This week's roundup of Houston innovators includes Michael Torres of CrossBridge Bio, Aileen Allen of Mercury, and Ryan Reisner of SeekerPitch. Photos courtesy

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes three innovators across therapeutics, venture capital, and HR software.

Michael Torres, CEO of CrossBridge Bio

CrossBridge Bio, formed during the TMC Innovation’s Accelerator for Cancer Therapeutics program, closed a $10 million seed round led by TMC Venture Fund and CE-Ventures. Photo via crossbridgebio.com

A Houston biotech company based off research out of UTHealth Houston has raised seed funding to continue developing its cancer-fighting therapeutic.

CrossBridge Bio, formed during the TMC Innovation’s Accelerator for Cancer Therapeutics program, closed a $10 million seed round led by TMC Venture Fund and Crescent Enterprises' VC arm, CE-Ventures. The round also included participation from Portal Innovations, Alexandria Venture Investments, Linden Lake Labs, and several pre-seed investors.

“We are thrilled to have the support of such experienced investors who share our vision of bringing transformative cancer therapies to patients in need,” Michael Torres, CEO of CrossBridge Bio, says in a news release. Torres served as an entrepreneur in residence of ACT. Continue reading.

Aileen Allen, venture partner at Mercury

Aileen Allen joined Mercury as venture partner and is on the board of the Houston Angel Network. Photo courtesy of Mercury

When Aileen Allen was contemplating a big career move — swapping sides of the table from tech company to venture investor — she was motivated by driving gender and experience diversity amongst decision makers.

"I've worked for VC-backed companies for most of my career and had the opportunity as an executive to be in the boardroom during that time," she says on the Houston Innovators Podcast. "One of my takeaways was that very few of my board members looked like me. I had one or two women on any of my boards at a time in totality, and very few of my board members had been operators."

"I'd really like to change that, and I'd like there to be better representation and diversification in the boardroom," she adds. Continue reading.

Ryan Reisner, president and founder of SeekerPitch

Ryan Reisner is the\u00a0president and founder of SeekerPitch and The Reisner Group. Photo via LinkedIn

Confident job seekers have mostly been of the mindset that if they can just get in front of an employer, they can sell themselves into an offer for the open position. The obstacle then, is getting through the screening process to get an actual interview.

Until recently, the price of admission for starting or progressing in a desired career was a resume and cover letter stellar enough to catch the eye of the human resources and recruiting team. Outside of being buried in the immense pile of resumes recruiters do not have the bandwidth to get to, standing out in the sea of candidates can be daunting.

Resumes do not tell the full story as it is and it’s almost impossible for applicants to put their potential, soft skills and work personality into a document to be reviewed. So, what’s the solution?

It is a multi-layered problem, which requires a multi-layered solution, but one of the options gaining steam in the recruitment space is provided by SeekerPitch, a Houston-based HR technology platform utilizing generative AI to make hiring and interviewing more efficient.

“I've noticed that there's a ton of people that slip through the cracks,” says Ryan Reisner, president and founder of SeekerPitch and The Reisner Group. “And we spend all our time interviewing people to see if they have the soft skills. Resumes are hard skills. And now with AI, anybody can build the same exact resume. Everybody can say they have communication skills, leadership skills, and a lot of people say they have those." Continue reading.

Resumes do not tell the full story as it is and it’s almost impossible for applicants to put their potential, soft skills and work personality into a document to be reviewed, but this Houston startup has a solution. Photo via Getty Images

Houston startup to transform hiring process with AI, video-optimized platform

cha-cha-changes

Confident job seekers have mostly been of the mindset that if they can just get in front of an employer, they can sell themselves into an offer for the open position. The obstacle then, is getting through the screening process to get an actual interview.

Until recently, the price of admission for starting or progressing in a desired career was a resume and cover letter stellar enough to catch the eye of the human resources and recruiting team. Outside of being buried in the immense pile of resumes recruiters do not have the bandwidth to get to, standing out in the sea of candidates can be daunting.

Resumes do not tell the full story as it is and it’s almost impossible for applicants to put their potential, soft skills and work personality into a document to be reviewed. So, what’s the solution?

It is a multi-layered problem, which requires a multi-layered solution, but one of the options gaining steam in the recruitment space is provided by SeekerPitch, a Houston-based HR technology platform utilizing generative AI to make hiring and interviewing more efficient.

