Rice University bioengineers are designing a vascularized, insulin-producing implant for Type 1 diabetes. Photo by Jeff Fitlow courtesy of Rice University

A team of bioengineers at Houston's own Rice University have created an implant that can produce insulin for Type 1 diabetics. The device is being created by using 3D printing and smart biomaterials.

Omid Veiseh, an assistant professor of bioengineering, and Jordan Miller, associate professor of bioengineering, have been working on the project for three years and have received support from JDRF by way of a grant. Veiseh has a decade of experience developing biomaterials that protect implanted cell therapies from the immune system an Miller has spent more than 15 years specializing in 3D print tissues with vasculature, or networks of blood vessels.

"If we really want to recapitulate what the pancreas normally does, we need vasculature," Veiseh says in a news release. "And that's the purpose of this grant with JDRF. The pancreas naturally has all these blood vessels, and cells are organized in particular ways in the pancreas. Jordan and I want to print in the same orientation that exists in nature."

The challenge with Type 1 diabetes is balancing insulin intake, and studies estimate that less than a third of Type 1 diabetics in the U.S. are able to achieve target blood glucose levels consistently. Veiseh and Miller are working toward demonstrating that their implants can properly regulate blood glucose levels of diabetic mice for at least six months. To do that, they'll need to give their engineered beta cells the ability to respond to rapid changes in blood sugar levels.

"We must get implanted cells in close proximity to the bloodstream so beta cells can sense and respond quickly to changes in blood glucose," Miller says, adding that the insulin-producing cells should be no more than 100 microns from a blood vessel. "We're using a combination of pre-vascularization through advanced 3D bioprinting and host-mediated vascular remodeling to give each implant several shots at host integration."

Another challenge these experts are facing is a potential delay that can happen if the implant is too slow to respond to high or low blood sugar levels.

"Addressing that delay is a huge problem in this field," Veiseh says. "When you give the mouse — and ultimately a human — a glucose challenge that mimics eating a meal, how long does it take that information to reach our cells, and how quickly does the insulin come out?"

By incorporating blood vessels in their implant, he and Miller hope to allow their beta-cell tissues to behave in a way that more closely mimics the natural behavior of the pancreas.

Volumetric Biotechnologies has announced its moving its HQ to the East End Maker Hub. Image courtesy of East End Maker Hub

3D-printing startup to move into rising Houston innovation and maker hub

moving around Hou

The East End Maker Hub has landed perhaps its most intriguing tenant thus far — a Houston startup that makes 3D-printed human organs.

Volumetric Biotechnologies Inc. has leased 11,200 square feet at the East End Maker Hub to serve as its headquarters and manufacturing center. Jordan Miller, co-founder of Volumetric, says one of the benefits of being located at the hub will be access to a cleanroom operated by Alchemy Industrial, a 3D manufacturer of medical devices. Earlier this year, Houston-based Alchemy leased more than 5,400 square feet at the East End hub.

Volumetric will occupy space in the first phase of the 307,000-square-foot project East End Maker Hub. That phase of the $37 million project is set to open soon. The startup's current 5,000-square-foot headquarters is at 7505 Fannin St., near the Woman's Hospital of Texas and south of the Texas Medical Center.

Miller says Volumetric's new home will help it "maintain and accelerate our already breakneck progress." Volumetric's 12 biological, chemical, mechanical, and electrical engineers focus on producing human organs and tissues like the liver, kidney, pancreas, lung, and heart using a mix of medical-grade plastics and human cells.

"We're straining to scale our company as fast as our team is inventing and progressing our technologies. It's an absolutely wonderful problem to have," Miller says.

Volumetric hopes to commercialize its 3D-printed organs in 2021. Founded in 2018, Volumetric is a privately held spin-out of Rice University's Department of Bioengineering. It has received $1.8 million in funding, according to Crunchbase. Investors include Silicon Valley-based Sand Hill Angels, and the Springfield, Virginia-based Methuselah Foundation and Methuselah Fund.

Local Realtor Mike Pittman, a development associate with Pearland-based project partner Urban Partnerships Community Development Corp., recruited Volumetric to the hub. He says he's also working with a distillery, a coffee roaster, and a medical gown manufacturer on leasing space there.

The first phase of the East End Maker Hub is set to open soon. Image courtesy of East End Maker Hub

Once the East End Maker Hub opens, Houston's East End District will be home to the largest maker hub in Texas and one of the largest such facilities in the U.S. Being built in three phases on a 21-acre site at 6501 Navigation Blvd., the East End Maker Hub aims to create an environment that gives members of the community access to trade skills and career opportunities, and to provide businesses a place for innovation and manufacturing. The hub's second and third phases are on track to be finished in 2021.

