10 can't-miss Houston business and innovation events for March

where to be

Here's your one-stop shop for innovation events in Houston for March. Photo via Getty Images

It's time to look at what's on the agenda for Houston innovators for the month of March — a busy one, from the end of Tech Rodeo and the start of CERAWeek, plus many more things to add to your calendars.

Note: This post might be updated to add more events.


March 2 — CodeLaunch Houston

Improving is hosting CodeLaunch Houston — a high energy startup pitch competition — which will round out Houston Tech Rodeo, which is taking place from Monday, February 17, through Thursday, March 2. Check out the finalists here.

The event is Thursday, March 2, from 6 to 9 pm, at 713 Music Hall. Click here to register.

March 4 — Softeq Chili Showdown

Softeq is hosting its chili cookoff event and official after-party of Houston Tech Rodeo. The event will include the broader Houston community, drive awareness of startup development resources available to the community, demonstrate new technology, feature local culture, and promote local startup job creation, all while benefiting Lemonade Day, a fun, experiential program that teaches youth how to start, own and operate their very own business.

The event is Saturday, March 4, from 10 am to 2 pm, at Truck Yard Houston. Click here to register.

March 6 — Energy Workforce of the Future Summit

At this year's summit, Ally Energy will unveil the Energy Workforce Outlook study on workforce transition and hear from leaders, policymakers, startup CEOs, investors, and innovators about how to take all energy forward.

The event is Monday, March 6, from 8 am to 2 pm, at The Petroleum Club of Houston. Click here to register.

March 6 — Transition on Tap at Greentown Labs

Transition On Tap is Greentown Labs' monthly networking event devoted to fostering conversations and connections among the climate and energy transition ecosystem in Houston and beyond. Entrepreneurs, investors, students, and friends of climatetech are invited to attend, meet colleagues, discuss solutions, and engage with our growing community.

The event is Monday, March 6, at 5 pm, at Greentown Houston. Click here to register.

March 6-10 — CERAWeek by S&P Global

CERAWeek by S&P Global returns to downtown Houston. The annual conference brings energy leaders from around the world to discuss the industry's trends and future. The Agora track focuses on the future of energy, which includes clean energy and innovation.

The conference is Monday, March 6, to Friday, March 10, at The George R. Brown Convention Center. Click here to register.

March 7 — Energy Tech Venture Day

The Rice Alliance Energy Venture Day is a fast-paced event connecting nearly 40 energy ventures with venture capitalists, corporate innovation groups, industry leaders, academics and service provider. Ventures will give 3-minute pitches with a networking reception so you can meet the energy ventures and learn more about their technologies.

The event is Tuesday, March 7, from 3 to 6:30 pm, at Rice University. Click here to register.

March 8 — Navigating Careers: Insights & Inspiration from Women Who Have Done It All

In today’s career landscape for C-level leaders, directors, university innovators, entrepreneurs, and founders, what does success look like? How do women navigate barriers, turn challenges into opportunities, and tackle whatever comes their way with poise and confidence? Join us at the Ion for a panel featuring high-profile women thought leaders, entrepreneurs, and influencers--all on top of their field and all with incredible journeys and stories. These women will share their wisdom and wit in authentic ways. A not-to-miss panel, followed by breakout room discussions with each panelist!

The event is Wednesday, March 8, from 8:30 to 11 am, at the Ion. Click here to register.

March 8 — International Women’s Day Luncheon

This luncheon aims to celebrate womanhood while acknowledging and getting inspired for the challenge of promoting progress.

The event is Wednesday, March 8, from 11 am to 2 pm, at Sesh Coworking. Click here to register.

March 9 — Dream Big Ventures Investor Studio Series: Energizing Latino/a Investors

Join the Ion for a fireside chat with Dream Big Ventures Founder & CEO Staci LaToison, and Angeles Investors CEO & Board President David Olivencia, to discuss trends in venture capital and angel investing, and how they are helping increase access to capital for underrepresented founders.

