This month, TMCi is welcoming a slew of health tech and cancer innovators who will advance solutions in medicine over the next several months. Image via TMC.edu

The Texas Medical Center has announced the latest cohorts of its two health tech accelerators.

The Texas Medical Center Innovation has named eight companies that are in the Spring 2023 Accelerator for HealthTech cohort. TMCi also announced 21 participants are set to join the 2023 Accelerator for Cancer Therapeutics cohort. Both programs connect the entrepreneurs and innovators to experts at TMC’s campuses to solve unmet clinical needs and reach the next business milestone.

“At TMC Innovation, we start with a promise of uniting cutting-edge innovators in science and medicine with the talent found at the Texas Medical Center," says Emily Reiser, associate director of TMC Innovation, in a news release. "Our 2023 cohort members are tackling some of the most critical issues we face today in healthcare.

"We are excited to welcome a new group of researchers and companies to the TMC Innovation Factory, and to work collaboratively with our new cohort members and our partners from across the Texas Medical Center," she continues.

Here's what 2023 can expect from these two program's cohorts.

TMCi HealthTech Accelerator

The six-month, twice annual HealthTech Accelerator — originally launched in 2014 with over 225 alumni companies — focuses on digital health and medical device startups. The spring cohort are addressing solutions across maternal medicine, mental health, diagnostics, patient experience, and artificial intelligence.

"Uniting talented professionals from across the globe provides a unique opportunity for innovation, creativity, and development in diverse areas of expertise," says Devin Dunn, head of the Accelerator for Healthtech at TMCi, in the release. "Our tailored program maximizes participants' experiences while determining the best match between these companies and Texas Medical Center’s network."

The cohort was selected following a November bootcamp that introduced potential startup members to the TMC and the Houston health care community.

The following companies will join the TMC this month:

  • Based in Roseville, Minneapolis, Bloom Standard is deploying the first self-driving pediatric ultrasound to earlier diagnose heart and lung conditions in primary care, remote and under-resourced settings.
  • San Francisco-based Ejenta automates remote monitoring and care using AI technology exclusively licensed from NASA. “Intelligent agents” learn from connected devices, claims and EMR data to monitor patients, predict health and to provide automated support for patients and automated workflow for clinicians.
  • Kintsugi, based in Berkley, California, is on a mission to see mental health more clearly by developing novel voice biomarker infrastructure to detect signs of depression and anxiety from short clips of free-form speech.
  • San Francisco-based Lana Health is modernizing patient experiences, across the care continuum with an end-to-end, scalable platform, enabling frictionless care transitions, high patient satisfaction, and better clinical outcomes.
  • Liberate Medical, from Crestwood, Kentucky, improves outcomes for mechanically ventilated patients using its breakthrough, non-invasive, respiratory muscle-protective, neurostimulation device, VentFree.
  • Limbix, headquartered in Palo Alto, has a mission to improve mental health with accessible technology.
  • Nua Surgical, from Galway, Ireland, Nua Surgical is an award-winning Irish start-up dedicated to innovating in women’s health.
  • Houston-based Prana Thoracic is developing solutions for the detection and intervention of early-stage lung cancer.

Accelerator for Cancer Therapeutics

The TMC has announced the 21 researchers and companies tapped to join the 2023 Accelerator for Cancer Therapeutics.

The nine-month program, funded by the Cancer Prevention and Research Institute of Texas in partnership with the Gulf Coast Consortia and the University of Texas Medical Branch, supports investigators and early-stage biotechnology companies with innovative solutions in cancer therapeutics. Participants will be mentored by a group of scientific, business, and innovation leaders to ultimately be positioned to apply for grants and pitch to investors and corporate partners to further the development of their innovative cancer solutions.

“For this third cohort, we focused on a strategic and extensive recruitment process, including the evaluation of 1,679 cancer research projects. From 56 applications, we selected 21 participants that will gain access to valuable resources, integrated training and mentorship to prepare for clinical trials,” says Ahmed AlRawi, program manager of Accelerator for Cancer Therapeutics, in the release. “Our 2023 cohort represents our most diverse cohort to date, including eight companies led by women entrepreneurs. We are excited to continue the momentum and build off the successes of our previous years.”

Forty-five participants have gone through the accelerator program since its launch in 2021, and collectively, the entrepreneurs have raised more than $90 million in funding and three projects are in the clinic.

The 2023 cohort participants are focused on a wide range of therapeutic assets, including small molecule, antibody, peptide/protein, cell therapy, and other. The 2023 cohort kicks off their nine-month program in January.

