Houston tech company adds 3 members to its C-suite

growing team

Softeq has named three members to its executive team. Photos courtesy of Softeq

A tech development company has expanded its executive suite with three new additions to its team.

Softeq Development Corp. has hired Craig Ceccanti as COO, Albert Esser as chief delivery officer, and Edwin Lemus as chief people officer. The new hires' roles were effective as of June 1. The Houston company, founded in 1997, creates hardware and software solutions for its clients. Softeq also runs a venture fund and studio for startups from around the world.

“With the significant growth of our engineering services business plus the addition of our Venture Studio and $40 million Venture Fund, we saw an opportunity to welcome new leaders with global experience and fresh thinking to continue evolving our business and scaling for the future,” says Christopher A. Howard, founder and CEO of Softeq, in a news release. “This is a huge investment in our team, and with the addition of these three leaders to our C-suite we will centralize our global leadership team in Houston while providing support and expertise to our team across 22 countries and clients worldwide.”

About the new executives:

  • Craig Ceccanti is a serial entrepreneur. He founded Pinot’s Palette and oversaw its franchise growth and exit before joining the founding team of sEATz — now Rivalry Technologies. The sports tech startup provides a mobile ordering software for stadiums, as well as hospital and hospitality destinations. Most recently, he founded and ran T-Minus Solutions, a custom software development company. As COO, Ceccanti will oversee the day-to-day operations of Softeq and work to improve internal and external processes.
  • With three decades of experience in tech and consulting at Daimler AG, GE, Emerson, Hilti, and Dell, Albert Esser will lead the delivery organization, which includes including solutions engineering, project management, and resource management. As chief delivery officer, he's tasked with expanding "the team’s capabilities and agility by adding to the global network of consultants," per the release, as well as leading Softeq's adoption of emerging new technologies like IoT, AI/ML, vision systems, industrial automation, robotics, cloud applications, and cyber security.
  • Edwin Lemus has 22 years of talent-related experience, and, as chief people officer, he will continue to grow the Softeq team and build a company culture for the workforce that stretches across 22 offices around the world.

Softeq Venture Studio launched over a year ago with its inaugural cohort in 2021, and the fund was launched last year. The latest cohort was announced in March.

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Softeq Venture Studio's growing portfolio of startups in its accelerator work out of FUSE Workspace in City Centre. Image via fuseworkspace.com

Houston tech company adds 22 startups to its accelerator

now accelerating

A Houston early-stage accelerator has named 22 startups to its latest cohort.

Softeq Development Corp. has announced the companies joining the Softeq Venture Studio, the tech services company's accelerator program. A total of 22 companies have joined the program — hailing from the United Kingdom, Iceland, Mexico, Peru, and across the United States. This addition nearly doubles the program's portfolio, bringing the total number of startups to 49.

“This year has been a significant one for the Softeq Venture Fund and our portfolio companies. Due to the hard work of our team and the success achieved by previous founders, we’ve seen our investors and our entrepreneurs evolve to be more global than ever, and with more ambitious plans to revolutionize their industries," says Christopher A. Howard, founder and CEO of Softeq, in a news release. "We continue to attract world-class founders to Houston for our program that de-risks startups and investments."

Howard also announced a new limited partner. Houston entrepreneur Craig Ceccanti — co-founder of Pinot’s Palette and Rivalry Technologies — is the latest investor to join the $40 million Softeq Venture Fund, which is anticipated to close by the end of the year.

“Investors constantly search for opportunities that balance opportunity and risk, and ones that help us grow and maximize returns while maintaining a measure of stability and diversification,” says Ceccanti in the release. “Joining the Softeq Venture Fund is an exciting opportunity because it provides a de-risked investment opportunity plus the ability to participate in a hands-on fashion in Houston within these high-growth industries.”

The trend among the new cohort joining the program for the next three months includes health tech, sports tech, fintech, e0-commerce, Web 3.0, and more. Participating starups will have access to FUSE Workspace, as well as support and guidance from Softeq Venture Studio staff, Softeq engineers, local mentors, investors, and earlier cohort members.

