The Ion taps John Reale for startup and investor role

new hire

Houston startup and investment leader John "JR" Reale has a new role at the Ion. Photo courtesy Rice Alliance.

The Ion has named John "JR" Reale as its director for startups and investor engagement.

In his new role, Reale, a longtime leader in Houston’s startup ecosystem, will work to strengthen the innovation district's founder and investor network.

"Here’s what I’ve come to believe: the Ion is not just a building, not just a real estate play, and not just another innovation district. COVID, remote work, and shifting market dynamics changed the rules. Key ingredients like co-working, events, and community, while impactful, are no longer enough on their own," Reale shared on a LinkedIn post announcing the move. "What’s needed are advantages ... We need to intentionally design a system that repeatedly delivers advantages so founders can pull forward their visions."

Reale previously served as executive in residence and venture partner at TMC Venture Fund and co-founded Station Houston. He also serves as managing director of Integr8d Capital. He's an investor and serves on the board of directors for a number of venture-backed companies, including Cart.com, Lionguard and others.

The Ion will host "Today Is Day One – A conversation with John (JR) Reale" to welcome Reale to the role on Tuesday, Oct. 21. Reale will be joined at the event by Heath Butler, partner at Mercury, to discuss their thoughts on shaping Houston's founders ecosystem, as well as the Ion’s Founder Advantage Platform.

"On top of this connected architecture, we will build product. That product will be the Founder Advantage Platform to remove friction, compress time, and compound outcomes," Reale continued on LinkedIn. "This is the system that will drive repeatable experiences, and naturally, make these journeys so much more fun."

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John "JR" Reale joins the Houston Innovators Podcast for a two-part series of interviews discussing Houston innovation, the Texas Medical Center, investment trends, and more. Photo via TMC.edu

Longtime Houston innovator talks investment trends and ecosystem evolution

houston innovators podcast episode 136

Over the years, John "JR" Reale may have transitioned to various roles within the Houston innovation ecosystem, but the people he was working with stayed the same.

"My focus is always on partnering with founders — I just get to do it with two amazing hats," Reale says on this week's episode of the Houston Innovators Podcast.

Those two hats are as executive in residence at Texas Medical Center Innovation and as managing director of Integr8d Capital, an early-stage fundless venture capital firm that invests with intentionality. Reale joined the podcast for a special two-part series. The first episode is out now and focuses on his career in innovation and investment. The second part, which comes out next week, covers health tech innovation and his work with Texas Medical Center.

Most people might know Reale as one of the co-founders of Station Houston, a hub for tech innovation and entrepreneurship that launched in 2015 and dissolved into a few entities like The Ion and Capital Factory in 2018. Reale says on the show that Station's success came at a crucial time for Houston.

"Our big insight was ultimately around two things. One, we had a great empathy about how lonely and challenging it is being a founder. It was about building an authentic community where folks wanted to be," Reale says on the show. "Later in 2016 and 2017, we had this idea of separating space for the services and the things that founders need — especially in a big city like Houston."

Reale says Station was focused on the founders and providing a centralized location for support — something that sprawling Houston didn't have before.

"Our mission was really simple," he says, "it was to serve entrepreneurs. We knew who we wanted to serve, and we knew it meant a lot of different things."

Around the time of Station, Mayor Sylvester Turner's office asked Reale to join a task force with Amanda Edwards and several other impactful parties. The mission there was to get everyone on the same page and not only see the city's potential for innovation, but work on developing it.

"We went through a journey as a task force," Reale says. "A lot of it was about learning together. One of the big insights were about meeting people where they were. You're bringing all different pockets of the community together, and it's not about dictating what people have to do."

When it comes to pointing to a turning point in Houston, Reale doesn't mince words.

"One of the most important moments for Houston was when we got kicked in the teeth with the Amazon HQ2 bid," he says. "Amazon came back with the shortlist of the 20 cities in North America — and Houston isn't on it. I remember being excited. It was arguably the most innovative company in the world saying 'no thank you.'"

Rather than feel defeated or disappointed, Reale says he was excited about the rejection. It was an opportunity to spur more work that needed to be done.

"That was the gut punch that folks needed to realize," he says. "Moments like that cause real reflection. Failure like that forces you to ask a different set of questions."

The pandemic has meant for another, though very different, turning point and opportunity — especially when it comes to investment.

"Over the last few years we've seen a positive impact of the pandemic — it's changed the barriers to capital coming into different geographies, and I think that's sustainable. We've created new norms and behaviors of where capital will go," he says.

There's still room to grow and opportunities to come to fruition — especially within the early-stage investment community, Reale says.

"I'd like to see more funds launch here with very intentional strategies — particularly seed and early-stage work. You usually find those to be more geographically close," he says. "That's an opportunity. And I'd like to see more awesome operators turned investors."

Reale shares more about Integr8d Capital and what he's working on now on the podcast episode, as well as in next week's episode. Listen to the first interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


From new tech jobs in Houston to an entrepreneurship minor at Rice University, here are some short stories in Houston innovation. Shobeir Ansari/Getty Images

Rice creates entrepreneurship minor, Houston tech jobs grow, and more innovation news

Short stories

While much of the city's news — along with the rest of the country — has been focused on COVID-19, headlines are starting to resemble some sense of normalcy again.

