3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Spencer Randall of CryptoEQ, Andy Grolnick of Graylog, and Imran Alibhai of Tvardi. Courtesy photos

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from software to cryptocurrency — recently making headlines in Houston innovation.

Spencer Randall, co-founder and principal at CryptoEQ

Spencer Randall, principal and co-founder of CryptoEQ, joins the Houston Innovators Podcast to discuss how his company has grown alongside the cryptocurrency industry. Photo courtesy of CryptoEQ

It's an interesting time for cryptocurrency and no one knows that better than Spencer Randall, principal and co-founder of Houston-based CryptoEQ, a company that's built a platform for resources and information for everyone interested in cryptocurrency and digital assets.

"CryptoEQ is really built to be the North Star for digital asset research and information. We provide market insights for both newcomers and folks that are already well-versed in cryptocurrency and digital assets," Randall says on this week's of the Houston Innovators Podcast. "The idea of the company is to help shepherd folks along and guide them on their crypto journey."

Recently the company entered into a partnership with The Cannon, an entrepreneurial hub with locations across Houston, to provide a one-of-a-kind crypto starter pack to help onboard innovators to the cryptosphere worldwide. Click here to read more and stream the episode.

Andy Grolnick, CEO of Graylog

A Houston company that's created a centralized log management solution has closed a new round in funding. Photo courtesy of Graylog

Houston-based Graylog closed its $18 million growth equity round led by new investors Harbert Growth Partners and Piper Sandler Merchant Banking, as well as existing investors Houston-based Mercury Fund and Integr8d Capital.

"This investment will enable us to accelerate our global go-to-market strategies and enhancements to the award-winning solutions we deliver for IT, DevOps, and Security teams," says Andy Grolnick, CEO of Graylog, in a press release. "We're excited to have the support of new and existing investor partners to help us realize our potential." Click here to read more.

Imran Alibhai, CEO at Tvardi

Tvardi Therapeutics Inc. has fresh funds to support its drug's advancement in clinical trials. Photo courtesy of Tvardi

Houston-based, cancer-fighting company Tvardi Therapeutics Inc. closed its $74 million series B funding round led by new investors New York-based Slate Path Capital, Florida-based Palkon Capital, Denver-based ArrowMark Partners, and New York-based 683 Capital, with continued support and participation by existing investors, including Houston-based Sporos Bioventures.

"We are thrilled to move out of stealth mode and partner with this lineup of long-term institutional investors," says Imran Alibhai, CEO at Tvardi. "With this financing we are positioned to advance the clinical development of our small molecule inhibitors of STAT3 into mid-stage trials as well as grow our team."  Click here to read more.

Spencer Randall, principal and co-founder of CryptoEQ, joins the Houston Innovators Podcast to discuss how his company has grown alongside the cryptocurrency industry. Photo courtesy of CryptoEQ

Houston startup shines bright as cryptocurrency's 'North Star'

Houston innovator's podcast episode 89

When Spencer Randall and his co-founders dreamt up the idea for CryptoEQ in 2018, they couldn't have even imagined how huge of a presence cryptocurrency would have in the world.

Within the past year, publicly traded companies holding Bitcoin on their balance sheet, El Salvador has announced its adopting Bitcoin as legal tender, dozens of other "altcoins" have emerged, and, as of earlier this month, thousands attended the biggest crypto event in the world.

Helping its users navigate it all is Houston-based CryptoEQ, which has, over the past 18 months, seen 10x growth in users and revenue — recently reaching the 30,000 user milestone.

"CryptoEQ is really built to be the North Star for digital asset research and information. We provide market insights for both newcomers and folks that are already well-versed in cryptocurrency and digital assets," Randall says on this week's of the Houston Innovators Podcast. "The idea of the company is to help shepherd folks along and guide them on their crypto journey."

The platform, which offers both free and paid membership, has expanded to be able to offer something for everyone, despite their cryptocurrency proficiency. In fact, recently the company entered into a partnership with The Cannon, an entrepreneurial hub with locations across Houston, to provide a one-of-a-kind crypto starter pack to help onboard innovators to the cryptosphere worldwide. The new offering launches this week.

"We have a lot of roots at the Cannon — we actually started building CryptoEQ at the original location of the Cannon. So, it's really cool to come full circle and buildout a crypto starter pack with the Cannon team," Randall says.

He shares more about the state of cryptocurrency and how he's seen his company grow on the episode. Listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


Register for some of these informative online events happening throughout the month of March. Photo via Getty Images

10+ can't-miss Houston business and innovation events online in March ​

where to be online

March marks a full year of attending online events — from Zoom panels to virtual conferences. But, the shows must go on with another month full of online innovation and startup events that Houston innovators need to know about.