The event is Thursday, March 9, from 5 to 7 pm, at the Ion. Click here to register.

March 10 — TMC Innovation: Federal Health Innovation Day

TMCi is hosting a Federal Health Innovation Day with participation from various federal government agencies focused on health care and innovation. There will be opportunity for face time with the representatives and food will be provided.

The event is Friday, March 10, from 8 am to 2 pm, at TMC Innovation. Click here to register.

March 10-19 — SXSW (in Austin)

Houston founders, investors, and other tech community members will make their way to Austin for SXSW, an interactive festival that is again bringing startup pitches, thought leadership, and more. The Greater Houston Partnership's Houston House returns on March 13 at the Fairmont Hotel, and will be open to badge holders.

The conference is Friday, March 10, to Sunday, March 19, in Downtown Austin. Click here to register.

March 27-28 — Mission Innovate: Reimagining Space Technology to Solve Today’s Challenges

Innovators from around the greater Houston area will convene for a two-day event to innovate, disrupt, and create commercial space companies. Entrepreneurs will work with licensable intellectual property from NASA’s IP portfolio to solve some of the largest problems facing the industry. Experienced and first-time founders will form teams, ideate, and pitch their ideas to renown technology entrepreneurs, including members of the innovation teams at NASA! As part of the event, teams will be taught critical startup methodologies, advised by experienced business leaders, and network with an entire community that dreams of shaping the commercial space industry.

The event is Monday, March 27, to Tuesday, March 28, at The Cannon West Houston. Click here to register.

March 29 — The Cannon Fish Creek Grand Opening Party

Celebrate the opening of The Cannon Fish Creek, which is located in Montgomery, Texas, within the Woodforest community.

The event is Wednesday, March 29, from 4 to 6 pm, at The Cannon Fish Creek. Click here to register.

These are the events to attend each day during the Houston Tech Rodeo 2023. Photo via Getty Images

5 can't-miss events at Houston Tech Rodeo 2023

where to be

Houston innovators — a week of panels, networking opportunities, and more has been coordinated just for you. Are you ready to make the most of it?

Houston Tech Rodeo from Houston Exponential officially starts next week with swag pick up on Sunday, February 26. The programming runs from Monday, February 27, through Thursday, March 2, and wraps up with a chili cook off on Saturday, March 4. There are 30 events to choose from across the Houston innovation corridor near downtown. The full schedule, which launched earlier this month, is available online. Check it out to register for what all you want to attend and for more detailed info.

Each day has themes — space, life science, energy, emerging tech, etc. — and one to two locations for activations. Every day has a happy hour for those interested in networking opportunities, panels for opportunities to hear from industry experts, and more.

Here are five of the Houston Tech Rodeo events you definitely want to make sure you attend.

Networking — #LaunchCity Happy Hour

Start off the week strong with a happy hour at The Ion from 6 to 8 pm on Monday, February 27. The networking event wraps up the first full day of Tech Rodeo and follows space tech-focused programming. If you're able to make it earlier, don't miss the Founder's Live pitch event at Common Desk starting at 3:30 pm or the Future of Space Tech panel at 4:15 pm that will feature representatives from NASA, Axiom, and Intuitive Machines.

Panel — Navigating the Entrepreneurial Landscape: Accessing the Resources You Need to Succeed

If you're a Houston founder, you won't want to miss the first panel of day two of Tech Rodeo. The panel, "Navigating the Entrepreneurial Landscape: Accessing the Resources You Need to Succeed," starts at 9 am on Tuesday, February 28, and will feature experts from a handful of organizations who will speak to resources available for startups and small businesses. The full morning of programing will be hosted at Houston Community College's Central Campus.

Pitch — Rodeo for the Rest of Us Reverse Pitch

Sesh Coworking is hosting an inclusive networking breakfast on Thursday, March 2, beginning at 9 am and followed by a unique opportunity for startups. Sesh is flipping the script on the traditional pitch process and putting the mics in the hands of investors. Expect direct access to these VCs and angels at the Rodeo For the Rest of Us reverse pitch as well as more networking over lunch.