For this roundup of short stories within Houston innovation, there's a mix of news items pertaining to the coronavirus, as well as news items outside of the pandemic — from a new minor program at Rice University to Baylor College of Medicine testing for a COVID treatment.

Rice University introduces entrepreneurship minor

Rice University plans to offer undergraduate students an opportunity to minor in entrepreneurship. Courtesy of Rice University

Three of Rice University's programs — the Liu Idea Lab for Innovation and Entrepreneurship, Jones Graduate School of Business, and Brown School of Engineering — are teaming up to provide undergraduate students an opportunity to minor in entrepreneurship.

"Entrepreneurship and the creation of new businesses and industries are critical to Houston and Texas' future prosperity and quality of life," says Yael Hochberg, Rice finance professor who leads Lilie, in a release. "Rice students continuously seek to lead change and build organizations that can have real impact on our world. In today's new and uncertain world, the skills and frameworks taught in the new minor are particularly important."

According to a news release, the minor's curriculum will provide students with professional skills within entrepreneurship, such as problem solving, understanding customers and staff, communication, and more. The program will be housed in Lilie, which features a coworking space, graduate and undergraduate entrepreneurship courses, the annual H. Albert Napier Rice Launch Challenge, and other courses.

Houston named No. 12 for tech jobs

Houston's tech jobs are growing — just not at an impressive rate, according to a new report. Christina Morillo/Pexels

CompTIA has released its Cyberstates 2020 report that identifies Houston as No. 12 in the country for tech jobs. However, the Bayou City was ranked No. 38 for job percent growth. Austin and Dallas appear in the top 10 of each of the Cybercities rankings.

According to the report, Houston has a net total of 235,802 tech jobs, an increase of 826 jobs between 2018 and 2019. This figure means a growth of 25,904 jobs between 2019 and 2010. The full report is available online.

While Houston misses the top 10 metros, Texas ranks No. 2 for net tech employment and net tech employment growth. The Lone Star State came in at No. 4 for projected percent change in the next decade. The state was also recognized as No. 2 for number of tech businesses.

Baylor College of Medicine tests existing drug for COVID-19 cure

A Houston institution is looking into an existing vaccine for coronavirus treatment. Andriy Onufriyenko/Getty Images

Baylor College of Medicine researchers — along with colleagues at four other institutions — are testing to see if the bacille Calmette-Guerin vaccine, known as BCG, can work against COVID-19.

"Epidemiological studies show that if you're BCG vaccinated, you have a decreased rate of other infections," says Dr. Andrew DiNardo, assistant professor of medicine – infectious diseases at Baylor, in a news release.

The vaccine has been found to help protect against yellow fever and influenza, and, according to DiNardo, the vaccine could show 30 to 50 percent improvement in immune response in patients with the coronavirus. The team is currently looking for subjects to participate in a clinical trial to test the vaccine.

While research is preliminary, the theory is that BCG changes the way the body responds to a pathogen, according to the release.

"Think of DNA like a ball of yarn," DiNardo explains in the release. "Some pieces of the ball of yarn are open and able to be expressed. Other pieces are wrapped up tight and hidden away, and those genes are repressed. It's a normal way for cells to turn certain genes on and off. BCG opens up certain parts of this ball of yarn and allows the immune system to act quicker."

Plug and Play announces physical space in Houston

Plug and Play Tech Center's local team will work out of the Ion. Courtesy of Rice University

Since entering the Houston market last year, Silicon Valley's Plug and Play Tech Center has hosted numerous events, named its first cohort, and hired Payal Patel to lead the local operations. However, the local operations still, until recently, lacked a plan for a physical space in town.

"Plug and Play intends to set up its permanent office in Houston in Rice's Ion development," says Patel in a statement. "We have engaged in preliminary discussions with Rice Management Company to secure office space for the building's expected Q1 2021 opening."

Until then, says Patel, who is director of corporate partnerships for Plug and Play in Houston, the Plug and Play team will have its base at Station Houston, which recently merged with Austin-based Capital Factory. At present, the local team is hiring to build up its team and has five open jobs on HTX Talent, a job portal for Houston tech.

UH professor named a Guggenheim fellow

A University of Houston professor has been honored with a prestigious award. Photo courtesy of University of Houston

A University of Houston mechanical engineer has been selected for a Guggenheim Fellowship. Pradeep Sharma is the only recipient in the engineering category.

The M.D. Anderson Chair Professor of mechanical engineering and chairman of the department, Sharma uses mathematics and technology to breakdown physical phenomena across a number of disciplines.

The Guggeinheim Foundation has funded more than $375 million in fellowships to over 18,000 individuals since its inception in 1925. This year, the organization selected 173 individuals.