The participants include:

  1. Dr. Amit K. Tripathi – UNT-Health Science Center
  2. Dr. Darshan Gandhi (ImproveBio, LLC)
  3. Dr. Frank McKeon (Tract Pharmaceutical) – University of Houston
  4. Dr. Hemanta Baruah (Aakha Biologics)
  5. Dr. Joshua Gruber – UT-Southwestern
  6. Dr. Kyoji Tsuchikama – UT Health Science Center-Houston
  7. Dr. Maralice Conacci Sorrell – UT-Southwestern
  8. Dr. Michael Buszczak – UT-Southwestern
  9. Dr. Nadezhda (Nadia) German -Texas Tech-Lubbock
  10. Dr. Parsa Modareszadeh (HemePro Therapeutics) – UT-Dallas
  11. Dr. Robert Kruse (HydroGene Therapeutics)
  12. Dr. Xiang Zhang – Baylor College of Medicine
  13. Dr. Youngwook Won (Singular Immune, Inc.)
  14. Dr. Zhi-Ping Liu (Raphael Pharmaceutical LLC) – UT-Southwestern
  15. Dr. Jonathan Arambula (InnovoTEX Inc.)
  16. Dr. Isaac Chan – UT-Southwestern
  17. Dr. Olga Granaturova (Ruptakine Inc.) – UT Health Science Center-Houston
  18. Dr. Jim Song (Tranquility Biodesign) – Texas A&M-College Station
  19. Dr. Rosa Selenia Guerra-Resendez (Quetzal Bio, LLC) – Rice University
  20. Dr. Cassian Yee (Mongoose Bio, LLC) – UT-MD Anderson Cancer Center
  21. Dr. Manjeet Rao (Niragen, Inc.) – UT Health Science Center-San Antonio


The Dynamic One building in TMC Helix Park is expected to deliver later this year. Rendering via TMC.edu

Rising TMC development names Houston health care institution as anchor tenant

coming soon

TMC Helix Park, formerly known as TMC3, has announced its first anchor tenant.

The Texas Medical Center and Beacon Capital Partners announced that Baylor College of Medicine will be the anchor tenant of the Dynamic One building at TMC Helix Park. The facility is will be the first to deliver of the four TMC Helix Park industry buildings. The Topped off in December, the Dynamic One building is being developed by Beacon in collaboration with Zoë Life Science and is scheduled to open before the end of the year.

“Beacon is excited that Dynamic One will be our first entry into the fast-growing Houston Life Science market,” says Fred Seigel, president and CEO of Beacon, in a news release. “This state-of-the-art environment is designed to enable and encourage collaboration and will greatly accelerate the innovative lifesaving discoveries that emerge when industry and academic research work side-by-side.”

Baylor College of Medicine will lease 114,000 square-feet of lab and office space in the 355,000-square-foot building. BCM's goal is to house lab space for novel diagnostics and therapeutics — and provide space to house startups.

The organization is expanding its presence in Houston after decades of residing in the region.

“Baylor College of Medicine moved to Houston in 1943 and was the first institution built in the Texas Medical Center," says Dr. Paul Klotman, president and CEO and executive dean of Baylor, in the release. "Our researchers and scientists will have the opportunity to access the uniquely concentrated research environment being developed at TMC Helix Park, facilitating the continuing advancement of innovation and compassionate care."

TMC Helix Park, which includes more than 5 million-square-feet of space across 37-acres, also expects to deliver its research facility, the TMC3 Collaborative Building, later this year.

“Baylor College of Medicine is a major force in life sciences discovery and commercialization at TMC," says Bill McKeon, president and CEO of TMC, in the release. "Their move to TMC Helix Park will serve as a catalyst for enhanced collaboration with TMC’s other esteemed Institutions, as well as with industry leaders from around the world."

BCM is the first anchor tenant announced for TMC Helix Park. Rendering via TMC.edu

A TMC construction update, a Q&A with UH's med school donor, and other top health tech stories of 2022. Image courtesy of Elkus Manfredi Architects

Here are Houston's top health tech innovation stories of the year

2022 in review

Editor's note: As 2022 comes to a close, InnovationMap is looking back at the year's top stories in Houston innovation. In Houston, home to the world's largest medical center, health tech and innovation news is abound — from startups being named among the most promising by investors to new details on the Texas Medical Center's expansion. Here are five Houston health tech-focused articles that stood out to readers this year — be sure to click through to read the full story.


Houston organizations announce 10 most promising life science startups

Houston's medical innovation community congregated to discuss breakthrough innovations in health care. Photo via Getty Images

What startups are creating the future of health care? A Houston conference this week gathered to discuss.