The soon-to-open first phase will feature "white box" suites, ranging in size from 420 square feet to 20,000 square feet, that cater to three sectors:

  • Innovation (robotics, 3D printing, and R&D)
  • Crafting (ceramics, fine woodworking, and screen printing)
  • Light fabrication (food production).

Aside from Alchemy, tenants recently lined up for the hub include Houston-based Waste Management Inc., whose R&D team will occupy more than 3,500 square feet, and Houston-based construction technology company Rugged Robotics Inc., which is renting 1,700 square feet.

"We're not the place for software companies, but our innovation area is the place for hardware companies — those that are into drones, robotics, 3D printing," Pittman says.

The project's hardware innovation element could boost Houston's manufacturing economy, he says. A recent analysis by the Smartest Dollar website found that 7.5 percent of the Houston metro area's workforce is employed in manufacturing. From 1999 to 2019, the number of manufacturing jobs in Houston grew by just 1.9 percent.

So far, the nonprofit TXRX Labs makerspace is the hub's largest tenant, having signed a lease for 65,000 square feet in the first phase. TXRX Labs and Urban Partnerships Community Development teamed up to develop the hub. TXRX contributed $1.25 million in equity, and Urban Partnerships Community Development raised $35.75 million in capital.

Houston-based Stewart Builders is the general contractor for the East End Maker Hub, and Houston-based Method Architecture is the architect of record.

Aside from supplying room for businesses and nonprofits to grow, the hub seeks to provide training and jobs for local residents. Pittman says the hub — located within a tax-advantaged Opportunity Zone — encourages its tenants to hire people who live within a three-mile radius.

"You don't have to go and get a Ph.D. in nuclear science for these jobs to be able to attain really good wages for your family," he says.

Phases two and three of the hub are expected in 2021. Image courtesy of East End Maker Hub

Human-tissue printing technology, blockchain networks, health care solutions, game-changing software — all this innovation and more is coming out of Houston startups. Courtesy photos

Editor's Picks: Top 10 Houston startup feature stories of 2019

2019 in review

Thousands of startups call Houston home. According to the Greater Houston Partnership's data, the Houston area added 11,700 firms between 2013 to 2018. And, if you consider Crunchbase's tally, at the end of 2018, Houston had over 1,400 tech startups on the investment tracking website's radar.

This past year, InnovationMap featured profiles on dozens of these Houston startups — from blockchain and software companies to startups with solutions in health care and oil and gas. Here are 10 that stood out throughout 2019.

Topl — a blockchain startup connecting every step of the way

Houston-based Topl can track almost anything using its blockchain technology. Getty Images

For Topl, 2019 was a year of laying the groundwork. In a January 2019 article on InnovationMap, Kim Raath, president of the Houston-based blockchain company, explained that Topl's mission originated out of the fact that 60 percent of the world lives on $10 a day — and it's in the poorest regions of the world where it's the hardest to get funding for a new business.

Raath says that in her experience backpacking and volunteering all around the world she learned that banks are too overwhelmed to evaluate these potential businesses. Topl has created a technology where banks can easily generate a report on these entrepreneurs that evaluates and makes a loan or investment recommendation on the business.

"We are a generation that wants a story," she says. "We want an origin, and don't want to be fooled. And, because you might be able to reduce the cost by having this transparency, you might be able to bring down the cost on both sides."

Later that year, the company closed a 20 percent oversubscribed $700,000 seed round. With the money, Topl will be able to grow its platforms, provide better product features, and increase marketing efforts. Topl's customers are drawn to the technology because of the business efficiency the blockchain adds to their supply chain, but they are also excited about how having this technology differentiates them from their competition. Raath says she's interested in growing Topl's ability to do joint marketing campaigns with their customers.

Incentifind — finding green incentives for commercial and residential building

Natalie Goodman founded Incentifind, which connects home builders and commercial developers with green incentives. Courtesy of Incentifind

When asked about the origin story of IncentiFind — a Houston-based startup that connects real estate developers and home builders with green construction incentives — founder Natalie Goodman doesn't mince words.

"We're a complete accident," Goodman tells InnovationMap in an interview in March. "I'm an architect. We didn't set out to have a startup."

IncentiFind's mission is to increase the amount of green developments and construction projects in the U.S. The company is equipped with a massive database of green incentives that are offered by utility, county, city, state and federal agencies. Many home builders or commercial developers don't take advantage of green incentives because they're simply not aware of them, Goodman says. Commercial developers can expect to spend around $1,500 with IncentiFind, while homeowners can expect to spend between $50 and $150.