Here's a roundup of virtual events not to miss this month — from workshops and webinars to summits and pitch parties. Note: This post might be updated to add more events.

March 1-5 — CERAWeek by IHSMarkit

In lieu of the week-long, in-person mega-conference that is the annual CERAWeek by IHSMarkit, the 2021 iteration will be completely virtual. Need some ideas of what panels and talks not to miss? Click here for five recommendations of what to attend.

The conference takes place Monday, March 1, to Friday, March 5. Click here to register.

March 2 — Houston Innovates: Digital transformation and Innovation in Oil & Gas

Digital forces are changing the skills an executive needs to manage organizations. In a world that's become increasingly digital, energy companies can sometimes find it hard to adapt. Join General Assembly Houston for a panel discussion with:

  • Sameer Khan, digital leader (MarTech and Transformation) at ExxonMobil
  • Sarah Vega, vice president of IT & Change at SmartestEnergy
  • Ricky Burns, business transformation team lead at BP
  • Jose Beceiro, senior director of Global Energy 2.0 at the Greater Houston Partnership

The event is on Tuesday, March 2, at 9:30 am. It's free and can be accessed online. Click here to register.

March 2 — Ladies Who LaUNCH #13: The Female Superpower

In 2020, 40 percent of US businesses were owned by women and generated $1.8 trillion. With these numbers in mind, it comes as no surprise that the presence of women in entrepreneurship and investing is growing.

Why do women-led companies financially outperform their male counterparts? And what are the "female superpowers" behind our ability to excel in these fields? Join featured speaker, Megan Bent, as she explores the research, data, and her own experience in the importance of female leadership in entrepreneurship and investing, and how to leverage your differences to your advantage.

The event is on Tuesday, March 2, at noon. It's free and can be accessed online. Click here to register.

March 3 — What's Next in Crypto?

Baker Botts and TeamBlockchain are hosting a webinar discussing trends in cryptocurrency. Key speakers from the sector include:

  • Ali Dhanani, partner at Baker Botts
  • Sarah Beaumont, associate at Baker Botts
  • Jonny Fry, co-founder & CEO at TeamBlockchain Ltd
  • Spencer Randall, principal & co-founder at CryptoEQ
  • Ankush Jain, chief investment officer at Aaro Capital

The event is on Wednesday, March 3, at 11 am. It's free and can be accessed online. Click here to register.

March 9 — Investing in Medical Devices

Join the Texas HALO Fund for a conversation with three of the fund's portfolio companies: Adient Medical, Allotrope Medical, and PathEx.

The event is on Tuesday, March 9, at noon. It's free and can be accessed online. Click here to register.

March 10 — Open Project Night: Achieving Gender Equality in Houston and Beyond

Impact Hub Houston is bringing you a monthly opportunity to come together to work on solutions for some of Houston's most pressing issues. Our city is full of changemakers across all ages, cultures, skillsets, and industries. This is your chance to conned and collaborate for the greater good.

The event is on Wednesday, March 10, at 5 pm. It's free and can be accessed online. Click here to register.

March 10 — Conversations with Latinx Entrepreneurs in Houston

Latinx entrepreneurs are starting small businesses faster than the rest of the startup population and becoming a bigger part of the total U.S. market every day. Join General Assembly for a panel of Houston Latinx leaders as they share stories about their heritage, failures and success.

The event is on Wednesday, March 10, at 6 pm. It's free and can be accessed online. Click here to register.

March 11 — How to Sell Without Being "Salesy"

In celebration of Women's History Month, Catherine Brown and Leela Madan, both serial entrepreneurs and founders of Houston-based Founder's Compass offer their advice on selling your business.

The event is on Thursday, March 11, at 10 am. It's $30 and can be accessed online. Click here to register.

March 11 — Inspire Seminar with Leslie Wise

Join Enventure for a talk and Q&A with the president and principal consultant of Evidence Matters, Leslie Wise. Inspire is one part of Lilie's three-program career exploration series. The goal of Inspire is to share an individual's career journey so that trainees can see one of the many paths that can be taken, learn about the reality of working in these fields, and gain valuable advice from key leaders to better prepare themselves for their own career journey.

The event is on Thursday, March 11, at noon. It's free and can be accessed online. Click here to register.

