Houston health tech startup moves into new office amid major growth

growth

BrainCheck has moved to a new office as it grows its team and expands its product. Natalie Harms/InnovationMap

Following a series A round of fundraising, a Houston digital health startup is on a bit of a hiring spree, leading to new office space the company has room to grow into.

BrainCheck, which was founded in 2015 by neuroscientist David Eagleman, is a cognitive assessment startup that has developed a software tool for primary care doctors to use to assess their patients' cognitive health so that they can more quickly diagnose and treat them for maladies like dementia.

The 19-person company headquartered in Houston — with a secondary office in Austin focused on product development — has relocated its operations from coworking space in the Texas Medical Center to an office in the Rice Village area. The move was made possible by an $8 million series A financing round that closed in October.

"It's pretty exciting to have reached this milestone where we need more space," Yael Katz, co-founder and CEO of BrainCheck, tells InnovationMap. "We were pretty much bursting at the seams in our old office."

The move comes at a time when the company is building out its team. Katz says she is looking to fill a few roles within marketing, sales, and R&D. The team expects to expand to around 25 people by the end of Q1 and then again to 32 employees by the end of the year.

The new positions are needed in part to support the company's product development growth. Rather than just assessing cognitive health, BrainCheck is piloting some automated care plan technology.

"We have a lot of new product development that's underway," Katz says. "A big focus is expanding the output of the cognitive assessment into the cognitive care management."

Following the BrainCheck assessment, this new software will automate a cognitive care plan that doctors can then customize for his or her patients.

"The care plan process right now takes a very long time for the doctors to do, and therefore is very seldom done," Katz says.

And, in some cases, care plans aren't done because there's no cure or limited medications that help these types of cognitive diseases.

"A lot of people think of dementia sometimes as something there's no treatment for," Katz says. "It's true that there are limited pharmaceutical treatments for it, but there's evidence that comprehensive management of the disease is effective."

BrainCheck has opened the door on cognitive assessment. Traditional cognitive assessment used to only be done through a lengthy process and only by a small group of neuropsychologists. It's difficult for patients to find a neuropsychologist and then book an appointment.

"There's a big need to empower primary care doctors to have that ability to assess and manage patients' cognitive help," Katz says, explaining that this creates a perfect market for BrainCheck.

Houston, home to the largest medical center in the world, had a lot of trending health tech stories this year. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

Houston-based medical device companies pitch at TMCx Demo Day

Local legends

Earlier this month, 16 medical device companies wrapped up their time at the Texas Medical Center's accelerator program and pitched their companies to fellow health professionals, guests, and more. While each made important connections in the local ecosystem during the program, a quarter of the entrepreneurs had roots in Houston already.

Four of the 16 TMCx09 companies that are headquartered in Houston. They have built solutions within sepsis, surgery, and transplant spaces in health care. Here's a little more about the homegrown companies that pitched at the event.

CorInnova

Photo via corinnova.com

The standard practice for acute heart failure patients is very invasive, says William Altman, CEO of CorInnova.

"The problem with existing devices is that they have invasive blood contact," Altman says. "Problem with that is blood contact is bad. It can cause up to 15 percent rate of stroke, which could kill you, and after five to seven days it provides 10 percent rate of blood destruction and has a 47 percent rate of kidney disfunction."

CorInnova's technology features a device that can be easily inserted through a 1-inch incision, and then be used for increase blood pumping by 50 percent.

"Surgeons tell us this is less invasive than minimally invasive aortic valve replacement, which is a widely done surgery, so this promises widespread adoption for our technology as we get it approved," Altman says.

The human prototype is expected to be ready in two years, with the next year being focused on animal studies. CorInnova is raising $12 million to accomplish its goals.

Ictero Medical

Getty Images

An estimated 10 to 15 percent of the United States population will get a gallstone in their lifetime. Should one of those stones cause trouble or blockages, the only solution is to remove the gallbladder completely through surgery. However, Matthew Nojoomi, CEO and co-founder of Ictero Medical, has another idea.

Ictero Medical has created a minimally invasive treatment that uses cryoablation to defunctionize the gallbladder without having to remove it.

"The CholeSafe System not only treats the source of the disease, but it leverages existing clinical workflows that doctors use to access the gallbladder," says Nojoomi, adding that the process only uses mild station and pain control.

The company expects to get to humans in the next two years, and has launched a financing round.