Lazarus 3D — 3D printed organs to better train surgeons

Lazarus 3D is using 3D printing to help advance surgeons' skills. Photo via laz3d.com

It's pretty standard for surgeons in training to practice complicated surgeries on produce — slicing bananas open and sewing grapes back together. But for a pair of Baylor College of Medicine-educated doctors, that didn't seem like sufficient prep for working with living bodies; fruit surgery was not fruitful enough. In 2014, Drs. Jacques Zaneveld and Smriti Agrawal Zaneveld founded Lazarus3D to build a better training model — and layer by layer, they created models of abs and ribs and even hearts with a 3D printer.

"We adapted pre-existing 3D printing technology in a novel proprietary way that allows us to, overnight, build soft, silicone or hydrogel models of human anatomy," Jacques, who serves as CEO, tells InnovationMap in July. "They can be treated just like real tissue."

This year, the company grew to seven people and aims to expand even more to add to its sales and manufacturing teams. Having been funded mostly by friends and family investors, Lazarus3D plans enter its first equity round to raise $6 million, InnovationMap reported last summer.

Mental Health Match — connecting people to the right therapists

Ryan Schwartz realized online dating was easier than finding a therapist. He created a tool to change that. Courtesy of Mental Health Match

Nearly five years ago, Ryan Schwartz sat in a coffee shop in crisis mode. His mother had just died suddenly and he was struggling to find an appropriate therapist. Across the table, his friend sat making a profile on a dating app. Quickly, her endeavor was complete and she was ready to swipe right, but Schwartz was still on the hunt for mental help.

"In two minutes she could have a profile matching her with a partner potentially for the rest of her life and I was sitting there for hours and hours trying to find a therapist," he told InnovationMap in June. "I thought it should be easier to find a therapist than a life partner. That's what sent me on my journey."

That journey reached a watershed last month when Schwartz launched Mental Health Match, a website designed to pair patients with their ideal therapist. The idea gained traction as Schwartz described it to people he met and found that many said they had experienced similar difficulties in finding the right practitioner for their needs.

Grab — making ordering food at the airport easier

Houston-based Grab makes it so you're waiting in one less line at the airport. Getty Images

Most airport lines are unavoidable, but a Houston startup has cut out at least some of those lines with its mobile ordering app. Houston-based software company Grab was founded by Mark Bergsrud in 2015, who worked in senior leadership roles for almost 20 years at Continental Airlines and then United Airlines, following the merger. For Bergsrud, Grab feels like another major mobile game changer the industry experienced.

"I spent many years thinking about the travel experience and how to make it better and faster," Bergsrud told InnovationMap in July. "This feels like how mobile check in felt. There was a problem customers didn't know they had — check in wasn't that difficult anyway, but to be able to have that control, people love it."

Grab now has a presence in over 37 airports around the world, including Dallas and Austin though, ironically, not yet either of Houston's airports. Expansion is in the works for Grab, which closed a multimillion-dollar Series A round this year — London-based Collinson Group was the sole contributor.

NurseDash — An app that connects nurses to shifts

Houston-based NurseDash is the Uber of staffing nursing shifts in medical facilities. Photo via nursedash.com

Across the country, medical facilities are short on nurses. Agencies play a role in matchmaking nurses to open shifts, but agencies charge a high percentage for placement and lack transparency, says Andy Chen, former CFO for Nobilis Health Corporation. That's why he and Jakob Kohl created their app, NurseDash in 2017. The project manager for the app is in New York, but official headquarters in Houston's Galleria area, where a staff of five works with the team spread out around the world.

Since its debut, NurseDash has attracted 40 facilities in Houston, InnovationMap reported in May, including hospitals, surgery centers, and senior living, and about 400 nurses. Chen says he isn't sure just what to call his technology yet, but compares it to the ride hailing of Uber or Lyft and calls it "a virtual bulletin board."

Syzygy — hydrogen cells battery to minimize natural gas

Trevor Best, CEO of Syzygy Plasmonics, walked away from EarthX $100,000 richer. Photo via LinkedIn

A Houston technology company is doing something that, for many decades, wasn't thought to be possible. Syzygy Plasmonics is creating a hydrogen fuel cell technology that produces a cheaper source of energy that releases fewer carbon emissions. The hydrogen-fueled technology originated out of research done over two decades by two Rice University professors, Naomi Halas and Peter Nordlander.