The 10th annual Texas Life Science Forum hosted by BioHouston and the Rice Alliance for Technology and Entrepreneurship engaged thought leadership within the life science community with panels, discussions, and more. Additionally, 49 companies pitched their solutions across medical device, therapeutics, pharmaceuticals, and more to the crowd.

The event also named the 10 most promising life science companies selected by investors and presented by the Greater Houston Partnership. Read more.

Houston hospital system to open new innovative location

Houston Methodist broke ground on a 400-bed hospital in Cypress. Rendering courtesy of Houston Methodist

Houston Methodist will soon break ground on a “smart” hospital in Cypress that is poised to be the smartest of its nine hospitals.

The $650 million Cypress hospital will be modeled after Houston Methodist West and Houston Methodist The Woodlands hospitals. However, the Cypress location is on track to outdo them in terms of smart technology.

“Our commitment to innovation is one more way we set ourselves apart from other hospital systems, and we are committed to making this new hospital the most technologically advanced and innovative hospital ever,” Dr. Marc Boom, president and CEO of Houston Methodist, says in a note to employees. Read more.

Following $50M gift,Tilman Fertitta reveals goals for eponymous medical school at University of Houston

Fertitta and his family have gifted $50 million to UH's medical school. Photo courtesy

As Houston’s most high-profile billionaire and owner of the posh 5-star Post Oak Hotel and Houston Rockets, Tilman J. Fertitta has become synonymous with over-the-top opulence and big-time entertainment.

But the CEO of the massive Feritta Entertainment empire’s latest move has nothing to do with penthouses or point guards, but rather a legacy, game-changing appropriation meant to aid his home state’s health.

The longtime UH board member and former chairman and his family have just pledged $50 million to the University of Houston College of Medicine. In turn, the new medical school has been christened the Tilman J. Fertitta Family College of Medicine. Read more.

TMC unveils details of new bioport, Helix Park at annual Greater Houston Partnership event

TMC gave an update on TMC3 — now called TMC Helix Park — and introduced a new bioport project. Courtesy of Elkus Manfredi Architects

Within the next five to 10 years, the Texas Medical Center you know today will be double the size. That's what Bill McKeon, president and CEO of the TMC, said at yesterday's State of the Texas Medical Center event hosted by the Greater Houston Partnership.

The biggest project contributing to the TMC's growth is TMC3, a campus expansion that will bring 37 acres and 5 million square feet of space to the TMC, is now known as Helix Park. The name is a nod to the shape of the park and walkway design at the center of the campus. The TMC3 Collaborative Building — the first multi-institutional research facility in TMC’s history — will be the first of the project to deliver and is currently under construction and slated for completion in 2023.

However, the big news of the event was the TMC BioPort, the organization's upcoming biomanufacturing and medical supplies distribution engine. This new campus will span several hundred acres just down the road from TMC and will drive the much-needed repatriation of critical medical supplies and new cell and gene therapies, per a news release. Read more.

Overheard: Houston experts discuss women in med tech, insight from investors, and more

Health care innovators joined Houston Methodist and Texas A&M University's ENMED program to discuss women in health care innovation and venture capital investment. Photo courtesy of Houston Methodist

Houston's health innovation community is making strides every day toward greater quality of care and technology adoption — but what challenges is the industry facing these days?

Through a partnership between Houston Methodist and Texas A&M University's ENMED program at Houston Tech Rodeo, health innovators weighed in on topics surrounding the industry, including biases and investment opportunities.

Missed the conversation? Here are seven key moments from the panels that took place at A&M's new ENMED building in the Texas Medical Center on Thursday, March 3. Read more.

Here's your latest roundup of innovation news you may have missed. Photo via Getty Images

Houston unicorn raises $200M series D, startup snags national award, and more innovation news

Short stories

It's been a busy month so far with plenty of Houston startup news, major ecosystem events, and more — and there might be some headlines you may have missed.

In this roundup of short stories within Houston startups and tech, Solugen raises another mega round of funding, CorInnova snags a prestigious award, applications are open for two programs, and more.

Houston unicorn chemicals company raises $200M series D

Solugen closed its Series d funding round at $200 million. Photo via Getty Images

Houston-based Solugen has announced its latest round of investment to the tune of $200 million. The company, which reached unicorn status after its $357 million series C round last year, uses its patented Bioforge processes to produce "green" chemicals from bio-based feedstocks.

"Solugen is reimagining the chemistry of everyday life with enzymes found in nature. We make chemicals better, faster, cheaper, and without fossil fuels from right here in Houston, Texas. Whether you care about the climate, local competitiveness, or just plain old profits, we have good news: it's working," the company states in its news release.

