From a new cancer-detecting device to a digital resource for childhood cancer survivors, here are some cancer-fighting innovations from Houston. Getty Images

Not all heroes wear capes. Some wear lab coats. Almost daily, it seems there's a new breakthrough or discovery for life-saving innovations.

These three cancer-related innovations are coming out of Houston, and they are ones to watch.

University of Houston's biosensor for prostate cancer reoccurrence

Dmitri Litvinov, professor of electrical and computer engineering at the University of Houston, is on a mission to bring an effective, low-cost test for prostate cancer recurrence to doctor's offices everywhere. Photo via uh.edu

Researchers from the University of Houston have teamed up with their colleagues at the University of Pennsylvania to try to get a biosensor that can detect the recurrence of prostate cancer into the doctor's office.

The research is funded by a $399,988 grant from the National Science Foundation and led by Dmitri Litvinov, principal investigator and professor of electrical and computer engineering at UH.

"Such tests exist in clinical laboratories, but there remains a critical need for inexpensive, versatile and high-sensitivity diagnostic platforms which can bring the performance to the point of care or doctor's office," says Litvinov in a release.

The biosensor platform would be less than $3 per test — an alluring fact for patients and health care providers — and would function more or less like a pregnancy test, but without a simple positive or negative response. Rather, the test can assess how much prostate-specific antigen is in a patient's blood

"Our technology has potential to help improve survival rates with more accessible, affordable and easier testing," Litvinov says.

Rice University's study that points to new cancer-fighting drug

José Onuchic co-authored a study that's opening doors for a new approach in cancer drug development. Photo by Jeff Fitlow/Rice University

A recent study in the Proceedings of the National Academy of Sciences revealed that a cancer-linked version of the protein mitoNEET can shut the gateways of mitochondria cells that supply chemical energy.

José Onuchic, a physicist and co-director of Rice University's Center for Theoretical Biological Physics, co-authored the paper and noted that the gateways, called voltage-dependent anion channels, or VDACs, typically open and shut to allow the passage of metabolites and other small molecules between mitochondria and the rest of the cell.

"The VDAC channel transports all types of metabolites between the cytosol and the mitochondria," says Onuchic in a release. "Dysfunction of this channel is involved in many diseases including cancer and fatty liver disease."

Co-author Patricia Jennings, a structural biologist at UCSD, explains in the news release.

"The discovery that mitoNEET directly gates VDAC, the major porin of mitochondria, as well as the accompanying structural analysis and predictions for this interaction, affords a new platform for investigations of methods to induce cancer cells to commit cell suicide, or apoptosis/ferroptosis, in a cancer-specific, regulated process," she writes.

The study opens doors for a new approach to cancer-treating drugs.

"Fine-tuning a drug that specifically alters the redox-state of interaction between VDAC and mitoNEET would allow the development of new weapons to battle multiple cancers," Onuchic says.

Baylor College of Medicine's digital tool for childhood cancer survivors

Baylor College of Medicine has created an online resource for childhood cancer survivors. Photo via bcm.edu

Childhood cancer survivors face a lifetime of obstacles to overcome, and Baylor College of Medicine and Texas Children's Cancer Center have developed a resource to help these patients have the best quality of life in remission.

Passport for Care, a free online resource, features a "survivorship care plan" for the patient, his or her doctor, and family members. The program's new Screenings Recommendations Generator tool can provide a childhood cancer survivor with potential late effects and how to manage their care.

"This tool is especially helpful for patients who have moved on to other doctors who they did not see as a child and who might not be familiar with their particular treatment and the subsequent health risks," says Dr. David Poplack, founder of the Passport for Care and associate director of the Texas Children's Cancer and Hematology Centers, in a news release. "It helps physicians understand their patient's history and know how to address future health problems."

Over 37,000 cancer survivors are using Passport for Care at 138 clinics around the world. Additionally, patients can also register through the Screenings Recommendations Generator.

Passport for Care is funded by the Cancer Prevention & Research Institute of Texas, as well as through a grant from Hyundai Hope on Wheels.

"We created Passport for Care with the goal of empowering survivors in their healthcare decisions," Poplack says. "Their care doesn't end when cancer treatment is over. Survivorship care is a lifelong journey."

A new prostate cancer treatment at Houston Methodist is enhancing the system's patient care. Getty Images

New technology gives this Houston hospital a competitive edge

Guest column

As the top ranking hospital in Texas and one of the biggest employers in Houston, Houston Methodist Hospital is poised to treat the thousands of Texan men who will be diagnosed with prostate cancer this year.