Syzygy's technology, CEO Trevor Best told InnovationMap in August, is structured more like a battery than that of a combustion engine. Inside the technology, there are cells, lights, and mirrors making as bright as possible, which then spurs a reaction that creates energy. It has the potential to be cheaper — it's made with cheaper materials — and, of course, cleaner than traditional fueling technology with fewer carbon emissions released.

This new photocatalytic chemical reactor has the potential to shake up the industrial gas, chemical, and energy industries — something that hasn't gone unnoticed by investors. Syzygy just closed a $5.8 million Series A round, and the funds will allow for Syzygy to continue to develop its technology and grow its team. Best tells InnovationMap that he expects to launch a full-size pilot by the end of 2020 and is already in talks with potential clients who are interested in the technology for industrial purposes.

Volumetric — 3D printed human tissue

Houston researchers are commercializing their organ 3D printing technology. Jordan Miller/Rice University

There may come a time when you or someone you love is in need of a new pair of lungs. Or perhaps it's a liver. It's not a scenario anyone dreams of, but thanks to Houston company Volumetric, you may never end up on a waiting list. Instead, that organ is made to order and 3D printed using a mix of medical plastics and human cells.

And this possibility isn't necessarily in the distant future. On the cover of the May 3 issue of the journal Science, is a contraption that looks a bit like a futuristic beehive. It's a working air sac complete with blood vessels, the beginnings of a technology that is perhaps only a decade from being implanted in humans. And it was crafted on a 3D printer in Jordan Miller's lab at Rice University. Miller and his bioengineering graduate student Bagrat Grigoryan are primed to profit from their inventions.

In 2018, they started Volumetric Inc., a company that sells both the hydrogel solutions used for printing organs like theirs and the printers themselves. Touring Miller's lab in the Houston Medical Center is a visual timeline of his team's progress designing printers. The version being manufactured is a slick little number, small enough to fit under chemical exhaust hoods, but fitted with everything necessary to print living tissues. It's made and sold in cooperation with CellInk, a larger bioprinting company.

"Our technology is based on projection," Miller told InnovationMap in May. Specifically, it's stereolithography, a type of 3D printing that produces the finished product layer-by-layer. Shining colored light of the right intensity turns the polymers into a solid gel.

Voyager — Email-less communication tool for maritime shipping

Voyager, a Houston SaaS company, has received fresh funds to develop its bulk shipping software. Tom Fisk/Pexels

Houston software startup Voyager is making waves in its quest to improve efficiency — and stem billions of dollars in losses — in the maritime bulk-shipping business. Now, it's got some fresh capital to help it achieve that mission.

InnovationMap reported in August that Houston-based Voyager revealed it secured $1.5 million in seed funding from four investors from around the world: Austin-based ATX Venture Partners, Houston- and California-based Blue Bear Capital, New York City-based GreenHawk Capital, and Oman-based Phaze Ventures. Previous investors include Boulder, Colorado-based Techstars and Spring-based Knightsgate Ventures.

With its software-as-a-service offering, Voyager aims to modernize the workflows of operators in the maritime bulk-commodities industry. The company says its technology will become more vital as autonomous shipping and internet- and Internet of Things-enabled cargo vessels grow in popularity. Voyager's technology enables all communication tied to a shipment to be handled via its web dashboard and app, essentially creating a one-stop shop for people who need to track messages about maritime bulk shipments.

"With Voyager, what it allows companies to do is essentially have all of those counter parties working together in a shared environment to manage the voyage together — entirely email free," Matthew Costello, CEO, tells InnovationMap in December.

Galen Data — cloud-based platform for connecting medical devices to the internet

Houston-based Galen Data is growing its clientbase and just formed two new partnerships with medical device companies. Photo via galendata.com

Educated as an engineer, Chris DuPont has stepped outside his professional comfort zone to generate funding for his Houston-based startup, Galen Data Inc. DuPont's pool of technical contacts in Houston is "wide and deep," he says, but his pool of financial contacts had been shallow.

Overcoming obstacles in Houston's business waters, DuPont has raised two rounds of angel funding — he declines to say how much — that have enabled Galen Data to develop and market its cloud-based platform for connecting medical devices to the internet, including pacemakers and glucose monitors. DuPont is the startup's co-founder and CEO.

Galen Data's patent-pending technology lets medical device manufacturers tailor the cloud-based software to their unique needs. DuPont says his company's software is geared toward medical devices that are outside, not inside, hospitals and other healthcare facilities. He declines to divulge how many customers the startup has.

Hatched within Houston-based Tietronix Software Inc., DuPont's previous employer, Galen Data launched in 2016 but didn't roll out its first product until 2018. Galen Data's emergence comes as the market for internet-connected mobile health apps keeps growing. One forecast envisions the global space for mobile health exceeding $94 billion by 2023.

