Houston medical device company launches is product in the U.S. and hires new exec

Early bird gets the worm

A Houston company is changing the game when it comes to early bleed detection, and now the company can provide its life-saving service to the United States.

Saranas Inc., which received FDA approval for its Early Bird Bleed Monitoring System in March, announced that it is launching its device in the US. at the Transcatheter Cardiovascular Therapeutics Conference next week in San Francisco. The device is designed to detect and track bleeding complications related to endovascular procedures. These medical procedures treat problems, such as aneurysms, that affect blood vessels.

"As the first and only early bleed detection system on the market, the Early Bird is ideally positioned to play a key role in making the rapidly expanding, minimally-invasive catheter-based procedures safer by providing physicians with bleed monitoring in real-time," says Saranas president and CEO, Zaffer Syed, in a news release. "With the launch of the Early Bird, physicians will now have a standard of care to monitor the bleed status of the patient during and post procedure, receive timely notifications of actual bleeds, and potentially reduce the severity of bleeding complications and resulting costs, while protecting clinical outcomes in patients undergoing endovascular procedures."

Around 20 percent of patience suffer a bleeding complication during endovascular procedures, like transcatheter aortic valve replacement, endovascular aneurysm repair, and percutaneous hemodynamic support, and, according to a report in the Journal of the American Medical Association, these complications result in higher mortality, longer hospital stays, and higher medical bills.

In other exciting news for the company, Saranas hired Tom Lucas as vice president of sales and marketing. He has 28 years of experience in medical sales, and he is tasked with business development, marketing, sales, and more for the company.

"Tom is a critical strategic hire for Saranas as we launch our first product in the U.S.," Syed says in the release. "His expertise will be invaluable as we expand distribution of the Early Bird into additional centers of excellence."

Saranas began its clinical trials last year after raising $2.8 million. The company revealed the results of those trials earlier this year, leading to the FDA approval.

"Our first-in-human study demonstrated that clinical concordance with Early Bird detection and CT scans (primary endpoint) was near perfect, and the early discovery of bleed onset and progression during the procedure occurred in 31 percent of cases with 69 percent occurring post procedure," says Saranas Chief Medical Officer Dr. Philippe Généreux in the release. "Compared to the current paradigm of waiting for symptoms, which could take hours to develop, the Early Bird allows physicians to detect bleeding in real-time and take the necessary actions quickly to protect the outcomes of the procedure and aid recovery for the patient."

The results are in for Houston-based Saranas' clinical trials. Courtesy of Saranas

Houston early bleeding detection device company reveals results of its clinical trials

blood tests

A Houston-based startup is closer to taking flight with a medical device designed to catch bleeding complications during medical procedures that involve blood vessels.

On May 22, researchers presented the results of a study showing the Early Bird Bleed Monitoring System from Houston-based Saranas Inc. detected various levels of bleeding in 63 percent of the patients who underwent endovascular procedures. These procedures treat problems, such as aortic aneurysms, that affect blood vessels.

No troubles were reported with the Early Bird device during the clinical trial, the researchers say.

Before this study, the Early Bird device hadn't been tested in humans. In all, 60 patients in five states participated in the clinical trial, which ran from August to December last year. Findings of the study were unveiled at the Society for Cardiovascular Angiography Interventions 2019 Scientific Sessions in Las Vegas.

The study's authors say they plan to continue evaluating the device at medical institutions that want to better manage bleeding during endovascular procedures.

"This is the first time we're seeing how this device could help in a real-world patient setting, and we were very encouraged by the results. Right now, patients have a risk of vessel injury when undergoing endovascular procedures where the femoral artery or vein is used for vascular access," Dr. Philippe Genereux, principal investigator for the study and a cardiologist at Morristown Medical Center in Morristown, New Jersey, says in a news release.

"This technology allows us to detect bleeding in real-time," Genereux adds, "which means we can take action quickly and improve the outcomes of the procedure and recovery for the patient."

In March, the Early Bird device — invented at Houston's Texas Heart Institute — received the U.S. Food and Drug Administration's approval as a "novel" medical device.

Saranas says Early Bird is the first and only device of its type. The FDA approval and the promising results of the clinical trial pave the way for the eventual launch of the device into the healthcare market.

A forecast from professional services firm KPMG predicts the global market for medical devices will reach nearly $800 billion by 2030. Early Bird aims to capture a sliver of that market by addressing an expensive and potentially fatal problem. One-fifth of patients experience bleeding complications during large-bore endovascular procedures. Research shows these complications are associated with a greater risk of death, longer hospital stays, and higher healthcare costs.

The Early Bird device is meant to decrease those complications by quickly alerting medical professionals to signs of bleeding during endovascular procedures.