"It's exceptionally encouraging to be able to share such positive news at this terribly challenging time," Sharma says in a news release from UH. "The artists, writers, scholars and scientific researchers supported by the fellowship will help us understand and learn from what we are enduring individually and collectively."

Houston health system to participate in coronavirus plasma study

HCA Houston Healthcare is participating in a plasma treatment program. Getty Images

HCA Healthcare Gulf Coast Division has announced that it will be participating in a national study to see if plasma from recovered COVID-19 patients can help current COVID patients in severe conditions.

"We are proud to take part in this important study. We are asking for the help of our community to spread awareness about plasma donation for patients facing COVID-19 not only in Houston, South Texas and Corpus Christi, but also around the world," says Mujtaba Ali-Khan, chief medical officer at HCA Healthcare Gulf Coast Division, in a news release.

Per the study, the following HCA Healthcare Gulf Coast Division Hospitals will be participating:

  • HCA Houston Healthcare Clear Lake
  • HCA Houston Healthcare Conroe
  • HCA Houston Healthcare Kingwood
  • HCA Houston Healthcare Southeast
  • HCA Houston Healthcare West
  • HCA Houston Healthcare Tomball
  • HCA Houston Healthcare North Cypress
  • HCA Houston Healthcare Northwest
  • HCA Houston Healthcare Mainland
  • HCA Houston Healthcare Medical Center
  • Corpus Christi Medical Center
  • Rio Grande Regional Hospital
  • Valley Regional Medical Center

"This trial is just the first step, but hopefully it will help us determine if plasma transfusions can be a treatment for critically ill patients with COVID-19," says Carlos Araujo-Preza, MD, critical care medical director at HCA Houston Healthcare Tomball, in the release.

Dr. Araujo-Preza safely discharged his first plasma patient last week. The patient is recovering from home following their treatment.

The hospital system is looking for eligible volunteers to donate plasma via the American Red Cross to help treat current patients.

Early stage energy venture firm calls for startups

Industrial software

BBL Ventures is looking for energy companies to pitch. Getty Images

Houston-based BBL Ventures, which looks to connect tech startups to industrial and energy corporations, is seeking energy tech startups to pitch.

"Digital transformation, automation, emerging technologies and sustainability have never been more important to these industries than in this challenging macro environment," says Patrick Lewis, founding managing partner of BBL Ventures, in an email. "We are launching a 6-week challenge campaign to find BEST in class solutions to BIG pain points in the energy and industrial sectors."

In the email, Lewis lists over a dozen challenges or pain points from the organization's corporate partners. The goal would be to find startups with to solutions to any of these identified pain points. Winners of the pitch competition are eligible for POCs, pilots, and funding.

For more information and to submit a pitch, visit BBL's website. BBL is also introducing the program with a virtual kick-off panel on May 21 at 2 pm. Registration is available online.

Capital Factory has doubled down on Houston, and Founder and CEO Josh Baer shares how it's all part of his Texas Manifesto. Photo courtesy of Capital Factory

Capital Factory founder plans to double portfolio companies in Houston this year

Q&A

A statewide accelerator program has doubled down on Houston, and it's just the beginning.

Austin-based Capital Factory, which also has a presence in Dallas, recently merged with Station Houston in an effort to expand their mentor network and grow its startup portfolio with the addition of Houston companies.

As of today, Capital Factory has 40 startups from Houston in its portfolio, says Josh Baer, founder and CEO of Capital Factory, and Baer says he expects to add an additional 40 in 2020. The Station merger will help spur that growth and also play into Capital Factory's greater Texas Manifesto mission to advance innovation statewide.

"This is not just about adding one more city," Baer says. "It's really about how there's a lot of unique things that Houston brings that are going to make the whole picture a lot stronger."

Baer sat down with InnovationMap to discuss the details of the merger, how Capital Factory will be tuned into The Ion, and how Houston startups can tap into Capital Factory — both locally and at this year's SXSW.

InnovationMap: Capital Factory has been active in Houston for a few years and announced a partnership with The Cannon last year. How has that activation been going?

Josh Baer: We've been in Houston for quite a while now. We started off with our Texas Manifesto almost three years ago and the first thing we did was a listening tour of all the different cities, and we spent a bunch of time in Houston.

Part of the growth we've seen in part is from our partnership with The Cannon as they've opened. They've been a great partner allowing us to reach all of Houston because Houston is really big. It's not like Austin where you can primarily service from one place. We're not builders, that's not our role. We want to be wherever everybody else is doing great things. And that's The Cannon, The Ion, and the Texas Medical Center and all the other places too. There's lots of room for different flavors and focuses and groups, and we need to be at all those places.

IM: What's Capital Factory's presence in Houston and how do you see it growing?

JB: Last year, we hired our first two employees in Houston — that was Kendrick and Brittany, our mentor coordinator and venture associate — so that we could build our mentor network and connect them into the rest of Texas and source the best companies and connect them to the rest of Texas. Last year with those two employees, we brought in 14 Houston companies into our accelerator.

In total right now, we have 40 companies ever that have joined our accelerator from Houston, which is still a pretty significant number. This year, we expect more than 40 companies to join the accelerator from Houston.