Meeting — Houston Innovation Town Hall

Don't miss the unique opportunity to hear from the Houston innovation community at this unique event. The town hall on Thursday, March 2, will start with announcements from HX and a few other players in the ecosystem, and wrap up with a conversation with Houston's mayoral candidates — Chris Hollins, Lee Kaplan, and Amanda K Edwards — that begins at 4 pm at 713 Music Hall in the Post.

Competition — CodeLaunch by Improving

The weeks programming concludes with a high energy event and startup pitch competition. CodeLaunch by Improving, which announced its finalists earlier this month, will host its main event at 713 Music Hall from 6 to 9 pm. RSVP to Tech Rodeo to get your ticket to the event.


Houston Tech Rodeo returns with 2023 programing across space, health, emerging tech, and more. Image via houstontechrodeo.com

Houston Tech Rodeo drops schedule for 2023 events

ready to rodeo

Houston Tech Rodeo returns this year — and the lineup of panels and networking opportunities has been released online.

The four-day summit was originally introduced in 2020 by Houston Exponential to shine a spotlight on Houston's tech and startup ecosystem. Last year, HX changed ownership, converted into a for-profit business, and named Natara Branch as the new CEO. With the new ownership comes a new era for HTR — complete with AI-generated media, a goal for a record-breaking finale event with CodeLaunch, and more.

"The biggest theme of Tech Rodeo this year is around being aware," Branch tells InnovationMap. "We want entrepreneurs to know what resources are out there, that they are supported, and that there are all these entities out here that are conducting themselves in a manner that is really centered around supporting them."

"We hope that when entrepreneurs and startups walk away from Tech Rodeo this year, it will really feel to them like there's more momentum in this city than there has been in the past so that we can be a top-tier startup destination," she continues.

This year's schedule is divided across a few themes and all events are being held in the Houston Innovation District in Midtown.

  • Monday, February 27: Space Tech at the Ion
  • Tuesday, February 28: Global Mindset at HCC Central Campus and Energy Tech at Greentown Labs
  • Wednesday, March 1: Bio Economy at TMC Innovation and Emerging Tech at The Cannon - Downtown
  • Thursday, March 2: Townhall and CodeLaunch Finale at Sesh Coworking and 713 Music Hall
The week's events will attract founders, investors, startup development organizers, and more. When HTR launched its free tickets online, Branch says they received around 800 registrants in one day. At the center of everything HX does is the Houston founders, Branch says.
"It was supper important to us to make sure that entrepreneurs have access," she says. "It's free to entrepreneurs — they are number one in who should attend."

More information and registration is available at houstontechrodeo.com.

Head to houstontechrodeo.com for up-to-date schedule information. Graphic courtesy of HX

Check out this curated list of innovation events in Houston for February. Photo via Getty Images

10 can't-miss Houston business and innovation events for February

where to be

It's time to look at what's on the agenda for February for Houston innovators — from pitch competitions to networking events.

Here's a roundup of events not to miss this month. Mark your calendars and register accordingly.

Note: This post might be updated to add more events.

Feb. 8 — Digital Marketing Luncheon

Join Insperity, a partner of The Cannon, and digital marketing expert, Danny Gavin, at The Cannon Downtown for a lunch and learn.

The event is Wednesday, February 8, at noon, at The Cannon Downtown. Click here to register.

Feb. 9 — Innovation on Tap: Fred Higgs, Engineering at Rice University

Discuss research in the speaker’s engineering lab at Rice University on key Industry 4.0 technologies, namely additive manufacturing.

The event is Thursday, February 9, at 4 pm, at the Ion. Click here to register.

February 10 — Women in Leadership Conference 

The 23rd annual Women in Leadership Conference will be held in-person at Rice University. The conference has been a beacon of inspiration in the Houston community, empowering women to accomplish their career goals. In panel discussions and interactive workshops, attendees hear from leaders across different industries, explore various approaches to leadership, and discuss future opportunities for success.