As explained by the Texas Heart Institute, the Early Bird employs a sheath — a plastic tube that helps keep arteries and vessels open — embedded with sensors that measure the electrical resistance across a blood vessel. When the Early Bird senses a change in the electrical resistance, medical professionals receive audible and visual notifications about potential internal bleeding. If detected early, this bleeding can be minimized.

Altogether, Saranas has raised $12 million from investors, including a $2.8 million round in May 2018. The company was founded in 2013.

"What attracted me to Saranas is that our solution has the potential to meaningfully reduce serious bleeding complications that worsen clinical outcomes and drive up healthcare costs," says Zaffer Syed, who joined the startup as president and CEO in 2017. "In addition, our device may support access of important minimally invasive cardiac procedures by allowing them to be performed more safely."

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Statewide accelerator hires new Houston staffer and embraces 'virtual first' approach amid COVID-19

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For years, Capital Factory has existed to promote innovation and grow startups across Texas and has expanded from its headquarters in Austin to Dallas, Houston, and beyond. In light of COVID-19, the organization has pivoted to make sure it can work with startups remotely and online.

"I think Capital Factory has successfully embraced virtual first," says Bryan Chambers, vice president of the accelerator and fund at Capital Factory. "I think it's gone well and it feels like we're just hitting our stride."

Chambers admits that the onset of the coronavirus had a great effect on Capital Factory — SXSW being canceled did its damage on the organization, which has a huge presence every year. However, cross-state startup collaboration is the driving force behind Capital Factory's Texas Manifesto.

"We're one big state, and we're one big startup ecosystem," Chambers says. "The resources across Dallas, Houston, Austin, North Texas, and San Antonio are available for everybody. Candidly, COVID aligns with that. There's no better time — COVID is erasing the boundaries in a virtual world."

In addition to navigating the transition to virtual operations, Capital Factory has also introduced its newest Houston staff member, as Adrianne Stone has started this week as venture associate for the organization. Stone received her Ph.D in Translational Biology and Molecular Medicine from Baylor College of Medicine before heading out to the West Coast and working at 23andme. She brings both her experience with health tech and Silicon Valley to her position.

"The mindset in Silicon Valley is different from how it is here in Texas — in good ways and bad ways. It was interesting to be exposed to a very potent startup vibe," Stone tells InnovationMap. "I'm looking forward to being able to meet all the cool companies, founders, and investors we have here in the Houston area."

Stone replaces Brittany Barreto, who helped in coordinating her replacement and is staying on part-time for the rest of August to help with training and immersion into the ecosystem. Barreto, who is one of the founders of the recently launched startup masterclass Founder's Compass, has also introduced a new brand called Femtech Focus, that includes a podcast where she talks to innovators in the women's health and wellness space.

"I'm ready to get back into the founder's saddle," Barreto says, adding that there's more to come for Femtech Focus.

Throughout her tenure, Barreto has overseen Capital Factory's Houston portfolio companies — both identifying potential investment opportunities and connecting startups to resources and mentors. She passes the torch to her former BCM classmate, and says she's excited to do so to a fellow Ph.D.

"The last year and a half, I've working really hard on laying this foundation. I don't want all that hard work to go away, so I cared a lot about who was going to take my position," she says. "I wanted to make sure that all my founders had someone who cared about them as much as I do."

Impact Hub Houston has new HQ, HCC creates AI program, and more innovation news

Short stories

Houston's innovation ecosystem has been booming with news, and not all make the news. For this roundup of short stories within Houston innovation, a Houston startup incubator has a new home, a local school creates AI-focused program, Astros manager taps into sports tech, and more.

Impact Hub Houston makes downtown partnership

Impact Hub Houston has a new headquarters in downtown. Photo courtesy of Central Houston

Impact Hub Houston, a nonprofit organization that promotes and accelerates sustainability-focused startups, is resident partner at Downtown Launchpad, according to Central Houston and the Downtown Redevelopment Authority.

The organization now has a 10-year lease and a new headquarters for its team and events. Impact Hub joins two accelerator programs — MassChallenge Texas and gener8tor — which both have a global presence and launched in Houston in the past two years.

"We celebrate Central Houston's vision in launching this 'vertical village' and appreciate their ongoing support in including Impact Hub Houston as a part of it," says Grace Rodriguez, CEO and executive director of Impact Hub Houston, in a news release. "It takes a village to raise an entrepreneur, and now we have that village with the infrastructure and community to raise generations of diverse innovators. It's another exciting step towards our goal to build an authentically inclusive and equitable entrepreneurial ecosystem that looks like Houston and works for all in our region."

