Photos: The Cannon Houston's downtown space expects to open its doors early next month

ready for liftoff

The Cannon Houston's third location is planned to open on December 9. Photo courtesy of The Cannon

A Houston entrepreneurial hub plans to open its third coworking space location only a few weeks after its main campus debuted in West Houston.

The Cannon Houston's newest location will be a 17,000-square-foot space on the top floor of The Cannon Tower at Amegy on Main in Downtown Houston. The opening date for the new space is Monday, December 9.

The announcement follows the grand opening of The Cannon's 120,000-square-foot flagship space, which is now close to being completely leased by startups and small businesses, and represents another step in the company's ambitious expansion plan.

"We've long known that we will need multiple locations across Houston in order to serve our mission of supporting Houston's entrepreneurs, and we are thrilled to work with an incredibly forward-thinking organization like Amegy to continue to fulfill this mission," says Cannon founder and president, Lawson Gow, in a news release. "The Cannon Tower at Amegy on Main will be unlike any other space in the city, in which we will be developing a 'vertical village' of innovation, programs, and resources, transforming Amegy on Main into a hub for Downtown Houston's entrepreneurs."

Gow — who is the son of David Gow, owner of InnovationMap's parent company, Gow Media — recently transitioned into his position as The Cannon named Jon Lambert as CEO earlier this month.

The Cannon's space is just one part of the equation that is the Downtown Launch Pad — a joint project between Central Houston, Downtown Redevelopment Authority, The Cannon, and Amegy Bank. The Amegy building will also house MassChallenge and gener8or, as well as event and common space for programming on the 11th floor.

"Amegy Bank is thrilled to be a part of the expansion of the innovation community by offering space, amenities, and business development support," says Kelly Foreman, Amegy Bank's senior vice president and manager of corporate real estate and facilities, in a news release. "We have a long track record of helping businesses grow, and creating this space for a hub of start-ups and accelerators is yet another way to do just that."

Moving forward, The Cannon will play a role in expanding workspace, resources, and programming in the building. The space is now open for leasing, and the first 100 members to join the new space will receive free parking for the course of their membership.

Plans for growth

Photo courtesy of The Cannon

The Cannon Houston will be a major player as the Downtown Launch Pad expands throughout the building.

At The Houston Innovation Summit's first panel of the week, representatives from The Cannon, Amergy Bank, and Central Houston discussed game-changing plans for the Downtown Launch Pad. Image courtesy of The Cannon

3 takeaways from The Houston Innovation Summit's first panel

ICYMI

The Houston Innovation Summit is in full swing, and the first panel of the week's events started strong. Representatives from The Cannon Houston, Amegy Bank, and MassChallenge took the stage at Amegy Bank's downtown office — soon to be converted into the Downtown Launch Pad — to discuss big picture topics within Houston Innovation.

Grace Rodriguez hosted the panel that covered diversity and inclusion efforts, the growth of The Cannon, and what you can expect from Launch Pad. Here's what you may have missed from the event.

The Downtown Launchpad will shake up the innovation ecosystem

Robert Pieroni, director of economic development for Central Houston and an advisory board member for MassChallenge, set the scene for Houston innovation a few year ago. Houston was overlooked for the Amazon headquarters, and it was the wakeup call Houston needed.

Now, the city, with the help of organizations like Central Houston, has attracted major top 10 accelerators in the world to town and plans to house them in the same space — the Downtown Launch Pad, which is a joint venture project between Central Houston, Downtown Redevelopment Authority, The Cannon, and Amegy Bank.

The Launch Pad will occupy a few floors in the Amegy building to start. There will be coworking and event space, as well as a floor dedicated to MassChallenge and gener8tor — the two new-to-Houston accelerators.

"We'll be the only place in the United States that has co-located two top 10 accelerators," Pieroni says.

The project also is working with an incubator yet to be announced to help bring into the fold undeserved startups and entrepreneurs in Houston, and there will also be a bootcamp targeted directly at the disadvantaged within the innovation ecosystem.