“I've noticed that there's a ton of people that slip through the cracks,” says Ryan Reisner, president and founder of SeekerPitch and The Reisner Group. “And we spend all our time interviewing people to see if they have the soft skills. Resumes are hard skills. And now with AI, anybody can build the same exact resume. Everybody can say they have communication skills, leadership skills, and a lot of people say they have those.

“But when it's all said and done, you interview those people to find out if they truly have them, and many of them don't have them. So, the resume is just a door opener. The door closer is the soft skills. So, with me being an underdog and growing up in underserved communities and just hoping to be found and applying to a bunch of places, I asked, what do I need to do to stand out from the crowd?”

Creating a solution

In addition to adding value during the actual interview, SeekerPitch solves the problem of feedback for applicants. Photo via SeekerPitch

That thought sparked the idea for the SeekerPitch platform and its signature feature that enables candidates to create video cover letters and skill-specific videos, allowing them to showcase their soft skills and personality.

In short, static candidate profiles come to life via SeekerPitch’s Pitch Sessions feature, which is purpose-built for job seekers to flesh out their full self and for employers to host multiple rounds of interviews with actionable insights from the platform’s generative AI to facilitate well-informed hiring decisions.

“Our product gives the employer a 30-second elevator pitch of an individual so they can interview people that are better fits for the jobs they are trying to fill,” says Reisner. “Unlike our competitors, we are normalizing ‘speed interviewing’ to maintain a more personal, holistic approach to the virtual interview.

“While the employer is interviewing the candidate in real time, the platform is transcribing the interview so the built-in AI model can give feedback such as culture fit, other mechanisms such as specific skills for a sales position and a total summary on that candidate’s ability to succeed in the role, which is enabling employers to make better hiring decisions and is vastly increasing the quality of the talent pool.”

In addition to adding value during the actual interview, SeekerPitch solves the problem of feedback for applicants.

“After the interview is completed, the employer has three choices: interested, still deciding and not interested,” adds Reisner. “And then if the employer is still deciding, it gives them a 72-hour countdown to make a decision and once that 72-hour window is over, that candidate is automatically rejected.

“What we have found is that job seekers, whether they're in the running or not, they just want to know, if they are moving forward or not. With our platform, they’re not stranded in feedback limbo for two plus weeks, so they love that part. They also like the holistic part where they're being judged off of who they are, their authenticity, and also their personality traits.”

Benefiting both sides of the equation

Ryan Reisner is the president and founder of SeekerPitch and The Reisner Group. Photo via LinkedIn

Another prime feature for employers is the video job description, which is expanding its reach with its intended audience: job seekers.

With everyone, including those in the candidate pool, now watching short-form videos on TikTok, Instagram, Snapchat, and YouTube as a lifestyle, employers can reach the next generation of the workforce using video job postings via the platform.

“Statistics show that 90 percent of job seekers don't even read job descriptions,” says Reisner. ”So, employers are automatically getting a poor candidate pool because it's easy to apply for job seekers and they just apply because it’s a numbers game. But what we have found is that the video job descriptions are an engaging medium that has vastly increased the quality candidate pool, as opposed to quantity.”

Another facet of SeekerPitch’s goal to streamline hiring is the automated scheduling process, whereby the platform uses chatbots to chat in real time with job seekers to get the best availability for interview time slots.

“We’ve also implemented an AI feature that helps the interviewer prepare for the interview based on the candidate’s profile, application and resume,” says Reisner. “It will provide questions to the interviewer that they might not have otherwise thought to ask to dive deeper into the candidate’s overall fit for the role. And based on the candidate's answers, more questions will populate tailored to that candidate.

“Then, after that interview is completed, and the employer is interested in moving the candidate forward in the interview process, it queues up the next interviewer in line to schedule that second or next round interview and so on. This automatically synchs with the employer’s applicant tracking system to get the employer all the way through the hiring process.”

Leveling the playing field

SeekerPitch won the third annual CodeLaunch Houston. Photo by Natalie Harms/InnovationMap

SeekerPitch’s goal is to also raise awareness about unconscious bias in the hiring process and point it out so that an employer can review any biases their team may have and improve upon them for their process moving forward.

Thanks to the platform’s unprecedented growth and innovation, SeekerPitch won over the crowd at the third annual CodeLaunch Houston event in March. The company has now moved on to CodeLaunch “World Championship” event in Dallas latter this month. The competition brings together the 8 best and the fastest-growing startups to compete for $50,000 in deployed investments and showcase their potential to venture capitalists and angel investors from across the country.

Whether or not SeekerPitch wins the competition, they’ll continue to make strides in the hiring vertical.

