This four Houstonians saw a need in their industries and — rather than accepting the status quo — found a solution. Courtesy photos

4 Houston innovators to know this week

Who's who

The crux of innovation is identifying a problem and using your skills to ideate a solution. Each of these four innovators had their "aha" moments that led to their research and development moments, and now to where they are today.

Smriti Agrawal Zaneveld and Jacques Zaneveld, founders of Lazarus 3D

Photo courtesy of Lazarus 3D

It seemed a little antiquated that surgeons were still practicing their techniques on various fruits. Baylor College of Medicine-educated Drs. Jacques Zaneveld and Smriti Agrawal Zaneveld founded Lazarus3D in 2014 to build a better training model — and layer by layer, they created models of abs and ribs and even hearts with a 3D printer.

"We adapted pre-existing 3D printing technology in a novel proprietary way that allows us to, overnight, build soft, silicone or hydrogel models of human anatomy," says Jacques, who serves as CEO. "They can be treated just like real tissue."

Read the full story here.

Guy de Carufel, founder and CEO of Cognitive Space

Photo courtesy of Guy du Carufel

Guy du Carufel knows that in just a matter of years, there will be so many satellites orbiting the early and collecting data, there's not going to be enough people to monitor them. And, frankly, people shouldn't have to. That's why du Carufel created an artificial intelligence-enabled, cloud-based technology that can track and manage each of these satellite clusters on behalf of the cluster's owner.

"We're currently at an inflection point where the satellite industry is expected to grow up to five folds in the next 10 years because of the large companies building up these satellites," du Carufel says. "There are around 2,000 satellites active right now, and that's expected to grow to over 10,000 in the next 10 years."

Read the full story here.

Jim Havelka, founder and CEO of InformAI

Photo courtesy of InformAI

Hospitals and medical centers can be tough places to keep track of data — but that doesn't have to be the case. Jim Havelka founded InformAI to help doctors and health care providers tap into their data to provide better diagnoses and preventative care.

"There were several things missing," says Havelka. "One was access to very large data sets, because it wasn't really until the last five or 10 years that digitalization of data, especially in the health care vertical became more widespread and available in a format that's usable. The second convergence was the technology, the ability to process very large data sets."

Houston-based Procyrion has closed a $30 million round — doubling its total funding to date. Getty Images

Houston medical device company closes $30 million round

Follow the money

A clinical-stage medical device company based in Houston has rounded up $30 million for its Series D funding. Procyrion Inc.'s round was lead by Bluebird Ventures — a new funding partner for the company.

Procyrion is developing a blood pump, called the Aortix™ system, that's optimized for patients with heart and kidney failure. Joining in on the round with Bluebird are return investors, including Fannin Partners, Scientific Health Development, the State of Texas, and an undisclosed strategic investor. This round has now more than doubled the company's total funding, bringing that figure now to $59 million.

"Of the more than 1 million patients per year in the U.S. admitted to the hospital with acute decompensated heart failure, 25 to 30 percent also have worsening renal function," says Eric S. Fain, president and CEO of the company, in a release. "These are typically the most difficult to treat patients with high mortality and rehospitalization rates."

The funds, Fain says, will go toward advancing the medical device, specifically enhancing the system's ability to decongest cardio renal patients in the company's pilot program.

"Today there is a major gap in effective therapies that are available to treat these critically ill patients, and as such, there is a significant opportunity to improve patient outcomes," Fain continues in the release. "The Aortix device is uniquely designed and positioned in the body to simultaneously decrease the workload of the heart and improve kidney function."

The Aortix device is a solution for patients who haven't seen success from medical therapy, but don't have the immediate need for a transplant or more drastic solution. The device is thinner than a pencil, the release says, and can be inserted in a matter of minutes in a cath-lab setting. The size and ease of application could be transformational for the large population of heart patients that would need it.

In addition to the funds, Jeff Bird, managing director of Bluebird Ventures, will join the company's board of directors.

"The Procyrion Aortix device provides an elegant solution for managing heart failure, a serious and difficult-to-treat problem," says Bird in the release. "We are excited to work with this experienced team as they begin clinical testing."