Building on its legacy of delivering advanced cancer treatment, the healthcare giant is one of the first hospitals in the United States to offer men a benign approach to treating localized prostate cancer, using high intensity focused ultrasound, or HIFU. HIFU is a minimally invasive procedure that allows patients to maintain their quality of life with potentially fewer side effects.

Changing the standard of care

For decades, men diagnosed with prostate cancer have had three ways to manage their disease. The first is watchful waiting or active surveillance. Prostate cancer is often slow growing and may not impact the patient during his lifetime. Despite reassuring data in large randomized trials, some patients are still uncomfortable with a diagnosis of cancer and prefer treatment.

On the other end of the spectrum is the complete treatment of the prostate, which involves either surgically removing the entire organ (radical prostatectomy) or radiation, which can last up to eight weeks, with five rounds of treatment per week. Both treatments are known to cause long term erectile dysfunction and incontinence.

But for men diagnosed with localized prostate cancer, this new HIFU treatment bridges the gap between these three approaches. Unlike diagnostic ultrasound, which people are more familiar with, HIFU uses high-frequency sound waves to heat up and burn cancerous tissue, causing cell death. Think of holding a magnifying glass above a leaf on a sunny day. The sun's rays shine through the lens and cause the leaf to burn.

New and improved

Courtesy of Houston Methodist

With HIFU, the urologist destroys the cancerous tissue without damaging other surrounding structures, which include nerves, blood vessels and muscle tissue. While HIFU has only been able to treat the entire prostate or large areas, Houston Methodist has a new technology, called the Focal One, that can zero in on specific areas to treat. The doctor can draw precise contours around the diseased tissue, destroy only that portion of the prostate and minimize any damage to surrounding tissue. This further decreases the possibility of incontinence and erectile dysfunction.

A competitive edge

Focal One gives Houston Methodist Hospital urologists the ability to plum the depths of something until recently considered heresy. The possibility of focal therapy to ablate only the diseased portion of the prostate is similar to performing a lumpectomy to remove only the diseased tissue of the breast in breast cancer. And focal therapy still leaves doctors with the options of radical surgery or radiation, should the cancer return. They don't necessarily burn any bridges.

Although focal HIFU treatment is available around the world for localized prostate cancer and studies in Europe have demonstrated its safety and efficacy, there are no long term follow up data in the U.S. at this time. So far, treatment complication rates in HIFU have shown to be as good as or better than other therapies. But urologic surgeons in the US generally need 10 years of data to establish focal therapy as a standard treatment, which is why it is important for cancer centers that embrace HIFU to enroll patients in an ongoing registry trial.


------

Brian Miles, M.D, is a practicing urologist and professor of urology at the Institute for Academic Medicine at Houston Methodist.

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

10+ can't-miss Houston business and innovation events for June

Where to be

It's time to look at what's on the agenda for June for Houston innovators — from pitch competitions to networking events.

Here's a roundup of events not to miss this month. Mark your calendars and register accordingly.

Note: This post might be updated to add more events.


June 2 — Boost Your Brand's Online Visibility with a Book

Discover the untapped potential of self-publishing a book to establish your expertise, increase your visibility, and build your network. If you have ever considered publishing a book someday, this event is for you.

The event is Friday, June 2, from 8:30 to 10:30 am, at Impact HUB (Amegy Building - 1801 Main St 10th floor.) Click here to register.

June 2 — Best AI Tools for Business Innovation and Growth

This informative workshop is aimed at introducing participants to the latest AI tools available for businesses to innovate and grow. The interactive sessions will provide practical insights and expert advice from speakers who are experts in the field of AI. Participants will learn about the various AI tools that can be used for businesses, including machine learning, natural language processing, computer vision, and more.

The event is Friday, June 2, from 10 to 11 am, online. Click here to register.

June 7-9 — The Future of Global Energy Conference

To highlight Houston's role in the global energy transition, the Greater Houston Partnership, Houston Energy Transition Initiative, and Center for Houston's Future will host a dynamic three-day conference focusing on the role community engagement, innovation and technology, workforce, and funding play in implementing Houston's energy transition strategy.

The event is Wednesday, June 7, to Friday, June 9. The event is hybrid at various locations in Houston. Click here to register.

June 8 — Out in Tech Houston | Monthly Mixer

Out in Tech provides an inclusive networking space for LGBTQ+ people and allies working in tech. Join this relaxed, social-mixer event, hosted on the second Thursday of every month.