IM: How will Capital Factory be involved in The Ion?

JB: Well we are so happy that we have exactly the role we would want to have at The Ion. And that is having some prime space right in the middle of it, and we're located not in the coworking space but in the event space because that's really, we want to be — we want to be where everyone is meeting and activating.

One of the things that we'll focus on is building out the mentor network at The Ion and connecting it into the rest of our mentor network. We're not going to be the only accelerator there. There's going to be a bunch of accelerators there. There's gonna be a bunch of mentor networks. And we're excited to partner with all of those and many more probably bring great people into our networks. I'm pretty confident we'll be the biggest mentor network there and we'll be the default one. We'll be the main one that everybody's part of, and particularly because it connects into everything else. But we'll do that in a really collaborative way.

IM: You kind of dove headfirst into the Dallas innovation ecosystem with a real estate play. Why did making these partnerships make more sense for Houston?

JB: Well, Capital Factory isn't backed by a big university or a billionaire, or a pension fund or something. It's really backed by entrepreneurs. And so while we're fortunate that we do have capital to invest in these startups, our value is not really like the capital like that builds buildings. It takes a lot of money and a lot of capital and that comes from universities and different types of investors and from communities right from the city and others that are part of that.

And so in Dallas, when we looked at that market, there was a real need — nobody was building a place like this, so we had to. We needed a center of gravity. Dallas is big too — other people will build more and we're going to need to be at those places too, just like in Houston.

But in Houston, not only did we are Texas Medical Center, and then we already had The Cannon and there's going to be The Ion, which are hundreds of thousands of square feet of prime real estate that's going to be amazing. We don't want to recreate that or compete with that. We want to be part of that.

So, if somebody else is already putting up tens or a hundreds of millions of dollars to build the building, I don't need to do that. I want to be part of that. My value is not capital. It's bringing the people into the building. It's activating the building and bringing programming into it, and that's where Capital Factory really adds the most value.

IM: How exactly did the merger with Station Houston come about?

JB: You know, it goes all the way back to the very beginning. I'm pretty sure that I was one of the first people that the founders of Station talked to when they were getting started when Emily and Blair and others were working on it. You know, Capital Factory was the place they came to look at. And, I was friends with all of them, and we were very open book about it, and said, "Hey, you know, here's how we work. We should see how we can work together." Because of that, we've always had a good relationship — Station was the first place that we ever went on a bus trip to Houston. We've had lots of overlap between our mentor networks and startups that we work with and others.

And Station has gone through some different changes over the years — leadership and their model evolved from for profit to nonprofit and onward. And through those changes, we just kept moving closer and closer together. It became really clear, especially with the launch of The Ion, that it was really the perfect opportunity for us to align ourselves even more closely and really connected fully into the rest of what's happening in the rest of the state.

IM: I’ve spoken to Gabriella Rowe, former CEO of Station, about it and she really sees it as a return to Station’s roots as an organization. How do you see the merger for Capital Factory?

JB: Well for us, you know, I really like the analogy of a stool. Everybody knows that to have a good foundation, a stool needs to have three legs. And, our mission in connecting Texas together through our Texas Manifesto. [Austin and Dallas were] working and working well, but it still wasn't a strong foundation. Ramping this up across Dallas and Houston, it completes the foundation and gives it a really strong footing and a really powerful footing to make it a Texas wide play.

We don't see this as a cookie cutter kind of thing. Each city is different. Each city has different needs and brings different things [to the table]. And we see that for sure from Houston. The type of entrepreneurs and companies that we've worked with are different. They're working on big, messy problems — robots and dangerous things. And that is exciting and attracts other partners — the big companies and the army and others that want tap into that too. And so, this is not just about adding one more city. It's really about how there's a lot of unique things that Houston brings that that's going to make the whole picture a lot stronger.

IM: What’s the status of the merger at this point?

JB: The paperwork's done, and we're taking a very intentionally slow process with [the execution of the merger]. We told everybody, "you shouldn't expect to see a lot to change fast." We want to be careful and thoughtful. So, we're going to listen a lot, and we're going to make changes slowly. And our goal is that for all the Station members, this is just a value add. They get everything they had before, plus now they get more. Now they get access to the Capital Factory network now, and they get access over time to more at the ion.

[But bigger picture,] it's not done at all. We barely started. We're still really listening and learning, so I don't feel like much has happened yet. The beginning part is, right now, every station Houston member has access to the rest of the Capital Factory network — both physically and virtually. They can go to Austin or Dallas. They can go to The Cannon. And more importantly than that, they can use our online network of union.vc, which is a website where they can log in, create a profile, and they can see all the other startups and mentors across the state and they can be seen by them. And that's what we can do to help connect them all together.

IM: Capital Factory kept Station’s remaining staff, right? Will Capital Factory be hiring more staff in Houston? 

JB: Right, we now have five Houston employees, three of them used to be Station's. We do expect to hire, but we don't have any specific roles to announce, but we have over a dozen people on the team in Dallas now two years into it.