The device is thinner than a pencil and can be inserted in less than 10 minutes. Photo via procyrion.com

Houston researchers are commercializing their organ 3D printing technology, a local hospital has a tiny medical device with a big impact, and more in health tech. Jordan Miller/Rice University

3 health technologies developed in Houston that are changing the industry

Game changers

There's a huge opportunity for breakthrough medical technology in Houston thanks in large part to major universities, the Texas Medical Center, and other resources within health care startups.

From a new tiny implant that can deliver medicine into the patient remotely to printable human tissue, here are three health technologies coming out of Houston innovators to look out for.

Houston Methodist's tiny drug delivery implant

This tiny implant can have a big effect on patients. Courtesy of Houston Methodist

Houston Methodist nanomedicine researchers have developed an implant the size of a grape that can deliver medicine via a remote control. The device has applications in arthritis, diabetes, and heart disease treatment.

The battery-powered nanochannel deliver system uses Bluetooth technology and can dole out continuous, predetermined dosages for up to a year without refills. A proof-of-concept for the device published in Lab on a Chip.

"We see this universal drug implant as part of the future of health care innovation," says Alessandro Grattoni, chair of the nanomedicine department at Houston Methodist. "Some chronic disease drugs have the greatest benefit of delivery during overnight hours when it's inconvenient for patients to take oral medication. This device could vastly improve their disease management and prevent them from missing doses, simply with a medical professional overseeing their treatment remotely."

The devices can be programed for different dosage sizes and different release settings, which affect the voltage for the medicine delivery.

Houston Methodist has a number of new technologies it's introduced into its hospital system — click here to read about a few more.

NurseDash's resourceful scheduling tool

Houston-based NurseDash is the Uber of staffing nursing shifts in medical facilities. Photo via nursedash.com

Filling open nursing shifts has always been a challenge for hospitals and medical centers, and they've been forced to rely on outsourced companies to coordinate nurses to fill the shifts. NurseDash puts the power back in the hands of freelance nurses and the medical institutions that want to hire them.

Andy Chen, former CFO for Nobilis Health Corporation and co-founder of NurseDash, says the standard practice is hiring these agencies to fill shifts, and, while they promise to send someone, they don't even know who they'll be sending for a shift just hours away. This antiquated system prioritizes who comes in first, rather than a nurse's specialties or qualifications.

Since its debut, NurseDash, which is based in Houston's Galleria Area, has attracted 40 facilities in Houston, including hospitals, surgery centers, and senior living, and about 400 nurses. Chen says he isn't sure just what to call his technology yet, but compares it to the ride hailing of Uber or Lyft and calls it "a virtual bulletin board."

The company has already expanded beyond Houston to northeast Ohio, which the founders say has a similar competitive dynamic to the Houston market. The next goal is to hit the rest of the top 10 largest cities in the United States. To read more about the app and startup, click here.

Volumetric's human tissue-printing technology

Rice University bioengineer Daniel Sazer prepares a scale-model of a lung-mimicking air sac for testing. Jeff Fitlow/Rice University

In a world where organ transplants means an incredible amount of time, money, and patience, there might soon be another option on the operating table. Volumetric is a startup that came out of a human tissue-printing technology developed at Rice University.

Jordan Millar developed the 3D printer in his lab at Rice, and still has ongoing research within the technologies. However, Miller says he very strategically chose to launch a for-profit company in 2018 — mainly, to provide access.

"If we want to do translational research, commercialization is important," reasons Miller. "We need to build the market to get that technology into the world."

Right now, the device is printing scaled down organs, and a contraption that looks a bit like a futuristic beehive, graced the cover of the May 3 issue of the journal Science. It's a working air sac complete with blood vessels, the beginnings of a technology that is perhaps only a decade from being implanted in humans. To read more about Volumetric, click here.


Houston researchers are commercializing their organ 3D printing technology. Jordan Miller/Rice University

Houston researchers are commercializing their human tissue-printing technology

3d-printed organs

There may come a time when you or someone you love is in need of a new pair of lungs. Or perhaps it's a liver. It's not a scenario anyone dreams of, but thanks to Houston company Volumetric, you may never end up on a waiting list. Instead, that organ is made to order and 3D printed using a mix of medical plastics and human cells.