PATH EX

Photo via tmc.com

Currently, sepsis is hard to identify in patience. Even if a patient is in a hospital, and that hospital knows the patient has sepsis, the individual still has a 38 percent chance of dying, says Sinead Miller, CEO of PATH EX.

"Right now the problems associated with sepsis are very clear," she says. "It's the leading cause of death in our ICUs, and it's also associated with the highest hospital cost and readmission rates."

PATH EX's technology allows medical professionals to better diagnose and treat sepsis. The PATH EX therapeutic device can be hooked up to a patient and flow his or her blood through the machine to capture bacteria, clean and recirculate the blood, and faster diagnose what sort of bacteria the patient has attracted. The device technology is similar to hemo hemodialysis, Miller explains.

The Houston company, which recently won big at the Ignite Healthcare Network's Fire Pitch Competition, was named an honoree within the Johnson and Johnson Breakthrough Medical Technologies Quickfire Challenge.

The company was recently received clearance from the Food and Drug Administration as a breakthrough device technology. PATH EX closed its $615,000 seed round — with plans for a series A next year — and has received $1 million in SBIR grant funding. The company was founded two years ago, and relocated to call Houston HQ this year.

Volumetric

Jordan Miller/Rice University

Volumetric is banking on their technology being among the inventions that will lead the medical industry into the future. The human tissue-printing technology company has created the 3D printer and the "ink" that can create whole organs for transplant.

"We can create complicated vascular architectures inside of soft water-based gels, in this case, mimicking the structure and function of human lung tissue," says Jordan Miller, CEO. "We can oxygenate red blood cells."

The company is commercializing its technology and has three streams of revenue, which as generated almost $1 million in revenue in Volumetric's second year. The company is also in the process of closing its seed round of fundraising.

Earlier this year, the startup, which works out of Rice University, was featured on the cover of Science magazine.

In 2020, the TMCx program will become a needs-based accelerator looking to solve problems the Texas Medical Center's member institutions face on a regular basis. Courtesy of TMC

TMC Innovation Institute announces redesign of its acceleration program for 2020

X-citing news

TMCx has been helping medical device and digital health startups create solid business plans and lasting relationships with Texas Medical Center institutions for five years, and on the accelerator's fifth anniversary, the team announced it's mixing things up a little to better accomplish those goals.

On Nov. 7, TMCx celebrated the conclusion of its ninth cohort, and 16 medical device companies pitched to a crowd at the TMC Innovation Institute. The companies in this cohort, just like the ones before it, were selected based on their technologies that solved a problem using digital health or medical devices. However, previously, the TMC's member institutions weren't directly part of the process until after the cohort was selected.

Based on feedback from alumni, member institutions, corporate partners, and stakeholders, TMCx has redesigned the program so that next year, the accelerator will focus on the specific needs of the needs that the organizations within the TMC have identified.

"Our focus going forward is on our member institutions — the clinics, the hospitals, and our partners who really bring forward these technologies into the future," says Emily Reiser, innovation strategist at the TMC Innovation Institute.

TMCx will become a needs-based accelerator program, Reiser says, and the team at the accelerator will partner with member institutions to run specific cohorts matched to their areas of interests.

The first step will be to identify these areas of interest, then in February of 2020, TMCx will invite a number of companies related to those interests to Houston for two weeks. The TMCx team, member institutions, and other stakeholders will get to interact with the companies and see how they stack up against each other, and to see if they can really fill the needs of the hospitals, clinics, and more.

Finally, after narrowing down the companies, the final startups and entrepreneurs will be invited to participate in a six-month accelerator program that will provide the same resources, connections, and programming that TMCx has always provided to advance the health startups.

Reiser says the TMCx team and all its partners will help identify the missing pieces these companies have and provide solutions, as well as making the right connections to all the right pilot partners, investors, clinical trial experts, and more.

"We'll be here to help them fill those gaps and make sure they have lasting relationships with our clinical partners in the hospitals," Reiser says.

A recap of all the innovation happening at the Texas Medical Center, innovators to know, and Houston startup news trended this week. Courtesy of TMC

5 most popular innovation stories in Houston this week

What's trending

Editor's note: This week was full of innovation events — and there's many more coming up this month. Event coverage, innovators to know, and more startup news trended on InnovationMap this week.

3 Houston innovators to know this week

Meet this week's Houston innovators to know. Courtesy photos

This week, some key Houston innovators to know include the CEO of a tech company that's demystifying Google's SEO, a local entrepreneur who just raised millions in funding, and the newest addition to the Houston innovation ecosystem. Continue reading.