March 16-20 — SXSW

Another conference is pivoting to virtual attendance this year. SXSW has flipped the switch to being online only for 2021. SXSW's seven conference themes are A New Urgency; Challenging Tech's Path Forward; Cultural Resilience in the Arts; The Rebirth of Business; Transforming the Entertainment Landscape; Connection in Disconnection; and An Uncharted Future. Stay tuned to InnovationMap for a Houston innovator's guide to the conference.

The conference takes place Tuesday, March 16, to Saturday, March 20. Click here to register.

March 17 — Top Legal Considerations for Startups

Join Rice University's Liu Idea Lab for Innovation and Entrepreneurship for a session with corporate and securities lawyer Aaron Barker, who specializes in advising companies from formation to exit, will give you the inside knowledge to help you launch your venture, and possibly save you from making a rookie mistake.

The event is on Wednesday, March 17, at 4 pm. It's free and can be accessed online. Click here to register.

March 23 — Igniting Leadership: Elevating Professionalism

Join Ignite's conversation between Board Member Kelli Newman and Baylor College of Medicine's Dr. Ellen Friedman focus on insights the Director of BCM's Center for Professionalism has to share. In addition to the importance of emotional intelligence, practical methods for addressing problems before they escalate and professionalism for "women in a man's field," Dr. Friedman will answer your questions with practical advice for elevating your own professionalism.

The event is on Tuesday, March 23, at 6 pm. It's free and can be accessed online. Click here to register.

March 24 — Houston Startup Showcase

The Houston Startup Showcase is a flagship event from The Ion, formerly known as Demo Day. This event will allow for developing companies to receive feedback from subject matter experts and showcase their successes thus far. The event is a year-long series of monthly pitch competitions, and results in a final winner to close the series in November. Companies are encouraged to apply online to pitch.

The event is on Wednesday, March 24, at 6 pm. It's free and can be accessed online. Click here to register.

The Texas Medical Center is buzzing with recent innovation news, from Texas A&M University naming its buildings, Houston Methodist is introducing a new technology, and more. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

Startup closes series A, Houston hospital taps into new tech, and more local innovation news

short stories

Houston's innovation ecosystem has been booming with news, and it's likely some might have fallen through the cracks.

For this roundup of short stories within Houston innovation, Deloitte is looking for tech companies to honor, a few Houston innovators have fresh funds, buildings rising in the Texas Medical Center now have names, and more.

Texas A&M names buildings in Innovation Plaza

Texas A&M University has named the buildings that will be a part of its Innovation Plaza. Photo courtesy of Texas A&M University System

The Texas A&M University System has revealed the names of the three buildings in the Texas A&M Innovation Plaza rising near the Texas Medical Center: Discovery Tower, Life Tower, and Horizon Tower.

Discovery Tower is the future home of A&M's EnMed program and is currently being renovated from an 18-story office building. Life Tower, which is expected to deliver in June 2022, is a 19-story, 714-bed student housing tower for Texas A&M medical students and Prairie View A&M University nursing students. Lastly, the Horizon Tower will be a 17-story, 485,000 square-foot integrated building that will feature a 13-story parking structure at the bottom.

SecurityGate closes series A

Ted Gutierrez, CEO of SecurityGate, announced the closing of his company's series A. Courtesy of Security Gate

SecurityGate.io, a software-as-a-service cybersecurity startup based in Houston, has closed its series A fundraising round. Houston Ventures led the capital raise. The amount raised has not been disclosed.

"It was very attractive to us how tightly tuned SecurityGate.io is to the needs of their customers," says Chip Davis, managing partner at Houston Ventures, in a news release. "Successful enterprise software companies generally know they are instruments of change for their customers."

Davis says the feedback from SecurityGate's customers was what sealed the deal.

"Digital transformation is no easy task in highly dynamic environments, especially when the risk of cyberattacks keeps rising daily. We're excited to partner with Houston Ventures who sees this market growing, and our clients that see our vision of the future," says Ted Gutierrez, CEO of SecurityGate, in the release.

Well Health launches at Houston Methodist

Thanks to tech from the West Coast, a Houston hospital has optimized virtual visits. Courtesy of Methodist Hospital/Facebook

Through a partnership with California-based WELL Health Houston Methodist was able up the ante on virtual visits during the pandemic. According to a news release, WELL enabled Houston Methodist to deliver over 260,000 text messages to patients Houston Methodist. The messages educated them about virtual care, schedule visits, and more.

"The ability to communicate back and forth, assuring patients that we are here for them both virtually and in-person is crucial as we continue to safely provide care in the midst of this pandemic," says Tesha Montgomery, vice president of operations and patient access at Houston Methodist, in the release.