From Amegy's perspective, the bank is committed to growing the building to being something unique and effective for startups, says Andy Buchmann, vice president of corporate real estate and property management at Amegy Bank.

"We are hopeful that this is only the first two floors that we have figured out, and we hope there are other three or four that come behind it as it grows into a real hub for startups in the years to come," Buchmann says.

The Cannon's new CEO has global growth on the mind

Earlier this month, The Cannon Houston brought on Jon Lambert to serve as CEO as the company plans to grow and scale. Lambert, who joined the panel, says that the Downtown Launch Pad was well timed for The Cannon as it's looking to find the optimal areas of the city to grow.

"The distribution of the city is unlike any other in terms of the pockets of where people live and work," Lambert says, adding that The Cannon has an opportunity to reach these pockets.

Looking beyond Houston — and even Texas, the company is poised for growth by taking its model to cities — nationally and even globally — that are underserved when it comes to coworking and incubation space.

"You'd be astonished at some of the people reaching out to us," Lambert says on the panel. Some of this interest, Lambert adds, is setting up The Cannon as a global entry point for international companies looking to do business in Houston.

Inclusivity is the priority

With global initiatives and with Houston being the most diverse city in America, the city's innovation ecosystem has a great responsibility to provide inclusion, and each of the panelists maintains that their organizations have that as a top priority.

The Launch Pad is being developed with this in mind, and Pieroni says it's in the perfect place to do that. Amegy Bank has long been committed to small businesses and the building's location — across the street from METRO's Downtown Transit Center — makes it so that anyone in Houston can get to the hub.

Gener8tor and MassChallenge are also committed to providing programming at no cost, which will open doors to the entire community to get involved.

"As a part of our agreement with gener8tor, the will host free lunch and learns with the community monthly," Pieroni says. "We are working with MassChallenge to make them even more frequent."

The Downtown Launch Pad will house accelerator programs MassChallenge and gener8tor and coworking space from The Cannon. Photo courtesy of Downtown Launch Pa

New innovation ‘vertical village’ announced for downtown Houston

Coming soon

The Cannon Houston, a startup incubator and coworking space, and Houston-based Amegy Bank announced a partnership to create a 17,000-square-foot innovation space in downtown.

The Downtown Launch Pad is expected to open on a few floors of the Amegy Bank building at 1801 Main St. in the spring. Along with coworking space, the new hub will house MassChallenge Texas, which had its inaugural cohort earlier this year, and gener8tor, an early acceleration program announced in last month.

Mayor Sylvester Turner announced the project at Central Houston Inc.'s annual meeting on October 24. Both the accelerators that will be in the new hub received a combined combined $4 million in economic development grants from the Downtown Redevelopment Authority to be distributed over the next five years.

"Central Houston and the Downtown Redevelopment Authority are committed to establishing Downtown Houston as a nexus for innovation and a leader in urban entrepreneurship," says Bob Eury, president of both entities, in a news release. "We've found strong, strategic partners in Amegy Bank and The Cannon, both of which are committed to fostering and sustaining a vibrant innovation culture in Houston, from startup to production."

Amegy Bank has tapped Gensler for the redesign. The 13th floor of the building will house the coworking space powered by The Cannon. This space is expected to open before the end of the year.

"We originally created The Cannon to be the missing piece in Houston's startup ecosystem," says Lawson Gow, founder and CEO of The Cannon and Cannon Ventures. Gow is the son of David Gow, owner of InnovationMap's parent company, Gow Media. "Through the Cannon Tower and The Downtown Launch Pad, we are excited to join up with Central Houston, the Downtown Redevelopment Authority and Amegy Bank to create an entire 'vertical village' of innovation—a system of floors at Amegy on Main that will provide Houston's entrepreneurs with all the programs and resources they need to thrive."

The building's 10th and 11th floors will also be a part of the Downtown Launch Pad. The 10th floor will house the two accelerators, and the 11th floor will be a dedicated event space. The lobby of the building will be a common space for all members of the Cannon Tower and will have meeting rooms, a game room, work stations, a coffee bar, and a deli.