“Video is powerful,” says Reisner. “It can tell a story, so our platform makes it a better experience for the job seeker, giving them a competitive edge and helps them stand out from the crowd. We’ve only been in business for six months, but we will continue to disrupt the industry with this platform, especially with the proliferation of AI.”

SeekerPitch won the third annual CodeLaunch Houston. Photo by Natalie Harms/InnovationMap

2 Houston workforce solutions startups win at annual software pitch competition

winner, winner

The third annual CodeLaunch Houston event resulted in two winners — one chosen by the audience, the other by judges — both tackling separate issues in the future of work.

SeekerPitch, a next-generation hiring platform that provides artificial intelligence-enhanced and video technology tools to both job hunters and hiring teams, took the grant prize, which was voted on by the audience of the February 28 event. The team was supported by Honeycomb Software, which won last year's competition too with its startup partner, E360.

"In Gen Z right now, landing an interview is like winning the lottery," Ryan Reisner, president and founder of SeekerPitch, says in his pitch at the event. "And employers have their own set of problems — they're having a hard time connecting with the next generation."

iShiftX, supported by Houston-based Blue People, secured the judges' award with a tie-breaking vote. The company, founded by Landi Spearman, uses digital twin technology to provide 24/7 leadership coaching at a scalable level.

"Leaders have the biggest impact on our teams, our children, on the future, and on the next generation," Spearman says in her final appeal to judges and the audience. She called out the burnout and stress of leadership and coaching, and she pitched her tech enabled solution.

In addition to SeekerPitch and iShiftX, four other startups with their development support partners pitched, including:

The competition consisted of three rounds where two startups went head-to-head, and attendees were asked to vote for their favorite pitch. SeekerPitch, iShiftX, and Allonge Financial made it to the final round before the two winners were announced based on a final round of voting.
This week's roundup of Houston innovators includes Gaurav Khandelwal of Velostics, Samantha Hepler of SeekerPitch, and Zain Shauk of Dream Harvest. Courtesy photos

3 Houston innovators to know this week

WHO'S WHO

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from logistics tech to sustainability — recently making headlines in Houston innovation.

Gaurav Khandelwal, CEO and founder of Velostics

Velostics has fresh funding to support growing its logistics software solution. Photo courtesy of Velostics

The logistics industry has a lot of room for improved optimization — and that's exactly what Gaurav Khandelwal set out to do when he founded Velostics. The company just raised its $2.5 million seed round that will go toward recruiting top talent for Velostics's team, particularly in its account management, inside sales, and marketing departments, as well as continuing to develop the AI-driven product, which has an impact for both its users and the environment.

“Idling trucks waiting outside facilities emit over 42 million tons of CO2 annually — eight times the US national average. By orchestrating the movement of trucks in and out of facilities, not only do we provide tremendous supply chain benefits, we also help the environment," Khandelwal says in the release. "We’re excited to partner with our customers and our investors to solve global congestion.” Click here to read more.

Samantha Hepler, CEO and founder of SeekerPitch

Samantha Hepler had the idea for SeekerPitch based on her own ill-fated job hunt experience. Photo courtesy of SeekerPitch

When Houstonian Samantha Hepler was trying to find a job, she couldn't even get in the door. Due to algorithms and antiquated hiring processes, she was overlooked.

"I knew if I could just get through the door, a company would see the value in me," Hepler tells InnovationMap. "I wasn't being seen, and I wasn't being heard. I didn't know a way to do that."

This experience gave her the idea for SeekerPitch, a platform that allows job seekers to create an account and tell their story — not just their job history. The platform prioritizes video content and quick interviews so that potential hires can get face-to-face with hiring managers. Click here to read more.

Zain Shauk, co-founder and CEO of Dream Harvest

Dream Harvest picked up funding to open a 100,000-square-foot indoor farming facility in Houston. Photo courtesy of Dream Harvest

Houston-based Dream Harvest Farming Co., which specializes in sustainably growing produce, has landed a $50 million investment from Orion Energy Partners to open a 100,000-square-foot indoor farming facility in Houston. The facility will enable the company to dramatically ramp up its operations.

Zain Shauk, co-founder and CEO of Dream Harvest, says his company’s method for growing lettuce, baby greens, kale, mustards, herbs, collards, and cabbage helps cut down on food waste.