"Our first Bioforge has been operating for a year and Solugen is running a nearly nine figure business with high margins selling commodity and specialty chemicals," the statement continues. "We have established ourselves with top tier customers for our existing solutions and fortune 100 technology partners to build a robust pipeline of future molecules that will help us achieve our goal of 10 mil tons of CO2 removed from the atmosphere."

According to the company, this latest raise has increased Solugen's valuation to over $2 billion. The round was led by investors Kennivik, Lowercarbon Capital, and Refactor Capital.

Houston health tech company wins funding from national organization

CorInnova has won a prestigious award. Photo via corinnova.com

Houston-based CorInnova was named one of five awardees from the National Capital Consortium for Pediatric Device Innovation's “Make Your Medical Device Pitch for Kids!” competition. Each honoree received a share of $150,000 in grant funding from the U.S. Food and Drug Administration. The awards ranged from $20,000 to $50,000 to support the advancement of pediatric medical devices.

CorInnova has designed a minimally invasive biventricular non-blood contacting cardiac assist device to treat heart failure.

The 2022 competition was moderated by California-based MedTech Innovator. The other four pediatric device innovation awardees included:

  • Innovation Lab, from La Palma, California, created a mechanical elbow brace stabilizes tremors for pediatric ataxic cerebral palsy to improve the performance of Activities of Daily Living.
  • Prapela, based in Biddeford, Maine, created the first innovation to improve the treatment of apnea of prematurity in over twenty years.
  • Tympanogen, from Richmond, Virginia, replaces surgical eardrum repair with a nonsurgical clinic procedure
  • Xpan, based in Concord, Ontario, has created a universal trocar enables safest and most dynamic access and effortless upsizing in conventional/mini/robotic procedures.

"We are delighted to recognize these five innovations with critical NCC-PDI funding that will support their journey to commercialization. Improving pediatric healthcare is not possible without forward-thinking companies that seek to address the most dire unmet needs in children’s health,” says Kolaleh Eskandanian, vice president and chief innovation officer at Children’s National Hospital and principal investigator of NCC-PDI, in a news release. "We know all too well how challenging it is to bring pediatric medical devices to market, which is why we have created this rich ecosystem to identify promising medical device technologies and incentivize investment. We congratulate this year’s winning innovators and applaud their efforts to help bridge these important care gaps that are impacting children.”

Houston real estate tech scores funding from Amazon entity

DOSS is a real estate tech company. Photo via Getty Images

Houston-based DOSS, which was chosen this summer for the inaugural Black Founders Build with Alexa cohort, has received funding from the Amazon Alexa Fund. The startups in the program were selected based on their ability to innovate with Alexa and build the next generation of voice, artificial intelligence, and ambient experiences technology.

DOSS is a digital brokerage that uses tech to make homeownership more affordable, and the company has developed a technology where customers are able to ask for real-estate advice and tips, search for home listings, get neighborhood information, and recent sales data, according to a news release from the company. They will also eventually be able to request to be connected with home service providers that serve their respective area.

CEO Bobby Bryant and COO Chris Norton founded DOSS in 2016. Last year, the company participated in the Google for Startups Black Founders program, receiving $100,000 from the fund.

TMC Innovation's Biodesign program applications open

Applications are open through the end of the year. Photo via tmc.edu

Applications are now open for the 2023 TMCi Biodesign program at the Texas Medical Center's Innovation Factory. TMC is looking for candidates with relevant backgrounds for starting a digital health or medical device company, such as: engineering, medicine, hospital administration, R&D (prototyping), software development, finance, legal, regulatory, reimbursement, or technical. Candidates must have at least 1 to 2 years of industry work experience or have prior startup history. It is preferred that applicants have earned an advanced degree.

The position is an in-person, full-time requirement that will begin August 2023 and will span nine months with an opportunity to extend for up to two months.

Applications close on December 31. Candidates will undergo a series of interviews in January and then will be extended offers in the spring.

HX Venture Fund calls for startups to meet visiting VC

Calling all Houston tech startups. Image via Screenshot

HX Venture Fund, a fund-of-funds that encourages and enables non Houston-based VCs to tap into the local innovation ecosystem, is hosting Creighton Hicks, partner at Austin-based LiveOak Venture Partners, later this month.

The organization is looking for Houston startups that are building a tech or tech-enabled services company raising a seed to series B round now or in the next six months. Startups have until November 18 to submit their interest via an online form.