“During our startup journey, we participated in leading technology accelerator Y Combinator. Later on, we realized through our users’ feedback we needed to improve our product with additional technology expertise and support to reach our full potential,” says Gerardo Briones, founder and CEO of new cohort startup Pagaloop of Mexico City. “That’s why we chose to participate in the Softeq Venture Studio. Softeq engineers have experience building enterprise-grade applications that scale up. We also get more opportunities to meet investors to bring our product to all of Latin America.”

The complete list of the new cohort of the Softeq Venture Fund, according to the news release, includes the following companies:

  • Adkaddy gets brands out of your email and into a powerful brand management tool. From discovery to promotions, shipping and receipts, this is digital commerce your way.
  • Allkind is benefiting reproductive healthcare globally by innovating fertility matching, empowering personal goals & improving modern family building.
  • atease is where 133 million government and military employees with strict rental requirements find approved, affordable, and reimbursable lodging options.
  • Boxes provides convenient, space-efficient, highly measurable, sampling and trial vending technology for premium CPG companies looking to reach customers where they shop and live.
  • Hapi is a stock trading platform with no minimums and no commissions focused on consumers in Latin America.
  • HelloDoctor puts qualified, responsive, and affordable doctors on the screens of 89 million cell phones of patients in Mexico. Healthcare just got better in Latin America.
  • Hightag is an automated media capture and delivery system that helps mountain bikers, skiers, and other action sport athletes capture and share their greatest moments.
  • IncentiFind is the nation’s go-to database of green building incentives, transforming U.S. real estate through $70 billion in incentives.
  • JamFeed aggregates artists' social media and music streaming content into an automated no-code website where artists can control their brand, their business, and their relationship with fans in one platform in less than 5 minutes.
  • Lesson Squad helps brands turn their customers into loyal users by creating a branded hub where customers can take lessons, enter competitions, and discover products.
  • LVED is an easy to use expert guided platform that provides everything families need to plan, organize, legally document end of life wishes, and memorialize loved ones.
  • Mesada is a digital remittance company that is utilizes blockchain technology to offer fast, efficient, and easy money transfers throughout the Latin American region.
  • Motusi is a whole-body wearable with AI to generate deeper insights related to movement quality and injury insights to help athletes progress in their performance or recovery.
  • MyShoots is an app for shooting sports organizations to connect with and market to their clients more efficiently, while allowing field-sports brands to connect with their customers.
  • Pagaloop is a fintech company that allows Latin American businesses more control over their cash flow when performing B2B transactions.
  • RESCUNOMICS offers a mobile app that helps save lives by expediting rescuer protocols and providing visibility into building floor plans and more.
  • sEATz connects fans to concessions and merchandise for in-seat delivery or pick-up reducing concession lines, increasing throughput, improving sales, and driving fan satisfaction.
  • SpecsX is transforming eye care into a virtual care model reducing costs, inconvenience for patients and providers, and giving everyone access to perfect vision.
  • Struttur Sports is an NFT platform where athletes share their experiences by connecting and combining digital and In Real Life events to create the deep interactions sports fans crave.
  • Svarmi is a digital platform that defines and prioritizes areas where business and progress influence nature providing meaningful, insightful metrics and proof of regulatory compliance.
  • SynvergySvn digitizes the movements of athletes with integrated wearables like the J-Sleeve so players, coaches, and trainers can diagnose muscle memory and improve repeat performance.
  • WulfTech protects and preserves the health of high-value K9 working dogs through smart wearable technology for government agencies, the military, and first responders.

The Softeq Venture Studio announced its inaugural cohort a year ago, and the fund was launched earlier this year. In August, Softeq expanded to New Hampshire to reach more startups and entrepreneurs.

Through a partnership with New Hampshire investors, Softeq has expanded its venture studio out of state. Image via hrknsscowork.com

Houston tech company's venture studio secures $5M investment, expands out of state

investing in investors

A Houston tech services company has announced fresh funding and a new location for its venture studio focused on growing startups.