The event is Friday, February 10, at 8 am, at McNair Hall at Rice University. Click here to register.

Feb. 15 — Real Talk from Real VCs

Join this event for a candid fireside chat on venture capital and its role in supporting and growing innovative startups.

The event is Wednesday, February 15, at 5:30 pm, at the Ion. Click here to register.

Feb. 16 — Engage VC: Lerer Hippeau

Lerer Hippeau is an early-stage venture capital firm founded and operated in New York City. Since 2010, they have invested in entrepreneurs who embody audacity, endurance, and winning mindset – good people with great ideas who aren't afraid to do hard things. Join the HX Venture Fund to hear Caitlin Strandberg, Partner at Lerer Hippeau discuss her perspective on how to build and scale a great company, what early-stage investors are looking for, why Houston, and market trends among other topics.

The event is Thursday, February 16, at 8:30 am, at the Ion. Click here to register.

Feb. 16 — Female Founders and Funders

Calling all rockstar female founders and investors in the Houston area. Mark your calendars for this month's Female Founders and Funders meetup. Coffee and breakfast is provided and the event is free to attend.

The event is Thursday, February 16, at 9 am, at Sesh Coworking. Click here to register.

Feb. 21 — Web3 & HOU: Demystifying the Web3 Space Panel I

Join us to learn more about Web3 and its numerous applications.

The event is Tuesday, February 21, at 6 pm, at the Ion. Click here to register.

Feb. 22 — The Trailblazer’s Guide to Cultivating Authenticity

In this fun and interactive workshop presented by Erica D’Eramo of Two Peirs Consulting, we’ll look at how to foster a leadership style that works for you, even in the absence of role models.

The event is Wednesday, February 22, at 2 pm, at Sesh Coworking. Click here to register.

Feb. 22 — Houston Startup Showcase

The Houston Startup Showcase is a year-long series of monthly pitch competitions. Founders will pitch at the Ion and compete for the grand prize package. Watch the startups pitch their company and see who the judges will name the champion of the Houston Startup Showcase 2023.

The event is Wednesday, February 22, at 6 pm, at the Ion. Click here to register.

Feb. 23 — Navigating Innovation in the Corporate World

Join us for a fireside chat with leaders from Houston's largest employers, including Microsoft and Chevron to discuss how they have navigated successful careers in technology and innovation.

The event is Thursday, February 23, at 11:30 am, at the Ion. Click here to register.

Feb. 27-March 2 — Houston Tech Rodeo

The Houston Tech Rodeo is a conference showcasing the best and brightest of the Houston startup community in the region and beyond by putting investors, entrepreneurs, industry leaders, and creative minds in a room to talk about the biggest innovations and the future of tech sandwiched by some happy hours and friendly competition.

The events run Monday, February 27, through Thursday, March 2, at various locations in Houston. Click here to register.

Note: This post might be updated to add more events.


In the latest round up of Houston innovation news you may have missed, applications open for fast-growing tech awards, energy startups join latest cohort, and more. Photo via Getty Images

Houston startup grows C-suite, Deloitte opens awards apps, SDO names leader, and more innovation news

short stories

The Houston innovation ecosystem has been especially busy this year, and for this reason, local startup and tech news may have fallen through some of the cracks.

In this roundup of short stories within Houston innovation, local organizations announce new innovators, Deloitte opens apps for its annual tech awards, Houston Tech Rodeo prepares for its annual events, and more.

Early stage accelerator names new Houston leader

Kate Evinger will lead gBETA Houston. Photo via LinkedIn

A Houston early-stage startup accelerator has named its new director. Kate Evinger has joined gener8tor's gBETA Houston as director. She will run the third gBETA cohort in Houston, adding to the 10 alumni from the two cohorts held in 2020.

Evinger has replaced Anu Pansare, who was previously named director in February. Pansare, who replaced the accelerator's inaugural director Eléonore Cluzel, moved on to another opportunity, Evinger says.

