New biotech lab, accelerator emerges in Houston to speed up commercialization of life-saving cures

ready to launch

The first of Rice University's new moonshot initiatives, the Rice Biotech Launch Pad was announced on the 61st anniversary of President John F. Kennedy's address at Rice Stadium. Photo by Gustavo Raskosky/Rice University

A new initiative from Rice University is launching with an ambitious goal — to take biotech innovations from concept to clinical trials in five years or less.

The Rice Biotech Launch Pad is a newly announced initiative that will expedite Rice University's health and medical technology innovations. The accelerator, which will occupy 15,000 square feet of space on campus, will be funded through federal grants and donations.

“The Rice Biotech Launch Pad will ensure that our faculty and students have the skills, partnerships, tools and support to create technologies that can transform our city and the world,” Rice President Reginald DesRoches says in a press release. “More importantly, the accelerator will provide a pathway for these creations and discoveries to be turned into medical cures that significantly impact people’s lives. Rice researchers have been doing this for years. This development will allow them to do even more and at a quicker, more efficient pace.”

Leading the program are two seasoned experts: associate professor of bioengineering at Rice, Omid Veiseh, and biotech entrepreneur Paul Wotton, who co-founded Avenge Bio and other startups with technology discovered in Veiseh’s lab. Veiseh will serve as faculty director, and Wotton will lead as executive director. Veiseh says the team behind the new lab will assist faculty in their mission to garner funding — via grants from organizations such as ARPA-H, DARPA and the NIH — as well as creating pathways for licensing revenue for the university.

“We have the infrastructure, financial backing and talent in Houston to do more in creating new medicines to cure disease," Veiseh says in the release. "This is a thriving environment that warrants more attention and dedication to bring forward Houston’s medical discoveries. I am proud to help make this happen.”

The accelerator’s founding advisory council members from Rice are:

  • Paul Cherukuri, Rice’s vice president for innovation.
  • Jacob Robinson, professor of electrical and computer engineering and of bioengineering and founder and CEO of Motif Neurotech.
  • Ashok Veeraraghavan, professor of electrical and computer engineering and computer science and co-founder of Synopic.
  • Yael Hochberg, head of the Rice Entrepreneurship Initiative and the Ralph S. O'Connor Professor of Finance and Entrepreneurship at the Jesse H. Jones Graduate School of Business.

“The Biotech Launch Pad is the first in a series of Rice Moonshots that are hyper-focused on building a ‘speed and scale’ innovation ecosystem across Houston," Cherukuri says. "We at Rice are committed towards driving the Biotech Launch Pad in collaboration with our partners within the Texas Medical Center and the new Helix Park campus.”

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Applications are now open for the Summer Venture Studio. Photo via rice.edu

Rice University kicks off new program for student startup founders

student entrepreneurship

Students at Rice University will have a new opportunity to have a taste of entrepreneurship this summer.

The Liu Idea Lab for Innovation and Entrepreneurship, or Lilie, has established a new startup accelerator program called the Summer Venture Studio. The program, which will run May 15 through August 7, is open to students of any major or year, including recent graduates.

“The Summer Venture Studio will empower student teams to accelerate their ventures and hit escape velocity,” says Kyle Judah, executive director of Lilie, in a news release. “We believe that with the right personalized program and resources, and led by our team of experienced founders, we can unlock students’ limitless potential to create the next generation of pillar companies for Houston, Texas and the world.”

The accepted students will work full-time with Lilie's one-on-one mentorship, programming, and up to $15,000 in equity-free funding per team — all provided in a dedicated coworking space.

“Summer Venture Studio offers Rice students the opportunity to work on their venture ideas with individualized programming customized to their experience, background and venture stage,” says Yael Hochberg, the Ralph S. O’Connor Professor in Entrepreneurship and head of the Rice Entrepreneurship Initiative. “The program is designed to blend seamlessly into students’ curricular and co-curricular experience throughout the academic year, ensuring that each student is met where they are in experience and entrepreneurial knowledge.”

The accelerator is looking for student teams of up to five members. The team lead must be a current student or have graduated within a month of the program's start. Applications are now open online and will be evaluated on a rolling basis.

