the national dental industry. Austin-based CharterUp, an online marketplace specializing in real-time instant transportation booking, ranked No. 2 nationally and No. 1 in the state.

It's not the first award that Specialty1 Partners is celebrating this year. Dudum and his co-founder and co-CEO, Matthew Hadda, were named regional winners for the 2023 EY Entrepreneurs of the Year awards.

Companies on the 2023 Inc. 5000, released August 15, are ranked by percentage growth in revenue from 2019 to 2022. To qualify for the list, a company must have been founded and generating revenue by March 31, 2019. The company also must have been U.S.-based, privately held, for-profit, and independent as of December 31, 2022. The minimum revenue required for 2019 was $100,000; the minimum for 2022 was $2 million.

In all, 482 Texas-based companies made this year’s list, and 95 of those are Houston-based. The report says eight businesses are newly-founded, 59 are repeat honorees, and more than 9,400 jobs were added thanks to these companies.

The 10 remaining Houston-area businesses ranking among the top 500 include:

  • No. 81 – Hawthorne Capital, 5,574 percent growth rate
  • No. 89 – Valiant Capital, 5,223 percent growth rate
  • No. 162 – Intervene K-12, 3,207 percent growth rate
  • No. 205 – Mission Driven Meat & Seafood, 2,720 percent growth rate
  • No. 292 – BODY20, 1,931 percent growth rate
  • No. 360 – Cobalt Engineering and Inspections, La Marque, 1,588 percent growth rate
  • No. 383 – Jess Lea Boutique, Magnolia, 1,519 percent growth rate
  • No. 393 – Gasochem International, 1,469 percent growth rate
  • No. 441 – Supreme Jewelers, Friendswood, 1,315 percent growth rate
  • No. 489 – Just Made Foods LLC, 1,198 percent growth rate

Here are the other Texas companies appearing in the state’s top 20 are:

  • No. 2 – CharterUp, Austin, 111,130 percent growth rate
  • No. 4 – Green Light Distribution, Coppell, 41,090 percent growth rate
  • No. 13 – Blue Hammer Roofing, Dallas, 19,510 percent growth rate
  • No. 14 – eTrueNorth, Mansfield, 19,130 percent growth rate
  • No. 19 – Publishing.com, Austin, 16,497 percent growth rate
  • No. 85 – Archer Review, Dallas, 5,378 percent growth rate
  • No. 90 – Norwood, Austin, 5,189 percent growth rate
  • No. 104 – 24HourNurse Staffing, Pittsburg, 4,520 percent growth rate
  • No. 110 – Advantis Medical Staffing, Dallas, 4,302 percent growth rate
  • No. 112 – CloudServus, Austin, 4,215 percent growth rate
  • No. 144 – Maveneer, Dallas, 3,630 percent growth rate
  • No. 145 – Ashland Greene, Dallas, 3,617 percent growth rate
  • No. 152 – Physical Therapy Biz, Dallas, 3,542 percent growth rate
  • No. 155 – Curis Functional Health, Dallas, 3,444 percent growth rate
  • No. 175 – TimelyCare, Fort Worth, 3,015 percent growth rate
  • No. 180 – LeasePoint Funding Group, Austin, 2,920 percent growth rate
The full list of businesses can be found on inc.com.

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This article originally ran on CultureMap.

GoExpedi, an e-commerce software company, represents Houston's tech and startup ecosystem on this year's Inc. 5000. Image courtesy of GoExpedi

Houston e-commerce startup cracks Inc. 5000 — here's who makes the 2022 list

by the numbers

In the latest edition of its roundup of fastest growing privately held companies, Inc. magazine has recognized dozens of Houston organizations.

Houston startup GoExpedi, an industrial supply chain and analytics company, is the highest ranking local tech company on the list. GoExpedi ranked No. 675 in the 2022 edition of Inc. 5000, with a 924 percent growth rate between 2018 and 2021.

"The team at GoExpedi is honored to rank number 675 among America's Fastest-Growing Private Companies on the Inc. 5000 Annual List," says Tim Neal, CEO of GoExpedi, in a news release. "GoExpedi has grown exponentially since launching in 2017 due to our forward-thinking and innovative supply chain solutions."