IM: How can Houston startups make the most of SXSW this year?

JB: Honestly, our goal is to be the easy button. The first thing is come to Capital Factory. Capital Factory is an official South by Southwest house. This year, it's all official programming. And of course, the type of programming that you're going to see is focused on startups and government and defense.

We'll have Fast Company, Deloitte, Booz Allen, the army, and the air force — all kinds of other people there. And so that's an easy place to plug in. And for entrepreneurs who are part of our network, they don't have to have South badge to do that. They can be part of what's going on at Capital Factory as members.

IM: For startups wanting to get involved with Capital Factory, what's step one?

JB: The first step is to come to The Cannon or Station and meet us possible. And the person that first person they want to meet is Brittany Barreto, who's our venture associate. That's her job is to scout startups and meet them and help kind of bring them into the funnel.

Sesh, a female-focused coworking space, opening in Montrose was one of this week's top stories. Photo courtesy of Sesh

5 most popular innovation stories in Houston this week

What's trending

Editor's note: Houston innovators, a new coworking space, and more trended on InnovationMap this week. Plus, what a non-Houston-based venture capitalist does and learns on his first visit to town.

3 Houston innovators to know this week

Marc Nathan, Meredith Wheeler, and Maggie Segrich are this week's Houston innovators to know. Courtesy photos

Passion is usually the motivator for starting a business, and this week's innovators to know have an undeniable passion for what they are doing.

Marc Nathan is passionate about Texas startups — it's why he started and still maintains a comprehensive newsletter of Texas innovation news. Meanwhile, Maggie Segrich and Meredith Wheeler are passionate about bringing together a community of women with Sesh Coworking.

Click here to continue reading.

2 startups win big at Accenture's ​Houston-based health tech competition

For the first time, Accenture hosted its HealthTech Innovation Challenge finals at the Texas Medical Center's Innovation Institute. Photo courtesy of Accenture

Two health tech companies walked away from Accenture's HealthTech Innovation Challenge with awards. Regionals took place in Boston and San Francisco, and Houston was selected to host the finals last week.

New York-based Capital Rx was selected as the 2020 Innovation Champion of the Accenture HealthTech Innovation Challenge, and Minneapolis-based Carrot Health was given the second-place award for Top Innovator. The program, which was first launched in 2016, aims to pair startups with health organizations to drive innovative solutions to real challenges in health care.

"The submissions we received this year demonstrate the momentum of discovery and digital innovation in healthcare," says Brian Kalis, managing director of digital health and innovation at Accenture, in a news release. "Healthcare organizations continue to advance their digital transformation agendas — enhancing access, affordability, quality and experience to drive innovation that improves the lives of consumers and clinicians. We look forward to working with these companies and others to continue to help advance solutions that address the industry's toughest challenges."

Click here to continue reading.

First female-focused coworking space opens in Houston

Sesh Coworking is committed to providing quality coworking space for women and by women. Photo courtesy of Sesh

For so long, women have been influenced on how to behave professionally at work and expected to leave home life at home. But two female entrepreneurs are flipping the switch on that way of thinking with their new coworking space.

"We as women show up in our work lives as a whole person. We don't compartmentalize and forget about all the other things happening in our lives," says Meredith Wheeler, co-founder and chief creative officer of Sesh Coworking. "We wanted a space that reflected that and embraced it."

Sesh officially opened its doors this week at its new 2,000-square-foot space in Montrose (1210 W Clay St #18). Wheeler co-founded the company with Maggie Segrich after hosting coffee and coworking meetups for women around Houston for over two years.

Click here to continue reading.

Former Station Houston CEO says Capital Factory merger was about taking the organization 'back to its roots'

Gabriella Rowe has transitioned from CEO of Station Houston into her role as executive director of The Ion following Station's merger with Austin-based Capital Factory. Courtesy of Station Houston

Among the top news for Houston's innovation ecosystem for the year so far has been the announcement that Austin-based Capital Factory has merged with Station Houston.

The merger is officially completed, and how the combined startup development organization will interact with Houston's entrepreneurs is clear for Gabriella Rowe: It's about bringing Station Houston's mission back to why it was founded in the first place.

Click here to continue reading and to stream the podcast.

Here's how a visiting venture capitalist explores Houston's startup ecosystem for the first time

Pat Matthews of Active Capital visited Houston with a collaboration with the HX Venture Fund. Photo courtesy of Active Capital

When Houston Exponential established the HX Venture Fund, the goal was to bring out-of-town capital and investors into the city of Houston. The fund of funds invests in a portfolio of venture capital funds with the hope that those funds find a way back into the Houston startup ecosystem.

After a little over a year, HXVF has invested in five funds: Boston-based .406 Ventures, Austin-based Next Coast Ventures, Boston-based OpenView Venture Partners, Washington D.C.-based Updata Partners, and Austin-based LiveOak Venture Partners.

Click here to continue reading.

