This week's innovators to know represents a homecoming, an accelerator launch, and a call for tech education. Courtesy photos

This week's innovators to know span across industries — from sports tech to education, but they are all fighting for something here in Houston. Here's what they are focused on bringing to the Houston innovation ecosystem.

Mike T. Brown, founder of Win-Win

Courtesy of Win-Win

Mike T. Brown decided to move his Silicon Valley sports tech platform that gamifies charitable donations to his hometown of Houston. Win-Win, which launched in 2016 and since raised $1.2 million in funding, is ready to scale and launch full-scale during the 2019 NFL season.

"I couldn't be more excited about returning to Houston to become a part of the city's tech revolution," says Brown in the release. "After visiting The Cannon, I immediately felt the energy and have witnessed their commitment to pushing Houston's tech startup movement. I can't wait to get fully plugged into the city's ecosystem, to start hiring local talent and raising money from local investors." Read more about Brown and Win-Win here.

Yvette Casares Willis, director of strategic partnerships for MassChallenge Texas

Courtesy of MassChallenge Texas

Yvette Casares Willis has been working to put Houston on the map for MassChallenge Texas, and her work is finally coming to fruition. The organization opened applications for its inaugural cohort last week. As excited as she is to work with the cohort, Willis is looking forward to what it means for the program to arrive in Houston and help to connect the dots across the city's innovation ecosystem.

"I'm excited about what Houston has to offer," says Willis, who is the director of partnerships for the organization. "We have everything we could possibly provide in this ecosystem to be amazing, as long as we all work together. If we can all collaborate and if we all have the same mission, we can really make a difference in Houston." Read more about Willis and MassChallenge Texas here.

TeKedra Pierre, internship coordinator at The Village School

Courtesy of The Village School

Tekedra Pierre's job is to help students be aware of real-life needs in the workforce through internship programs. And what's extremely clear to Pierre is the need for more professionals in tech — specifically the cybersecurity space. She wrote a piece for InnovationMap on the subject.

"Employers struggle to keep employees up to speed on the latest technologies and skill sets needed to succeed and thrive in the rapidly changing and evolving business landscape," she writes. "To remain competitive, Houston businesses must attract qualified workers to fill these positions that range from cybersecurity to industrial technology, engineering and medicine. And the earlier we can reach them, the better." Read Pierre's piece here.

Yvette Casares Willis leads partnerships for MassChallenge Texas. Courtesy of MassChallenge

Accelerator program executive to connect the dots within Houston's innovation ecosystem

Featured Innovator

For Yvette Casares Willis, Houston already has what it takes to be a strong innovation ecosystem. Now, it's about working together to get the city where it needs to be, and MassChallenge hopes to do that with its new chapter in Houston.

"I'm excited about what Houston has to offer," says Willis, who is the director of partnerships for the organization. "We have everything we could possibly provide in this ecosystem to be amazing, as long as we all work together. If we can all collaborate and if we all have the same mission, we can really make a difference in Houston."

MassChallenge Texas announced its new Houston program in January. Applications for the inaugural cohort will be officially open as of tonight's launch party for the program. The organization, which has locations around the world, looks for early stage startups that haven't raised more than $500,000 in equity-based funding and have generated less than $1 million in revenue over the past year. The cohort will support 25 startups with free GreenStreet office space, mentorship, investment opportunities, and more, all the while taking no equity in the companies.

Willis has been the organization's boots on the ground in Houston, since MassChallenge Texas is run out of Austin. She spoke with InnovationMap about what MassChallenge's Houston program means to her and the city.

InnovationMap: Why did the city need something like this?

Yvette Casares Willis: We're a little unique to what Houston already has. Houston has a lot of great organizations, but MassChallenge is unique in the fact that we're industry agnostic, we're a nonprofit, and we offer a different business model to be added into the local ecosystem.

IM: Having worked in Houston, what do you feel you bring to the table for MassChallenge?