Real estate firm Disrupt Equity is the overall top Houston performer, and the sole Houston company to break the top 200 in the report. The company charted an impressive 2,975 percent growth rate between 2018 and 2021. The firm pushes complete multifamily real estate investment offerings that are earmarked as able to achieve and even exceed projections, clearly a safe haven in one of the biggest — and hottest — real estate markets in the entire nation.

Disrupt claims an impressive ROI for clients: The company boasts a "proven track record with over a dozen full cycle exits averaging over 36 percent annualized return to investors," director of investor relations, Tarek Moussa, tells CultureMap.

"We could not be more ecstatic to hear that Disrupt Equity has been announced as the fastest growing company in Houston by Inc 5000," says Feras Moussa, Disrupt's managing partner, in a statement. "We believe success in real estate, especially in today's economic environment, comes from being a great operator and having a strong team behind you. We believe this has been a large contributor to our success and helps us to continue to provide incredible passive real estate investment opportunities to our investors."

Speaking of real estate, another Houston firm performed well. Construction Concepts, which specializes in commercial design and build in Houston and Austin, ranked No. 497 overall, with 1,251 percent growth over three years. 5111 VENTURES, listed as a full-service real estate brokerage firm specializing in technology-driven residential and commercial sales and consulting services, was No. 558 with 1125 percent growth over three years.

In all, 468 Texas-based companies made this year’s Inc. 5000. Dallas-Fort Worth firms performed especially well:

  • No. 13 StaffDNA, Plano, 19,699 percent growth rate
  • No. 17 Blue Hammer Roofing, Dallas, 15,911 percent growth rate
  • No. 116 TimelyMD, Fort Worth, 3,852 percent growth rate
  • No. 142 Curis Functional Health, Farmers Branch, 3,380 percent growth rate
  • No. 148 SmartLight Analytics, Plano, 3,317 percent growth rate
  • No. 168 Digital Thrive, Dallas, 3,056 percent growth rate
  • No. 172 Forester Haynie, Dallas, 2,984 percent growth rate

Here are the other Texas companies appearing in the state’s top 20 and in the top 500 overall.

  • No. 60 AdOutreach, Austin, 6,052 percent growth rate
  • No. 62 Webforce, Austin, 6,009 percent growth rate
  • No. 117 Homestead Brands, Austin, 3,839 percent growth rate
  • No. 174 Disrupt Equity, Houston, 2,975 percent growth rate
  • No. 188 24HourNurse Staffing, Pittsburg, 2,801 percent growth rate
  • No. 201, Everly Health, Austin, 2,643 percent growth rate
  • No. 209, Texas Solar Integrated, San Antonio, 2,559 percent growth rate
  • No. 212, Apple Blvd Boutique, Frisco, 2,555 percent growth rate
  • No. 285 Element 26, Austin, 1,948 percent growth rate
  • No. 312 Boostlingo, Austin, 1,820 percent growth rate
  • No. 317 Cover Desk, Austin, 1,800 percent growth rate
  • No. 325 Canopy Management, Austin, 1,758 percent growth rate
  • No. 497 Construction Concepts, Houston, 1,251 percent growth rate

Companies on the 2022 Inc. 5000 are ranked by percentage growth in revenue from 2018 to 2021. To qualify for the list, a company must have been founded and been generating revenue by March 31, 2018. The company also must have been U.S.-based, privately held, for-profit, and independent as of December 31, 2021. The minimum revenue required for 2018 was $100,000; the minimum for 2021 was $2 million.

"The accomplishment of building one of the fastest-growing companies in the U.S., in light of recent economic roadblocks, cannot be overstated," says Scott Omelianuk, editor in chief of Inc. "Inc. is thrilled to honor the companies that have established themselves through innovation, hard work, and rising to the challenges of today."

A total of 90 Houston-area companies made the list last year, including Homestead Brands, Onit, GoCo.io, Velentium, Softeq, Poetic, Techwave, and more.

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This article originally ran on CultureMap. Steven Devadanam and Natalie Harms also contributed to this story.

This Houston company is among the fastest-growing businesses in the state. Sean Pavone/Getty Images

Houston e-commerce company ranks as one of fastest-growing business in Texas, says Inc.

A Houston-based company is among the 100 fastest growing businesses in the nation.