From robots to immunotherapy, TMC talks innovation at its annual address

The Texas Medical Center's CEO, Bill McKeon, ran down a list of exciting updates and innovations from the organization's member institutions at the annual State of the TMC. Photo via tmc.edu

In the Greater Houston Partnership's annual State of the Texas Medical Center address, TMC CEO Bill McKeon shared a status update of sorts for all the goings on at the largest medical center in the world.

McKeon ran down the list of member institutions to briefly touch base on each organization's innovations and growth. In the address, which took place at the Marriott Marquis on October 31, McKeon discussed exciting construction projects, new accelerator programs, and more. Continue reading.

Exclusive: The Cannon Houston restructures, brings on new executive to lead operations

Just after celebrating its new 200,000-square-foot flagship location, The Cannon Houston has named a new CEO to further grow the coworking space and startup hub. Photo courtesy of The Cannon

After celebrating the opening its flagship coworking space the same week it announced another location in downtown, startup hub and coworking company, The Cannon Houston, has another big announcement: a new CEO.

A former global consultant for KPMG, Jon Lambert has been named The Cannon's CEO. He will also support day-to-day operations at The Cannon's three locations. Meanwhile, Lawson Gow, founder of the company and former CEO, will move to president of The Cannon. Gow, who is the son of InnovationMap's parent company's CEO, will focus on partnerships and business development, as well as continuing to be the face of the company. Continue reading.

Houston biomedical startup granted $1.5M, Chevron taps into Plug and Play, and more innovation news

Money moves, big deals, and more lead this roundup of innovation news. Pexels

Hitting headlines this month are innovation news stories from battling the opioid crisis and funding to TMCx companies and Houston as a whole earning recognition. In this innovation news roundup, two Houston startups pocket some cash, Chevron links up with Plug and Play, and more. Continue reading.

10+ can't-miss Houston business and innovation events for November

From enlightening talks and conventions to networking opportunities, here's where you need to be in November. Getty Images

Looking for some help navigating an innovation-filled month in Houston? Look no further.

November is jam packed with Houston business and innovation events — from huge conventions like SpaceCom and Global Corporate Venture taking over downtown on the same days to the Digital Fight Club battling it out in Houston for the first time and The Houston Innovation Summit planning a week of programming. Continue reading.

As the city grows, Houston faces more and more challenges from transportation and infrastructure to gentrification and climate change. Getty Images

Overheard: Expert panel weighs in on the future of Houston — from mobility to climate change

Eavesdropping in houston

As technology and infrastructure evolves, Houston is growing and evolving with it — in both good ways and bad.

On October 30, Gensler hosted its annual Evolution Houston forum that brings together various personalities and industries to discuss the future of the city of Houston. The panelists discussed gentrification, climate change, mobility, smart cities, and so many other hot topics Houstonians hear or think about on a regular basis.

Missed the event? Here are some powerful quotes from the discussion.

“I like to think of Houston as an adolescent city, struggling for its identity.”

— Peter Merwin, design principal at Gensler, who adds, "If you look at places like New York, London, Paris — those are all luxury cities. They are fully formed, and a consequence of that is that they become unaffordable. It's something that we have to be careful about in Houston."

“One of the things that has been echoed by many of the artists and many of the poor people over the last few years is, [people] ‘want the culture but they don’t want us.’ It’s very reflective when you go [into the communities.]”

— Kam Franklin, activist and singer-songwriter of The Suffers. Franklin described how she would move from the various neighborhoods she's lived in after they've grown in culture. She would see such a huge increase in her rent as people were more willing to pay the premium to live in these newly desirable neighborhoods because of the culture, but its pricing out the original inhabitants. Franklin added, "I'm not going to tell any of y'all where I moved."

“We have to continue to support the diversification of mobility options.”

— Abbey Roberson, vice president of planning at the Texas Medical Center. Roberson says transportation is something she particularly focuses on considering how many people filter in and out of the TMC on a daily basis. The medical center wouldn't be able to support the traffic with out various modes of transportation — busses, light rails, etc. Roberson adds that this translates to the rest of the city. "We can't just be doing one thing or the other."

“We’re creating this great culture of trail activation.”

— Steve Radom, founder & managing principal at Radom Capital LLC, which developed Heights Mercantile off a bike path and is now building out The MKT, which is also along the same bike path. Radom notes that the city has seen a 300 percent year over year in walkability and a 70 percent increase in bike traffic.

“Climate change is not something the city of Houston can change alone.”