TMC gave an update on TMC3 — now called TMC Helix Park — and introduced a new bioport project. Courtesy of Elkus Manfredi Architects

TMC unveils details of new bioport, Helix Park at annual Greater Houston Partnership event

coming soon

Within the next five to 10 years, the Texas Medical Center you know today will be double the size. That's what Bill McKeon, president and CEO of the TMC, said at yesterday's State of the Texas Medical Center event hosted by the Greater Houston Partnership.

The biggest project contributing to the TMC's growth is TMC3, a campus expansion that will bring 37 acres and 5 million square feet of space to the TMC, is now known as Helix Park. The name is a nod to the shape of the park and walkway design at the center of the campus. The TMC3 Collaborative Building — the first multi-institutional research facility in TMC’s history — will be the first of the project to deliver and is currently under construction and slated for completion in 2023.

However, the big news of the event was the TMC BioPort, the organization's upcoming biomanufacturing and medical supplies distribution engine. This new campus will span several hundred acres just down the road from TMC and will drive the much-needed repatriation of critical medical supplies and new cell and gene therapies, per a news release.

"During COVID, we saw the weakness of our supply chain," McKeon says at the event. "There is a huge effort by this country as a part of national security to make sure drug and vaccine production is moved back into the United States."

The new campus will also have an on-site upskill training center and create over 100,000 new job opportunities.

“Houston is advancing its position as the leading destination for life science discovery,” McKeon says in the release. “Through our holistic, expansive vision, we are building every vital component necessary to advance the largest life science ecosystem in the world.”

As explained at the event, the growing TMC is anchored by four districts: the TMC Medical Campus and the TMC Innovation Factory, which are already fully open and operating for years now, and the upcoming TMC Helix Park and TMC BioPort, which are both underway.


Bill McKeon gave the address at the State of the Texas Medical Center.

Check out these conferences, pitch competitions, networking, and more in the month of August. Photo via Getty Images

10+ can't-miss Houston business and innovation events for August

where to be

Houstonians are transitioning into a new summer month, and the city's business community is mixing in networking and conference events with family vacations and time off. Here's a rundown of what all to throw on your calendar for August when it comes to innovation-related events.

This article will be updated as more business and tech events are announced.


August 1 — Beyond Bias: Essentials for an Equitable Community

During this seminar, Tracie Jae, Founder of The Quiet Rebel, will share a paradigm shift designed to disrupt the current DEI model.

Diversity, Equity, and Inclusion (DEI) is the accepted workforce best practice. As organizations continue to find the mix of techniques for their particular culture, we began to see the addition of other words like Belonging, Justice, and Access. Meanwhile, the impact appears the same - a focus on making space for “others” rather than actively creating a welcoming environment of mutual respect and acknowledgement. We have chosen to modify rather than innovate.

The event is Monday, August 1, 10 am to noon, at The Ion. Click here to register.

August 3 — Bayou Startup Showcase

The showcase features 24 companies from four accelerators: RED Labs, OwlSpark, RED Launch and BlueLaunch. You will be able to engage with these businesses, sign up for pre-orders, and buy products at their booths. Teams have recorded their pitches for you to learn about them in advance, watch during the event, or review afterward.

The event is Wednesday, August 3, 5 to 8 pm, at Saint Arnold Brewing Company. Click here to register.

August 4 — National Cancer Institute | SBIR Funding Opportunities

The TMCi Accelerator is excited to partner with the National Cancer Institute for a discussion about small business funding opportunities.

The event is Thursday, August 4, 1 to 3 pm, online. Click here to register.

August 8 — Intro to Finance Automation

Understand the benefits of finance automation and how to identify meaningful automation opportunities in your business. Learn from firsthand experiences of FinOptimal’s Founder & CEO, Jesse Rubenfeld.

The event is Monday, August 8, 10 am to noon, at The Ion. Click here to register.

August 11 — Illuminate Houston: An Innovation Conversation

Illuminate Houston is an event series highlighting business leaders who challenge the way we think about the future, featuring dynamic formats where speakers and attendees discuss trends, technologies, and issues that define how we do business. The Partnership welcomes Roberta L. Schwartz, Ph.D., Executive Vice President and Chief Innovation Officer of Houston Methodist on Thursday, August 11.

The event is Thursday, August 11, 1 to 2:30 pm, at Partnership Tower. Click here to register.

August 11 — Summer in the City: UH Students' Showcase Day

Throughout the "Summer in the City" class, students from the University of Houston Honors College have learned about creativity, leadership, entrepreneurship, and smart cities. Taking a mixed-media approach, and benefiting from guest lectures by Robert Cremins, Director of Creative Work: A Pre-Professional Program at UH, as well as panel discussions featuring entrepreneurs, innovators, and founder at the Ion, students have developed their design thinking and innovation skills and tackled problems experienced in Houston.