Homestead Brands, an e-commerce business comprised of the Lori Wall Beds and Organic Swings brands, grew 3,916 percent from 2017 to 2020, according to the newly released Inc. 5000 list. That makes the Humble-based business the eighth-fastest-growing private company in Texas and the 98th nationally.

"We are a team of A players determined to build the kind of company we all wish we could have worked at from the start of our careers: a place where everybody is valued, challenged, and comes to work with a sense of purpose," Homestead Brands says on its website.

A total of 90 Houston-area companies made the list. Other tech companies making the cut includes Onit, GoCo.io, Velentium, Softeq, Poetic, Techwave, and more.

Companies on the 2021 Inc. 5000 are ranked according to percentage growth in revenue from 2017 to 2020. To qualify, companies must have been founded and generating revenue by March 31, 2017. They also must be U.S.-based, privately held, for-profit, and independent. The minimum revenue threshold for 2017 is $100,000; the minimum for 2020 is $2 million. Among the 5,000 companies on the list, the average median three-year growth rate stood at 543 percent, and median revenue reached $11.1 million.

"The 2021 Inc. 5000 list feels like one of the most important rosters of companies ever compiled," Scott Omelianuk, editor-in-chief of Inc., says in an August 17 news release. "Building one of the fastest-growing companies in America in any year is a remarkable achievement. Building one in the crisis we've lived through is just plain amazing. This kind of accomplishment comes with hard work, smart pivots, great leadership, and the help of a whole lot of people."

San Antonio-based Texas Solar Integrated took the top spot statewide and ranked 11th nationally with a growth rate of 22,381 percent. The company installs commercial and residential solar energy systems.

"At Texas Solar, we treat our customers like family. We believe that successful relationships with partners and homeowners alike develop through transparency and the trust for doing things right the first time," the company says on its website.

The top-ranked company from the Austin area is Empowering a Billion Women, landing at No. 28. The company, which does business as EBW Worldwide, focuses on social, health, and economic empowerment of women. The company saw three-year revenue growth of 10,676 percent.

"Access to opportunity, education, and a support system for success is key to breaking the historical biases that have previously held women back from reaching their fullest social, health, and economic potential," says Linda Pringle Evans, dean of The EBW Business School for Women.

In Dallas-Fort Worth, Pomerenke Holdings is the top-ranked company on the Inc. 5000. Holding down the No. 73 spot, the automotive remarketer grew 5,164 percent from 2017 to 2020.

"Being ranked 73rd in a tough economic year for so many demonstrates the outstanding work and dedication of our team and partners," says Joey Pomerenke, founder and CEO of Pomerenke Holdings.

Following are other Texas companies that made the top 200 in the Inc. 5000, along with their three-year growth rates:

49. Residential real estate platform OJO Labs, Austin, 6,767 percent
77. Book club operator Literati, Austin, 4,898 percent
79. Tea-by-the-box purveyor Sips by, Austin, 4,754 percent
87. YouTube ad platform AdOutreach, Austin, 4,515 percent
120. Staffing agency Rayne Staffing, Houston, 3,390 percent
141. Dental services provider Endo1 Partners, Houston, 2,936 percent
165. Healthcare consulting firm ReMedi Health Solutions, Houston, 2,547 percent
169. Mortgage lender NXT Mortgage, Coppell, 2,496 percent
196. Software provider Noblesoft Technologies, Irving, 2,200 percent

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This article originally ran on CultureMap.

From Houston heating up as a startup city to a new startup accelerator program launching, here are this week's top stories. Photo by Tim Leviston/Getty Images

5 most popular innovation stories in Houston this week

What's trending

Editor's note: It's hot in Houston — like, really hot. It's hard to think of doing anything, much less hustling like any good startup leader and entrepreneur. But of course, the startup show must go on. Top stories this week include some of those entrepreneurs, a new nonprofit accelerator program for women in health care, and more.

3 female Houston innovators to know this week

This week's innovators to know are all female leaders in different industries within Houston innovation. Courtesy photos

Female leaders play a huge role in the Houston innovation ecosystem. This week's innovators to know are all women — and are each representatives for different industries. From health care and nonprofits to education, meet this week's who's who of Houston innovation. Continue reading.

Houston oil and gas software exec eyes M&A activity following private equity deal

Travis Parigi, CEO of LiquidFrameworks, is excited about the new doors that have been opened for his company. Courtesy of LiquidFrameworks

Travis Parigi has built his software within his own company for about 14 years. Now, he's in a position to further develop his product at a faster rate.