And this possibility isn't necessarily in the distant future. On the cover of the May 3 issue of the journal Science, is a contraption that looks a bit like a futuristic beehive. It's a working air sac complete with blood vessels, the beginnings of a technology that is perhaps only a decade from being implanted in humans. And it was crafted on a 3D printer in Jordan Miller's lab at Rice University.

Yes, there are shades of another Houston story — Denton Cooley's implantation of the first artificial heart — but Cooley only inserted the organ. Miller and his bioengineering graduate student Bagrat Grigoryan are primed to profit from their inventions.

In 2018, they started Volumetric Inc., a company that sells both the hydrogel solutions used for printing organs like theirs and the printers themselves. Touring Miller's lab in the Houston Medical Center is a visual timeline of his team's progress designing printers. The version being manufactured is a slick little number, small enough to fit under chemical exhaust hoods, but fitted with everything necessary to print living tissues. It's made and sold in cooperation with CellInk, a larger bioprinting company.

"Our technology is based on projection," Miller explains. Specifically, it's stereolithography, a type of 3D printing that produces the finished product layer-by-layer. Shining colored light of the right intensity turns the polymers into a solid gel.

But why start a company when Miller and Grigoryan are already busy with research?

"If we want to do translational research, commercialization is important," reasons Miller. "We need to build the market to get that technology into the world."

Miller explains that usually the inventor of a technology is the best one to bring it to market.

"When we were building this technology in the lab we saw the potential for commercialization," he recalls. "We do see that this technology is highly scalable. We do think it can have a positive impact on tissue models in a lab."

Those tissue models could one day make not just scientists, but also animal rights activists, very happy. With the technology that Volumetric is developing, scientists could eventually print human cells so well that animal models would be far less accurate in predicting the success that the product being tested would have on humans.

As academics, though, Miller and Grigoryan weren't sure how to start a company. Fortunately, there is the National Science Foundation (NSF) and its I-Corps program. The pair spent a couple of weeks doing a regional program that taught scientists how to commercialize their technology.

"They want to see funded research get out of the lab," Miller says, explaining that they moved on to the national I-Corps program while Miller was on sabbatical from teaching at Rice, allowing them to interview potential customers.

This gave them the confidence to launch last year. Grigoryan now works full-time at the Med Center incubator and accelerator, Johnson & Johnson's JLabs. He has a team of two other scientists on staff.

"It would have been a lot harder to get started if we didn't have a space like JLabs available," Miller says. It also helps, he adds, that JLabs takes no equity, only helping the fledgling brand to finalize its market and get hooked in with potential investors.

Volumetric has its demo units ready to go and expects to start shipping printers in late June, pending final certifications.

"We believe we have technology to make organ replacements for people," Miller says.

And someday soon, long waits for a new set of lungs and a life of antirejection drugs could be a thing of the past.


Rice University bioengineers (from left) Bagrat Grigoryan, Jordan Miller and Daniel Sazer and collaborators created a breakthrough bioprinting technique that could speed development of technology for 3D printing replacement organs and tissues. Photo by Jeff Fitlow/Rice University

Houston, home to the largest medical center in the world, was ranked the second in the nation for emerging life science clusters. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

Houston named a top city for emerging life sciences market

Up and coming

From a real estate and employment perspective, Houston is the second in the nation for emerging life sciences market, according to a new report.

CBRE released the top 10 cities for life sciences, as well as nine cities that have seen recent growth in the industry. While the Northeast and California dominated the list of the established markets, three Texas cities took top spots on the emerging list. Austin ranked behind Houston at No. 3 and the Dallas/Fort Worth area claimed the No. 7 spot. The top emerging life science cluster was the Seattle area.

The ranking was based on each metro's three-year growth in life sciences employment, National Institutes of Health funding, life science educational opportunities, number of medical research and health-services institutions, and the amount of high-tech workers.

"We've watched the life sciences sector for quite a few years in Houston as it steadily grew, but within the past few years it has grown exponentially," says CBRE Houston's First Vice President Scott Carter in a release. "TMC3 is obviously going to be a catalyst for continued growth in life sciences."