Softeq Development Corp. announced an additional commitment of $5 million to the Softeq Venture Fund. With the investment, Softeq has a new partnership that will work toward creating a satellite venture studio in New Hampshire with local investors. Launch New Hampshire will leverage the Softeq Venture Studio platform to back qualified startups from within and outside New Hampshire, according to a news release from Softeq.

“It’s a great time to invest in startup companies, and we saw an opportunity to bridge the gap between the growing innovation community here in Houston and the untapped investment community in New Hampshire,” says Christopher A. Howard, founder and CEO of Softeq, in the release. “We’re excited about this partnership because it provides the Softeq Venture Studio with a source of high-quality startups while also fostering the innovation ecosystem in New Hampshire and New England.”

The Softeq Venture Studio announced its inaugural cohort last year, launching to act as an investor and accelerator program that provides mentors, resources, and workspaces for promising tech startups. This is the first expansion of the program and the latest investment into the Softeq Venture Fund, which has raised over $25 million of its $40 million goal.

Michael and Jamie Simchik, New Hampshire real estate developers, and Terry Anderton, an experienced technology entrepreneur, are the founders of Launch NH. The satellite cohort will work out of HRKNSScowork in Concord, New Hampshire.

“New Hampshire has been slow to adopt an innovation ecosystem, but with nearby Boston enjoying continued startup successes, we have the unique opportunity to leverage what is happening in Massachusetts, as well as in Vermont and Maine,” says Simchik, founder and CEO of HRKNSScowork. “By working with Softeq, we want to help build the innovation community statewide and drive broad-based startup activity in the region, similar to what Softeq has accomplished in its Houston headquarters.”

Anderton founded Wagz, which was recently acquired, an early participant in the Softeq accelerator program. Through his experience with Softeq, the company says he wanted to help bring the program other startups in the region.

The Softeq Venture Studio has made investments into 27 startups from across the globe since it launched in 2021. Over the next three years, per the release, Softeq intends to invest in 40 companies each year, including at least 12 via Launch NH.

The Softeq Venture Studio has named 14 startups — two from Houston — to its third cohort. Photo via Getty Images

Houston tech company's venture studio names new partner and cohort

developing tech

A Houston-based tech company has named a new limited partner and 14 new startups to its venture arm.

Softeq Development Corporation announced its third group of early-stage startups to join the Softeq Venture Studio, which is geared at helping its resident startups quickly develop their technology and build their businesses. With 14 startups, the summer 2022 cohort is the largest yet and brings the total portfolio to 27 companies. Additionally, the $40 million Softeq Venture Fund welcomed Royal Eagle Capital Partners, a Houston-based investment firm, as a limited partner with its $3 million commitment.

“We are thrilled to see how much the Softeq Venture Studio has grown since 2021,” says Christopher A. Howard, founder and CEO of Softeq, in a news release. “We’re also pleased to welcome Royal Eagle Capital Partners as an investment partner in our Venture Fund, which allowed us to achieve more than 50 percent of our funding goal in just five months. We look forward to building on this partnership and growing Softeq in North America, Latin America, and beyond.”

Softeq is also celebrating a recent expansion into Latin America and staffing the new regional office with 30 engineers. The company has plans to grow to 150 employees in the region over the next year.

“The Softeq Venture Fund presents a unique opportunity to diversify our holdings within the alternative investments space. The concept of risk mitigation in venture investments resonates with investment firms globally, and we are excited to be working with Softeq and the amazing talent of their early-stage companies,” said Mark Valdez — co-founder, managing partner, and chief investment officer at Royal Eagle Capital Partners — in the release. "The emphasis on growth in Latin America by Softeq was a driving factor for our commitment and will open the door to new opportunities in Mexico and beyond.”

The Q2 2022 cohort is from across the United States with even some international representatives. The companies are using tech to solve problems across industries from human resources and wellness to med-tech and sports-tech and more. Applications are open for the next cohort online.