"We want to be at the forefront of that technology curve," DuPont tells InnovationMap in May. "We might be six months early, we might be a year early, but it's starting to happen."

Four Houston companies showed the city what they're made of at TMCx's recent Demo Day. Courtesy of TMCx

Houston-based medical device companies pitch at TMCx Demo Day

Local legends

Earlier this month, 16 medical device companies wrapped up their time at the Texas Medical Center's accelerator program and pitched their companies to fellow health professionals, guests, and more. While each made important connections in the local ecosystem during the program, a quarter of the entrepreneurs had roots in Houston already.

Four of the 16 TMCx09 companies that are headquartered in Houston. They have built solutions within sepsis, surgery, and transplant spaces in health care. Here's a little more about the homegrown companies that pitched at the event.

CorInnova

Photo via corinnova.com

The standard practice for acute heart failure patients is very invasive, says William Altman, CEO of CorInnova.

"The problem with existing devices is that they have invasive blood contact," Altman says. "Problem with that is blood contact is bad. It can cause up to 15 percent rate of stroke, which could kill you, and after five to seven days it provides 10 percent rate of blood destruction and has a 47 percent rate of kidney disfunction."

CorInnova's technology features a device that can be easily inserted through a 1-inch incision, and then be used for increase blood pumping by 50 percent.

"Surgeons tell us this is less invasive than minimally invasive aortic valve replacement, which is a widely done surgery, so this promises widespread adoption for our technology as we get it approved," Altman says.

The human prototype is expected to be ready in two years, with the next year being focused on animal studies. CorInnova is raising $12 million to accomplish its goals.

Ictero Medical

Getty Images

An estimated 10 to 15 percent of the United States population will get a gallstone in their lifetime. Should one of those stones cause trouble or blockages, the only solution is to remove the gallbladder completely through surgery. However, Matthew Nojoomi, CEO and co-founder of Ictero Medical, has another idea.

Ictero Medical has created a minimally invasive treatment that uses cryoablation to defunctionize the gallbladder without having to remove it.

"The CholeSafe System not only treats the source of the disease, but it leverages existing clinical workflows that doctors use to access the gallbladder," says Nojoomi, adding that the process only uses mild station and pain control.

The company expects to get to humans in the next two years, and has launched a financing round.

PATH EX

path ex

Photo via tmc.com

Currently, sepsis is hard to identify in patience. Even if a patient is in a hospital, and that hospital knows the patient has sepsis, the individual still has a 38 percent chance of dying, says Sinead Miller, CEO of PATH EX.

"Right now the problems associated with sepsis are very clear," she says. "It's the leading cause of death in our ICUs, and it's also associated with the highest hospital cost and readmission rates."

PATH EX's technology allows medical professionals to better diagnose and treat sepsis. The PATH EX therapeutic device can be hooked up to a patient and flow his or her blood through the machine to capture bacteria, clean and recirculate the blood, and faster diagnose what sort of bacteria the patient has attracted. The device technology is similar to hemo hemodialysis, Miller explains.

The Houston company, which recently won big at the Ignite Healthcare Network's Fire Pitch Competition, was named an honoree within the Johnson and Johnson Breakthrough Medical Technologies Quickfire Challenge.

The company was recently received clearance from the Food and Drug Administration as a breakthrough device technology. PATH EX closed its $615,000 seed round — with plans for a series A next year — and has received $1 million in SBIR grant funding. The company was founded two years ago, and relocated to call Houston HQ this year.

Volumetric

Jordan Miller/Rice University

Volumetric is banking on their technology being among the inventions that will lead the medical industry into the future. The human tissue-printing technology company has created the 3D printer and the "ink" that can create whole organs for transplant.

"We can create complicated vascular architectures inside of soft water-based gels, in this case, mimicking the structure and function of human lung tissue," says Jordan Miller, CEO. "We can oxygenate red blood cells."

The company is commercializing its technology and has three streams of revenue, which as generated almost $1 million in revenue in Volumetric's second year. The company is also in the process of closing its seed round of fundraising.

Earlier this year, the startup, which works out of Rice University, was featured on the cover of Science magazine.

Houston researchers are commercializing their organ 3D printing technology, a local hospital has a tiny medical device with a big impact, and more in health tech. Jordan Miller/Rice University

3 health technologies developed in Houston that are changing the industry

Game changers

There's a huge opportunity for breakthrough medical technology in Houston thanks in large part to major universities, the Texas Medical Center, and other resources within health care startups.