The event is Thursday, August 11, 5:30 to 7 pm, at the ion. Click here to register.

August 16 — Softeq Venture Studio Public Demo Day 

The Softeq Venture Studio invested $125,000 in cash and services in each of the fourteen early-stage startups to help them refine their business model, build their technology, and prepare them to scale. With 14 startups, the Q2 2022 cohort is the largest yet and brings the total portfolio to 27 companies. In this capstone event, founders have seven minutes each to present their pitch deck, demo their product, outline their ask, and answer questions.

The event is Tuesday, August 16, 5 to 7:30 pm, at The Ion. Click here to register.

August 16 — Enventure "Inspire" Seminar Series - Entrepreneurship

The "Inspire" Seminar Series was developed by Enventure to help students learn about the reality of working in the biotech and biomedical fields. The series consists of a number of events starring guest speakers coming from different areas in the biotech and biomedical industries. Dr. Lauren Cornell is an experienced research scientist with a strong history of military collaborations.

The event is Tuesday, August 16, 6 to 7:30 pm, online. Click here to register.

August 18 — Evolve Houston Relaunch Event

This past year, Evolve introduced a new logo and website to continue embarking on its mission to improve air quality and reduce greenhouse gas emissions through transportation electrification.

The event is Thursday, August 18, 8:30 am to 12:30 pm, at George R. Brown Convention Center. Click here to register.

August 18 — Transition on Tap

Transition On Tap is Greentown Labs' monthly networking event devoted to fostering conversations and connections among the climate and energy transition ecosystem in Houston and beyond. Entrepreneurs, investors, students, and friends of climatetech are invited to attend, meet colleagues, discuss solutions, and engage with our growing community. I

The event is Thursday, August 18, 5 to 7 pm, at Greentown Houston. Click here to register.

August 22 — Startup-Inside-a-Business 102: How to Find SIB Without Spending Any Money

Founders will learn how to look at their companies differently, to see how the capabilities and systems they’ve already created can be reconfigured to multiply growth, value, and valuation. Learn a step-by-step approach to finding the best potential startup inside and insights for estimating the potential value that’s waiting to be unlocked.

This workshop is the second in a series of three Startup-Inside-a-Business Workshops.

The event is Monday, August 22, 10 to 11:30 am, at The Ion. Click here to register.

August 29 — Startup-Inside-a-Business 103: Build One w/out Disrupting Existing Business

Founders will learn how getting investors involved early can end the need for founder cash investments while simultaneously establishing a higher company valuation. They’ll also learn how to manage the tradeoff between cost, risk, and reward by using proven techniques to gain proof before scaling up.

This workshop is the last in a series of three Startup-Inside-a-Business Workshops.

    The event is Monday, August 29, 10 to 11:30 am, at The Ion. Click here to register.

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    CultureMap Emails are Awesome

    7 lessons from a Houston-based unicorn startup founder

    taking notes

    At a fireside chat at SXSW, a Houston founder pulled back the curtain on his entrepreneurial journey that's taken him from an idea of how to make the chemicals industry more sustainable to a company valued at over $2 billion.

    Gaurab Chakrabarti, the CEO and co-founder of Solugen, joined the Greater Houston Partnership's Houston House at SXSW on Monday, March 13, for a discussion entitled, "Building a Tech Unicorn." In the conversation with Payal Patel, principal of Softeq Ventures, he share the trials and tribulations from the early days of founding Solugen. The company, which has raised over $600 million since its founding in 2016, has an innovative and carbon negative process of creating plant-derived substitutes for petroleum-based products.

    The event, which quickly reached capacity with eager SXSW attendees, allowed Chakrabarti to instill advice on several topics — from early customer acquisition and navigating VC investing to finding the right city to grow in and setting up a strong company culture.

    Here are seven pieces of startup advice from Chakrabarti's talk.

    1. Don’t be near a black hole.

    Chakrabarti began his discussion addressing the good luck he's had standing up Solugen. He's the first to admit that luck is an important element to his success, but he says, as a founder, you can set yourself up for luck in a handful of ways.

    “You do make your own luck, but you have to be putting in the work to do it," Chakrabarti says, adding that it's not an easy thing to accomplish. “There are things you can be doing to increase your luck surface area."

    One of the principals he notes on is not surrounding yourself with black holes. These are people who don't believe in your idea, or your ability to succeed, Chakrabarti explains, referencing a former dean who said he was wasting his talent on his idea for Solugen.