Based in Houston's Downtown Launchpad, gBETA's third cohort of early stage startups will soon start its free 7-week program, which is designed to help participating companies gain early customer traction and develop key metrics that will make them more marketable for future investment.

Evinger has been a part of the gener8tor family since 2016 when she joined the team as associate for gBETA Madison. She was promoted to program manager in 2019 when she graduated from Indiana University with degrees in finance, entrepreneurship and corporate innovation, according to a news release.

"Downtown Launchpad's inclusive set of tools, resources and opportunities empower Houston founders to accelerate and scale their businesses to solve humankind's boldest challenges," says Robert Pieroni, director of economic development at Central Houston, in a news release. "Kate Evinger brings experience and valuable insights to the gBETA Houston program and will help us continue to support founders, Houston-based partners and the community."

Houston Tech Rodeo launches registration and names headliner

Master P will be the headlining guest for Houston Tech Rodeo. Photo courtesy of HTR

Houston Tech Rodeo, a week-long collaboration of events hosted by Houston Exponential, has opened registration and announced Percy Miller, also known as musical artist Master P, as the headliner.

Miller, who began his career as an international rap artist, later became a CEO, investor, and founder of Nemesis RR.

"I'll be sharing my journey, my secrets, my success, my feelings, and my rebuilding. Transitioning from international artist to CEO to investing in philanthropy, I want to educate you and give you that gain," says Miller in a news release. "I want to add diversity into technology and the automotive industry."

HTR kicks off May 16 at Saint Arnold Brewing Company with live music, beer, and swag bag pick ups with registration. The week concludes on May 23. Registration is free and available online.

Houston industrial blockchain company expands C-suite

Data Gumbo has a new C-level executive. Photo courtesy of Data Gumbo

Data Gumbo, a Houston-based industrial smart contract network powered by blockchain — announced that it has brought on Robin Macmillan as chief corporate development officer to lead the company's corporate development team.

"The sheer breadth of Macmillan's experience will serve as an invaluable asset to Data Gumbo as we continue to exponentially grow and mature our company into new industrial markets and further solidify our leadership in energy," says Andrew Bruce, CEO and founder of Data Gumbo, in a news release. "Macmillan has the experience to expand Data Gumbo's commercial market penetration to aid companies in undertaking digital transformation with smart contracts to reveal streamlined efficiencies and cost savings, sustainability insights across supply chains and transactional certainty in any commercial relationship."

Macmillan has over 40 years of experience in the energy industry, most recently at National Oilwell Varco and is the vice president of drilling services at the International Association of Drilling Contractors,

"There is tremendous opportunity right now to change how business is executed," says Macmillan in the release. "Data Gumbo is poised to deliver trust through automated, auditable blockchain-backed smart contracts that execute transactions in real-time. I am thrilled to be a part of the Data Gumbo executive team as the company is in a period of hyper growth into new industries, serving as a harbinger for significant digital transformation across commercial relationships and transparent, accurate sustainability impact data."

Deloitte opens annual tech awards nominations

Calling all fast-growing tech companies. Image via Deloitte

Deloitte's Technology Fast 500 awards — which celebrate the fastest growing, most innovative technology, media, telecommunications, life sciences and energy tech companies in the country — has opened applications for its 2021 program.

Applications opened online on April 9 and will remain open until June 29. Winners will be announced on November 15. The program ranks applicants based on percentage of fiscal year revenue growth and the list is compiled from applications. For more information, visit the Technology Fast 500 website.

"Each year, we are excited to see the variety of Houston's Fast 500 applicants, which represent the city's positive momentum in both diversifying its core competencies and highlighting the boom in technology innovations coming to market," says Amy Chronis, vice chair and Houston managing partner at Deloitte LLP. "We look forward to seeing what Houston's innovators will bring in 2021."