Houston has seen four new accelerators enter the market this year. Photo by Zview/Getty Images

Breaking down Houston's 4 new startup accelerator programs

Excelling in accelerating

It's official — 2019 is the year of accelerators in Houston. Four different accelerator programs have announced plans to launch Houston programs this year so far — and they are all bringing something different to the table.

All four of the programs represent global programs or big companies recognizing the potential in Houston, which, according to Yael Hochberg, head of the Rice University Entrepreneurship Initiative, is a key part of the equation.

"When you're talking about a place like Houston, what we need here right now is interest from the outside," Hochberg says. "We need some certification by people from the outside that in fact this is a destination for innovation and entrepreneurship."

Houston's most successful accelerator has been homegrown — right out of the Texas Medical Center. TMCx is on its ninth cohort since it launched in 2014.

Also founded in Houston, SURGE Accelerator had a different fate. It launched in 2011 and closed in 2016. Hochberg says there are a number of reasons for the program's demise including disengaged corporations.

"I do feel there's a lot of opportunity around this, and I don't think we should look at SURGE as some sort of indicator of what will happen to an accelerator in the city," she says. "If anything, I would look at TMCx and look at the potential that we see from that."

The biggest benefit to these accelerator programs, Hochberg says, is the new influx of startups that come to Houston. It's not only the accelerators' cohorts, but just the feasibility of the success and resources available. More startups translates to more investments.

"When you have startup activity and good startups, then money, private investment money will follow," Hochbergs says. "Private investment money doesn't just show up."

But bringing in these programs puts the pressure on the city to focus on the environment it's providing new companies and talent. Innovative companies thrive in major metros with things like protected bike lanes, city living, sustainability — and Houston needs to work on these things, Hochberg says, adding that Houston's ability to boast on its single-family homes is less and less attractive to younger demographics.

Building the city up with these types of infrastructure is going to be key when it comes to retaining these startups that accelerators bring in.

"We can create accelerators from here until tomorrow," Hochberg says. "People will send a couple of people down for two days a week to Houston sit at the accelerator, but they'll keep their company somewhere else and not actually move to Houston. Maybe if you're lucky, they'll open up like a little satellite office. We don't want that."

So, what exactly are the differences between these four new startup accelerators? Here's a breakdown of each.

MassChallenge Texas

Photo via greenstreetdowntown.com

MassChallenge Texas first announced its Houston program in January. The Boston-based accelerator program is currently in its final phase of deciding its inaugural cohort. The program is for early stage companies, and is industry agnostic. Jon Nordby, former director of strategy at Houston Exponential, leads the Houston program as managing director.

Launch: July 2019
Location: Downtown Houston
Number of cohort companies: 25
Length: 6 weeks — July through August
Origin: Boston
Requirements: The program looks for applicants that haven't raised more than $500,000 in equity-based funding and have generated less than $1 million in revenue over the past year.
Equity requirements: None.
Prizes on the line: Free office space, mentorship, and, usually, monetary prizes. (Currently, the organization hasn't confirmed cash prizes for the inaugural cohort.)

Founder Institute

Houston's new Founder Institute chapter has teamed up with Alice. Image courtesy Founder Institute

Founder Institute Houston is the earliest stage accelerator that's not associated with a university. Companies must be in the pre-funding stage of growth, and, while 30 companies will be chosen per cohort, only a fraction will complete the full 14 weeks. The Silicon Valley-originated concept now has chapters in almost 200 cities around the world. FI announced its new chapter in Houston in March after first launching in Austin.

Launch: May 2019
Location: Downtown (out of Station Houston)
Number of cohort companies: 30
Length: 14 weeks
Origin: Silicon Valley
Requirements: Company must be pre-funding.
Equity requirements: 4 percent
Prizes on the line: Cash prizes, discounts, access to worldwide alumni network, etc.

Plug and Play Tech Center

Ahead of entering the Houston market later this year, Silicon Valley's Plug and Play hosted three days of programming surrounding innovation in energy and health care. Natalie Harms/InnovationMap

Plug and Play Tech Center confirmed they were entering the Houston market earlier this month. The Silicon Valley organization has 30 locations all over the world and plans to open five new locations in the United States over the next six months to a year — one being Houston.