YCW: My role covers the entire state, but I have been boots on the ground for MassChallenge in Houston and it's been exciting to bring this to where I'm from. I have over 20 years in the Houston market in the corporate environment — my background is in professional sports and entertainment.

IM: As the director of partnerships for MassChallenge, what have you been able to accomplish?

YCW: In the last 10 months, I've been able to meet with several community and corporate partners to talk about MassChallenge. I've seen a lot of excitement. We're working on collaborating, so that when we do have our cohort, we can provide them with the best opportunities to partner with the community and corporations."

IM: What are you most excited about for Houston's MassChallenge program?

YCW: I feel like Houston has all of the best ingredients to be an amazing ecosystem. MassChallenge is going to play a big part of bridging all of the different organizations together. I see that everything is here, but it needs to come together, and I think MassChallenge is really good at doing that wherever they are.

IM: What's next for MassChallenge?

YCW: In my role, when I talk to other organizations, I see a lot of interest between collaborations between Houston and other cities in Texas, but I also see a lot of excitement globally. Houston's a global city and a lot of people are excited about the network MassChallenge has around the world.

------

Portions of this interview have been edited.

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Houston-area lab grows with focus on mobile diagnostics and predictive medicine

mobile medicine

When it comes to healthcare, access can be a matter of life and death. And for patients in skilled nursing facilities, assisted living or even their own homes, the ability to get timely diagnostic testing is not just a convenience, it’s a necessity.

That’s the problem Principle Health Systems (PHS) set out to solve.

Founded in 2016 in Clear Lake, Texas, PHS began as a conventional laboratory but quickly pivoted to mobile diagnostics, offering everything from core blood work and genetic testing to advanced imaging like ultrasounds, echocardiograms, and X-rays.

“We were approached by a group in a local skilled nursing facility to provide services, and we determined pretty quickly there was a massive need in this area,” says James Dieter, founder, chairman and CEO of PHS. “Turnaround time is imperative. These facilities have an incredibly sick population, and of course, they lack mobility to get the care that they need.”

What makes PHS unique is not only what they do, but where they do it. While they operate one of the largest labs serving skilled nursing facilities in the state, their mobile teams go wherever patients are, whether that’s a nursing home, a private residence or even a correctional facility.

Diagnostics, Dieter says, are at the heart of medical decision-making.

“Seventy to 80 percent of all medical decisions are made from diagnostic results in lab and imaging,” he says. “The diagnostic drives the doctor’s or the provider’s next move. When we recognized a massive slowdown in lab results, we had to innovate to do it faster.”

Innovation at PHS isn’t just about speed; it’s about accessibility and precision.

Chris Light, COO, explains: “For stat testing, we use bedside point-of-care instruments. Our phlebotomists take those into the facilities, test at the bedside, and get results within minutes, rather than waiting days for results to come back from a core lab.”

Scaling a mobile operation across multiple states isn’t simple, but PHS has expanded into nine states, including Texas, Oklahoma, Kansas, Missouri and Arizona. Their model relies on licensed mobile phlebotomists, X-ray technologists and sonographers, all trained to provide high-level care outside traditional hospital settings.

The financial impact for patients is significant. Instead of ambulance rides and ER visits costing thousands, PHS services often cost just a fraction, sometimes only tens or hundreds of dollars.

“Traditionally, without mobile diagnostics, the patient would be loaded into a transportation vehicle, typically an ambulance, and taken to a hospital,” Dieter says. “Our approach is a fraction of the cost but brings care directly to the patients.”

The company has also embraced predictive and personalized medicine, offering genetic tests that guide medication decisions and laboratory tests that predict cognitive decline from conditions like Alzheimer's and Parkinson’s.

“We actively look for complementary services to improve patient outcomes,” Dieter says. “Precision medicine and predictive testing have been a great value-add for our providers.”

Looking to the future, PHS sees mobile healthcare as part of a larger trend toward home-based care.