Energy incubator announces latest cohort

Fifteen energy startups are joining the Plug and Play family. Gif courtesy of Plug and Play

Plug and Play Tech Center has announced 154 startups into its 2021 summer program — 15 of which were named to the Houston-based Batch 8 Energy Program. During the course of the next three months, these companies will receive access to our corporate, venture capital, and mentor network.

The new energy cohort consists of the following companies:

This week's Houston innovators to know roundup includes Harvin Moore, James Lancaster, and Joshua Baer. Courtesy photos

3 Houston innovators to know this week

who's who

Today starts the Houston Tech Rodeo — a week full of innovation-focused events — and its sure to corral entrepreneurs and investors across the city spur discussions of innovation and technology.

This week's Houston innovators to know includes the man at the helm of the organization behind the Tech Rodeo, plus two investors that are making moves in Houston as well as statewide.

Harvin Moore, president of Houston Exponential

Courtesy of HX

Houston Exponential has helped to coordinate over 30 innovation-focused events for the inaugural Houston Tech Rodeo, which will take place March 2 to 6 — in coordination with the start of the Houston Livestock Show And Rodeo — and will feature panels about diversity, reverse pitch events with startups and accelerators, on-stage office hours, and more.

"Really one of the things that makes a tech ecosystem like Houston really work and purr is when people get together, and people are able to bump into each other and bounce ideas off each other. Businesses do well, ideas thrive, and things happen," Harvin Moore, president of HX, says on the Houston Innovators Podcast. "We basically saw this as an opportunity to let the startup development organizations in town schedule their events around a particular week that really look good on a calendar."

Click here to read more and stream the episode.

James Y. Lancaster, Texas branch manager for Arkansas-based VIC Technology Venture Development

Courtesy of VIC

James Lancaster, Texas branch manager for Arkansas-based VIC Technology Venture Development, knows most startups fail for one of three reasons — no market need, running out of money, and not having a strong team. In his most recent guest article for InnovationMap, Lancaster dives into this third reason with key things founders must think about to give their startup the best shot at success.

"Like market need, evaluating the management team is on virtually every venture capitalist's list of what they look for in their target investments and you need to get it right," Lancaster says.

Click here to read more.

Joshua Baer, founder and CEO of Capital Factory

Courtesy of Capital Factory

While not technically a Houstonian, this Austinite gets an honorary title for his work here. Austin-based accelerator and investment organization Capital Factory recently merged with Station Houston, and CEO and Founder Joshua Baer says it's just the beginning of his focus on Houston startups.

"In total right now, we have 40 companies ever that have joined our accelerator from Houston, which is still a pretty significant number," he tells InnovationMap. "This year, we expect more than 40 companies to join the accelerator from Houston."

Click here to read more.Click here to read more.

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Houston space company lands latest NASA deal to advance lunar logistics

To The Moon

Houston-based space exploration, infrastructure, and services company Intuitive Machines has secured about $2.5 million from NASA to study challenges related to carrying cargo on the company’s lunar lander and hauling cargo on the moon. The lander will be used for NASA’s Artemis missions to the moon and eventually to Mars.

“Intuitive Machines has been methodically working on executing lunar delivery, data transmission, and infrastructure service missions, making us uniquely positioned to provide strategies and concepts that may shape lunar logistics and mobility solutions for the Artemis generation,” Intuitive Machines CEO Steve Altemus says in a news release.

“We look forward to bringing our proven expertise together to deliver innovative solutions that establish capabilities on the [moon] and place deeper exploration within reach.”

Intuitive Machines will soon launch its lunar lander on a SpaceX Falcon 9 rocket to deliver NASA technology and science projects, along with commercial payloads, to the moon’s Mons Mouton plateau. Lift-off will happen at NASA’s Kennedy Space Center in Florida within a launch window that starts in late February. It’ll be the lander’s second trip to the moon.

In September, Intuitive Machines landed a deal with NASA that could be worth more than $4.8 billion.

Under the contract, Intuitive Machines will supply communication and navigation services for missions in the “near space” region, which extends from the earth’s surface to beyond the moon.