Pat Matthews of Active Capital visited Houston with a collaboration with the HX Venture Fund. Photo courtesy of Active Capital

Here's how a visiting venture capitalist explores Houston's startup ecosystem for the first time

a day in the life

When Houston Exponential established the HX Venture Fund, the goal was to bring out-of-town capital and investors into the city of Houston. The fund of funds invests in a portfolio of venture capital funds with the hope that those funds find a way back into the Houston startup ecosystem.

After a little over a year, HXVF has invested in five funds: Boston-based .406 Ventures, Austin-based Next Coast Ventures, Boston-based OpenView Venture Partners, Washington D.C.-based Updata Partners, and Austin-based LiveOak Venture Partners.

The fund of funds is also regularly hosting those five funds — as well as a mix of potential portfolio fund members — in Houston for what the HXVF calls "immersion days" where the venture capitalists can meet local startups, innovation leaders, and even fellow investors that they could eventually co-invest with.

"The goals of these days are to have venture capitalists travel to Houston, meet with our entrepreneurs (and the startup development organizations like Station, Cannon and WeWork that support them), and provide both capital and expertise in company building to the tech companies," says Sandy Guitar Wallis, managing partner at HXVF. "The venture capitalists also meet with HX Venture Fund corporate LPs, who can be customers or acquirers of their portfolio companies."

Just this month alone, HXVF is hosting four funds — two from their portfolio and two that they haven't yet invested in. San Antonio-based Active Capital, which has raised a $21 million fund, is among the visiting VCs this month. The fund's founder, Pat Matthews, an entrepreneur turned venture capitalist, has shared his busiest day — February 5 — as well as his perspective on Houston innovation with InnovationMap.

A morning too busy for breakfast

After waking up at the Hotel Derek, Matthews starts his second day in Houston by taking a Lyft to the Greater Houston Partnership for what he believes to be a breakfast meeting with Wallis and Guillermo Borda of HXVF, but the group has too much to discuss that a meal falls by the wayside.

Before this trip, Matthews hasn't visited Houston in a professional capacity. While Active Capital is based just down I10 in San Antonio, the firm's investments are split almost in half by deals done in Texas versus the rest of the world. Active Capital focuses on B2B SaaS investments — usually leading — in seed or series A rounds.

Matthews has called Texas home for around a decade. He founded an email marketing startup in Virginia, which was acquired by San Antonio-based Rackspace. He relocated to join Rackspace and worked on growing the organization for six years before creating Active Capital.

Following the meeting — still unfed, Matthews meets up with Serafina Lalany from Houston Exponential to carpool to The Cannon on the west side of town.

Loading up on carbs and fireside chats

Matthews forgoes his usual carb aversion to eat slices of Domino's pizza at The Cannon before beginning his first of three fireside chats with Houston innovators. Patrick Schneidau, CEO of Truss, leads the conversation at The Cannon. (Schneidau is a board member of InnovationMap's.) After the chat, Matthews has a meeting with a startup before heading back into town.

With one fireside chat down, Matthews heads into his second one of the day at Station Houston with Joe Alapat, founder of Liongard. Matthews observes that each of the entrepreneurs who interviewed him had great questions, and seemed to be far along with their companies. Meanwhile, any of the people he met before or after the chat seemed to be at a much earlier stage in their startup journey.

The last fireside chat was hosted by Rakesh Agrawal of Snapstream at WeWork's Jones Building location. Matthews and Agrawal attempted to set up a Facebook livestream for the conversation, but an issue with the technology wouldn't allow for the stream.

An evening of good food and great mentorship

With meetings and fireside chats done, Matthews heads straight to a dinner with Blair Garrou, founder and managing director of Mercury Fund. The two venture capitalists dine at Eunice and split several appetizers and a bottle of wine while discussing their own recent investments and interests. Matthews, who met Garrou in 2014, thinks of him as a great mentor in venture capital.

Matthews headed back to the hotel after dinner and crashes hard after the long day. He would head back to San Antonio on a Vonlane bus — he gets a lot of work done on his trips — the next day.

What's next for Active Capital and Houston?

Matthews says he left Houston with an overall positive opinion of the city, and says it's similar to other Texas cities, aside from Austin, in its startup presence and capacity. While he assumed he'd meet energy and space startups, he realized Houston had a lot more going on than that.

"It definitely seemed like there was a lot of passion and a lot of hustle," Matthews says. "And it seems like the city is really working to support and cultivate that and keep it in Houston. I was inspired."

Throughout the visit, Matthews handed out his business card and some conversations have developed from those connections, he says. Another representative from Active Capital who is focused on sourcing deals with startups will visit next, and Matthews says he also thinks that he'll return to Houston to continue conversations he's been having, including some with other investors.

"I could definitely see doing deals in Houston," Matthews tells InnovationMap.

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Meet 6 mentors who are helping the Houston startup scene flourish

meet the finalists

Few founders launch successful startups alone — experienced and insightful mentors often play an integral role in helping the business and its founders thrive.

The Houston startup community is home to many mentors who are willing to lend an ear and share advice to help entrepreneurs meet their goals.

The Mentor of the Year category in our 2025 Houston Innovation Awards will honor an individual like this, who dedicates their time and expertise to guide and support budding entrepreneurs. The award is presented by Houston City College Northwest.