Here are the 14 companies making up the cohort:

  • Concerto Commerce, based in Southlake, Texas, is an eCommerce platform that combines automated catalog management and payment processing to streamline reseller operations.
  • New York City-based Dailyhuman is a software platform designed to help companies retain employees by fostering safety, trust, and connection in the workplace.
  • Headquartered in Houston, FrakBlock is a blockchain-based predictive tool providing financial products for the adulting process of young teens in Latin America.
  • High Tech Ranch Solutions, from The Woodlands, is a digital ranch management system designed by ranchers to bring monitoring to the palm of your hand.
  • Santa Barbara, California-based Homesavi is a platform that helps first-time homebuyers understand the home-buying process and guides them to their dream home.
  • Louder.ai is an advertising platform that revolutionizes how people can support causes they care about and see the impact of their donations.
  • Mallard Bay, founded out of Louisiana State University, is a marketplace for guided hunting and fishing trips that streamlines booking and administrative processes for consumers and outfitters. The company won Softeq's prize at the Rice Business Plan Competition.
  • RYN is a social platform to help families in the Middle East find and employ household migrant workers providing better working and living conditions.
  • Delaware-based SAmAS Gamify is building a gamified psychometric assessment platform that helps employers evaluate and select the most qualified candidates.
  • Founded in North Carolina, ShopAgain is an AI-powered customer retention platform redefining personalized customer experiences for eCommerce businesses.
  • Houston-based TeeMates Golf is a mobile app that connects golfers worldwide using social media, tee time linking, and offers a merchandise marketplace.
  • ViiT Health, based in Mexico, is a non-invasive technology to help people measure and monitor blood sugar levels more accurately without a finger prick lancet.
  • WellnessWins is a CRM to streamline intake processes for private therapy clinics to reduce waitlists and increase access to mental health care.
  • WorkHint helps retail companies manage on-demand hourly talent to increase flexibility, reduce cost, and generate actionable data-driven insights.
Payal Patel has a new gig. Photo courtesy

Houston tech company hires innovator to lead startup accelerator

new gig

A Houston software company has announced a new leader of its venture studio that supports tech startups.

Softeq Development Corp. has named Payal Patel as director of the Softeq Venture Studio. The studio, which announced its inaugural cohort last fall, a startup accelerator that provides business mentoring and engineering development resources. Recently, Softeq announced the $40 million Softeq Venture Fund that will support the operations and invest in member companies.

“We’re thrilled to have Payal join the team at Softeq. Her in-depth knowledge of the Houston startup community combined with her management consulting background makes her uniquely qualified for her new role,” says Christopher A. Howard, Softeq founder and CEO.

Patel will oversee programming and operation for the studio, and she will help in in selecting startups for investment as principal of the fund.

“I’m excited to join the talented team at Softeq," she says. "Having been a part of the Houston tech and startup community for a few years, I see a niche our team can fill. We aim to do our part supporting founders by providing capital, advice, and helping level up the community."

Patel joins Softeq most recently from Plug and Play's Houston office, which focuses on energy and sustainability startups, where she served as director of the program. She began her career as a management consultant for restructuring firm Alvarez & Marsal before she transitioned to running the corporate business development function for Station Houston.

Softeq Venture Studio is currently accepting applications for its spring cohort, which will run April to June, and applications are available online. The deadline for applications is Saturday, March 19. Candidates who apply for the program receive $125,000 in cash and services in exchange for 6 percent equity in their eligible company.

A Houston software company has announced its new venture fund. Photo via Getty Images

Houston tech company launches $40M fund to invest in early-stage startups

money moves

A Houston company that recently launched an innovation studio to support startups has now announced that they are launching a new fund to take startup support to the next level.

Houston-based Softeq Development Corporation, a global full-stack development company, launched The Softeq Venture Fund, a $40 million venture fund to invest in seed and series A startup rounds. According to a news release, more than half the fund will be deployed to power the Softeq Venture Studio, Softeq's recently launched accelerator program.