"Amegy Bank has a long history of reinvesting in the local community and supporting Texas families and businesses," says Kelly Foreman, senior vice president and corporate real estate and facilities manager for Amegy. "Now, through our partnerships with The Cannon and The Launch Pad, we are taking our commitment to small businesses to the next level by converting a part of Amegy on Main into a hub for emerging technology and start-up companies that aligns all the players across the entrepreneurial spectrum—corporations, mentors, investors, service providers and the startups themselves. This combination of offerings and capabilities will unlock significant value for Downtown, helping to attract and retain companies from not only Houston, but from around the country."

The funds will go toward bringing a new, pre-accelerator program to Houston. Shobeir Ansari/Getty Images

Downtown Redevelopment Authority approves $1.25 million grant for new-to-Houston accelerator program

New to town

Houston has yet again attracted a nationally recognized accelerator program to downtown. Wisconsin-based genera8tor has announced its plans to launch its pre-accelerator program, gBETA, in Houston in spring of next year thanks to a $1.25 million grant approved by the Downtown Redevelopment Authority.

"With gener8tor joining nonprofit global accelerator MassChallenge in Downtown, the Houston innovation ecosystem will be home to two nationally ranked accelerators," says Bob Eury, president of Central Houston and the Downtown Redevelopment Authority, in a news release. "This agreement furthers Central Houston's long-term goal to create a collaborative Innovation District within Downtown and helps bridge the gap between small local startups and the city's growing innovation economy."

The grant will not exceed $1.25 million and will be paid out over the next five years. Gener8tor will have two gBETA cohorts a year, and the seven-week program will have a max of five teams across industries. The program will be equity-free and at no cost to participants accepted into the program. The program will also host six lunch-and-learn events that will be free and open to the Houston innovation ecosystem.

"The city of Houston's leadership is supporting its community members to be the economic drivers of tomorrow," says Abby Taubner, partner at gener8tor and managing director of gBETA, in the release. "We are humbled and excited to be part of the palpable excitement surrounding the local startup ecosystem, and cannot wait to roll up our sleeves and get to work."

According to gener8tor, a third of gBETA graduates will advance to a later stage equity-based accelerator program or raise a seed round of at least $50,000, and gBETA graduates from across the organization's eight states have collectively raised $57.7 million and created 716 jobs.

This announcement comes on the heels of MassChallenge Texas launching its Houston program earlier this year, as well as Silicon Valley's Plug and Play Technology Center entering the Houston market as well this year. Houston's downtown landscape has become a major hotbed for tech and innovation, with UiPath opening a major Houston office and coworking space popping up across downtown.

"Innovation is the next economic frontier for Houston, and gener8tor's gBETA program will help bridge the gap between the city's legacy industries—energy, medicine, space exploration and the port—and our growing innovation ecosystem of startup accelerators, investors and entrepreneurs," says Mayor Sylvester Turner in the release. "gBETA is the latest leap into that future, following in the exciting footsteps of The Ion innovation hub; the relocation or expansion of Silicon Valley firms to Houston such as Bill.com, UiPath and Google Cloud; the plans for the Texas Medical Center's TMC3 translational research commercialization campus; and so much more."

Midway's GreenStreet in downtown will be the site of MassChallenge Texas' Houston program. Photo via greenstreetdowntown.com

MassChallenge Texas announces the 26 companies in its inaugural Houston cohort

Startup studs

Since announcing its entrance into the Houston innovation market in January, MassChallenge Texas has been scoring the city — and the rest of the world — for the accelerator programs inaugural cohort. Now, the organization is ready to announce its 26 startups ahead of the program's July 22 launch.

The 26 companies come from three countries and six states, and half have female founders. The startups are mostly within the health care and high tech industries — eight companies reside in each of those categories. Two companies are energy related, and one company has a social impact focus. The remaining seven companies are categorized as "general," according to the release.

