Support Houston startups by shopping local this holiday season. Photos courtesy

Editor's note: We are in the thick of the holidays, and I'm willing to bet a good chunk of you are still doing your gift shopping, right? Why not give a little business to local startups as you shop for friends and family this year.

Need some more ideas? Browse last year's roundup of Houston startup-created gift ideas and check out the 2019 startup gift guide as well for even more options.

For your cousins in college: Cheers

Cheers Health has expanded its product line as it evolves as a wellness-focused brand. Photo courtesy of Cheers

Houston-based Cheers has a collection of products that prioritize your health — especially after overindulging in some holiday cheersing. In 2021, the Houston startup introduced a few new products including a canned beverage that's perfect for anyone looking to properly hydrate before, during, or after drinking — or any time for that matter. Give the gift of Cheers.

For your business-minded father: Lead From The Core by Jay Steinfeld

Blinds.com founder Jay Steinfeld has released his new book this week. Photos courtesy of Jay Steinfeld

Houston innovator and founder of Blinds.com Jay Steinfeld can now add bestselling author to his resume, and you can add his book to someone's stocking. Steinfeld told InnovationMap that he originally set out to write about his entrepreneurial journey and it became a much broader guide to business decision making. Give the gift of Lead From The Core.

For your dog-loving aunt: Fido

A Houston startup is bringing all the dogs to the yard. Photo courtesy of Fido

Gifting to the family pet? Treat them with some Chill Chews and Clear Ears from Fido, a new e-commerce pet wellness brand based in Houston. The company is founded by Houstonians Brad Madrid and Bobby Dwyer and is available in Houston and beyond. Give the gift of Fido.

For your sneakerhead nephew: Tradeblock

Tradeblock — launched in Houston by three childhood friends — coordinates sales of sneakers for collectors across the country. Image via tradeblock.us

Here's a gift shopping idea from a Houston startup that's changing the sneaker game — one step at a time. A group of self-proclaimed sneakerheads founded Tradeblock in 2020, and the app is a new sneaker trading platform that provides collectors with a secure way to collect and trade shoes. After a successful beta, the Houston-based startup has recently launched a new mobile app available for iOS and Android users. Give the gift of shoes from Tradeblock.

For your digital nomadic sister: Splay

The idea for Splay, a unique device perfect for a mobile workforce, was born on the Rice University campus. Images courtesy

Due to the pandemic and the gig economy, more and more of the workforce is working remotely — and away from their 2-screen setup at the office. Splay, created by Houston-based Arovia, solves the challenges with its collapsible screen and projector. The product is currently in its manufacturing stage but maybe this one's worth waiting for. Give the gift of Splay.

Support Houston startups by shopping local this holiday season. Photos courtesy

5 innovative gift ideas from Houston startups

shop local

The holidays are fully upon us, and in the spirit of giving, why not give a little business to local startups as you shop for friends and family this year?

Browse this year's roundup of Houston startup-created gift ideas below, and then click here to check out last year's gift ideas too for eight more options for you.

Low-carb treats from ChipMonk Baking

Give the gift of healthy desserts with ChipMonk Baking. Photo via chipmonkbaking.com

Houstonians David Downing and Jose Hernandez were tired of having such limited options when it came to finding healthy dessert alternatives. So, they founded ChipMonk Baking, a local, mail-order bakery that creates treats using monk fruit and allulose, a low-calorie (0.4 calories per gram) rare sugar that's found naturally in foods such as raisins, dried figs, and kiwi. Hernandez began developing ChipMonk's recipes to satisfy his taste for cookies after being diagnosed with type-2 diabetes.

An online business, ChipMonk offers every snacks from cookies and bites to mixes and sweeteners. There are also a few bundles to choose from as well as a free, downloadable holiday cookbook

Skin-healthy athletic wear from Élastique

Emeline Kuhner-Stout, founder of Élastique Athletics, wanted to create a product that was easy to wear and benefitted lymphatic health. Photo courtesy of Élastique Athletics

Moms know how to make the most of their time, and that's exactly how Emeline Kuhner-Stout came across the idea for Élastique Athletics, a clothing line that promotes skin health and reduces cellulite.