“For generations, the state of Texas has been home to world-renowned tech companies who have greatly contributed to our regional success. As a local entrepreneur, advisor, and angel investor, it’s been my dream for many years to create a venture fund benefiting startups," says Christopher A. Howard, founder and CEO of Softeq, in the release. "I am proud to increase our support of the state’s early-stage tech community. Our investment fund is designed to attract tech visionaries from both inside and outside the state and grow innovative concepts in Houston."

Jumana Capital, a single-family office also based in Houston and founded in 2018, has made a "sizable investment" in the fund, per the release.

“The Softeq team has successfully engineered, developed, and launched technology solutions for enterprise and early-stage companies for 25 years. In partnership with Softeq, we are thrilled to play a role in the creation of their new fund and to support the entrepreneurs that come to Houston to develop cutting-edge technologies and build businesses,” says Chris Martin, managing director at Jumana Capital, in the release.

While the fund will mostly go into investing in and supporting studio companies, Softeq will also tap into the fund to "invest opportunistically."

In October, the company announced the six startups that make up the studio's inaugural cohort. The purpose of the studio was to identify startups with scalable solutions but that need guidance and support from Softeq and its network.

"Historically, most tech startups had a founder with development skills. However, we're now seeing more and more business people, doctors, and other professionals start companies, and they need a strong engineering partner to develop their products," Howard says in an October news release. "We take it several steps further with the Venture Studio providing technology business consulting, development services, and much-needed cash. We're a vested partner, so we also help secure follow-on funding for continued growth."

Applications are open for the spring 2022 cohort. More information and applications are available online.

Christopher A. Howard is the founder and CEO of Softeq. Photo courtesy of Softeq

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Intuitive Machines to buy satellite maker Lanteris for $800M

space deal

Houston-based aerospace company Intuitive Machines has agreed to buy satellite manufacturer Lanteris Space Systems for $800 million from private equity firm Advent International.

Intuitive Machines co-founder, president and CEO Steve Altemus said the combined revenue of his company and Palo Alto, California-based Lanteris exceeded $850 million as of Sept. 30, and their backlog of orders totaled $920 million.

Until recently, Lanteris operated as Maxar Space Systems. Its origins date back to 1957.

The deal—comprising $450 million in cash and $350 million in Class A shares of Intuitive Machines stock—is expected to close in the first quarter of 2026.

The acquisition “marks the moment Intuitive Machines transitions from a lunar company to a multi-domain space [company], setting the pace for how the industry’s next generation will operate,” Altemus said.

Altemus said the acquisition would enable Intuitive Machines to better compete for Earth orbit, lunar, Mars and deep space projects. Among the opportunities that would open up thanks to the Lanteris deal are the proposed Golden Dome missile defense system and a large lunar lander capable of carrying astronauts, he said.

“The new Intuitive Machines will combine rapid innovation and precision spacecraft production to meet the growing demand for responsive, high-reliability space infrastructure and services,” Altemus said.

Intuitive Machines, founded in 2013, develops lunar landers and provides aerospace services. In 2024, it became the first U.S. company to land a spacecraft on the moon in half a century.

Altemus said Intuitive Machines is already building three satellites for NASA’s near-space network, and it might upsize two more satellites now that it plans to buy Lanteris.

Aside from satellites, Lanteris is developing the power and propulsion element for NASA’s Gateway, a lunar orbiting command module that will support Artemis missions and deep space exploration.


Lanteris was a division of Maxar Technologies, which Advent and minority investor British Columbia Investment Management took private in a 2023 deal valued at $6.4 billion

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Meet 6 mentors who are helping the Houston startup scene flourish

meet the finalists

Few founders launch successful startups alone — experienced and insightful mentors often play an integral role in helping the business and its founders thrive.

The Houston startup community is home to many mentors who are willing to lend an ear and share advice to help entrepreneurs meet their goals.

The Mentor of the Year category in our 2025 Houston Innovation Awards will honor an individual like this, who dedicates their time and expertise to guide and support budding entrepreneurs. The award is presented by Houston City College Northwest.