Launch: Fourth quarter 2019
Location: Currently scouting for a location.
Number of cohort companies: 20
Length: Three months, twice a year.
Origin: Silicon Valley
Requirements: The program is stage agnostic, but cohorts are focused on a specific industry. Houston's likely to be health and energy/sustainability, though nothing is set in stone.
Equity requirements: None
Prizes on the line:In-house venture capital opportunities, corporate connections, etc.

Ion Smart Cities Accelerator

The historic Sears building in Midtown will transform into The Ion, a Rice University-backed hub for innovation. Courtesy of Rice University

In April, the city announced that Microsoft and Intel were backing a Smart Cities Accelerator program that would accelerate companies with solutions to some of Houston's key problems. The first cohort will be focused on solutions within resilience and transportation, but each cohort will have a different set of issues. With these rotating themes, every cohort will be different.

Launch: September 2019
Location: Station Houston (then later The Ion, when it opens)
Number of cohort companies: 10
Length: 10 months
Requirements: The first set of companies will be chosen for their ability to solve problems within mobility and transportation in Houston. (Other cohorts will have other topics.)
Prizes on the line: Pilot programs and permanent business from the city of Houston.

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New AI program powered by Mark Cuban opens applications for Houston students

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The Mark Cuban Foundation is partnering with digital consultant company Perficient’s Houston office to bring a one-of-its-kind, free artificial intelligence camp to high school students in Houston.

Applications, which are open now online, will close September 30.

“With the proliferation of AI, it’s more important than ever to increase AI education – especially among today’s youth,” Bill Davis, senior vice president at Perficient, says in a news release.

The curriculum will focus on the latest developments in the world of AI and Generative AI. The camp — held at Perficient’s Houston office on November 2, 9 and 16 — will provide students with necessary tools and technologies to help inspire a new generation of AI users and professionals. The camp aims to help underserved high school students with a focus on recruiting students of color, first generation college students, girls, and those from lower to moderate income households.

“As AI continues to become an undeniable force in all of our lives, it’s crucial that we open the door to this knowledge, especially to young people who want to explore it,” Cuban says in the release. “While technology expands and becomes more advanced, it becomes more critical that we ensure our students are prepared when they apply for schools or jobs in the future. Thanks to our work with Perficient, the bootcamp will offer an avenue to explore this fascinating field of technology to any student, no matter their means.”

Students can select from six tracks in the course that include healthcare, arts and entertainment, business and entrepreneurship, computer science, sports science, or education and career readiness. The AI Bootcamps are introductory and accessible to students in ninth through 12th grade with an interest in technology without any prior computer science experience. Transportation, resources and food will be provided.

As classes like STEM increase in popularity more programs have been created to help increase interest. More than 233,000 high school students in Texas took Career and Technical Education courses focused on STEM from 2020-2021.

“We’re proud to partner with the Mark Cuban Foundation to educate the next generation of technology leaders, mentoring students in AI, and ensuring the future of STEM,” Davis said in a news release.

UTSI's advisory board digs into cybersecurity's challenges, trends + tech

From The Board

In today's digital landscape, the convergence of Information Technology (IT) and Operational Technology (OT) presents both opportunities and challenges for critical infrastructure asset owners and operators.

UTSI, a leading systems integrator of OT technology, has assembled an OT Cybersecurity Advisory Board to address these challenges and highlight standard processes and best practices to evaluate and secure these environments.

“We are excited about the strength of our esteemed Advisory Board and are confident that these strategic alliances will enhance our competitiveness,” says Shaun Six, president of UTSI International.

A few of the drivers of OT and IT convergence include increased efficiency, enhanced data, and improved remote monitoring and control capabilities. It exists to promote the promise of connectivity, data visualization, and to enable AI and better decision-making.

Key challenges
However, there are challenges. Increased attack surface, legacy systems, and infrastructure, as well as differing security requirements and regulatory and compliance challenges are all present.

“As we witnessed our global infrastructure recover from the largest outage on July 19, this is a clear and present example of how the application of technology between IT/OT can have an impact on the underlying interdependencies in critical systems and infrastructure," says Cherise Esperaza, co-founder and president of Security Gate. "Therefore, there is an ever-increasing need for resources to be expended for this endeavor, and understanding the areas of risk alongside business outcomes as it relates to the convergence will be a critical to ensuring optimal availability of these systems.”