    2. The co-founder dynamic is the most important thing.

    Early on, Chakrabarti emphasizes how important having a strong co-founder relationship is, crediting Solugen's co-founder and CTO Sean Hunt for being his "intellectual ping-pong partner."

    “If you have a co-founder, that is the thing that’s going to make or break your company,” he says. “It’s not your idea, and it’s not your execution — it’s your relationship with your co-founder.”

    Hunt and Chakrabarti have been friends for 12 years, Chakrabarti says, and, that foundation and the fact that they've been passionate about their product since day one, has been integral for Solugen's success.

    "We had a conviction that we were building something that could be impactful to the rest of the world," he says.

    3. Confirm a market of customers early on.

    Chakrabarti says that in the early days of starting his company, he didn't have a concept of startup accelerators or other ways to access funding — he just knew he had to get customers to create revenue as soon as possible.

    He learned about the growing float spa industry, and how a huge cost for these businesses was peroxide that was used to sanitize the water in the floating pods. Chakrabarti and Hunt had created a small amount of what they were calling bioperoxide that they could sell at a cheaper cost to these spas and still pocket a profit.

    “We ended up owning 80 percent of the float spa market,” Chakrabarti says. “That taught us that, ‘wow, there’s something here.”

    While it was unglamourous work to call down Texas float spas, his efforts secured Solugen's first 100 or so customers and identified a path to profitability early on.

    “Find your niche market that allows you to justify that your technology or product that has a customer basis,” Chakrabarti says on the lesson he learned through this process.

    4. Find city-company fit.

    While Chakrabarti has lived in Houston most of his life, the reason Solugen is headquartered in Houston is not due to loyalty of his hometown.

    In fact, Chakrabarti shared a story of how a potential seed investor asked Chakrabarti and Hunt to move their company to the Bay Area, and the co-founders refused the offer and the investment.

    “There’s no way our business could succeed in the Bay Area," Chakrabarti says. He and Hunt firmly believed this at the time — and still do.

    “For our business, if you look at the density of chemical engineers, the density of our potential customers, and the density of people who know how to do enzyme engineering, Houston happened to be that perfect trifecta for us," he explains.

    He argues that every company — software, hardware, etc. — has an opportunity to find their ideal city-company fit, something that's important to its success.

    5. Prove your ability to execute.

    When asked about pivots, Chakrabarti told a little-known story of how Solugen started a commercial cleaning brand. The product line was called Ode to Clean, and it was marketed as eco-friendly peroxide wipes. At the time, Solugen was just three employees, and the scrappy team was fulfilling orders and figuring out consumer marketing for the first time.

    He says his network was laughing at the idea of Chakrabarti creating this direct-to-consumer cleaning product, and it was funny to him too, but the sales told another story.

    At launch, they sold out $1 million of inventory in one week. But that wasn't it.

    “Within three months, we got three acquisition offers," Chakrabarti says.

    The move led to a brand acquisition of the product line, with the acquirer being the nation's largest cleaning wipe provider. It meant three years of predictable revenue that de-risked the business for new investors — which were now knocking on Solugen's door with their own investment term sheets.

    “It told the market more about us as a company,” he says. “It taught the market that Solugen is a company that is going to survive no matter what. … And we’re a team that can execute.”

    What started as a silly idea led to Solugen being one step closer to accomplishing its long-term goals.

    “That pivot was one of the most important pivots in the company’s history that accelerated our company’s trajectory by four or five years," Chakrabarti says.

    6. Adopt and maintain a miso-management style.

    There's one lesson Chakrabarti says he learned the hard way, and that was how to manage his company's growing team. He shares that he "let go of the reins a bit" at the company's $400-$500 million point. He says that, while there's this idea that successful business leaders can hire the best talent that allows them to step back from the day-to-day responsibilities, that was not the right move for him.

    “Only founders really understand the pain points of the business," Chakrabarti says. "Because it’s emotionally tied to you, you actually feel it."

    Rather than a micro or macro-management style, Chakrabarti's describes his leadership as meso-management — something in between.

    The only difference, Chakrabarti says, is how he manages his board. For that group, he micromanages to ensure that they are doing what's best for his vision for Solugen.

    7. Your culture should be polarizing.

    Chakrabarti wrapped up his story on talking about hiring and setting up a company culture for Solugen. The company's atmosphere is not for everyone, he explains.

    “If you’re not polarizing some people, it’s not a culture,” Chakrabarti says, encouraging founders to create a culture that's not one size fits all.

    He says he was attracted to early employees who got mad at the same things he did — that passion is what makes his team different from others.