Below, meet the six finalists for the 2025 award. They support promising startups in the medical tech, digital health, clean energy and hardware sectors.

Then, join us at the Houston Innovation Awards this Thursday, Nov. 13 at Greentown Labs, when the winner will be unveiled. The event is just days away, so secure your seats now.

Anil Shetty, InformAI

Anil Shetty serves as president and chief medical officer for biotech company Ferronova and chief innovation officer for InformAI. He's mentored numerous medical device and digital health companies at seed or Series A, including Pathex, Neurostasis, Vivifi Medical and many others. He mentors through organizations like Capital Factory, TMC Biodesign, UT Venture Mentoring, UTMB Innovation and Rice's Global Medical Innovation program.

"Being a mentor means empowering early-stage innovators to shape, test, and refine their ideas with clarity and purpose," Shetty says. "I’m driven by the opportunity to help them think strategically and pivot early before resources are wasted. At this critical stage, most founders lack the financial means to bring on seasoned experts and often haven’t yet gained real-world exposure. Mentorship allows me to fill that gap, offering guidance that accelerates their learning curve and increases the chances of meaningful, sustainable impact."

Jason Ethier, EnergyTech Nexus

Jason Ethier is the founding partner of EnergyTech Nexus, through which he has mentored numerous startups and Innovation Awards finalists, including Geokiln, Energy AI Solutions, Capwell Services and Corrolytics. He founded Dynamo Micropower in 2011 and served as its president and CEO. He later co-founded Greentown Labs in Massachusetts and helped bring the accelerator to Houston.

"Being a mentor means using my experience to help founders see a clearer path to success. I’ve spent years navigating the ups and downs of building companies, struggling with cash flow, and making all the mistakes; mentoring gives me the chance to share those lessons and show entrepreneurs the shortcuts I wish I’d known earlier," Ethier says. "At Energytech Nexus, that role goes beyond just helping individual founders — it’s about creating a flywheel effect for Houston’s entire innovation ecosystem."

Jeremy Pitts, Activate Houston

Jeremy Pitts serves as managing director of Activate Houston, which launched in Houston last year. He was one of the founders of Greentown Labs in the Boston area and served in a leadership role for the organization between 2011 and 2015. Through Activate, he has mentored numerous impactful startups and Innovation Awards finalists, including Solidec, Coflux Purification, Bairitone Health, Newfound Materials, Deep Anchor Solutions and others.

"Being a mentor to me is very much about supporting the person in whatever they need. Oftentimes that means supporting the business—providing guidance and advice, feedback, introductions, etc," But just as important is recognizing the person and helping them with whatever challenges they are going through ... Sometimes they need a hype man to tell them how awesome they are and that they can go do whatever hard thing they need to do. Sometimes they just need an empathetic listener who can relate to how hard these things are. Being there for the person and supporting them on their journey is key to my mentorship style."

Joe Alapat, Liongard

Joe Alapat founded and serves as chief strategy officer at Houston software company Liongard and chief information officer at Empact IT, which he also owns. He mentors through Founder Fridays Houston Group, Software Day by Mercury Fund, SUPERGirls SHINE Foundation, Cup of Joey and at the Ion. He's worked with founders of FlowCare, STEAM OnDemand, Lokum and many other early stage startups.

"Being a mentor to me means unleashing an individual’s 10x—their purpose, their ikigai (a Japanese concept that speaks to a person’s reason for being)," Alapat says. "Mentoring founders in the Houston community of early stage, high-growth startups is an honor for me. I get to live vicariously through a founder’s vision of the future. Once they show me that compelling vision, I’m drawn to bring the future forward with them so the vision becomes reality with a sense of urgency."

Neal Dikeman, Energy Transition Ventures

Neal Dikeman serves as partner at early stage venture fund Energy Transition Ventures, executive in residence at Greentown Labs, and offices in and supports Rice Nexus at the Ion. He mentors startups, like Geokiln, personally. He also mentored Helix Earth through Greentown Labs. The company went on to win in the Smart Cities, Transportation & Sustainability contest at SXSW earlier this year. Dikeman has helped launch several successful startups himself, most recently serving on the board of directors for Resilient Power Systems, which was acquired by Eaton Corp for $150 million.

"Founders have to find their own path, and most founders need a safe space where they can discuss hard truths outside of being 'on' in sales mode with their team or board or investors, to let them be able to work on their business, not just in it," Dikeman says.

Nisha Desai, Intention

Nisha Desai serves as CEO of investment firm Intention and mentors through Greentown Labs, TEX-E, Open Minds, the Rice Alliance Clean Energy Accelerator, Avatar Innovations and The Greenhouse. She currently works with founders from Solidec, Deep Anchor Solutions, CLS Wind and several other local startups, several of which have been nominated for Innovation Awards this year. She's served a board member for Greentown Labs since 2021.