Increased monitoring

When it comes to security monitoring and incident response, it's vital to incorporate new tools to monitor, meeting the same standards as legacy assets and reporting vulnerabilities.

"Continuous monitoring is one of the most critical aspects of securing your IT/OT infrastructure," offers Eric Rippetoe, former CISO of Federal Energy Regulatory Commission and UTSI cybersecurity consultant. "Automated tools coupled with mature processes allow organizations to rapidly detect security threats and enable teams to quickly respond to address issues. Having a security incident and not knowing about it could result in huge remediation costs and major long-term reputational damage."

Emerging technology and trends
With the rise of AI, it makes sense now more than ever to follow the principle of "never trust, always verify." A Zero Trust architecture is a strategic approach to cybersecurity that secures an organization by eliminating implicit trust and continuously validating every stage of a digital interaction.

In line with this approach, UTSI International Corporation, as a Gold Partner of ThreatGEN, has been intensively utilizing ThreatGEN's AutoTableTop™ incident response tabletop exercise simulation tool. This advanced technology is helping UTSI provide meaningful tabletop exercises to their client base, particularly in high-risk SCADA and OT environments.

Clint Bodungen, president of ThreatGEN, emphasizes the tool's significance: "This tool is designed to sharpen incident response capabilities for teams operating in critical SCADA and OT environments. In these high-stakes settings, where system availability is paramount and the consequences of failure can be catastrophic, AutoTableTop™ provides an unparalleled platform for realistic, AI-driven tabletop exercises. It allows teams to practice and refine their responses to a wide range of scenarios, with practically zero planning time required, ensuring they're prepared for the unique challenges posed by industrial control systems where even a minor slip-up could have deadly consequences. This application of advanced simulation technology aligns with the industry's move towards more robust and realistic cybersecurity training, especially in sectors where the stakes are exceptionally high."

In conclusion
The convergence of IT and OT presents significant cybersecurity challenges for critical infrastructure. However, by understanding these challenges and implementing effective strategies, organizations can protect their essential systems from cyber threats.

“Maintaining an accurate inventory of assets poses a significant challenge for companies with control system networks," says Derek Harp, chairman, Control System Cyber Security Association International. "As outlined in our 2024 OT Cybersecurity Technology Report, not only is it difficult to identify these assets, but understanding their communication adds an additional layer of complexity. Typically, companies only gain a snapshot of their OT network status and assets' interactions during periodic assessments. Not surprisingly, our research also indicates that the frequency of these critical evaluations is increasing.”

The role of UTSI's OT Cybersecurity Advisory Board, along with the use of advanced tools like Security Gate and ThreatGEN, is pivotal in navigating this complex landscape. As the threat landscape continues to evolve, proactive measures and ongoing investment in cybersecurity will be crucial to safeguarding our most critical assets.

Play it back: Houston therapeutics co. sees momentum with expanded treatment opportunities

houston innovators podcast Episode 253

It's been a busy summer for Houston-based Coya Therapeutics, a clinical-stage biotech company that's creating revolutionary treatments for neurodegenerative diseases like Alzheimer’s, Parkinson’s, and ALS.

In July, Coya announced that has expanded its collaboration with Houston Methodist Research Institute, or HMRI. The publicly traded company also announced fresh funding from the Johnson Center for Cellular Therapeutics.

Last month, Coya reported that it has expanded its treatment research to see how GLP-1 drugs — a trending drug for weight loss — can enhance the effects of its proprietary therapeutics. By combining the medicines, Howard Berman, co-founder and CEO of Coya Therapeutics, says he thinks Coya can better treat these complex immune-based diseases.

Berman joined the Houston Innovators Podcast in April of 2023 to discuss taking Coya public and his passion for the company's mission.

"I was interested in what I could do for my dad," Berman says on the Houston Innovators Podcast, explaining how he took the meeting with Dr. Stanley Appel, who then presented him with some of his research. "By slide five my jaw had hit the ground.

"He had shown that he could stop the progression in one of his early trials of ALS," Berman says.

Berman shares more of the Coya Therapeutics story on the podcast, as well as how he sees Houston's potential as an emerging hub for biotech.

"The next number of years as we develop this therapeutic regimen for ALS, we have the potential to transform Houston into something more than it is currently," he says. "Our success will be the city's success."

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