The five-year deal includes an option to add five years to the contract. The initial round of NASA funding runs through September 2029.

Play it back: Houston home tech startup begins 2025 with fresh funding

HOUSTON INNOVATORS PODCAST EPISODE 272

One of the dozen or so Houston startups kicking of the new year with fresh funding is SmartAC.com, a company that's designed a platform that enables contractors in the HVAC and plumbing industries to monitor, manage, and optimize their maintenance memberships through advanced sensors, AI-driven diagnostics, and proactive alerts.

Last month, the SmartAC.com raised a follow-on round with support from local investor Mercury to continue growth and expansion of the product, which has evolved on many ways since the company launched in 2020, emerging from stealth with $10 million raised in a series A. In a May 2023 interview for the Houston Innovators Podcast, Founder and CEO Josh Teekell explained how he embraced the power of a pivot.

The company's sensors can monitor all aspects of air conditioning units and report back any issues, meaning homeowners have quicker and less costly repairs. While SmartAC.com started with providing the service and tech to homeowners directly, Teekell says he's had a greater interest in working with plumbers and HVAC companies who then deploy the technology to their customers.

"It became quite evident that homeowners don't care about air conditioning really at all until their system breaks," Teekell says on the show. "The technology is really built around giving those contractors as another way to gain a customer relationship and keep it."

Revisit the podcast episode below where Teekell talks about SmartAC.com's last raise.

SmartAC.com's previous round in 2023 — a $22 million series B — was used grow its team that goes out to deploy the technology and train the contractors on the platform.

"We've been very fortunate to get some of the biggest names in Houston on our cap table," Teekell says in the May 2023 conversation. "Since we're raising a bunch of money locally, everyone understands what a pain air conditioning can be."

Houston biotech company tests hard-to-fight cancer therapeutics

fighting cancer

A Houston-based, female-founded biotech company has developed a treatment that could prove to be an effective therapy for a rare blood cancer.

Cellenkos Therapeutics has completed promising Phase 1b testing of its Treg cell therapy, CK0804, in the fight against myelofibrosis. According to a news release from the Cellenkos team, the use of its cord-blood-derived therapeutics could signal a paradigm shift for the treatment of this hard-to-fight cancer.

Cellenkos was founded by MD Anderson Cancer Center physician and professor Simrit Parmar. Her research at the hospital displayed the ability of a unique subset of T cells’ capability to home in on a patient’s bone marrow, restoring immune balance, and potentially halting disease progression.

Myelofibrosis has long been treated primarily with JAK (Janus Kinase) inhibitors, medications that help to block inflammatory enzymes. They work by suppressing the immune response to the blood cancer, but don’t slow the progression of the malady. And they’re not effective for every patient.

“There is a significant need for new therapeutic options for patients living with myelofibrosis who have suboptimal responses to approved JAK inhibitors,” Parmar says. “We are greatly encouraged by the safety profile and early signs of efficacy observed in this patient cohort and look forward to continuing our evaluation of the clinical potential of CK0804 in our planned expansion cohort.”

The expansion cohort is currently enrolling patients with myelofibrosis. What exactly are sufferers dealing with? Myelofibrosis is a chronic disease that causes bone marrow to form scar tissue. This makes it difficult for the body to produce normal blood cells, leaving patients with fatigue, spleen enlargement and night sweats.

Myelofibrosis is rare, with just 16,000 to 18,500 people affected in the United States. But for patients who don’t respond well to JAKs, the prognosis could mean a shorter span than the six-year median survival rate outlined for the disease by Cleveland Clinic.

Helping myelofibrosis patients to thrive isn’t the only goal for Cellenkos right now.

The company seeks to aid people with rare conditions, particularly inflammatory and autoimmune disorders, with the use of CK0804, but also other candidates including one known as CK0801. The latter drug has shown promising efficacy in aplastic anemia, including transfusion independence in treated patients.

The company closed its $15 million series A round led by BVCF Management, based in Shanghai, in 2021. Read more here.

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