HCC introduces artificial intelligence program

Data science startup based in Houston focus on neuroscience software nabs $3.78M grant

A local college system is training the future AI workforce. Getty Images

Houston Community College is the first community college in the state to introduce a new program focused on artificial intelligence. The new Associate of Applied Science degree program has been approved by Southern Association of Colleges and Schools Commission on Colleges, according to a press release from HCC, and is available for the fall 2020 semester at HCC Southwest, HCC Northeast and HCC Southeast.

"It is the latest of HCC's ongoing efforts to embrace new technologies and keep a pulse on the ever-changing needs of the industry," HCC Chancellor Cesar Maldonado says in the release. "Offering an innovative program like AI will allow our students to take advantage of all the accelerated job openings in Houston, in Texas and beyond."

The new program exists to fill the rising need for AI professionals. Last year, the job site indeed.com identified machine learning engineers at the top of its annual list of the 25 best jobs, citing a 344 percent increase in job postings from 2015 to 2018 with an annual base salary of $146,000.

"Because of a dire shortage of AI specialists, many companies are offering big salaries," says G. Brown, Ph.D., program coordinator of Networking and Telecommunications at HCC Southwest, in the release. "AI specialists are in high demand by companies like Microsoft, Apple and Amazon, as well as NASA and SpaceX."

Rice project re-envisions dorm layouts

The dorm design created socially-distant spaces that can be used in times of a pandemic. Photo via rice.edu

Two Rice University students received top marks in the 2020 American Institute of Architects Houston (AIAH) Gulf Coast Green Student Competition for their pandemic-proof dorm design. Carrie Li and Mai Okimoto, both 2022 Rice master's of architecture students, won first place in the competition that challenged students to design a dorm for the University of Houston-Downtown that would adhere to the Centers for Disease Control's social distancing guidelines.

"Carrie and Mai's timely and innovative proposal is beautifully conceived, highly resolved and elegantly presented," says interim dean, John J. Casbarian, in a news release. "I am particularly struck by how seamlessly it addresses the pressing issues of flooding, natural ventilation and social distancing, and how well sited it is in relation to UHD while mitigating the adversity of the freeway expansion.The competition consisted of eight teams from Texas and Louisiana which presented to judges from Kirksey, PDR Corporation, Gensler, Walter P Moore and UH-D. Li and Okimoto's project features 432 units across three villages and even factored in the area's flooding challenges.

"[Our design] aims to: allow social interaction to happen on different scales, from the one-on-one connection to larger scale gatherings; provide the users with safe but varied circulation paths, through which natural ventilation also occurs; treat dining as a key socializing program; and address the site's flooding risks and impacts of the I-45 corridor expansion," Li says in the release.

City of Houston passes small business-focused economic relief initiative

A new program from the city of Houston is helping to provide funds for businesses affected by COVID-19. Getty Images

Last week, Mayor Sylvester Turner and the Houston City Council passed the city's Small Business Economic Relief Program, funded with $15 million of the City's allocated CARES Act 2020 funds. Small businesses can apply for up to $50,000 and the grant can be used for payroll, accounts payable, rent, mortgage, PPE for employees, marketing strategies, including creating an online presence and other sales alternatives.

"We know small businesses throughout Houston have suffered greatly due to the global pandemic, and it could take months or years before the business climate returns to normal," says Mayor Sylvester Turner in a news release. "I thank Vice Mayor Pro-Tem Martha Castex Tatum and other council members for bringing this program forward. We are working on other relief packages that will keep us Houston Strong as we navigate the public health crisis."

The program will be administered by Houston's Office of Business Opportunity and the Houston Business Development Inc.

To qualify for the SBERP, businesses must be located in Houston, have been in business for at least one year, provide evidence for revenue decrease due to COVID-19-caused closures, have less than $2 million in gross annual revenue pre-COVID-19, be in good standing with the city, and commit to complete technical assistance.

"The SBERP will help all sizes of small businesses move one step closer toward financial recovery. This program is intended to maximize the long-term, positive impact of these small businesses on our local economy through their contribution to job retention and the continued availability of their services," says Marsha Murray, director for the Office of Business Opportunity, in the release. "If our local small businesses did not qualify for other federal or local programs, or did not receive enough funds to mitigate the impact of the crisis, we encourage them to apply for this program."

Astros manager joins venture capital firm

Not only is Dusty Baker at the helm of the 2017 World Series-winning Astros, but he's also a founding partner of a sports-focused venture capital firm. Getty Images

The Houston Astros manager, Dusty Baker, is a founding partner of a new venture capital firm focused on sports tech and innovation. New York-based Turn2 Equity Partners is a new fund is beginning with a focus on amateur and professional baseball markets.

"For decades, baseball players, managers and executives have lended their credibility to brands as endorsers," Baker says in a press release. "With the establishment of Turn2 Equity, for the first time, faces of the game have the opportunity to own and influence people at all levels."