"When I first started mentoring, I viewed my role as someone who was supposed to prevent the founder from making bad decisions. Now, I see my role as a mentor as enabling the founder to develop their own decision-making capability," Desai says. "Sometimes that means giving them the space to make decisions that might be good, that might be bad, but that they can be accountable for. At the end of the day, being a mentor is like being granted a place on the founder's leadership development journey, and it's a privilege I'm grateful for."

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The Houston Innovation Awards program is sponsored by Houston City College Northwest, Houston Powder Coaters, FLIGHT by Yuengling, and more to be announced soon. For sponsorship opportunities, please contact sales@innovationmap.com.

Rice, Houston Methodist developing soft 'sleep cap' for brain health research

Researchers and scientists at Rice University and Houston Methodist are developing a “sleep cap” that aims to protect the brain against dementia and other similar diseases by measuring and improving deep sleep.

The project is a collaboration between Rice University engineering professors Daniel Preston, Vanessa Sanchez and Behnaam Aazhang; and Houston Methodist neurologist Dr. Timea Hodics and Dr. Gavin Britz, director of the Houston Methodist Neurological Institute and chairman of the Department of Neurosurgery.

According to Rice, deep sleep is essential for clearing waste products from the brain and nightly “cleaning cycles” help remove toxic proteins. These toxic proteins, like amyloids, can accumulate during the day and are linked to Alzheimer’s disease and other neurological issues.

Aazhang, director of the Rice Neuroengineering Initiative, and his team are building a system that not only tracks the brain’s clearing process but can also stimulate it, improving natural mechanisms that protect against neurodegeneration.

Earlier proof-of-concept versions of the caps successfully demonstrated the promise of this approach; however, they were rigid and uncomfortable for sleep.

Preston and Sanchez will work to transform the design of the cap into a soft, lightweight, textile-based version to make sleep easier, while also allowing the caps to be customizable and tailored for each patient.

“One of the areas of expertise we have here at Rice is designing wearable devices from soft and flexible materials,” Preston, an assistant professor of mechanical engineering, said in a news release. “We’ve already shown this concept works in rigid device prototypes. Now we’re building a soft, breathable cap that people can comfortably wear while they sleep.”

Additionally, the research team is pursuing ways to adapt their technology to measure neuroinflammation and stimulate the brain’s natural plasticity. Neuroinflammation, or swelling in the brain, can be caused by injury, stroke, disease or lifestyle factors and is increasingly recognized as a driver of neurodegeneration, according to Rice.

“Our brain has an incredible ability to rewire itself,” Aazhang added in the release. “If we can harness that through technology, we can open new doors for treating not just dementia but also traumatic brain injury, stroke, Parkinson’s disease and more.”

The project represents Rice’s broader commitment to brain health research and its support for the Dementia Prevention Research Institute of Texas (DPRIT), which passed voter approval last week. The university also recently launched its Rice Brain Institute.

As part of the project, Houston Methodist will provide access to clinicians and patients for early trials, which include studies on patients who have suffered traumatic brain injury and stroke.

“We have entered an era in neuroscience that will result in transformational cures in diseases of the brain and spinal cord,” Britz said in the release. “DPRIT could make Texas the hub of these discoveries.”

Autonomous truck company with Houston routes goes public

on a roll

Kodiak Robotics, a provider of AI-powered autonomous vehicle technology, has gone public through a SPAC merger and has rebranded as Kodiak AI. The company operates trucking routes to and from Houston, which has served as a launchpad for the business.

Privately held Kodiak, founded in 2018, merged with a special purpose acquisition company — publicly held Ares Acquisition Corp. II — to form Kodiak AI, whose stock now trades on the Nasdaq market.

In September, Mountain View, California-based Kodiak and New York City-based Ares disclosed a $145 million PIPE (private investment in public equity) investment from institutional investors to support the business combo. Since announcing the SPAC deal, more than $220 million has been raised for the new Kodiak.

“We believe these additional investments underscore our investors’ confidence in the value proposition of Kodiak’s safe and commercially deployed autonomous technology,” Don Burnette, founder and CEO of Kodiak, said in a news release.

“We look forward to leading the advancement of the commercial trucking and public sector industries,” he added, “and delivering on the exciting value creation opportunities ahead to the benefit of customers and shareholders.”

Last December, Kodiak debuted a facility near George Bush Intercontinental/Houston Airport for loading and loading driverless trucks. Transportation and logistics company Ryder operates the “truckport” for Ryder.

The facility serves freight routes to and from Houston, Dallas and Oklahoma City. Kodiak’s trucks currently operate with or without drivers. Kodiak’s inaugural route launched in 2024 between Houston and Dallas.

One of the companies using Kodiak’s technology is Austin-based Atlas Energy Solutions, which owns and operates four driverless trucks equipped with Kodiak’s driver-as-a-service technology. The trucks pick up fracking sand from Atlas’ Dune Express, a 42-mile conveyor system that carries sand from Atlas’ mine to sites near customers’ oil wells in the Permian Basin.

Altogether, Atlas has ordered 100 trucks that will run on Kodiak’s autonomous technology in an effort to automate Atlas’ supply chain.

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