In January, LiquidFrameworks entered into a partnership with private equity firm, Luminate Capital. The new financial partner has opened doors for Parigi and LiquidFrameworks — including putting merger and acquisition activity on the table.

"I have historically written stuff from the ground up, and we're going to continue to do that, but we want to give our customers more than that," Parigi tells InnovationMap. "And I've never had the opportunity to go out and strategically target opportunities where it makes sense to compliment the product. And I think that's going to be a very exciting thing to do." Continue reading.

Houston nonprofit launches accelerator program to give women-led startup a leg up within health care

Ignite Healthcare Network has hosted a pitch competition for a few years now, but this is the first year for its mini-accelerator program. Courtesy of Ignite

Within health care, female consumers make 80 percent of the buying power while women hold 65 percent of the workforce's jobs, according to a recent study. However, when you look at the C-suites in the industry, those percentages fall drastically, says Ayse McCracken.

"For as many women as there are involved in health care, it's not reflected in leadership," says McCracken, founder of Ignite Healthcare Network. "That's what brought us together."

Just 30 percent of health care C-suites are women — and only 13 percent have female CEOs, per the report by Oliver Wyman. Houston-based nonprofit Ignite is an organization comprised of over 150 of these rare female health care execs and focused on clearing a path for future female leaders in the industry. Continue reading.

Overheard: Experts weigh in on what the energy industry will look like in 2050 at Houston summit

From fossil fuels to clean and sustainable energy, here's what experts postulate the industry will look like in 2050. Natalie Harms/InnovationMap

There are a lot of things up in the air within the energy industry when you look at the next 40 years — clean energy, regulation regarding fossil fuels, carbon footprint, and so much more.

At the Society of Petroleum Engineers' inaugural SPE Dot Energy Leadership Summit, the big question was what does 2050 look like for the industry. Tasked with the discussion were three energy leaders — Deanna Zhang, energy tech investment banking associate at TudorPickering Holt & Co., Lees Rodionov, vice president of Global Stewardship at Schlumberger, and David R. Hall, managing director of Hall Labs — on a panel moderated by Gabriella Rowe, CEO of Station Houston. Continue reading.

National business magazine names Houston one of the 'hottest startup cities'

As a a part of its annual Inc. 5000 findings, the magazine named Houston the ninth hottest startup city in America. Photo by Tim Leviston/Getty Images

It's not just Texas' weather that's hot. Three Lone Star State cities made Inc. magazine's list of hot startups cities — and Houston came in at No. 9.

The list came out of the Inc. 5000 report — the magazine's list of the fastest-growing 5,000 privately-held companies in the United States. The list was ranked by the three-year revenue growth of each of the cities' companies.

Houston had a three-year revenue growth 117 percent with 84 Houston companies on the 2019 Inc. 5000 list. Continue reading.

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Houston's Ion District to expand with new research and tech space, The Arc

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Houston's Ion District is set to expand with the addition of a nearly 200,000-square-foot research and technology facility, The Arc at the Ion District.

Rice Real Estate Company and Lincoln Property Company are expected to break ground on the state-of-the-art facility in Q2 2026 with a completion target set for Q1 2028, according to a news release.

Rice University, the new facility's lead tenant, will occupy almost 30,000 square feet of office and lab space in The Arc, which will share a plaza with the Ion and is intended to "extend the district’s success as a hub for innovative ideas and collaboration." Rice research at The Arc will focus on energy, artificial intelligence, data science, robotics and computational engineering, according to the release.

“The Arc will offer Rice the opportunity to deepen its commitment to fostering world-changing innovation by bringing our leading minds and breakthrough discoveries into direct engagement with Houston’s thriving entrepreneurial ecosystem,” Rice President Reginald DesRoches said in the release. “Working side by side with industry experts and actual end users at the Ion District uniquely positions our faculty and students to form partnerships and collaborations that might not be possible elsewhere.”

Developers of the project are targeting LEED Gold certification by incorporating smart building automation and energy-saving features into The Arc's design. Tenants will have the opportunity to lease flexible floor plans ranging from 28,000 to 31,000 square feet with 15-foot-high ceilings. The property will also feature a gym, an amenity lounge, conference and meeting spaces, outdoor plazas, underground parking and on-site retail and dining.