Co-founded by sports venture capitalists Jarett Sims and Peter Stein, the firm's team also includes Jim Duquette, New York Mets general manager; Bobby Evans, who was formerly with the San Francisco Giants as general manager; and John Haegele, the former CEO of Van Wagner Sports & Entertainment.

GotSpot Inc. wins veterans competition

A Houston startup that's using technology to optimize short-term real estate space took home a prize in a virtual pitch competition. Image via LinkedIn

Houston-based GotSpot Inc. has claimed another pitching competition prize for veteran-owned businesses. Reda Hicks, founder of the Houston startup, received third place and $10,000 at the Ford Fund Virtual Pitch Competition last month. Memphis-based Pure Light Clean Air Services took first place and $15,000 and Raleigh, North Carolina-based Blue Recruit won second place and $10,000.

"The experiences, teamwork and skills learned in service of our country can serve as a solid foundation for these men and women as they build sustainable businesses," says Yisel Cabrera, manager of the Ford Motor Company Fund, in a news release. "We're proud to work with Bunker Labs to assist these inspiring entrepreneurs as they pursue new roads to success."

Calling all energy startups

Upstream startups can submit to a new virtual pitch competition. Photo via atce.org

The Society of Petroleum Engineers is calling for applications from energy startups to compete in a virtual pitch competition. Applications for the ATCE Startup Village, which is a collaboration between SPE and the Rice Alliance for Technology and Entrepreneurship, are live online and due by August 14. The competition will take place Tuesday, October 13.

The competition is free to compete and to apply, and open to early stage upstream technology companies. Each company selected to present will have 5 to 8 minutes to provide a "quick pitch" about their company to a group of venture capitalists, angel investors, and industry leaders. Judging will be based on innovative technology, commercial strategy and business plan, market potential, and management team and advisers.

Rice University research: Collaboration with the community can be key to success

houston voices

In Pittsburgh, a coalition of 100 community groups brokered a deal with developers of the Pittsburgh Penguins ice hockey team for $8.3 million in neighborhood improvements. In Oakland, California, developers of an $800 million high-tech complex promised local residents 50 percent of its construction jobs. And in Chicago, the Obama Presidential Center is working with residents to shield them from skyrocketing rents.

Community Benefits Agreements, or CBAS, as these agreements are called, are increasingly common between businesses and the places where they want to set up shop. But are they worth the money? To find out, Rice Business professor Kate Odziemkowska joined Sinziana Dorobantu of New York University to analyze market reactions to 148 CBA announcements between indigenous communities and mining firms in Canada. The financial value of these agreements, the researchers found, was real.

While it's easy to imagine that CBAs are just costly giveaways, they're more than goodwill gestures. Instead, they are legally enforceable contracts to distribute benefits from a new project and to govern the response to any potential social and environmental disruptions. For businesses, the researchers found, they are also good strategy, because they prevent costly, drawn-out conflict.

To conduct their research, Odziemkowska and Dorobantu analyzed a sample of 148 legally binding CBAs signed in Canada between mining firms and indigenous communities between 1999 and 2013. In Canada, mining companies and indigenous communities often hammer out agreements about extraction and use of local resources. Studying only the mining sector let the researches control for the economic variations that characterize different industries.

Since CBA negotiations cannot be disclosed, the announcement of such agreements represents new market information. To conduct their study, the researchers tracked the market reaction to these announcements, using a technique that measured short-term returns.

Creating CBAs from the start, they found, can head off catastrophic costs later. That's because even when a company has disproportionate economic strength, the public relations, legal and economic costs of community conflict can be draining. Consider the 1,900-kilometer Dakota Access oil pipeline, whose developers faced six months of round-the-clock protests that included nearly 15,000 volunteers from around the world. The drumbeat of litigation and negative news coverage still continues today.

In general, the researchers found, the more experience a community has with protests or blockades, the more firms gained from signing a CBA. Property rights protections also provide strong incentive for making a deal. Mining companies, for example, need access to land to do business. Communities with robust property rights to the resource or location sought by the firm have strong standing to stop that firm if they don't make a deal.

Because access to valuable resources like land or intellectual property can mean the difference between financial success or failure, Odziemkowska and Dorobantu said, the lesson from their findings extends far beyond Canadian mines. It's a lesson Disney learned the hard way when it failed to acknowledge the culture of Norway's Sami people in "Frozen." Assailed for cultural appropriation by using, but not crediting, traditional Sami music, Disney quickly made amends. After negotiating with the Sami people, Disney pledged to consult with them and portray them thoughtfully in the film's sequel.

The deal may have cost Disney on the front end, but it was nothing compared to the advantage of freezing out years of bad press.

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This story originally ran on Rice Business Wisdom. It's based on research by Kate Odziemkowska, an assistant professor of Strategic Management at Rice University's Jones Graduate School of Business.

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