Brain teasers

3 ways University of Houston researchers are innovating brain treatments and technologies

Three UH researchers are revolutionizing the way we think the brain works. Andriy Onufriyenko/Getty Images

While a lot of scientists and researchers have long been scratching their heads over complicated brain functionality challenges, these three University of Houston researchers have made crucial discoveries in their research.

From dissecting the immediate moment a memory is made or incorporating technology to solve mobility problems or concussion research, here are the three brain innovations and findings these UH professors have developed.

Brains on the move

Professor of biomedical engineering Joe Francis is reporting work that represents a significant step forward for prosthetics that perform more naturally. Photo courtesy of UH Research

Brain prosthetics have come a long way in the past few years, but a UH professor and his team have discovered a key feature of a brain-computer interface that allows for an advancement in the technology.

Joe Francis,a UH professor of biomedical engineering, reported in eNeuro that the BCI device is able to learn on its own when its user is expecting a reward through translating interactions "between single-neuron activities and the information flowing to these neurons, called the local field potential," according to a UH news release. This is all happening without the machine being specifically programmed for this capability.

"This will help prosthetics work the way the user wants them to," says Francis in the release. "The BCI quickly interprets what you're going to do and what you expect as far as whether the outcome will be good or bad."

Using implanted electrodes, Francis tracked the effects of reward on the brain's motor cortex activity.

"We assume intention is in there, and we decode that information by an algorithm and have it control either a computer cursor, for example, or a robotic arm," says Francis in the release.

A BCI device would be used for patients with various brain conditions that, as a result of their circumstances, don't have full motor functionality.

"This is important because we are going to have to extract this information and brain activity out of people who cannot actually move, so this is our way of showing we can still get the information even if there is no movement," says Francis.

Demystifying the memory making moments

Margaret Cheung, a UH professor, is looking into what happens when a memory is formed in the brain. Photo courtesy of UH Research

What happens when a brain forms a new memory? Margaret Cheung, a UH professor in the school of physics, computer science, and chemistry, is trying to find out.

Cheung is analyzing the exact moment a neuron forms a memory in our brains and says this research will open doors to enhancing memory making in the future.

"The 2000 Nobel laureate Eric Kandel said that human consciousness will eventually be explained in terms of molecular signaling pathways. I want to see how far we can go to understand the signals," says Cheung in a release.

Cheung is looking at calcium in particular, since this element impacts most of cellular life.

"How the information is transmitted from the calcium to the calmodulin and how CaM uses that information to activate decisions is what we are exploring," says Cheung in the release. "This interaction explains the mechanism of human cognition."

Her work is being funded by a $1.1 million grant from the National Institute of General Medical Science from the National Institutes of Health, and she's venturing into uncharted territories with her calcium signaling studies. Previous research hasn't been precise or conclusive enough for real-world application.

"In this work we seek to understand the dynamics between calcium signaling and the resulting encoded CaM states using a multiphysics approach," says Cheung. "Our expected outcome will advance modeling of the space-time distribution of general secondary messengers and increase the predictive power of biophysical simulations."

New tech for brain damage treatment

Badri Roysam, chair of the University of Houston Department of Electrical and Computer Engineering, is leading the project that uncovering new details surrounding concussions. Photo courtesy of UH Research

Concussions and brain damage have both had their fair shares of question marks, but this UH faculty member is tapping into new technologies to lift the curtain a little.

Badri Roysam, the chair of the University of Houston Department of Electrical and Computer Engineering, is heading up a multimillion-dollar project that includes "super microscopes" and the UH supercomputer at the Hewlett Packard Enterprise Data Science Institute. Roysam calls the $3.19 million project a marriage between these two devices.

"By allowing us to see the effects of the injury, treatments and the body's own healing processes at once, the combination offers unprecedented potential to accelerate investigation and development of next-generation treatments for brain pathologies," says Roysam in a release.

The project, which is funded by the National Institute of Neurological Disorders and Stroke (NINDS), is lead by Roysam and co-principal investigator John Redell, assistant professor at UTHealth McGovern Medical School. The team also includes NINDS scientist Dragan Maric and UH professors Hien Van Nguyen and Saurabh Prasad.