From a new tiny implant that can deliver medicine into the patient remotely to printable human tissue, here are three health technologies coming out of Houston innovators to look out for.

Houston Methodist's tiny drug delivery implant

This tiny implant can have a big effect on patients. Courtesy of Houston Methodist

Houston Methodist nanomedicine researchers have developed an implant the size of a grape that can deliver medicine via a remote control. The device has applications in arthritis, diabetes, and heart disease treatment.

The battery-powered nanochannel deliver system uses Bluetooth technology and can dole out continuous, predetermined dosages for up to a year without refills. A proof-of-concept for the device published in Lab on a Chip.

"We see this universal drug implant as part of the future of health care innovation," says Alessandro Grattoni, chair of the nanomedicine department at Houston Methodist. "Some chronic disease drugs have the greatest benefit of delivery during overnight hours when it's inconvenient for patients to take oral medication. This device could vastly improve their disease management and prevent them from missing doses, simply with a medical professional overseeing their treatment remotely."

The devices can be programed for different dosage sizes and different release settings, which affect the voltage for the medicine delivery.

Houston Methodist has a number of new technologies it's introduced into its hospital system — click here to read about a few more.

NurseDash's resourceful scheduling tool

Houston-based NurseDash is the Uber of staffing nursing shifts in medical facilities. Photo via nursedash.com

Filling open nursing shifts has always been a challenge for hospitals and medical centers, and they've been forced to rely on outsourced companies to coordinate nurses to fill the shifts. NurseDash puts the power back in the hands of freelance nurses and the medical institutions that want to hire them.

Andy Chen, former CFO for Nobilis Health Corporation and co-founder of NurseDash, says the standard practice is hiring these agencies to fill shifts, and, while they promise to send someone, they don't even know who they'll be sending for a shift just hours away. This antiquated system prioritizes who comes in first, rather than a nurse's specialties or qualifications.

Since its debut, NurseDash, which is based in Houston's Galleria Area, has attracted 40 facilities in Houston, including hospitals, surgery centers, and senior living, and about 400 nurses. Chen says he isn't sure just what to call his technology yet, but compares it to the ride hailing of Uber or Lyft and calls it "a virtual bulletin board."

The company has already expanded beyond Houston to northeast Ohio, which the founders say has a similar competitive dynamic to the Houston market. The next goal is to hit the rest of the top 10 largest cities in the United States. To read more about the app and startup, click here.

Volumetric's human tissue-printing technology

Rice University bioengineer Daniel Sazer prepares a scale-model of a lung-mimicking air sac for testing. Jeff Fitlow/Rice University

In a world where organ transplants means an incredible amount of time, money, and patience, there might soon be another option on the operating table. Volumetric is a startup that came out of a human tissue-printing technology developed at Rice University.

Jordan Millar developed the 3D printer in his lab at Rice, and still has ongoing research within the technologies. However, Miller says he very strategically chose to launch a for-profit company in 2018 — mainly, to provide access.

"If we want to do translational research, commercialization is important," reasons Miller. "We need to build the market to get that technology into the world."

Right now, the device is printing scaled down organs, and a contraption that looks a bit like a futuristic beehive, graced the cover of the May 3 issue of the journal Science. It's a working air sac complete with blood vessels, the beginnings of a technology that is perhaps only a decade from being implanted in humans. To read more about Volumetric, click here.


Houston researchers are commercializing their organ 3D printing technology. Jordan Miller/Rice University

Houston researchers are commercializing their human tissue-printing technology

3d-printed organs

There may come a time when you or someone you love is in need of a new pair of lungs. Or perhaps it's a liver. It's not a scenario anyone dreams of, but thanks to Houston company Volumetric, you may never end up on a waiting list. Instead, that organ is made to order and 3D printed using a mix of medical plastics and human cells.

And this possibility isn't necessarily in the distant future. On the cover of the May 3 issue of the journal Science, is a contraption that looks a bit like a futuristic beehive. It's a working air sac complete with blood vessels, the beginnings of a technology that is perhaps only a decade from being implanted in humans. And it was crafted on a 3D printer in Jordan Miller's lab at Rice University.

Yes, there are shades of another Houston story — Denton Cooley's implantation of the first artificial heart — but Cooley only inserted the organ. Miller and his bioengineering graduate student Bagrat Grigoryan are primed to profit from their inventions.

In 2018, they started Volumetric Inc., a company that sells both the hydrogel solutions used for printing organs like theirs and the printers themselves. Touring Miller's lab in the Houston Medical Center is a visual timeline of his team's progress designing printers. The version being manufactured is a slick little number, small enough to fit under chemical exhaust hoods, but fitted with everything necessary to print living tissues. It's made and sold in cooperation with CellInk, a larger bioprinting company.