"We have an incredibly diverse cohort of startups for our first MassChallenge Texas in Houston program," says Jon Nordby, managing director of MassChallenge Texas in Houston, in the news release. "The startups cross five industries, where 50 percent of the startups come from outside of Houston bringing talent from innovation hubs like New York, San Francisco, and Switzerland. Proving that Houston's global reach is not just for the Fortune 500 and that startups are looking for their place in the global economy, something that Houston is uniquely suited to offer."

As a part of MassChallenge, the selected startups aren't asked for equity in order to participate, and free coworking space, more than $250K in deals and discounts, and more prizes await the top companies at the conclusion of the six-week programming.

Throughout the accelerator, MassChallenge will provide training, guidance, and corporate connections with a large network of companies, such as Southwest Airlines, TMAC, WeWork, USAA, Upstream, Central Houston, the City of Houston, Lionstone, Midway, BAE Systems, BHP, Ingram Micro, the San Antonio Spurs, and the Houston Texans. Houston-based Reliant, an NRG company, is the latest corporate partner to join those ranks, according to the release.

Over 280 companies applied for the program, says Robert Pieroni, director of economic development for Central Houston, in the release, a clear indication for him that the Houston program was a good decision for both the city and MassChallenge.

"When we set out to find a partner to support our innovation initiatives, we were seeking a catalyst for Houston's innovation ecosystem," Pieroni says in the release. "We knew we needed an organization that matched Houston's global reach and our passion for bringing creative ideas to life through business."

Without further adieu, here are the 26 companies that begin their MassChallenge journey on July 22:

  • AeroGenics (Iowa,)
  • AeroMINE (Texas,): AeroMINE is a motionless wind turbine created for the building environment. It installs like solar panels but is more cost effective.
  • Animatus Biosciences, LLC (Texas): Animatus Biosciences is an R&D company focusing on the development of unique regenerative therapeutics based on our modified mRNA platform.
  • Ask Doss (Texas): DOSS is a Real Estate Operations System (ReOS) that will radically simplify how people search (voice activated) and transact real estate.
  • Bell Analytics (Texas)
  • Bright Angle (Texas): Bright Angle is a Pinterest style activity platform for teachers, students, parents, and admins that is the "chalkboard" of the 21st century
  • Camppedia Inc. (Texas): Camppedia plans to disrupt the $18B children's camps industry and in the process improve the lives of millions of working parents.
  • Captain (Texas): Captain is a user-friendly, multi-sided platform that connects outdoor sports adventurers and guides.
  • Celise (Virginia): Celise is a compostable disposables company in the foodservice industry that aims to replace and eliminate single-use plastic waste.
  • Combined Arms [CAX-X] (Texas): Combined Arms is a forward-thinking nonprofit that is committed to unleashing the impact of veterans on Houston.
  • DoBrain (Republic of Korea): DoBrain is a children's diagnosis app that detects neuropsychological markers indicative of developmental delays.
  • Door Space Inc. (Texas): Door Space built a cloud-based platform that automates professional credential management and verification for clinicians and their employers.
  • ElecTrip (Texas): ElecTrip offers city-to-city, door-to-door transportation services in private-professionally driven Teslas with Wi-Fi and laptop charging. Book online to any major Texas-based city.
  • FloodFrame (Texas): FloodFrame is a concealed flood protection system that utilizes the natural buoyant force of water to deploy and protect your home.
  • Māk Studio (Texas): Māk Studio is a fabrication studio in the heart of Houston. We design and fabricate custom walls and furniture for commercial interiors.
  • NeuroRescue (Ohio): NeuroRescue improves the standard of care used to treat stroke, brain injury, and cardiac arrest to increase neurological outcome by up to forty-percent.
  • Noleus Technologies Inc. (Texas): Noleus is a novel medical device that reduces post op ileus, saves post op hospital days and accelerates patient recovery
  • ORDRS (Texas)
  • PTC Wizard (New York): PTC Wizard helps K-12 schools streamline their scheduling and sign-up process thereby improving parent involvement and decreasing overhead.
  • RehabMaker Corp. (California): Rehabmaker is a manufacturer of exercise equipment that attaches to wheelchairs and allows people to move their legs.
  • Reveal Technologies (Texas)
  • Sensytec Inc. (Texas): Sensytec is revolutionizing the oil & gas, and construction industries by bringing smart cement technologies and real-time data collection.
  • Swoovy (Texas): Swoovy is a mobile app that connects single people and volunteer opportunities with nonprofits, as a date.
  • Waterdata (Ticino, Switzerland): Waterdata offers Liquidprice, an Intelligent pricing software that optimizes prices with AI by adapting to customers, competitors and market behavior quickly.
  • WellWorth (Texas)
  • Zero5 (California)
Downtown Houston has over 100,000-square-feet of new coworking space expected to open by the end of 2020. Shobeir Ansari/Getty Images