Below, meet the six finalists for the 2025 award. They support promising startups in the medical tech, digital health, clean energy and hardware sectors.

Then, join us at the Houston Innovation Awards this Thursday, Nov. 13 at Greentown Labs, when the winner will be unveiled. The event is just days away, so secure your seats now.

Anil Shetty, InformAI

Anil Shetty serves as president and chief medical officer for biotech company Ferronova and chief innovation officer for InformAI. He's mentored numerous medical device and digital health companies at seed or Series A, including Pathex, Neurostasis, Vivifi Medical and many others. He mentors through organizations like Capital Factory, TMC Biodesign, UT Venture Mentoring, UTMB Innovation and Rice's Global Medical Innovation program.

"Being a mentor means empowering early-stage innovators to shape, test, and refine their ideas with clarity and purpose," Shetty says. "I’m driven by the opportunity to help them think strategically and pivot early before resources are wasted. At this critical stage, most founders lack the financial means to bring on seasoned experts and often haven’t yet gained real-world exposure. Mentorship allows me to fill that gap, offering guidance that accelerates their learning curve and increases the chances of meaningful, sustainable impact."

Jason Ethier, EnergyTech Nexus

Jason Ethier is the founding partner of EnergyTech Nexus, through which he has mentored numerous startups and Innovation Awards finalists, including Geokiln, Energy AI Solutions, Capwell Services and Corrolytics. He founded Dynamo Micropower in 2011 and served as its president and CEO. He later co-founded Greentown Labs in Massachusetts and helped bring the accelerator to Houston.

"Being a mentor means using my experience to help founders see a clearer path to success. I’ve spent years navigating the ups and downs of building companies, struggling with cash flow, and making all the mistakes; mentoring gives me the chance to share those lessons and show entrepreneurs the shortcuts I wish I’d known earlier," Ethier says. "At Energytech Nexus, that role goes beyond just helping individual founders — it’s about creating a flywheel effect for Houston’s entire innovation ecosystem."

Jeremy Pitts, Activate Houston

Jeremy Pitts serves as managing director of Activate Houston, which launched in Houston last year. He was one of the founders of Greentown Labs in the Boston area and served in a leadership role for the organization between 2011 and 2015. Through Activate, he has mentored numerous impactful startups and Innovation Awards finalists, including Solidec, Coflux Purification, Bairitone Health, Newfound Materials, Deep Anchor Solutions and others.

"Being a mentor to me is very much about supporting the person in whatever they need. Oftentimes that means supporting the business—providing guidance and advice, feedback, introductions, etc," But just as important is recognizing the person and helping them with whatever challenges they are going through ... Sometimes they need a hype man to tell them how awesome they are and that they can go do whatever hard thing they need to do. Sometimes they just need an empathetic listener who can relate to how hard these things are. Being there for the person and supporting them on their journey is key to my mentorship style."

Joe Alapat, Liongard

Joe Alapat founded and serves as chief strategy officer at Houston software company Liongard and chief information officer at Empact IT, which he also owns. He mentors through Founder Fridays Houston Group, Software Day by Mercury Fund, SUPERGirls SHINE Foundation, Cup of Joey and at the Ion. He's worked with founders of FlowCare, STEAM OnDemand, Lokum and many other early stage startups.

"Being a mentor to me means unleashing an individual’s 10x—their purpose, their ikigai (a Japanese concept that speaks to a person’s reason for being)," Alapat says. "Mentoring founders in the Houston community of early stage, high-growth startups is an honor for me. I get to live vicariously through a founder’s vision of the future. Once they show me that compelling vision, I’m drawn to bring the future forward with them so the vision becomes reality with a sense of urgency."

Neal Dikeman, Energy Transition Ventures

Neal Dikeman serves as partner at early stage venture fund Energy Transition Ventures, executive in residence at Greentown Labs, and offices in and supports Rice Nexus at the Ion. He mentors startups, like Geokiln, personally. He also mentored Helix Earth through Greentown Labs. The company went on to win in the Smart Cities, Transportation & Sustainability contest at SXSW earlier this year. Dikeman has helped launch several successful startups himself, most recently serving on the board of directors for Resilient Power Systems, which was acquired by Eaton Corp for $150 million.