The growth within the industry has translated from employees and research to real estate, and Carter says CBRE currently has the 224,931-square-foot Texas A&M ALKEK building on the market — most of the facility is laboratory space.

"There has been substantial interest from investors in the top established life science markets," he continues. "They recognize Houston as an emerging market and see the value of placing capital in the Houston area."

The country's venture capital funding for the industry increased 86 percent last year to $15.8 billion, and, according to the release, the lab space under construction in the top five metros for life science growth expanded 101 percent last year to 6 million square feet.

"Multiple indicators point to sustained, strong growth for the life sciences industry, which makes life sciences labs and offices an ideal focus for developers and investors," says Steve Purpura, vice chairman leading CBRE's life sciences business. "Few industries offer this much expansion potential, but much of the activity happens in a select number of special markets."

Via the CBRE report

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California self-driving vehicle startup has all eyes on Houston — here's why

On a roll

Houston — with its sprawl and winding roads broken up across various neighborhoods — is particularly challenging when it comes to self-driving car navigation. And that's exactly why Nuro, a California-based tech startup that's raised over $1 billion in funding, decided to focus on the Bayou City for its autonomous vehicle delivery pilot programs.

"Houston is our first full-scale operations city," Sola Lawal, product operations manager in Houston, tells InnovationMap. "All eyes at Nuro are focused on Houston."

Last year alone, Nuro launched three pilots in six of Houston's ZIP codes from Bellaire to the Heights. The first of which was a partnership with Kroger in March, followed by the announcement of autonomous pizza delivery from Domino's in June. Last month, Nuro announced its latest delivery partner was Walmart.

Lawal explains Houston's appeal to Nuro in a few ways, but the challenging landscape is key. Nuro cars are learning from the narrow, tree-laden streets of West University or the pedestrian-heavy, ditch-lined paths in the Heights.

"There's a ton for us to learn, but it's a great microcosm of the United States in a number of different ways," he says.

In addition to its diversity within its street types, Houston, named the most diverse city in the country, represents an ideal customer base, says Lawal, a Houston native himself. Houstonians are open minded about new experiences.

"If you think and look across Houston, the average commute is over 60 minutes for people to get back and forth," Lawal tells InnovationMap. "As we surveyed across major cities we were interested in, Houston stood out as a place where customers said they don't want go to the grocery store if they don't have to or get in their cars again to pick up their pizza."

The third reason Houston was a great market for Nuro is the amount of regulatory support the state of Texas has — Gov. Greg Abbott announced the launch of the Texas Connected and Autonomous Vehicle task force a year ago — as well as the support at the city level.

"It's been a welcoming environment from the mayor's office down for us to be here," Lawal says.

Since entering the Houston market, Nuro's local operations have grown to over 100 employees. The company still has software operations out of California, and some work being done in Arizona, but the Houston is the largest — and growing as the company seeks new partnerships with more stores with a goal of eliminating errands once and for all.

"The way that we think about this is that this new technology and our mission of accelerating robotics for everyday life, is we will bring the people what they want," Lawal says when asked about what types of stores Nuro is looking to partner with.

Eventually, Lawal says, the plan would be to have every errand be delivery optimized with Nuro technology — from big-box stores like Walmart to your local florist.

"Our goal is to have a platform that retailers can connect to in order to provide easy and inexpensive delivery," he says.

Currently, Nuro's technology is still in learning mode. Nuro's fleet of Prius cars with staff onboard are driving up and down Houston streets mapping and taking notes on a daily basis. The company also has bots, called the R2 fleet, that are designed to be unmanned.

These bots are smaller than normal cars and are completely electric. Rather than being designed to protect passengers inside like traditional automobiles, the R2s are designed to be safe for people outside the vehicle.

"It's a new way of thinking about transportation and what our vehicles can and should do," Lawal says.

2020 is the year of these R2 bots, and some areas can expect to see them in action — specifically focused on Domino's pizza delivery — in just a matter of weeks.

Preparing Houston's tech workforce starts in school, says expert

Guest column

Recent studies have shown that nearly half of students enter college with an undecided major and as many as 70 percent of students change their major at least once during their four-year program, and it is predicted that by 2030, there will be a deficit of 7.9 million tech workers alone.

