X marks the spot

5 things to know about TMCx's newest cohort

TMCx's eighth cohort started Monday. Of the 21 companies, 10 are international and two are from Texas. Courtesy of TMCx

On Monday, 21 startups settled in for a wild, four-month ride at the Texas Medical Center's Innovation Institute, and TMCx's eighth cohort, which is focused on digital health, is officially ongoing.

The companies will be absorbing the curriculum and guidance from TMCx and its partners for the next four months, and this particular cohort is exciting for Lance Black, associate director at TMCx, for a few reasons.

"I'm really honored to be able to support these startup companies because, in my mind, it's this entrepreneur spirit that's going to change health care for the better," says Black.

From where the startups are from to where they're going, here's what you need to know about TMCx's eighth cohort.

Digital health companies are defined as those with a software component. 

Each year, TMCx hosts two four-month cohorts — one focusing on medical device companies and the other on digital health. Last fall, TMCx concluded its medical device cohort, so its time to turn the focus on digital health, which Black says TMCx defines as companies with a software element to their product.

The 21 companies in X8 focus on a myriad of medical issues — neurology, mental health, and oncology — as well as logistical applications — patient experience, hospital efficiency, process improvement, clinical decision support, and more.

Black says one type of cohort isn't harder than the other, but the process and curriculum is different. Medical device companies need to have an established prototype, which can take a while. Meanwhile, a digital health company can turn around an app in a matter of weeks.

It might be a bit of a gray area as to what all falls under digital health, but one thing's for sure — TMC is a great opportunity for the companies.

"Overall, our digital health companies do really well in the Texas Medical Center because there's a lot of large hospital systems that are eager and hungry to improve their processes in a number of ways," Black says. "So, we've seen digital health get picked up quickly."

It's the accelerator's most international cohort.

Black says his team evaluated hundreds of startups and, of the 150 companies, 70 were interviewed before getting pared down to 21. What was particularly surprising was the amount of international companies were interested. Ten of the cohort's startups are internationally based.

"What we really tried to do is put the blindfolds on for where they are from and what their background is and really look at the company and its technology, and pick the highest quality of the companies," Black says.

The countries represented are Canada, Australia, Israel, Denmark, and the United Kingdom.

"It shows not only what TMC has done but how Houston has come up in ranking as an international location for these companies," says Black. "For the majority of the 10, this is their first time in the U.S. They are looking at Houston as their entry to the U.S. market."

One Houston company made the cut.

Texas has two companies in the cohort — one from Austin and one from Houston.

Houston-based PreopMD makes the preoperative experience — for patients and clinicians — a whole lot easier. Improved patient communications and monitoring is the main goals of the company, and the website describes the technology as a "virtual operating room command center."

Austin-based Cloud 9 is on a mission to make mental health care more accessible to the population. According to their website, 20 percent of the population has mental health issues, but only 8 percent receive treatment. By engaging mental health care providers and making access to data and communication more available, Cloud 9 can help to fix the broken system.

There's a new guy in charge. 

After TMCx's former director, Erik Halvorsen, left his position in December, Black has stepped up to the plate as interim director to lead the cohort. The responsibilities are definitely different, Black says.

"As a strategist my focus was primarily the companies and being their point of contact," he says. "My day to day had a lot to do with communicating with the companies, and making sure they got the most out of the program. Now, in my current role, It's a little bit one step removed from that. I'm looking over the entire program and thinking about it strategically."

Black says that for him this means finding areas where the cohort can be improved or expanded.

It's the best time to be a TMCx company.

In the past few years, Black says the program has improved dramatically from the curriculum to the programing and what TMC has to offer its startups.

Now, the cohort has access to local talent through the intern program, fundraising events, the new Center of Device Innovation, and more.

"The more that we throw at them, the more they absorb and the better that they do," Black says. "So, we're always looking for ways to improve on their experience."


InformAI can use its data technology to help doctors with preventative care and diagnoses. Courtesy of InformAI

A Houston-based startup has a new technology that allows hospitals and medical establishments better access to its own data – which translates into more effective diagnoses and preventative care.

InformAI — founded by Jim Havelka, CEO, in 2017 — is introducing the technology to the Texas Medical Center. Havelka saw a need within the medical industry for this type of service.

"There were several things missing," says Havelka. "One was access to very large data sets, because it wasn't really until the last five or 10 years that digitalization of data, especially in the healthcare vertical became more widespread and available in a format that's usable. The second convergence was the technology, the ability to process very large data sets."

InformAI currently offers four unique solutions using artificial intelligence and deep learning algorithms: Paranasal Sinus Classifier; Brain Cancer Classifier; Patient Outcome Predictors; and Surgical Risk Predictors.

According to the website, both medical image classifiers assist physicians in detecting the presence of medical conditions. The Paranasal Sinus Classifier detects and distinguishes medical conditions prevalent in the paranasal sinuses. The classifier assists physicians by evaluating sinus medical conditions at the point of care, speeding up radiologist workflow by flagging medical conditions for further review, and providing a triage of pending sinus patient study reviews. The Brain Cancer Classifier focuses on several tumor types and has the potential to provide radiologists and surgeons with additional insights to inform their diagnoses and treatment plans.

In addition to the classifier solutions, the predictors are also key to patient care, as InformAI patient outcome predictors evaluate the risk of adverse outcomes from a surgical procedure.

"Our data set has 275,000 surgical procedures that we can use to look for patterns, and then use that to understand how a patient may react to going through that surgical procedure and that's a very valuable input to surgeons," Havelka tells InnovationMap. Patient outcome risks include mortality, stroke, prolonged ventilation, infection, re-operation, and prolonged hospitalization.

"The innovation is the ability to use artificial intelligence to augment the capabilities of the physician and flag diagnostics for them to consider," says Havelka. "For example, one of our image classifiers that reads three-dimensional CT scans has the equivalent of thirty lifetimes of an expert EMT built into it. It would take thirty lifetimes of an EMT to see that same number of scans, or number of patients, in their lifetime, so these tools are quite valuable to learn patterns that these expert physicians just wouldn't have seen in their lifetime."

InformAI currently has 10 full-time employees and works with radiologists-in-residence in building solutions and conducting research. The startup partners with the Texas Medical Center, Nvidia, Amazon, and Microsoft.

"They're quite interested in what we've built because it's really cutting edge technology that we're doing," Havelka tells InnovationMap.

Havelka and his team also work with some of the largest physician groups and imaging companies in the country to build products. "At the end of the day our core competency is the ability to take data, medical images or patient data, and put it into a usable format to assist physicians in making better treatment decisions for patients," says Havelka. "We can flag and detect patterns, disease states, and risk profiles that can improve the decision making of the physicians for the patient.

InformAI has plans to fundraise this year, with a goal of raising $5 million to $6 million in a round.