The event is Thursday, June 8, at 6:30 to 8:30 pm at Avant Garden. Click here to register.

June 9 — The Future of Global Energy Conference: Luncheon

The Future of Global Energy conference concludes with a gathering of experts and thought leaders, exploring the roadmap for Houston to lead the transition to an energy-abundant, low-carbon future. Panelists include:

  • Jim Gable, President, Chevron Technology Ventures
  • John Hall, President & CEO, Houston Advanced Research Center (HARC)
  • Dr. Ramanan Krishnamoorti, Chief Energy Officer, University of Houston
  • MODERATOR: Jane Stricker, Senior Vice President, Energy Transition & Executive Director, Houston Energy Transition Initiative, Greater Houston Partnership

The event is Friday, June 9, from 10 am to 3 pm, at Hilton Americas. Click here to register.

June 9-10 — Mission Innovate - Reimagining Space Technology to Solve Today’s Challenges

This summer, innovators from around the greater Houston area will convene for a two-day event to innovate, disrupt, and help design innovative solutions that can address gaps in numerous key areas. Entrepreneurs will work with licensable intellectual property from NASA’s IP portfolio to solve some of the largest problems facing the industry. Experienced and first-time founders will form teams, ideate, and pitch their ideas to renown technology entrepreneurs, including members of the innovation teams at NASA. As part of the event, teams will be taught critical startup methodologies, advised by experienced business leaders, and network with an entire community that dreams of shaping key areas in emerging technology.

The event is Thursday, June 9, to Friday, June 10, at the Cannon West Houston. Click here to register.

June 12-14 — Energy Drone & Robotics Summit

The most influential gathering of over 1,500 industrial, energy, and engineering leaders from around the globe where the key challenges and solutions are addressed for operating robotics, drones, satellites, and remote systems successfully and managing AI/data, from the stars to the sea floor.

The event is Monday, June 12, to Wednesday, June 14, at Woodlands Waterway Marriott & Convention Center. Click here to register.

June 13 — Investor Studio Series: VC Due Diligence Best Practices

During this event, Golden Section, a venture capital fund and founders studio obsessed with B2B SaaS product development, will discuss how VCs approach investing and conduct due diligence, and why this matters for founders. The presentation will cover:

  • Market changes that effect how VCs approach investing
  • What founders need to prepare for this new environment
  • How Golden Section approaches due diligence

The event is Tuesday, June 13, from 4 to 6 pm, at the Ion. Click here to register.

June 13 — Using ChatGPT to Grow Your Business

Learn how to harness the power of artificial intelligence and use ChatGPT to not only stay ahead of the game but to redefine it. Whether it's handling queries, managing customer relationships, or generating leads, AI can automate and enhance many aspects of your work. This session will guide attendees through the fascinating world of AI and show them how to leverage it for maximum results.

The event is Tuesday, June 13, from 11 am to 1 pm, at Amcap Mortgage. Click here to register.

June 15 — Female Founders and Funders Meetup

Monthly, every third Thursday, Softeq Venture Studio and Sesh Coworking invite all rockstar female founders and funders in the Houston area to network and empower each other.

The event is Thursday, June 15, from 9 to 10 am, at Sesh Coworking. Click here to register.

June 20 — Co-Creating the Future: An African Startup Symposium on Collaboration

This physical symposium explores opportunities for cross-border entrepreneurial collaboration between the US/Houston and Africa. From Idea to Impact, delving into the African startup ecosystem, highlighting growth and potential for cross-border collaboration, key sectors driving innovation and growth, and legal, regulatory, and cultural considerations and challenges for cross-border collaborations. Startups and investment opportunities will be showcased.

The Agenda:

6:00 pm - 6:10 pm - Introduction to the event and The Beta Collective
6:15 pm - 6:20 pm - Sponsors Highlight
6:20 pm - 6:35 pm - Startup showcase
6:35 pm - 6:40 pm - Panel Introduction
6:40 pm- 7:30 pm - Panel
7:30 - 7:50 pm - Q&A
7:50 - 8:00 pm- Closing and Thanks
8:00 - 8:30 pm - Strategic Networking

The event is Tuesday, June 20, from 6 to 8:30 pm, at The Ion. Click to register.

June 22 — Ultrasound. Integrated. Everywhere.

Pump & Pipes is hosting an event focused on thin-film ultrasound technologies from energy applications into aerospace, health, and medtech sectors.