"Our technology is based on projection," Miller explains. Specifically, it's stereolithography, a type of 3D printing that produces the finished product layer-by-layer. Shining colored light of the right intensity turns the polymers into a solid gel.

But why start a company when Miller and Grigoryan are already busy with research?

"If we want to do translational research, commercialization is important," reasons Miller. "We need to build the market to get that technology into the world."

Miller explains that usually the inventor of a technology is the best one to bring it to market.

"When we were building this technology in the lab we saw the potential for commercialization," he recalls. "We do see that this technology is highly scalable. We do think it can have a positive impact on tissue models in a lab."

Those tissue models could one day make not just scientists, but also animal rights activists, very happy. With the technology that Volumetric is developing, scientists could eventually print human cells so well that animal models would be far less accurate in predicting the success that the product being tested would have on humans.

As academics, though, Miller and Grigoryan weren't sure how to start a company. Fortunately, there is the National Science Foundation (NSF) and its I-Corps program. The pair spent a couple of weeks doing a regional program that taught scientists how to commercialize their technology.

"They want to see funded research get out of the lab," Miller says, explaining that they moved on to the national I-Corps program while Miller was on sabbatical from teaching at Rice, allowing them to interview potential customers.

This gave them the confidence to launch last year. Grigoryan now works full-time at the Med Center incubator and accelerator, Johnson & Johnson's JLabs. He has a team of two other scientists on staff.

"It would have been a lot harder to get started if we didn't have a space like JLabs available," Miller says. It also helps, he adds, that JLabs takes no equity, only helping the fledgling brand to finalize its market and get hooked in with potential investors.

Volumetric has its demo units ready to go and expects to start shipping printers in late June, pending final certifications.

"We believe we have technology to make organ replacements for people," Miller says.

And someday soon, long waits for a new set of lungs and a life of antirejection drugs could be a thing of the past.


Rice University bioengineers (from left) Bagrat Grigoryan, Jordan Miller and Daniel Sazer and collaborators created a breakthrough bioprinting technique that could speed development of technology for 3D printing replacement organs and tissues. Photo by Jeff Fitlow/Rice University

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Houston makes play to score soccer innovation

new goal

Houston is kicking up its 2026 FIFA World Cup bid by a notch or two with a new innovative initiative.

The Houston 2026 World Cup Bid Committee on October 14 committed to establishing the nonprofit Soccer Innovation Institute if Houston becomes a host city for the FIFA World Cup.

"The institute will rely on Houston's spirit of innovation to create a united community investment in building a legacy that goes well beyond the city," according to a news release announcing the potential formation of the nonprofit.

The soccer institute, made up of a network of experts and leaders from various global organizations, would conduct specialized think tanks and would support a series of community programs.

"As the energy capital of the world, the global leader in medicine, the universal headquarters for NASA, and the home to numerous sports tech companies, Houston has an abundance of resources that are unmatched by other cities," Houston billionaire John Arnold, chairman of the 2026 bid committee, says in a news release. "By bringing these organizations together under one umbrella, the Soccer Innovation Institute presents the ultimate opportunity to redefine the player and fan experience, and develop a lasting legacy for the long-term benefit of the FIFA World Cup."

Houston Mayor Sylvester Turner says the institute would align with the city's efforts to build a strong ecosystem for innovation, along with its passion for soccer.

"Houston is recognized as a leader in technology and innovation. We have many innovation hubs around the city that bring bright minds into collaborative spaces where the whole is greater than the sum of the parts," the mayor says.

Held every four years, the World Cup assembles national men's soccer teams from around the world in one of the most planet's most watched sporting events. The traditional 32-team tournament will expand to 48 teams in 2026. After 2026, the World Cup might be staged every two years.

Among those collaborating on the Houston 2026 bid are NRG, the Texas Medical Center, Shell, Chevron, the U.S. Soccer Foundation, the Council for Responsible Sport, the Houston Dynamo, the Houston Dash, the City of Houston, Harris County, and Houston First.

The FIFA World Cup 2026 will be played in 16 cities across the U.S., Mexico, and Canada. Houston and Dallas are among the 17 cities vying to become a U.S. host. A final decision is expected in the first half of 2022. If Houston is selected, it will host six World Cup games at NRG Stadium.

Between October 21 and November 1, World Cup delegates will visit eight cities in the running to be North American hosts: Houston, Dallas, Kansas City, Cincinnati, Denver, San Francisco, Seattle, and Monterrey, Mexico.