— Lara Cottingham, chief of staff & chief sustainability officer at the city of Houston. The city's climate action plan is a result of the devastating floods has seen almost annually. The plan is still being drafted but a version is expected to be released before the end of the year. Every city is facing sustainability challenges, and partnerships are what's going to drive change. "In Houston success means partnership," Cottingham adds.

“How do you talk about a city this big and diverse — every neighborhood has its own identity.”

—Jon Nordby, managing director of MassChallenge in Houston, discussed how Houston functions differently from other cities in that it its various neighborhoods — the Heights, Montrose, downtown — are different from each other.

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Booming Houston suburb hauls in top spot among growing U.S. cities

making moves

The Houston metro area's population is poised to continue booming over the next decade, so it should be no surprise that U-Haul calculated one Houston suburb as one of the top U.S. cities for growth.

In its annual report, released January 7, the company details migration trends across the U.S. Analyzing data from 2019, the moving and rental company placed Spring-The Woodlands at No. 14 among the 2019 U-Haul Growth Cities.

To determine the country's top 25 growth cities, U-Haul analyzed more than 2 million rental transactions over the calendar year. It then calculated the net gain of one-way U-Haul trucks entering an area versus those leaving an area.

Unlike U.S. Census Bureau or real estate data, the company says its U-Haul Growth Cities offers a snapshot of an area's retention rates versus strictly growth.

"While U-Haul migration trends do not correlate directly to population or economic growth, the company's growth data is an effective gauge of how well cities and states are attracting and maintaining residents," it explains in a release.

Three other Texas cities were perched on the list: the Austin suburb of Round Rock-Pflugerville (No. 5), the San Antonio suburb of New Braunfels (No. 11), and the Dallas suburb of McKinney (No. 17).

The top spot this year went to Raleigh-Durham, where arrivals accounted for nearly 51.4 percent of all one-way U-Haul traffic. In its explanation as to why the North Carolina hub is growing, the company points to the region's booming tech sector, which is says rivals that of Austin.

"We have tons of businesses coming here, bringing new residents in U-Haul trucks," said Kris Smith, U-Haul Company of Raleigh president, in a release. "Raleigh-Durham is rivaling Austin for attracting tech businesses and young professionals. We're seeing Silicon Valley talent and companies flock to the area. With a competitive cost of living, good wages, and job growth, Raleigh-Durham is experiencing a boom in population."

But when it came to the top growth state, neither Texas nor North Carolina got the No. 1 spot. That honor went to Florida, which took the crown from Texas, the winner in 2018. The Sunshine State claimed seven cities among the top 25, including five in the top 10.

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This article originally ran on CultureMap.

3 Houston innovators to know this week

Who's who

Houston is full of innovative people looking to make an impact — whether it's in the health tech, fashion, or science industries.

This week's innovators to know represent different industries within Houston, but they are all looking to leave a legacy in making a difference.

Yael Katz, co-founder and CEO of BrainCheck

Photo courtesy of BrainCheck

Yael Katz has seen the company she co-founded grow tenfold in its almost five years, and now she's watching that growth from a corner office with a great view of Houston.

BrainCheck, a cognitive assessment startup that has developed a software tool for primary care doctors to use to assess their patients' cognitive health, has moved into a new office space in the West University area following a series A round of fundraising.

Topper Luciani, founder and CEO of Goodfair

Photo courtesy of Goodfair

With the rise of fast fashion — in which huge clothing lines rapidly produce cheap clothing for consumers, humans are cycling through clothing at a detrimental rate.

According to a report from Business Insider, the fashion industry contributes 10 percent of the world's carbon emissions, is the second-largest user of the earth's water supply, and pollutes the oceans with microplastics.

"I realized that there was too much stuff out there," says Topper Luciani, founder and CEO of Houston-based Goodfair, "and there is an environmental crisis being caused by the clothing industry. They're manufacturing so many items, they're using slave labor, they're pumping dyes and other chemicals into rivers. It's absolutely wild." Read more.

Dorit Donoviel, director of the Translational Research Institute for Space Health

Libby Neder Photography

On the most recent episode of the Houston Innovators Podcast, Dorit Donoviel speaks of space health needs in ways that sound like futuristic science fiction. However, the director of the Translational Research Institute of Space Health is actively seeking solutions for issues and needs for living in space.

TRISH works hand in hand with NASA's Human Research Program to identify the program's biggest concerns, and then tap into professors, researchers, and scientists from Baylor College of Medicine, California Institute of Technology, the Massachusetts Institute for Technology, and other partners in order to innovate solutions.