"Founders have to find their own path, and most founders need a safe space where they can discuss hard truths outside of being 'on' in sales mode with their team or board or investors, to let them be able to work on their business, not just in it," Dikeman says.

Nisha Desai, Intention

Nisha Desai serves as CEO of investment firm Intention and mentors through Greentown Labs, TEX-E, Open Minds, the Rice Alliance Clean Energy Accelerator, Avatar Innovations and The Greenhouse. She currently works with founders from Solidec, Deep Anchor Solutions, CLS Wind and several other local startups, several of which have been nominated for Innovation Awards this year. She's served a board member for Greentown Labs since 2021.

"When I first started mentoring, I viewed my role as someone who was supposed to prevent the founder from making bad decisions. Now, I see my role as a mentor as enabling the founder to develop their own decision-making capability," Desai says. "Sometimes that means giving them the space to make decisions that might be good, that might be bad, but that they can be accountable for. At the end of the day, being a mentor is like being granted a place on the founder's leadership development journey, and it's a privilege I'm grateful for."

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The Houston Innovation Awards program is sponsored by Houston City College Northwest, Houston Powder Coaters, FLIGHT by Yuengling, and more to be announced soon. For sponsorship opportunities, please contact sales@innovationmap.com.

Rice, Houston Methodist developing soft 'sleep cap' for brain health research

Researchers and scientists at Rice University and Houston Methodist are developing a “sleep cap” that aims to protect the brain against dementia and other similar diseases by measuring and improving deep sleep.

The project is a collaboration between Rice University engineering professors Daniel Preston, Vanessa Sanchez and Behnaam Aazhang; and Houston Methodist neurologist Dr. Timea Hodics and Dr. Gavin Britz, director of the Houston Methodist Neurological Institute and chairman of the Department of Neurosurgery.

According to Rice, deep sleep is essential for clearing waste products from the brain and nightly “cleaning cycles” help remove toxic proteins. These toxic proteins, like amyloids, can accumulate during the day and are linked to Alzheimer’s disease and other neurological issues.

Aazhang, director of the Rice Neuroengineering Initiative, and his team are building a system that not only tracks the brain’s clearing process but can also stimulate it, improving natural mechanisms that protect against neurodegeneration.

Earlier proof-of-concept versions of the caps successfully demonstrated the promise of this approach; however, they were rigid and uncomfortable for sleep.

Preston and Sanchez will work to transform the design of the cap into a soft, lightweight, textile-based version to make sleep easier, while also allowing the caps to be customizable and tailored for each patient.

“One of the areas of expertise we have here at Rice is designing wearable devices from soft and flexible materials,” Preston, an assistant professor of mechanical engineering, said in a news release. “We’ve already shown this concept works in rigid device prototypes. Now we’re building a soft, breathable cap that people can comfortably wear while they sleep.”

Additionally, the research team is pursuing ways to adapt their technology to measure neuroinflammation and stimulate the brain’s natural plasticity. Neuroinflammation, or swelling in the brain, can be caused by injury, stroke, disease or lifestyle factors and is increasingly recognized as a driver of neurodegeneration, according to Rice.

“Our brain has an incredible ability to rewire itself,” Aazhang added in the release. “If we can harness that through technology, we can open new doors for treating not just dementia but also traumatic brain injury, stroke, Parkinson’s disease and more.”

The project represents Rice’s broader commitment to brain health research and its support for the Dementia Prevention Research Institute of Texas (DPRIT), which passed voter approval last week. The university also recently launched its Rice Brain Institute.

As part of the project, Houston Methodist will provide access to clinicians and patients for early trials, which include studies on patients who have suffered traumatic brain injury and stroke.

“We have entered an era in neuroscience that will result in transformational cures in diseases of the brain and spinal cord,” Britz said in the release. “DPRIT could make Texas the hub of these discoveries.”
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