In collaboration with NASA Tech Talks, and the Mingle Monday Health & MedTech series at The Ion, join Pumps & Pipes as they venture into a discussion on the use of ultrasound technologies from both terrestrial and space medicine perspectives.

The event is Thursday, June 22, from 6 to 9 pm, at the Ion. Click here to register.

June 28 — June Transition On Tap

Transition On Tap is Greentown Labs' monthly networking event devoted to fostering conversations and connections among the climate and energy transition ecosystem in Houston and beyond. Entrepreneurs, investors, students, and friends of climatetech are invited to attend, meet colleagues, discuss solutions, and engage with our growing community. If you’re looking for a job in climatetech or energy, trying to expand your network, or perhaps thinking about starting your own energy-related company, this is the event for you.

The event is Wednesday, June 28, from 5:30 to 7:30 pm, at the Ion. Click here to register.

Texans take note — council warns of summer energy shortfalls

heating up

The North American Electric Reliability Council issued a statement in its 2023 Summer Reliability Assessment earlier this month warning that energy shortages could be coming this summer for two-thirds of North America if temperatures spike higher than normal.

“Increased, rapid deployment of wind, solar and batteries have made a positive impact,” Mark Olson, NERC’s manager of reliability assessments, says in a news release. “However, generator retirements continue to increase the risks associated with extreme summer temperatures, which factors into potential supply shortages in the western two-thirds of North America if summer temperatures spike.”

For Texans, the combined risk of drought and higher than normal temperatures could stress ERCOT system resources, especially in a case of reduced wind. But before there’s a mad rush on generators, keep in mind, electricity consumers can take simple actions to minimize the possibility of widespread shortfalls.

Electricity demand begins rising daily around 2 pm in the summer and peaks in the final hours of daylight. These hours are generally not only the warmest hours of the day, but also the busiest. People return from work to their homes, crank down the air conditioner, turn on TVs, run a load of wash, and prepare meals using multiple electric-powered appliances.

In light of NERC's findings, Americans are recommended to take s one or two small steps to avoid unnecessary stress on the grid in the hours after coming home from work, we can prevent energy shortfalls. Modify routines now to get into the habit of running the dishwasher overnight, using the washer and dryer before noon or after 8 pm and pulling the shades down in the bright afternoon hours of the day. Delaying powering up devices – including EVs – until after dark and turning off and unplug items to avoid sapping electricity when items are not in use is also recommended, in addition to turning up thermostats a couple of degrees.

Meet the innovator who's leveraging big tech to advance Houston's ecosystem equitably

HOUSTON INNOVATORS PODCAST EPISODE 188

At a glance, Rob Schapiro's resume might not make the most sense. A trained geologist with decades of experience in the energy sector, Schapiro made the move to Microsoft three years ago.

"I saw this disconnect between technology companies and energy companies — they didn't really speak the same language," he says on this week's episode of the Houston Innovators Podcast. "I thought I could help potentially solve this problem and work between the two as a sort of translator."

Now, as Microsoft’s Energy Acceleration Program director and site leader for the company’s Houston office, which is located in the Ion, Schapiro is deeply embedded in Houston's innovation ecosystem and is dedicated to helping advance Houston's role energy transition in a sustainable and equitable way.

Inspired by the murder of George Floyd, Schapiro says he sought out opportunities in his personal life to expand his contribution to the community as an ally, and he became a big brother in Big Brothers Big Sisters. Microsoft, too, is active in supporting the community through partnering with local organizations, including SUPERGirls SHINE Foundation, the G-Unity Foundation Inc., and more.

"This has been one of the most rewarding aspects of my job, that I've had the ability to leverage the might of Microsoft and my own privilege to have an impact on real people," Schapiro says. "Microsoft's mission is to empower every person and every organization on the planet to achieve more, and when you think about how you do that, it's really daunting. We realized that in order to do that, it's going to require a workforce that looks really different than it does today."

Microsoft knows too well the changing workforce, both from a diversity perspective and when it comes to artificial intelligence and other new technology. In its recent Work Trend Index report, the company found that, rather than being afraid of AI replacing jobs, the majority of the workforce is interested in applying AI to mundane tasks.

Schapiro shares more about his view of how AI will affect the workforce, plus what all the energy industry needs to focus on amid the energy transition, on the podcast. He also weighs in on how Houston's innovation ecosystem has evolved and where he hopes it's going. Listen to the interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.