“Demand for our produce has far outpaced supply, an encouraging validation of our approach as well as positive news for our planet, which is facing the rising problem of food and resource waste,” Shauk says. “While we have the yields today to support our business, we are pleased to partner with Orion on this financing, which will enable us to greatly expand our production and increase access to our produce for many more consumers.” Click here to read more.

SeekerPitch exists to update the job hiring process in a way that benefits both the job seekers and recruiters. Photo via Getty Images

Houston startup shakes up antiquated hiring process for the next generation

new way to hire

Companies across the country have been requiring resumes and cover letters from their new hire hopefuls since the World War II era, and it's about time that changed. A startup founded in Houston has risen to the occasion.

Houstonian Samantha Hepler had the idea for SeekerPitch when she was looking for her next move. She felt like she had developed a formidable career in digital transformation and had worked with big name clients from Chevron to Gucci. However, she couldn't even get an interview for a role she felt she would be a shoe-in for.

"I knew if I could just get through the door, a company would see the value in me," Hepler tells InnovationMap. "I wasn't being seen, and I wasn't being heard. I didn't know a way to do that."

And she wasn't alone in this frustration. Hepler says she discovered she was one of the 76 percent of job candidates who get filtered out based on former job titles and keywords. At the same time, Hepler says she discovered that 80 percent of companies reported difficulty finding talent.

Samantha Hepler had the idea for SeekerPitch based on her own ill-fated job hunt experience. Photo courtesy of SeekerPitch

"I was just a symptom of a larger problem companies were facing," Hepler says. "Companies were using algorithms to dilute their talent pool, and then the hires they were making weren't quality because they were looking for people based on what they've done. They weren't looking at people for what they could do."

SeekerPitch, which is in the current cohort of gBETA Houston, allows job seekers to create an account and tell their story — not just their job history. The platform prioritizes video content and quick interviews so that potential hires can get face-to-face with hiring managers.

"We empower companies to hear the candidates' stories," Hepler says. "We're bringing candidates streaming to computer screens. We are the Netflix of recruiting."

Hepler gives an example of a first-generation college graduate who's got "administrative assistant" and "hostess" on her resume — but who has accomplished so much more than that. She put herself through school with no debt and in three years instead of four. SeekerPitch allows for these types of life accomplishments and soft skills into the recruiting process.

SeekerPitch profiles allow job seekers to tell their story — not just their past job experience. Photo courtesy of SeekerPitch

Over the past few years, a trend in hiring has been in equity and diversity, and Hepler says that people have been trying to address this with blurring out people's names and photos.

"Our belief is that connection is the antidote to bias," Hepler says, mentioning a hypothetical job candidate who worked at Walmart because they couldn't afford to take multiple unpaid internships. "They can't come alive on a resume and they won't stand a chance next to another person."

SeekerPitch is always free for job seekers, and, through the end of the year, it's also free for companies posting job positions. Beginning in January 2022, it will cost $10 per day to list a job opening. Also next year — Hepler says she'll be opening a round of pre-seed funding in order to grow her team. So far, the company has been bootstrapped, thanks to re-appropriated funding from Hepler's canceled wedding. (She opted for a cheaper ceremony instead.)

Right now, SeekerPitch sees an opportunity to support growing startups that need to make key hires — and quickly. The company has an ongoing pilot partnership with a Houston startup that is looking to hiring over a dozen positions in a month.

"As a startup, your key hires are going to make or break your company — but you have to hire quickly," Hepler says. "That's the ultimate challenge for startups. ... But if you don't hire well it can cost your company a lot of money or be the demise of your company. It's people who make a company great."

Here's what companies are in the latest cohort for gBETA. Photo courtesy of gBETA

Early-stage accelerator announces 5 startups to its fall 2021 Houston cohort

ready to grow

An early-stage accelerator has picked its latest cohort of five Houston companies.

The Fall 2020 cohort of gBETA Houston includes:

  • AllIDoIsCook is founded by Tobi Smith and focused on exposing the world to Africa's cuisine by manufacturing gourmet food products delivered directly to customer doors and available at grocers. Since launching, AllIDoIsCook has built out a manufacturing facility, shipped over 8,000 boxes and generated $1.1 million in revenue all without outside funding.
  • Chasing Watts makes it easy for cyclists to coordinate or find rides with fellow riders in their area with its web-based and native application. The company has over 3,000 users and grew 135 percent from Q2 to Q3 in new ride views.
  • DanceKard, founded by Erica Sinner, is a new dating platform that connects individuals and groups with one another by bringing the date to the forefront of the conversation and making scheduling faster and easier with special promotions featuring local establishments. Since launching in August of 2021, DanceKard has over 170 users on the platform.
  • Dollarito is a digital lending platform that helps the low-income Hispanic population with no credit history or low FICO score access fair credit. Founded by Carmen Roman, Dollarito applies AI into banking, transactional and behavioral data to evaluate the repayment capability more accurately than using FICO scores. The company has1,000 users on their waitlist and plans to beta test with 100 or more customers in early 2022.
  • SeekerPitch, founded by Samantha Hepler, operates with the idea that jobseekers' past job titles and resumes are not always indicative of their true capabilities. Launched last month, SeekerPitch empowers companies to see who jobseekers are as people, and get to know them through comprehensive profiles and virtual speed interviews, and the company already has 215 jobseekers and 20 companies on the platform, with one pilot at University of Houston and three more in the pipeline.

The companies kicked off their cohort in person on October 18, and the program concludes on December 14 with the gBETA Houston Fall 2021 Pitch Night. At this event, each company will present their five-minute pitch to an audience of mentors, investors, and community members.

"The five founding teams selected for our gBETA Houston Fall 2021 cohort are tackling unique problems they have each experienced personally, from finding access to cultural foods, fitness communities and authentic dating experiences to challenges with non-inclusive financing and hiring practices," says Kate Evinger, director of gBETA Houston, in the release. "The grit and passion these individuals bring to their roles as founders will undoubtedly have a tremendous impact in the Houston community and beyond."

The accelerator has supported 15 Houston startups since it launched in Houston in early 2020. The program, which is free and hosted out of the Downtown Launchpad, is under the umbrella of Madison, Wisconsin-based international accelerator, gener8tor.

"Downtown Launchpad is an innovation hub like no other, and I am so proud of what it is already and what it will become," says Robert Pieroni, director of economic development at Central Houston Inc., in the release. "The five startups selected for the gBETA Houston Fall 2021 cohort are exploring new challenges that can become high-impact Houston businesses."

gBETA announced its plan to launch in Houston in September 2019. The program's inaugural cohort premiered in May and conducted the first program this summer completely virtually. The second cohort took place last fall, and the third ran earlier this year.

"These founders are building their companies and benefiting from the resources Downtown Launchpad provides," Pieroni continues, "and the proof is in the data – companies in these programs are creating jobs, growing their revenues and exponentially increasing their funding, which means these small starts up of today, working in Downtown Launchpad, are growing into the successful companies of tomorrow."

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Houston scientists make breakthrough in hearing science and treatment research

sounds good

Researchers at Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital have successfully mapped which cell populations are responsible for processing different types of sounds.

Working with a team at the Oregon Health & Science University, the Houston scientists have classified where in the cochlear nucleus our brains connect with various sounds, including speech and music. The research was published in the new edition of Nature Communications.

“Understanding these cell types and how they function is essential in advancing treatments for auditory disorders,” Matthew McGinley, assistant professor of neuroscience at Baylor, said in a release. “Think of how muscle cells in the heart are responsible for contraction, while valve cells control blood flow. The auditory brainstem operates in a similar fashion — different cell types respond to distinct aspects of sound.”

Though scientists have long thought that there are distinct types of cells in the cochlear nucleus, they didn’t have tools to distinguish them until now.

Lead author on the study, Xiaolong Jiang, associate professor of neuroscience at Baylor, added: “This study not only confirms many of the cell types we anticipated, but it also unveils entirely new ones, challenging long-standing principles of hearing processing in the brain and offering fresh avenues for therapeutic exploration.”

Jiang and his team have cooked up a comprehensive cellular and molecular atlas of the cochlear nucleus, which will help them to create more targeted and more effective treatments for patients struggling with their hearing.

The strategies that aided them in creating these tools included single-nucleus RNA sequencing, which made it possible to define neuronal populations on a molecular level. Phenotypic categorizations of the cells were made possible with patch sequencing.

This is a watershed moment for the development of targeted treatments for individuals with auditory disorders, including those with impaired function in the auditory nerve, for whom cochlear implants don’t work.

“If we can understand what each cell type is responsible for, and with the identification of new subtypes of cells, doctors can potentially develop treatments that target specific cells with greater accuracy,” McGinley explains. “These findings, thanks to the work of our collaborative team, make a significant step forward in the field of auditory research and get us closer to a more personalized treatment for each patient.”

Houston shines among top 10 tech metros in the South, study says

Tops in Tech

A study analyzing top U.S. locales for the tech industry ranked Houston the No. 9 best tech hub in the South.