    Houston tech company to acquire IT infrastructure startup

    M&A moves

    Hewlett Packard Enterprise has announced its plans to acquire a San Jose, California-based startup.

    HPE, which relocated its headquarters to Houston from the Bay Area a couple years ago, has agreed to acquire OpsRamp, a software-as-a-service company with an IT operations management, or ITOM, platform that can monitor, automate, and manage IT infrastructure, cloud resources, and more.

    According to a news release from HPE, the OpsRamp platform will be merged with the HPE GreenLake edge-to-cloud platform, which supports more than 65,000 customers, powers over two million connected devices, and manages more than one exabyte of data with customers worldwide.

    The new integrated system "will reduce the operational complexity of multi-vendor and multi-cloud IT environments that are in the public cloud, colocations, and on-premises," per the statement.

    “Customers today are managing several different cloud environments, with different IT operational models and tools, which dramatically increases the cost and complexity of digital operations management,” says HPE's CTO Fidelma Russo in the release. “The combination of OpsRamp and HPE will remove these barriers by providing customers with an integrated edge-to-cloud platform that can more effectively manage and transform multi-vendor and multi-cloud IT estates.

    "This acquisition advances HPE hybrid cloud leadership and expands the reach of the HPE GreenLake platform into IT Operations Management,” she continues.

    HPE's corporate venture arm, Pathfinder, invested in OpsRamp in 2020. The company raised $57.5 million prior to the acquisition. Other investors included Morgan Stanley Expansion Capital and Sapphire Ventures, per TechCrunch.

    “The integration of OpsRamp’s hybrid digital operations management solution with the HPE GreenLake platform will provide an unmatched offering for organizations seeking to innovate and thrive in a complex, multi-cloud world. Partners and the channel will also play a pivotal role to advance their as-a-service offerings, as enterprises look for a unified approach to better manage their operations from the edge to the cloud,” says Varma Kunaparaju, CEO of OpsRamp, in the release.

    “We look forward to leveraging the scale and reach of HPE’s global go-to-market engine to deliver our unique offering and are excited for this journey ahead as part of HPE.”

    3 Houston innovators to know this week

    Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from space tech to software development — recently making headlines in Houston innovation.


    Michael Suffredini, CEO and president of Axiom Space

    Axiom's CEO announced a new mission and space suit design. Photo courtesy of Axiom Space

    It was a big news week for Axiom Space. The Houston company announced its next commercial space mission with NASA to the International Space Station a day before it unveiled its newly design space suit that will be donned by the astronauts headed to the moon.

    “We’re carrying on NASA’s legacy by designing an advanced spacesuit that will allow astronauts to operate safely and effectively on the Moon,” says Micahel Suffredini, CEO of Axiom, in a statement. “Axiom Space’s Artemis III spacesuit will be ready to meet the complex challenges of the lunar south pole and help grow our understanding of the Moon in order to enable a long-term presence there.”

    Called the Axiom Extravehicular Mobility Unit, or AxEMU, the prototype was revealed at Space Center Houston’s Moon 2 Mars Festival on March 15. According to Axiom, a full fleet of training spacesuits will be delivered to NASA by late this summer. Read more.

    Julie King, president of NB Realty Partners

    Houston's access to lab space continues to be a challenge for biotech companies. Photo via Getty Images

    In terms of Houston developing as an attractive hub for biotech companies, Julie King says the city still has one major obstacle: Available lab space.

    She writes in a guest column for InnovationMap that biotech startups need specialized space that can hold the right equipment. That's not cheap, and it's usually a challenge for newer companies to incur that cost.

    "However, with realistic expectations about these challenges, the good news is that once settled into a facility that is a fit, Houston’s emerging biotech companies can thrive and grow," she writes. Read more.

    Owen Goode, executive vice president at Zaelot

    Houston software development firm Axon is planning its Texas expansion thanks to its recent acquisition. Photo via LinkedIn

    Owen Goode is a huge fan of Houston. That's why when his software design firm, Axon, got acquired by Zaelot, led by CEO Jeff Lombard, in January, he made sure the deal would mean growth in the region.

    Zaelot is a global, software firm with a presence in 14 countries, mostly focused in the United States, Uruguay, and Iceland. With the acquisition of Axon, the combined company is poised to expand in Texas, beginning in Houston, Goode says.

    “Together we have a strong suite of offerings across a wide variety of domains including full-stack development, cloud/data engineering, design, staff augmentation, project management, and software architecture. We also have experience in multiple domains, including health care, aviation, defense, finance, and startups,” says Goode. Read more.