Research roundup

3 cancer-fighting innovations coming out of Houston institutions

From a new cancer-detecting device to a digital resource for childhood cancer survivors, here are some cancer-fighting innovations from Houston. Getty Images

Not all heroes wear capes. Some wear lab coats. Almost daily, it seems there's a new breakthrough or discovery for life-saving innovations.

These three cancer-related innovations are coming out of Houston, and they are ones to watch.

University of Houston's biosensor for prostate cancer reoccurrence

Dmitri Litvinov, professor of electrical and computer engineering at the University of Houston, is on a mission to bring an effective, low-cost test for prostate cancer recurrence to doctor's offices everywhere. Photo via uh.edu

Researchers from the University of Houston have teamed up with their colleagues at the University of Pennsylvania to try to get a biosensor that can detect the recurrence of prostate cancer into the doctor's office.

The research is funded by a $399,988 grant from the National Science Foundation and led by Dmitri Litvinov, principal investigator and professor of electrical and computer engineering at UH.

"Such tests exist in clinical laboratories, but there remains a critical need for inexpensive, versatile and high-sensitivity diagnostic platforms which can bring the performance to the point of care or doctor's office," says Litvinov in a release.

The biosensor platform would be less than $3 per test — an alluring fact for patients and health care providers — and would function more or less like a pregnancy test, but without a simple positive or negative response. Rather, the test can assess how much prostate-specific antigen is in a patient's blood

"Our technology has potential to help improve survival rates with more accessible, affordable and easier testing," Litvinov says.

Rice University's study that points to new cancer-fighting drug

José Onuchic co-authored a study that's opening doors for a new approach in cancer drug development. Photo by Jeff Fitlow/Rice University

A recent study in the Proceedings of the National Academy of Sciences revealed that a cancer-linked version of the protein mitoNEET can shut the gateways of mitochondria cells that supply chemical energy.

José Onuchic, a physicist and co-director of Rice University's Center for Theoretical Biological Physics, co-authored the paper and noted that the gateways, called voltage-dependent anion channels, or VDACs, typically open and shut to allow the passage of metabolites and other small molecules between mitochondria and the rest of the cell.

"The VDAC channel transports all types of metabolites between the cytosol and the mitochondria," says Onuchic in a release. "Dysfunction of this channel is involved in many diseases including cancer and fatty liver disease."

Co-author Patricia Jennings, a structural biologist at UCSD, explains in the news release.

"The discovery that mitoNEET directly gates VDAC, the major porin of mitochondria, as well as the accompanying structural analysis and predictions for this interaction, affords a new platform for investigations of methods to induce cancer cells to commit cell suicide, or apoptosis/ferroptosis, in a cancer-specific, regulated process," she writes.

The study opens doors for a new approach to cancer-treating drugs.

"Fine-tuning a drug that specifically alters the redox-state of interaction between VDAC and mitoNEET would allow the development of new weapons to battle multiple cancers," Onuchic says.

Baylor College of Medicine's digital tool for childhood cancer survivors

Baylor College of Medicine has created an online resource for childhood cancer survivors. Photo via bcm.edu

Childhood cancer survivors face a lifetime of obstacles to overcome, and Baylor College of Medicine and Texas Children's Cancer Center have developed a resource to help these patients have the best quality of life in remission.

Passport for Care, a free online resource, features a "survivorship care plan" for the patient, his or her doctor, and family members. The program's new Screenings Recommendations Generator tool can provide a childhood cancer survivor with potential late effects and how to manage their care.

"This tool is especially helpful for patients who have moved on to other doctors who they did not see as a child and who might not be familiar with their particular treatment and the subsequent health risks," says Dr. David Poplack, founder of the Passport for Care and associate director of the Texas Children's Cancer and Hematology Centers, in a news release. "It helps physicians understand their patient's history and know how to address future health problems."

Over 37,000 cancer survivors are using Passport for Care at 138 clinics around the world. Additionally, patients can also register through the Screenings Recommendations Generator.

Passport for Care is funded by the Cancer Prevention & Research Institute of Texas, as well as through a grant from Hyundai Hope on Wheels.

"We created Passport for Care with the goal of empowering survivors in their healthcare decisions," Poplack says. "Their care doesn't end when cancer treatment is over. Survivorship care is a lifelong journey."

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Building Houston

 
 

Karl Ecklund, left, and Paul Padley of Rice University have received a $1.3 million grant from the Department of Energy to continue physics research on the universe. Photo by Jeff Fitlow/Rice University

Two Rice University physicists and professors have received a federal grant to continue research on dark matter in the universe.

Paul Padley and Karl Ecklund, professors of physics and astronomy at Rice, have received a $1.3 million grant from the Department of Energy for their research to continue the university's ongoing research at the Large Hadron Collider, or LHC, a particle accelerator consisting of a 17-mile ring of superconducting magnets buried beneath Switzerland and France.

"With this grant we will be able to continue our investigations into the nature of the matter that comprises the universe, what the dark matter that permeates the universe is, and if there is physics beyond what we already know," Padley says in a press release.

This grant is a part of the DOE's $132 million in funding for high-energy physics research. The LHC has received a total of $4.5 million to date to continue this research. Most recently, Ecklund and Padley received a $3 million National Science Foundation grant to go toward updates to the LHC.

"High-energy physics research improves our understanding of the universe and is an essential element for maintaining America's leadership in science," says Paul Dabbar, undersecretary for science at the DOE, in the release. "These projects at 53 different institutions across our nation will advance efforts both in theory and through experiments that explore the subatomic world and study the cosmos. They will also support American scientists serving key roles in important international collaborations at institutions across our nation."

In 2012, Padley and his team discovered the Higgs boson, a feat that was extremely key to the continuance of exploring the Standard Model of particle physics. Since then, the physicists have been working hard to answer the many questions involved in studying physics and the universe.

"Over many decades, the particle physics group at Rice has been making fundamental contributions to our understanding of the basic building blocks of the universe," Padley says in the release. "With this grant we will be able to continue this long tradition of important work."

Paul Padley and his team as made important dark matter findings at the Large Hadron Collider in Europe. Photo via rice.ed

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