In order to better prepare the future workforce, schools are encouraging career exploration through hands-on experience. The Village School has created educational partnerships throughout Houston to offer students options to find their interests and better prepare them for postsecondary success.

Educational partnerships

Students are prone to changing their majors because often they will go into a field with an impractical idea of what a specific career actually entails. With partnerships between education and industry, Houston is able to better equip students to enter college with a realistic view of what to expect in their major.

While career-focused partnerships are beneficial for students, they also play a huge role in recruiting valuable skilled talent for years to come. A good impression, good mentors and great experience goes a long way when students start job searching.

Tuning into Houston's workforce

High school is the time for students to explore different career options. When students are placed in an internship program as early as the high school level, they are able to see exactly what the day to day looks like while building a foundation of professional development as they start to think about their future. It's important for students to have a realistic vision of what a career looks like.

There are numerous businesses in Houston that are working with high school students to help them gain experience.

For example, a few of the businesses that have partnerships with The Village School include Houston Methodist Hospital, Pimcore, M.D. Anderson Cancer Center, and Cisco. Students are able to gain experience in a variety of ways including:

  • Working alongside surgical technicians and experience open-heart surgery and quarantined situations
  • Learning from cancer researchers who study nicotine addiction in children and the effects on brain development
  • Leveraging data analytics to develop software helping internal team members organize calendars at a leading SAP company

All students finished their internship with a better understanding of the workforce and the skills necessary to perform in a professional environment.

Finding opportunities for everyone

If students don't attend a high school that offers internships there are still opportunities to gain experience. Many businesses are open to job shadowing or having students volunteer a few hours a week to gain experience over the summer months. The opportunity for experience is out there and available and these opportunities will continue to grow and become more accessible for all students. Houston families and businesses must work together to ensure students know their options before entering college.

Educational partnerships benefit both students and the community. It's crucial for Houston to prepare the next generation's workforce to succeed and fill jobs with capable talent. Students are able to see that while they may not think they are interested in a specific field there are opportunities within the field that match their strengths and interests.

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TeKedra Pierre is the internship coordinator at The Village School.

Booming Houston suburb hauls in top spot among growing U.S. cities

making moves

The Houston metro area's population is poised to continue booming over the next decade, so it should be no surprise that U-Haul calculated one Houston suburb as one of the top U.S. cities for growth.

In its annual report, released January 7, the company details migration trends across the U.S. Analyzing data from 2019, the moving and rental company placed Spring-The Woodlands at No. 14 among the 2019 U-Haul Growth Cities.

To determine the country's top 25 growth cities, U-Haul analyzed more than 2 million rental transactions over the calendar year. It then calculated the net gain of one-way U-Haul trucks entering an area versus those leaving an area.

Unlike U.S. Census Bureau or real estate data, the company says its U-Haul Growth Cities offers a snapshot of an area's retention rates versus strictly growth.

"While U-Haul migration trends do not correlate directly to population or economic growth, the company's growth data is an effective gauge of how well cities and states are attracting and maintaining residents," it explains in a release.

Three other Texas cities were perched on the list: the Austin suburb of Round Rock-Pflugerville (No. 5), the San Antonio suburb of New Braunfels (No. 11), and the Dallas suburb of McKinney (No. 17).

The top spot this year went to Raleigh-Durham, where arrivals accounted for nearly 51.4 percent of all one-way U-Haul traffic. In its explanation as to why the North Carolina hub is growing, the company points to the region's booming tech sector, which is says rivals that of Austin.

"We have tons of businesses coming here, bringing new residents in U-Haul trucks," said Kris Smith, U-Haul Company of Raleigh president, in a release. "Raleigh-Durham is rivaling Austin for attracting tech businesses and young professionals. We're seeing Silicon Valley talent and companies flock to the area. With a competitive cost of living, good wages, and job growth, Raleigh-Durham is experiencing a boom in population."

But when it came to the top growth state, neither Texas nor North Carolina got the No. 1 spot. That honor went to Florida, which took the crown from Texas, the winner in 2018. The Sunshine State claimed seven cities among the top 25, including five in the top 10.

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This article originally ran on CultureMap.