Concussions, which affect millions of people, have long been mysterious to scientists due to technological limitations that hinder treatment options and opportunities.

"We can now go in with eyes wide open whereas before we had only a very incomplete view with insufficient detail," says Roysam in the release. "The combinations of proteins we can now see are very informative. For each cell, they tell us what kind of brain cell it is, and what is going on with that cell."

The technology and research can be extended to other brain conditions, such as strokes, brain cancer, and more.

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Building Houston

 
 

The latest cohort from gBETA Houston has been announced and is currently underway at the Downtown Launchpad. Photo courtesy

A national startup accelerator has announced its fifth local cohort, which includes five Houston companies participating in the spring 2022 class.

Madison, Wisconsin-based gener8tor has announced today the five participating startups in gBETA Houston. The program will be led by Muriel Foster, the newly named director of gBETA Houston, which originally launched in Houston in 2020 thanks to a grant from from the Downtown Redevelopment Authority.

The program, which is designed to help guide early-stage startups find early customer traction, connect with mentors, and more, is based in the Downtown Launchpad, and is free and does not take equity in the participating companies. The cohort kicked off on April 21 and concludes on June 10.

The new cohort includes:

  • Founded by CEO Steffie Thomson a year ago, Getaway Sticks has designed a shoe that gives women the painless support they need using athletic foam to create a shoe that gives women the painless support they need. Getaway Sticks provides the solutions to women’s #1 wardrobe complaint of high heel pain. Since launch, the company has earned over $35,000 in revenue from over 150 customers.
  • Through a combination of software and hardware technology, LocBox is rethinking the shopping experience for online and local purchases. If you shop, ship, or have food delivered to your house, LocBox will make your life easier. Led by CEO Sterling Sansing, LocBox has previously participated in the Texas A&M MBA Venture Challenge.
  • SpeakHaus is focused on equipping young professionals and entrepreneurs with public speaking skills through its on-demand training platform and group coaching program. Since launching in October 2021, SpeakHaus has facilitated 6 corporate trainings and coached 61 business leaders generating over $49,000 in revenue. The company is led by CEO Christa Clarke.
  • Led by CEO LaGina Harris, The Us Space is creating spaces intentionally for women of color, women-led businesses, and women-centric organizations. Since launching in June 2021, The Us Space has created partnerships with more than a dozen community organizations, sustainable businesses, and organizations creating positive economic impact in the City of Houston.
  • Founded in August 2021, Urban Eatz Delivery is a food delivery service app that caters to the overlooked and underrepresented restaurants, food trucks, and home-based food vendors. Urban Eatz Delivery has earned over $88,000 in revenue, delivered to over 2,000 users, and worked with 36 restaurant and food vendors on the app. The company is led by CEO D’Andre Good.

“The five companies selected for the Spring 2022 cohort tackle unique problems that have propelled them to create a business that solves the issues they once faced," Foster says in a news release. "From public speaking, apparel comfort, and food delivery from underrepresented restaurant owners, these founders have found their niche and are ready to continue to make an enormous impact on the Houston ecosystem."

it's Foster's first cohort at the helm of the program. A Houston native, she has her master’s in public administration from Texas Southern University and a bachelor’s in marketing from Oklahoma State University. Her background includes work in the nonprofit sector and international business consulting in Cape Town, South Africa, and she's worked within programming at organizations such as MassChallenge, BLCK VC, and now gener8tor.

The program is housed at the Downtown Launchpad. The five startups will have access to the space to meet with mentors, attend events, and run their companies.

"Creating (the hub) was a little like a moonshot, but it’s paying off and contributing enormous impact to the city’s economy. The five startups selected for the gBETA Houston Spring cohort will continue that legacy,” says Robert Pieroni, director of economic development at Central Houston Inc., in the release. “As these entrepreneurs chase their dreams and create something epic, they will know Downtown Houston is standing behind them. I am so proud of what Downtown Launchpad is already, and what it will become.”

Muriel Foster, a native Houstonian, is the new director of gBETA Houston. Image via LinkedIn

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