Houston podcast network raises over $1 million

A podcast network with Houston ties has raised a seed round. Pexels

Lemonada Media, a podcast network with Houston roots that launched in September, has raised $1.38 million in a seed funding round led by Blue Collective, an early-stage venture capital firm. The fresh funds will allow for strategic growth for the two co-founders, Jessica Cordova Kramer, CEO, and Houstonian Stephanie Wittels Wachs, chief creative officer. Lemonada also plans to hire several positions including vice presidents across finance, production, and marketing.

"We are slated to be a content and talent incubator, spinning out new audio concepts and hit series that present humanity, unfiltered," says Wittels Wachs in a news release. "Now more than ever, people are hungry for content that addresses their lived experience, those that are mundane, and those that may be painful and isolating. Because our company was built off a mountain of personal grief and loss, Lemonada is well-situated to cut through the noise, create beautiful works of art, and make people laugh and feel less alone along the way."

Deloitte is looking for tech companies for annual competition

For the 26th year, Deloitte is looking for cutting edge tech companies. Photo courtesy of Deloitte

Deloitte has opened applications for its 2020 Technology Fast 500. The application is available online and closes July 17. To be eligible for the award, the startup must be in business for a minimum of four years, have its headquarters in North America, have fiscal year 2016 operating revenues of at least $50,000, a fiscal year 2019 operating revenues of at least $5 million USD with a growth rate of 75 percent or greater, and own proprietary intellectual property or proprietary technology which must be sold to customers in products or services that contribute to a majority of the company's operating revenues, according to the contest's rules.

Companies should also fall within one of the following industry categories: biotechnology/pharmaceutical, communications/networking, digital content/media/entertainment, electronic devices/hardware, energy tech, medical devices, semiconductor, or software/SaaS.

Lazarus 3D delivers PPE to Haiti

A few Houston innovators have helped get Haitians critical PPE. Photo courtesy of Orolait

A few Houston innovators have helped connect health care workers in Haiti to some PPE. Ana Rojas Bastidas, founder of Orolait, and Jacques and Smriti Agrawal Zaneveld of Lazarus 3D, teamed up to ship over 1,000 pieces of PPE to United States Foundation for the Children of Haiti which supported orphanages, schools, and a hospital called Hopital Espoir.

In the middle of April, Bastidas saw the organization's need for PPE and saw how Lazarus 3D was creating materials. The group in Haiti received the supplies by the beginning of June.

"I'm really proud of the collaboration between myself and the Lazarus 3D team," Bastidas says. "Smriti and Jacques are absolute gems and while our businesses are completely separate, we found a common problem we both had the resources to tackle."

CryptoEQ begins offering consulting packages

Need custom cryptocurrency support? CryptoEQ is here to help. Courtesy of CryptoEQ

A cryptocurrency startup based in Houston has expanded its service to include custom-consulting packages.

"With our personalized packages, gain the market insights you need to refine your cryptocurrency investing and trading strategies," writes Spencer Randall, co-founder and principal of CryptoEQ.

The packages come at three levels: the enthusiast, the professional, and the expert. The individualized support begins at $499, and more information can be requested from the startup by emailing team@cryptoeq.io.

This week's Houston innovators to know include Dakota Stormer, founder of Footprint; Jonathan Wasserstrum, founder of SquareFoot; and Spencer Randall, co-founder and principal of CryptoEQ. Courtesy photos

3 Houston innovators to know this week

Who's who

Technology can make a huge difference, and Houston innovators are tapping into tech to disrupt various industries from real estate to sustainability.

This week's Houston innovators to know all have a focus on using tech tools to move the needle, whether it's to demystify cryptocurrency, track your ecological footprint, or find your next office space.

Dakota Stormer, founder of Footprint

Dakota Stormer created the Footprint app to help users be more conscientious of their personal contribution to climate change. Photo courtesy of Footprint

Dakota Stormer firmly believes that individuals can make a difference on climate change. And, maybe more importantly, individuals want to try to make that difference. So, he created an app to help. Footprint's algorithm calculates an annual carbon footprint, then averages it out to a per-week measure. This way, users know their goals — and the app sends them suggestions and challenges, like "meatless Mondays," to help reduce their emissions.

"For one person, it doesn't seem like there's much that you can do," Stormer says. "But the number of people across the world that care about climate change — it's actually a majority, at this point."

Click here to read more.