"We did some research, and found that the best way to improve the appearance of your skin and move those fluids — because the cause [of cellulite] is really about those fluids that get trapped under your skin and cause a lot more negative effects other than skin appearance," Kuhner-Stout previously told InnovationMap.

She learned that exercise is the best move for improving lymphatic drainage, and another option is to do it manually through massaging and with compression. After around five years of research and development, Kuhner-Stout was able to release her first product for Élastique Athletics — a pair of leggings that have MicroPerle™ micro-massage beads in the compression leggings to massage the skin when worn.

Now, Élastique has three "wellnesswear" products available online.

Support local with Sesh Coworking

Sesh's gift sets are available for pick-up or delivery. Photo via girlsesh.com

Sesh Coworking is a space founded for women, by women, and that focus extends to the company's in-store and online market. Located in Montrose, Sesh opened its doors in February and was founded by Maggie Segrich and Meredith Wheeler to fill a need in the coworking sector.

"We as women show up in our work lives as a whole person. We don't compartmentalize and forget about all the other things happening in our lives," Wheeler previously told InnovationMap. "We wanted a space that reflected that and embraced it."

While the market supports local female-owned business year round, Sesh has some special items for the holidays. The company has produced a 2020 Holiday Haute List to help users find the perfect gift as well as some gift bundles for the working women of the world. These sets and more are available on Sesh's online store.

Stylish sanitizers from Cobalt

Cobalt's gift set comes with a bottle of each of the company's three FDA-approved cleaning products. Photo via cobaltclean.com

This year's pandemic inspired new products and companies aplenty, and one of them here in Houston is Cobalt founded by Houstonians Molly Voorhees and Christina Milligan. Their hand sanitizing and surface cleaning products blend the importance of cleanliness and safety with the added value of accessibility and a refined appearance.

As working parents of young children, the two women wanted to create a line of sanitizing products that boosted their confidence in the safety of their environments amid a pandemic and that they'd be proud to pull out of their purse on short notice.

"Cleaning products are in your bathroom or are in an ugly looking bottle or the back of our restaurant in massive chemical containers. There is really nothing for the on-the-go market," Voorhees says.

The company sells six FDA-approved sanitizers, sprays, keychains, and to-go kits that eliminate 99.9 percent of bacteria and viruses in easy to access, personal-sized, contemporary bottles, ranging from $14 to $30. The products are designed to be free of harsh, alcoholic odors and come in scents like peppermint and bubble gum.

The gift set, which is available online for $50, includes a bottle of hand sanitizer, surface spray, and mask refresher.

Humidity-conscious women's workwear from Cotidie

Cotidié's fabrics are lightweight and moisture wicking — similar to exercise clothing — making the pieces conducive to the Houston heat and humidity. Lauren Marek/Cotidié

Other than during Houston's brief winter, rocking a professional wardrobe is tough in humidity that is so iconic to Houston. Local entrepreneur Kristina Haag founded Cotidié to design clothes with this struggle in mind.

"With Cotidié, it is all about the functionality of the clothing," Haag previously told InnovationMap. "It is more traditional items, but the use of technical fabrics is our differentiating factor."

The online retailer, which launched in June 2019, offers dresses, jackets, pants, skirts, and tops, ranging between $60 and $200 in price. The fabrics, sourced from Italy and Taiwan, provide breathable comfort, along with an elastic, structured fit for a more tailored look. All items are moisture wicking and machine washable.

"Everything we use on the line is athletic technical fabric that you would typically find in workout attire, but I've repurposed these fabrics to use in a contemporary womenswear line," Haag tells InnovationMap. "I wanted to create a more foundational capsule clothing collection that women can draw their own inspiration from."

The full collection is available online, as are gift cards.

Bonus: 8 more gift ideas from Houston startups

From after-alcohol relief to a smart pillbox, these Houston-founded companies have innovative holiday gifts to offer. Images via Instagram

Here are eight more ideas for gifts made by Houston startups. Click here,

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."