“There’s an aging population that still lives at home with caretakers,” Dieter explains. “We go into the home every day, whether it’s an apartment, a standalone home, or assisted living. The goal is to meet patients where they are and reduce the need for hospitalization.”

Light highlighted another layer of innovation: predictive guidance.

“We host a lot of data, and labs and imaging drive most treatment decisions,” Light says. “We’re exploring how to deploy diagnostics immediately based on results, eliminating hours of delay and keeping patients healthier longer.”

Ultimately, innovation at PHS isn’t just about technology; it’s about equity.

“There’s an 11-year life expectancy gap between major metro areas and rural Texas,” Dieter says. “Our innovation has been leveling the field, so everyone has access to high-quality diagnostics and care, regardless of where they live.”

Aegis Aerospace appoints Houston space leader as new president

moving up

Houston-based Aegis Aerospace's current chief strategy officer, Matt Ondler, will take on the additional role of president on Jan. 1. Ondler will succeed Bill Hollister, who is retiring.

“Matt's vision, experience, and understanding of our evolving markets position us to build on our foundation and pursue new frontiers,” Stephanie Murphy, CEO of Aegis Aerospace, said in a news release.

Hollister guided Aegis Aerospace through expansion and innovation in his three years as president, and will continue to serve in the role of chief technology officer (CTO) for six months and focus on the company's technical and intellectual property frameworks.

"Bill has played an instrumental role in shaping the success and growth of our company, and his contributions leave an indelible mark on both our culture and our achievements," Murphy said in a news release.

Ondler has a background in space hardware development and strategic leadership in government and commercial sectors. Ondler founded subsea robots and software company Houston Mechatronics, Inc., now known as Nauticus Robotics, and also served as president, CTO and CSO during a five-year tenure at Axiom Space. He held various roles in his 25 years at NASA and was also named to the Texas Aerospace Research and Space Economy Consortium Executive Committee last year.

"I am confident that with Matt at the helm as president and Bill supporting us as CTO, we will continue to build on our strong foundation and further elevate our impact in the space industry," Murphy said in a news release. "Matt's vision, experience, and understanding of our evolving markets position us to build on our foundation and pursue new frontiers."

Rice University launches new center to study roots of Alzheimer’s and Parkinson’s

neuro research

Rice University launched its new Amyloid Mechanism and Disease Center last month, which aims to uncover the molecular origins of Alzheimer’s, Parkinson’s and other amyloid-related diseases.

The center will bring together Rice faculty in chemistry, biophysics, cell biology and biochemistry to study how protein aggregates called amyloids form, spread and harm brain cells. It will serve as the neuroscience branch of the Rice Brain Institute, which was also recently established.

The team will work to ultimately increase its understanding of amyloid processes and will collaborate with the Texas Medical Center to turn lab discoveries into real progress for patients. It will hold its launch event on Jan. 21, 2026, and hopes to eventually be a launchpad for future external research funding.

The new hub will be led by Pernilla Wittung-Stafshed, a Rice biophysicist and the Charles W. Duncan Jr.-Welch Chair in Chemistry.

“To make a real difference, we have to go all the way and find a cure,” Wittung-Stafshede said in a news release. “At Rice, with the Amyloid Mechanism and Disease Center as a catalyst, we have the people and ideas to open new doors toward solutions.”

Wittung-Stafshede, who was recruited to Rice through a Cancer Prevention and Research Institute of Texas grant this summer, has led pioneering work on how metal-binding proteins impact neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. Her most recent study, published in Advanced Science, suggests a new way of understanding how amyloids may harm cells and consume the brain’s energy molecule, ATP.

According to Alzheimer’s Disease International, neurodegenerative disease cases could reach around 78 million by 2030 and 139 million by 2050. Wittung-Stafshede’s father died of dementia several years ago.

“This is close to my heart,” Wittung-Stafshede added in the news release. “Neurodegenerative diseases such as dementia, Alzheimer’s and Parkinson’s are on the rise as people live longer, and age is the largest risk factor. It affects everyone.”