Jonathan Wasserstrum, founder and CEO of SquareFoot

SquareFoot — a real estate tech company with Houston roots — is entering the Houston market. Courtesy of SquareFoot

In 2011, Houston native Jonathan Wasserstrum founded SquareFoot to use tech tools to improve the commercial leasing experience in New York. Now, almost a decade later and fresh off of the closing of a $16 million series B funding round, SquareFoot is set to expand. First on the list of places to grow — Wasserstrum's hometown of Houston.

"Houston, in addition to being a leading market for business, is a city in transition," Wasserstrum says. "We've witnessed a growing trend of smaller companies cropping up, with startups showing that they're here to stay. I want SquareFoot to be a major part of the city's growth and evolution."

Click here to read more.

Spencer Randall, principal and co-founder of CryptoEQ

Cryptocurrency doesn't have to be a big, confusing risk with this Houston startup's technology. Courtesy of CryptoEQ

Spencer Randall got sucked into the cryptocurrency world. He found it all fascinating, and started attending — and even organizing — meetups in Houston. But he and his friends started realizing something that would turn into him co-founding CryptoEQ.

"There really wasn't a go-to resource (for cryptocurrency," Randall says on the most recent episode of the Houston Innovators Podcast. "What we wanted to do and what our mission today is to be the most trusted and intuitive analysis for cryptocurrencies."

Click here to read more.

Cryptocurrency doesn't have to be a big, confusing risk with this Houston startup's technology. Courtesy of CryptoEQ

Entrepreneur feels called to demystify cryptocurrency with his Houston startup

HOUSTON INNOVATORS PODCAST EPISODE 16

Spencer Randall, an engineer by trade, developed a fascination with cryptocurrency, and he wasn't able to shake it.

"Once I understood the technology, it wasn't really a choice. I felt compelled and driven to learn as much as I possibly could," he says on this week's episode of the Houston Innovators Podcast. "I'd say it was more of a calling."

His interest lead him to frequent cryptocurrency and blockchain meetups, and, when those started to feel all over the place, he started to host his own meetups, focused on key issues within the technology.

It was through these meetups that Randall met who would meet Brooks Vaughan, Norman Hamilton, Michael Thoma, and Joseph Romero, who would then become the co-founders of CryptoEQ.

"There really wasn't a go-to resource (for cryptocurrency," Randall says. "What we wanted to do and what our mission today is to be the most trusted and intuitive analysis for cryptocurrencies."

So, the group of entrepreneurs created CryptoEQ, which gives cryptocurrency investors a community to interact with and learn from. The company, which works out of The Cannon, launched its version 2 for the site this month and saw a 500 percent growth among users. CryptoEQ is also planning to grow its site and resources and is hiring a new full-time employee this year.

Randall discusses trends he's seen in the industry, plans for 2020, and more in the podcast episode. Listen to the full episode below — or wherever you get your podcasts — and subscribe for weekly episodes.


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Greentown Labs names Lawson Gow as its new Houston leader

head of hou

Greentown Labs has named Lawson Gow as its Head of Houston.

Gow is the founder of The Cannon, a coworking space with seven locations in the Houston area, with additional partner spaces. He also recently served as managing partner at Houston-based investment and advisory firm Helium Capital. Gow is the son of David Gow, founder of Energy Capital's parent company, Gow Media.

According to Greentown, Gow will "enhance the founder experience, cultivate strategic partnerships, and accelerate climatetech solutions" in his new role.

“I couldn’t be more excited to join Greentown at this critical moment for the energy transition,” Gow said in a news release. “Greentown has a fantastic track record of supporting entrepreneurs in Houston, Boston, and beyond, and I am eager to keep advancing our mission in the energy transition capital of the world.”

Gow has also held analyst, strategy and advising roles since graduating from Rice University.

“We are thrilled to welcome Lawson to our leadership team,” Georgina Campbell Flatter, CEO of Greentown Labs, added in the release. “Lawson has spent his career building community and championing entrepreneurs, and we look forward to him deepening Greentown’s support of climate and energy startups as our Head of Houston.”

Gow is the latest addition to a series of new hires at Greentown Labs following a leadership shakeup.

Flatter was named as the organization's new CEO in February, replacing Kevin Dutt, Greentown’s interim CEO, who replaced Kevin Knobloch after he announced that he would step down in July 2024 after less than a year in the role.

Greentown also named Naheed Malik its new CFO in January.

Timmeko Moore Love was named the first Houston general manager and senior vice president of Greentown Labs. According to LinkedIn, she left the role in January.

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This article originally appeared on our sister site, EnergyCapitalHTX.com.

Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

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