"Everyone tosses the word 'innovation' around, but that means, to us, taking risks in science. Health care, in particular, is very risk averse, but the space industry is taking risks every single day when they put people in a rocket and hurl them into space," Donoviel says on the podcast. "If we're going to mars, for example, we are going to put people at risk." Read more.

These 3 Houston research projects are aiming to fight or prevent cancer

Research roundup

Cancer remains to be one of the medical research community's huge focuses and challenges, and scientists in Houston are continuing to innovate new treatments and technologies to make an impact on cancer and its ripple effect.

Three research projects coming out of Houston institutions are providing solutions in the fight against cancer — from ways to monitor treatment to eliminating cancer-causing chemicals in the first place.

Baylor College of Medicine's breakthrough in breast cancer

Photo via bcm.edu

Researchers at Baylor College of Medicine and Harvard Medical School have unveiled a mechanism explains how "endocrine-resistant breast cancer acquires metastatic behavior," according to a news release from BCM. This research can be game changing for introducing new therapeutic strategies.

The study was published in the Proceedings of the National Academy of Sciences and shows that hyperactive FOXA1 signaling — previously reported in endocrine-resistant metastatic breast cancer — can trigger genome-wide reprogramming that enhances resistance to treatment.

"Working with breast cancer cell lines in the laboratory, we discovered that FOXA1 reprograms endocrine therapy-resistant breast cancer cells by turning on certain genes that were turned off before and turning off other genes," says Dr. Xiaoyong Fu, assistant professor of molecular and cellular biology and part of the Lester and Sue Smith Breast Center at Baylor, in the release.

"The new gene expression program mimics an early embryonic developmental program that endow cancer cells with new capabilities, such as being able to migrate to other tissues and invade them aggressively, hallmarks of metastatic behavior."

Patients whose cancer is considered metastatic — even ones that initially responded to treatment — tend to relapse and die due to the cancer's resistance to treatment. This research will allow for new conversations around therapeutic treatment that could work to eliminate metastatic cancer.

University of Houston's evolved brain cancer chip

Photo via uh.edu

A biomedical research team at the University of Houston has made improvements on its microfluidic brain cancer chip. The Akay Lab's new chip "allows multiple-simultaneous drug administration, and a massive parallel testing of drug response for patients with glioblastoma," according to a UH news release. GBM is the most common malignant brain tumor and makes up half of all cases. Patients with GBM have a ﬁve-year survival rate of only 5.6 percent.

"The new chip generates tumor spheroids, or clusters, and provides large-scale assessments on the response of these GBM tumor cells to various concentrations and combinations of drugs. This platform could optimize the use of rare tumor samples derived from GBM patients to provide valuable insight on the tumor growth and responses to drug therapies," says Metin Akay, John S. Dunn Endowed Chair Professor of Biomedical Engineering and department chair, in the release.

Akay's team published a paper in the inaugural issue of the IEEE Engineering in Medicine & Biology Society's Open Journal of Engineering in Medicine and Biology. The report explains how the technology is able to quickly assess how well a cancer drug is improving its patients' health.

"When we can tell the doctor that the patient needs a combination of drugs and the exact proportion of each, this is precision medicine," Akay explains in the release.

Rice University's pollution transformation technology

Photo via rice.edu

Rice University engineers have developed a way to get rid of cancer-causing pollutants in water and transform them into valuable chemicals. A team lead by Michael Wong and Thomas Senftle has created this new catalyst that turns nitrate into ammonia. The study was published in the journal ACS Catalysis.

"Agricultural fertilizer runoff is contaminating ground and surface water, which causes ecological effects such as algae blooms as well as significant adverse effects for humans, including cancer, hypertension and developmental issues in babies," says Wong, professor and chair of the Department of Chemical and Biomolecular Engineering in Rice's Brown School of Engineering, in a news release. "I've been very curious about nitrogen chemistry, especially if I can design materials that clean water of nitrogen compounds like nitrites and nitrates."

The ability to transform these chemicals into ammonia is crucial because ammonia-based fertilizers are used for global food supplies and the traditional method of creating ammonia is energy intensive. Not only does this process eliminate that energy usage, but it's ridding the contaminated water of toxic chemicals.

"I'm excited about removing nitrite, forming ammonia and hydrazine, as well as the chemistry that we figured out about how all this happens," Wong says in the release. "The most important takeaway is that we learned how to clean water in a simpler way and created chemicals that are more valuable than the waste stream."

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