These are the 3 downtown Houston coworking concepts expecting to deliver by end of 2020

Digesting downtown

Recently, Houston got a "needs improvement" on its coworking space report card — but the tide is changing as more and more coworking spaces plan to open in town — especially in the downtown sector.

Houston's current coworking space volume ranked it No. 15, according to a report from Colliers International, which fell behind Dallas and Austin. However, Houston has many future projects due to deliver in the next 18 months or so — including over 100,000 square feet of space in downtown alone.

Downtown has a slew of features that's made it attractive to coworking companies — public transportation, various retail and restaurant concepts, green spaces — but commercial real estate has typically been reserved for major corporations who can afford it, says Robert Pieroni, Central Houston's director of economic development.

"There's been a lot of new opportunities for companies — startups and companies who previously couldn't afford to be in the downtown market — to now be in the downtown market," Pieroni tells InnovationMap. "So, we've seen an influx of smaller companies particularly in the tech sector."

However, it's those major corporations sprinkled around downtown that have made Houston so attractive to startups and accelerators, Pieroni says, and these major corporations are willing to connect with entrepreneurs and startups.

"There's no difference on paper in our talent and the innovation hubs around the world," Pieroni says. "The one thing we have to offer startups that other places don't have to offer in Texas is we have the largest corporate presence in the state of Texas here in Houston."

The new coworking options are slowly changing the way commercial brokers approach leases for startups. Traditionally, brokers are wary of short-term leases.

"It's not because [the startups] are afraid they are going to go out of business," Pieroni says. "They're afraid that they are going to grow at such a rapid pace."

Two new-to-Houston tech companies opened offices in downtown Houston just this year. Oil and gas AI-enabled analytics platform, Ruths.ai, and global robotics company UiPath, which has a presence in 18 countries, moved into the Main&Co at 114 Main. And, Pieroni says, Central Houston expects more to come in that arena.

"We're having conversations daily with multiple companies that are evaluating coming to downtown Houston," he says.

Here's a breakdown of the three coworking spaces expecting to deliver in downtown Houston over the next 18 months.

Spaces brings second largest coworking space in downtown

Spaces, an Amsterdam-based coworking space company that entered the Houston market with a lease in Kirby Grove announced in 2017, has two more Spaces locations planned for end of 2019. Courtesy of Midway

Size: 63,000 square feet of workspace in repurposed retail space.

Estimated timeline: Opening later in 2019

Special features: Open space, smaller team rooms, private offices, phone booths, and a 3,000-square foot rooftop patio.

Other locations: Amsterdam-based Spaces has 3,300 flexible workspace locations across the world — another in Houston's Kirby Grove and one coming to Two Post Oak Central.

Overheard: "Spaces fits perfectly in GreenStreet, a mixed-use district that is being redeveloped as the new model of urban lifestyle," says Chris Seckinger, vice president and investment manager for Midway, in a release.

Life Time Work announces second Houston location

GreenStreet will soon have coworking space and a gym from Life Time. Courtesy of Midway Cos.

Square footage: 38,000 square feet of coworking space (additional 56,000 square feet of wellness space adjacent)

Estimated timeline: Opening in 2020.