Preleasing has begun for organizations interested in joining Rice in the building.

“The Arc at the Ion District will be more than a building—it will be a catalyst for the partnerships, innovations and discoveries that will define Houston’s future in science and technology,” Ken Jett, president of Rice Real Estate Company, added in the release. “By expanding our urban innovation ecosystem, The Arc will attract leading organizations and talent to Houston, further strengthening our city’s position as a hub for scientific and entrepreneurial progress.”

Intel Corp. and Rice University sign research access agreement

innovation access

Rice University’s Office of Technology Transfer has signed a subscription agreement with California-based Intel Corp., giving the global company access to Rice’s research portfolio and the opportunity to license select patented innovations.

“By partnering with Intel, we are creating opportunities for our research to make a tangible impact in the technology sector,” Patricia Stepp, assistant vice president for technology transfer, said in a news release.

Intel will pay Rice an annual subscription fee to secure the option to evaluate specified Rice-patented technologies, according to the agreement. If Intel chooses to exercise its option rights, it can obtain a license for each selected technology at a fee.

Rice has been a hub for innovation and technology with initiatives like the Rice Biotech Launch Pad, an accelerator focused on expediting the translation of the university’s health and medical technology; RBL LLC, a biotech venture studio in the Texas Medical Center’s Helix Park dedicated to commercializing lifesaving medical technologies from the Launch Pad; and Rice Nexus, an AI-focused "innovation factory" at the Ion.

The university has also inked partnerships with other tech giants in recent months. Rice's OpenStax, a provider of affordable instructional technologies and one of the world’s largest publishers of open educational resources, partnered with Microsoft this summer. Google Public Sector has also teamed up with Rice to launch the Rice AI Venture Accelerator, or RAVA.

“This agreement exemplifies Rice University’s dedication to fostering innovation and accelerating the commercialization of groundbreaking research,” Stepp added in the news release.

Houston team develops low-cost device to treat infants with life-threatening birth defect

infant innovation

A team of engineers and pediatric surgeons led by Rice University’s Rice360 Institute for Global Health Technologies has developed a cost-effective treatment for infants born with gastroschisis, a congenital condition in which intestines and other organs are developed outside of the body.

The condition can be life-threatening in economically disadvantaged regions without access to equipment.

The Rice-developed device, known as SimpleSilo, is “simple, low-cost and locally manufacturable,” according to the university. It consists of a saline bag, oxygen tubing and a commercially available heat sealer, while mimicking the function of commercial silo bags, which are used in high-income countries to protect exposed organs and gently return them into the abdominal cavity gradually.

Generally, a single-use bag can cost between $200 and $300. The alternatives that exist lack structure and require surgical sewing. This is where the SimpleSilo comes in.

“We focused on keeping the design as simple and functional as possible, while still being affordable,” Vanshika Jhonsa said in a news release. “Our hope is that health care providers around the world can adapt the SimpleSilo to their local supplies and specific needs.”

The study was published in the Journal of Pediatric Surgery, and Jhonsa, its first author, also won the 2023 American Pediatric Surgical Association Innovation Award for the project. She is a recent Rice alumna and is currently a medical student at UTHealth Houston.

Bindi Naik-Mathuria, a pediatric surgeon at UTMB Health, served as the corresponding author of the study. Rice undergraduates Shreya Jindal and Shriya Shah, along with Mary Seifu Tirfie, a current Rice360 Global Health Fellow, also worked on the project.

In laboratory tests, the device demonstrated a fluid leakage rate of just 0.02 milliliters per hour, which is comparable to commercial silo bags, and it withstood repeated disinfection while maintaining its structure. In a simulated in vitro test using cow intestines and a mock abdominal wall, SimpleSilo achieved a 50 percent reduction of the intestines into the simulated cavity over three days, also matching the performance of commercial silo bags. The team plans to conduct a formal clinical trial in East Africa.

“Gastroschisis has one of the biggest survival gaps from high-resource settings to low-resource settings, but it doesn’t have to be this way,” Meaghan Bond, lecturer and senior design engineer at Rice360, added in the news release. “We believe the SimpleSilo can help close the survival gap by making treatment accessible and affordable, even in resource-limited settings.”
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