Why small businesses are a big deal in Pearland

Small Business, Big Success

Here's a fun fact: 82 percent of businesses in Pearland are locally owned.

Besides providing a warm, fuzzy feeling, that fact actually has a big impact on what the the Lower Kirby city has to offer other companies that are looking to relocate.

Understanding that small businesses are vital to the local economy, the Pearland Economic Development Corporation does all it can to support the formation and growth of new businesses.

To gain a better understanding of the needs of local businesses, PEDC recently conducted a survey of all businesses in the community. The survey found that 92 percent of business owners felt that Pearland is a great place to live, work, and operate a business, and more than 80 percent of survey respondents gave excellent or good marks to Pearland as a place to do business — higher than the national comparison.

The city recently launched an online permitting portal that helps emerging businesses navigate the business registration process with a streamlined, easy-to-use interface that can be accessed anywhere, any time.

By answering just a few questions, potential new business owners can see all the necessary requirements and fees. And commercial permits are reviewed and approved within 20 days, on average.

Additionally, PEDC and community partners are creating an Entrepreneurship Hub, which will enhance Pearland's innovation entrepreneurship culture by creating events, programs, and activities for entrepreneurs and small business owners to inspire ideation and entrepreneurship.

The Hub will connect the city to local and regional entrepreneurship assistance programs, service providers, and funding sources to help businesses maximize their growth potential and overall success. Offerings of the Hub will include business plan competitions, proactive coaching, networking events, and student programs.

In addition to the resources offered, many small businesses that have relocated to Pearland cite the safety of the community and ease of access via multiple thoroughfares as top reasons that led them to the community.

Brask Neela, a small business founded in Louisiana, constructed a new manufacturing facility in Pearland to custom fabricate heat transfer equipment on 9.45 acres in Pearland's Industrial Drive Business Park. After its move to the Pearland area, the company can better service petrochemical and chemical customers in Texas City, Freeport, and Baytown, as well as global clients.

In addition to PEDC's assistance with land acquisition and attractive incentives, Brask Neela was drawn to the location's proximity to the workforce, the area's infrastructure, and open communications with the City of Pearland.

"Pearland provided incentives, proximity to workforce both for shop and office, infrastructure, and clear communication to address any needs with city officials," says Kevin Sareen, Brask Neela's business development manager.

Rollac Shutters manufactures exterior rolling shutters, solar zip shades, and awnings, and opened a 105,000-square-foot headquarters and manufacturing facility that allowed the company to engage in environmentally responsible manufacturing practices and integrate sustainability principles in its day-to-day operations.

"As a family-owned business, location and incentives were most important to us," says Eva Konrad, vice president at Rollac Shutters. "Pearland offered both and we love it here."

Houston-area school scores top 10 status in Texas

star pupils

A Houston-area school earned top honors in Texas in U.S. News & World Report's first-ever ranking of the state's best elementary schools.

Creekside Forest Elementary School comes in at No. 10. Creekside is nestled in the bustling Woodlands and in the Tomball Independent School District.

A public school, Creekside Forest Elementary boasts student population of 571, serving serves kindergarten through fifth grade. Impressively, according to the report, 93 percent of students here scored at or above the proficient level for math, and 87 percent scored at or above that level for reading.

Notably, the student-teacher ratio is at Creekside is 16:1, which is better than that of the district. The school employs 36 equivalent full-time teachers and one full-time school counselor.

The student population at Creekside is made up of 49 percent female students and 51 percent male students, with minority student enrollment at 43 percent. One percent of students here at economically disadvantaged.

According to the school's website, Creekside "is a learning community where all continuously strive for excellence."

Unlike its annual list of the country's best high schools, U.S. News & World Report didn't come up with a national ranking of elementary schools. Rather, it published a ranking for each state.

Myriad other Houston-area schools land later on the list, including West University Elementary at No. 17. According to U.S. News, the 10 best elementary schools in Texas are:

  1. William B. Travis Academy/Vanguard for the Academically Talented and Gifted, Dallas ISD.
  2. Windsor Park G/T Elementary School, Corpus Christi ISD.
  3. Old Union Elementary School, Carroll ISD.
  4. Carroll Elementary School, Carroll ISD.
  5. Hudson Elementary School, Longview ISD.
  6. Sudie L. Williams Talented and Gifted Academy, Dallas ISD.
  7. Canyon Creek Elementary School, Round Rock ISD.
  8. Carver Center, Midland ISD.
  9. Cactus Ranch Elementary School, Round Rock ISD.
  10. Creekside Forest Elementary School, Tomball ISD.
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This article originally ran on CultureMap.