Special features: Private offices, reserved desk, events, coffee, as well as other services.

Other locations: Last year, Minnesota-based Life Time Inc. opened its first location of Life Time Work in Pennsylvania as well as announced its second location headed to Houston's CIty Centre, which is expected to open later this year.

Overheard: "GreenStreet aligns well with our vision to meet the changing needs of consumers by bringing Life Time — through our athletic destinations and coworking space — as a lifestyle asset to bustling and successful developments," says Parham Javaheri, Minnesota-based Life Time's executive vice president of real estate and development, in a release. "We look forward to becoming an anchor to this new model of urban living in 2020."

Brookfield Properties' Houston Center renovation

Brookfield Properties is currently renovating Houston Center. One of the new amenities will be coworking space. Courtesy of Brookfield

Square footage: The total project is projected to be 4 million square feet, but it's unclear how much of that will be for the coworking aspect.

Estimated timeline: Construction should be concluded by late 2020.

Special features: A new central plaza and greenspace, a digital water wall, entertainment space, an iconic stair connection to new landscaped terraces, two-story glass façade, reclad skybridges, a new 10,000-SF fitness center, new dining and retail.

Other locations: Currently, Brookfield doesn't have any other coworking locations in Houston.

Overheard: "Brookfield continues to look to the future by transforming another of their Downtown properties into an amenity-rich development. This progressive, strategic shift accommodates the blurred lines of today's live-work-play corporate culture that tenants desire," says Bob Eury, Downtown District president, in a release. "In addition, the re-imagining of Houston Center and McKinney Street will add to Downtown's list of attractions creating a bustling linear space lined with restaurants, nightlife, parks and landscaping, connecting Main Street to Discovery Green and Avenida Houston."


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NASA unveils Artemis III astronauts at Johnson Space Center in Houston

To the moon

NASA on Tuesday, June 9, revealed the crew for its Artemis III mission, the next step in the space agency's plan to eventually land astronauts on the moon.

The announcement came two months after Artemis II's record-breaking trip around the moon that surpassed the distance record of Apollo 13.

NASA's Randy Bresnik, Frank Rubio, Andre Douglas and the European Space Agency's Luca Parmitano won't fly to the moon or land on the surface. Instead, they’ll orbit Earth while practicing docking their Orion capsule with two lunar landers.

“To the Artemis III crew, we wish you Godspeed on the journey ahead,” said NASA administrator Jared Isaacman.

Elon Musk’s SpaceX and Jeff Bezos’ Blue Origin are racing to deliver the lunar landers. The two-week demo is targeted for 2027. Blue Origin suffered a recent setback when its massive rocket exploded during an engine-firing test on the launch pad in Florida, shaking nearby homes and illuminating the sky with an orange fireball.

NASA's Jeremy Parsons said the setback is a learning opportunity and that the space agency is confident Blue Origin's rocket will be ready in time.

NASA's Artemis program aims to return astronauts to the moon's surface for the first time since the 1970s. A recent revamp of the program announced by Isaacman aims to fast-track it similarly to the Apollo era, adding the upcoming spaceflight around Earth before eyeing a lunar landing in 2028.

“We are certainly humbled as a crew to be able to be your crew that executes this Artemis III mission in space,” said Bresnik, Artemis III commander.

Added Douglas, mission specialist: “My brain — it is going a mile a minute right now. But my heart, it is so warm. It is so full."

In May, NASA awarded hundreds of millions of dollars in contracts to four companies, including Blue Origin, to build landers, rovers and drones for a future moon base. Isaacman said the goal of the moon base is to lay the foundation for a Mars expedition.

Meta to bring $115 million AI data center training initiative to Houston

ai workforce

Meta and Associated Builders and Contractors have entered into a partnership to invest $115 million in training programs for the construction of AI data centers, with a portion of the project launching in Houston.

The companies announced June 8 that they would open America’s Workforce Academies at ABC chapter training centers in Houston; Indianapolis; Baton Rouge, Louisiana; and Columbus, Ohio.

