Houston-based Action1 landed at No. 29 nationally and No. 1 in the software category in this year's Inc. 5000 ranking. Photo via Getty Images.

Dozens of Houston-area businesses appear in this year’s Inc. 5000 ranking of the 5,000 fastest-growing private companies in the U.S., with a security software provider capturing the region’s No. 1 spot on the list.

Landing at No. 29 nationally and No. 1 in the software category, the top-ranked Houston-area private company is Houston-based Action1. The company recorded median revenue growth of 7,188 percent from 2021 to 2024, according to the Inc. 5000.

It’s the first appearance on the Inc. 5000 list for Action1, founded in 2018.

Action1 produces patch management software. A patch, or fix, quickly repairs software to resolve functionality problems, improve security or add features, according to TechTarget.

“Modern organizations understand that proactive patch management is essential to staying ahead of today’s rapidly evolving threat landscape,” Mike Walters, co-founder and president of Action1, said in a news release. “Our continued hypergrowth reflects the increased demand for enterprise cybersecurity innovation. You can’t be just powerful and secure — you must also be simple to deploy and scale and cost-effective.”

Below are the Houston-area businesses that earned a ranking among the top 1,000 companies, including their industries and their three-year growth rate. To see the other Houston-area companies in the Inc. 5000, visit inc.com/inc5000/2025.

  • No. 29 Houston-based Action1, software (7,188 percent)
  • No. 49 Spring-based Bogey Bros Golf, retail (5,540 percent)
  • No. 84 Houston-based Turtlebox Audio, consumer products (3,818 percent)
  • No. 87 The Woodlands-based Allied Wealth, financial services (3,796 percent)
  • No. 319 Houston-based Strategic Office Support, business products and services (1,228 percent)
  • No. 324 Houston-based Novo Communications, security (1,212 percent)
  • No. 363 Houston-based OptiSigns, software (1,101 percent)
  • No. 385 Houston-based Cart.com, business products and services (1,053 percent)
  • No. 421 Houston-based Sydecar, financial services (962 percent)
  • No. 471 The Woodlands-based Acuity Technology Partners, IT services (869 percent)
  • No. 577 Stafford-based Dahnani Private Equity Group, real estate (718 percent)
  • No. 706 Houston-based Why Not Natural, consumer products (585 percent)
  • No. 709 Stafford-based Signarama Sugar Land, manufacturing (584 percent)
  • No. 744 Houston-based FINBOA, software (557 percent)
  • No. 747 Houston-based Amundson Group, human resources (557 percent)
  • No. 793 Houston-based Field Industries, manufacturing (533 percent)
  • No. 957 Friendswood-based Good Ranchers, food and beverage (448 percent)
  • No. 999 Houston-based ARIA Signs & Design, business products and services (428 percent)
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TMC lands $3M grant to launch cancer device accelerator

cancer funding

A new business accelerator at Houston’s Texas Medical Center has received a nearly $3 million grant from the Cancer Prevention and Research Institute of Texas.

The CPRIT grant, awarded to the Texas Medical Center Foundation, will help launch the Accelerator for Cancer Medical Devices. The accelerator will support emerging innovators in developing prototypes for cancer-related medical devices and advancing them from prototype to clinical trials.

“The translation of new cancer-focused precision medical devices, often the width of a human hair, creates the opportunity to develop novel treatments for cancer patients,” the accelerator posted on the CPRIT website.

Scientist, consultant, and entrepreneur Jason Sakamoto, associate director of the TMC Center for Device Innovation, will oversee the accelerator. TMC officials say the accelerator builds on the success of TMC Innovation’s Accelerator for Cancer Therapeutics.

Each participant in the Accelerator for Cancer Medical Devices program will graduate with a device prototype, a business plan, and a “solid foundation” in preclinical and clinical strategies, TMC says. Participants will benefit from “robust support” provided by the TMC ecosystem, according to the medical center, and “will foster innovation into impactful and life-changing cancer patient solutions in Texas and beyond.”

In all, CPRIT recently awarded $27 million in grants for cancer research. That includes $18 million to attract top cancer researchers to Texas. Houston institutions received $4 million for recruitment:

  • $2 million to the University of Texas MD Anderson Cancer Center to recruit Rodrigo Romero from Memorial Sloan Kettering Cancer Center in New York City
  • $2 million to MD Anderson to recruit Eric Gardner from Weill Cornell Medicine in New York City

A $1 million grant also went to Baylor College of Medicine researcher Dr. Akiva Diamond. He is an assistant professor at the medical college and is affiliated with Baylor’s Dan L. Duncan Comprehensive Cancer Center.

Houston students develop cost-effective glove to treat Parkinson's symptoms

smart glove

Two Rice undergraduate engineering students have developed a non-invasive vibrotactile glove that aims to alleviate the symptoms of Parkinson’s disease through therapeutic vibrations.

Emmie Casey and Tomi Kuye developed the project with support from the Oshman Engineering Design Kitchen (OEDK) and guidance from its director, Maria Oden, and Rice lecturer Heather Bisesti, according to a news release from the university.

The team based the design on research from the Peter Tass Lab at Stanford University, which explored how randomized vibratory stimuli delivered to the fingertips could help rewire misfiring neurons in the brain—a key component of Parkinson’s disease.

Clinical trials from Stanford showed that coordinated reset stimulation from the vibrations helped patients regain motor control and reduced abnormal brain activity. The effects lasted even after users removed the vibrotactile gloves.

Casey and Kuye set out to replicate the breakthrough at a lower cost. Their prototype replaced the expensive motors used in previous designs with motors found in smartphones that create similar tiny vibrations. They then embedded the motors into each fingertip of a wireless glove.

“We wanted to take this breakthrough and make it accessible to people who would never be able to afford an expensive medical device,” Casey said in the release. “We set out to design a glove that delivers the same therapeutic vibrations but at a fraction of the cost.”

Rice’s design also targets the root of the neurological disruption and attempts to retrain the brain. An early prototype was given to a family friend who had an early onset of the disease. According to anecdotal data from Rice, after six months of regularly using the gloves, the user was able to walk unaided.

“We’re not claiming it’s a cure,” Kuye said in the release. “But if it can give people just a little more control, a little more freedom, that’s life-changing.”

Casey and Kuye are working to develop a commercial version of the glove priced at $250. They are taking preorders and hope to release 500 pairs of gloves this fall. They've also published an open-source instruction manual online for others who want to try to build their own glove at home. They have also formed a nonprofit and plan to use a sliding scale price model to help users manage the cost.

“This project exemplifies what we strive for at the OEDK — empowering students to translate cutting-edge research into real-world solutions,” Oden added in the release. “Emmie and Tomi have shown extraordinary initiative and empathy in developing a device that could bring meaningful relief to people living with Parkinson’s, no matter their resources.”