The academies will offer career readiness and safety training, plus five weeks of hands-on education. Participants who complete the program will be granted a job offer from contractors working on Meta projects.

“The AI revolution is bringing change but also historic opportunities,” Dina Powell McCormick, Meta president and vice-chairman, said in a news release. “Skilled workers electrified rural America one pole at a time. They manned the factories that built the arsenal that won World War II. Now a new generation will pour the foundations and lay the fiber that secures American strength in this new age.”

Overall, the Meta and ABC aim for the academies to build a more sustainable pipeline of skilled construction workers and ensure safety and job readiness for the surging number of data center projects underway.

“This new program is an innovative talent solution that is a critical part of addressing the construction industry’s ongoing workforce shortage and creates an accelerated, new-entrant strategy for job seekers ... The sustained demand for data center construction technicians means the industry needs an all-of-the-above approach to address this shortage and grow the construction talent pool,” Michael Bellaman, ABC president and CEO, added in the release.

In Texas, Meta, the parent company of Facebook and Instagram, has launched or broken ground on data centers in El Paso, Fort Worth and Temple. The company announced in March that it planned to grow its El Paso Data center by 1 gigawatt, representing more than a $10 billion investment.

Apart from Meta, Texas has attracted data center development to power other giants like Google and Amazon in recent years. In turn, Texas has been predicted to become the biggest data center market. Commercial real estate services provider JLL reported this spring that the state could topple Northern Virginia as the world’s largest data-center market by 2030. Similarly, CBRE predicted that Houston's data center capacity could double by 2028. Read more here.

New Houston biotech co. lands $30M for pulmonary fibrosis drug

drug money

Most of us can claim a scar or two on our bodies. But when scarring develops inside the body, it’s known as a fibrotic disorder. A freshly launched Houston company, Oorja Bio Inc., is working on a treatment that can help to repair cells and reduce the damage wrought by the growth of fibrotic tissue in patients.

Late last month, Oorja Bio hit the scene with a pair of big announcements. Not only has the company raised a $30 million Series A thanks to founding investor California-based Westlake BioPartners, but it has also already paved the way for a Phase 2 study to take place this year.

Oorja Bio received Investigational New Drug (IND) clearance from the U.S. Food and Drug Administration (FDA), allowing the company to test its treatment in patients with idiopathic pulmonary fibrosis (IPF), a scarring of the lung tissue. IPF affects more than 150,000 adults in the United States and can result in a range of symptoms from shortness of breath to organ failure and death as it progresses.

Oorja Bio’s lead drug candidate, ORJ-001, was shown in a Phase 1 in-human trial to demonstrate “therapeutically relevant exposure and favorable tolerability” in 64 healthy adult volunteers in whom it was administered daily or weekly, according to a news release. Pre-clinical studies of ORJ-001 showed durable target tissue engagement and biomarker activity in bleomycin-induced lung fibrosis.

Administered subcutaneously, ORJ-001 is intended to improve and even restore function in cells that can reduce the signaling that causes IPF. It stops advancement of IPF and also allows for tissue repair. Currently available treatments for the disease can slow the development of IPF down, but do not address the declining lung function that’s inherent in its progression.

“The clinical and preclinical results from our studies to date give us confidence that ORJ-001 represents a novel treatment approach with the potential to repair and reverse fibrosis and modify disease progression in IPF,” Dr. Janethe Pena, CMO of Oorja Bio, said in the release.

“Our team is energized to deliver on our goal of redefining the future of fibrotic diseases, beginning with ORJ-001,” CEO and founder Sujay Kango added. “As we advance ORJ-001 in the clinic, we are embracing the paradigm shift in our biological understanding of IPF pathology that aligns with the central role of the alveolar epithelium. ORJ-001 was designed with this biology in mind and may provide, for the first time, a therapeutic intervention that repairs and reverses fibrosis and promotes disease modification.”

Most patients live only three to five years following their IPF diagnosis. Soon, ORJ-001 and Oorja Bio could give them a fighting chance.

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