The report by commercial real estate platform CommercialCafe examined the top 20 Southern metros across nine metrics, such as the growth rates of tech establishments and employment, median tech earnings, a quality of life index, and more.

Like other Texas metros, the study attributes Houston's tech powerhouse status to its growing presence of major tech companies. However, Houston leads the nation with the highest number of patents granted between 2020 and 2024.

"The second-largest metro by population in the South, Houston led the region with an impressive 8,691 tech patent grants in the last five years," the report said. "Once synonymous with oil, Houston is increasingly making its mark as a cleantech hub — and patents reflect this shift."

Houston also experienced an impressive 14 percent growth in tech establishments, with nearly 500 new tech companies moving to the metro. An impressive 32 percent job growth rate also accompanied this change, with over 30,500 tech jobs added between 2019 and 2023.

Here's how Houston stacked up across the remaining five rankings:
  • No. 11 – Tech establishment density
  • No. 15 – Median tech earnings
  • No. 19 – Median tech earnings growth
  • No. 20 – Tech job density
  • No. 20 – Quality of life index

In a separate 2024 report, Houston was the No. 22 best tech city nationwide, showing that the city is certainly making efforts to improve its friendliness toward the tech industry in 2025.

Other top Texas tech hubs in the South
The only other Texas metros to earn spots in the report were Austin (No. 1) and Dallas-Fort Worth (No. 4). Most notably, CommercialCafe says Austin saw a 25 percent increase in tech company density from 2019 to 2023, which is the third-highest growth rate out of all 20 metros.

"Moreover, the metro’s tech scene thrives on a diverse range of segments, including AI and green energy (bolstered by the University of Texas), as well as globally recognized events like [South by Southwest]," the report says. "Thus, with tech companies accounting for more than half of all office leasing activity in 2024, Austin remains a magnet for innovation, talent and investment."

Dallas, on the other hand, has a far greater diversity when it comes to its tech sector and its thriving economic opportunities.

"Not to be outdone, Dallas-Fort Worth moved up from sixth to fourth in this year’s rankings, driven by a 25.9 percent growth in tech company presence — the second-highest increase among the top 20 metros," the report said. "For instance, companies like iRely (which relocated to Irving, Texas) and Diversified (now in Plano, Texas) have joined homegrown successes, such as StackPath and Bestow."

The top 10 best tech metros in the South are:

  • No. 1 – Washington, D.C.
  • No. 2 – Austin, Texas
  • No. 3 – Raleigh, North Carolina
  • No. 4 – Dallas-Fort Worth, Texas
  • No. 5 – Huntsville, Alabama
  • No. 6 – Baltimore, Maryland
  • No. 7 – Durham, North Carolina
  • No. 8 – Atlanta, Georgia
  • No. 9 – Houston, Texas
  • No. 10 – Charlotte, North Carolina
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This story originally appeared on our sister site, CultureMap.com.

Houston startup, researchers awarded millions to develop Brain Mesh implant

brain health

Houston startup Motif Neurotech and several Rice research groups have been selected by the United Kingdom's Advanced Research + Invention Agency (ARIA) to participate in its inaugural Precision Neurotechnologies program. The program aims to develop advanced brain-interfacing technologies for cognitive and psychiatric conditions.

ARIA will invest $84.2 million over four years in projects that “explore and unlock new methods to interface with the human brain at the circuit level,” according to a news release.

Three of the four Rice labs will collaborate with Houston health tech startup Motif Neurotech to develop Brain Mesh, which is a distributed network of minimally invasive implants that can stimulate neural circuits and stream neural data in real time. The project has been awarded approximately $5.9 million.

Motif Neurotech was spun out of the Rice lab of Jacob Robinson, a professor of electrical and computer engineering and bioengineering and CEO of Motif Neurotech. It will be developed in collaboration with U.K.-based startup MintNeuro, which will help develop custom integrated circuits that will help to miniaturize the implants, according to a separate release.

Robinson will lead the system and network integration and encapsulation efforts for Mesh Points implants. According to Rice, these implants, about the size of a grain of rice, will track and modulate brain states and be embedded in the skull through relatively low-risk surgery.

The Rice lab of Valentin Dragoi, professor of electrical and computer engineering at Rice and the Rosemary and Daniel J. Harrison III Presidential Distinguished Chair in Neuroprosthetics at Houston Methodist, will conduct non-human primate experimental models for Brain Mesh. Kaiyuan Yang, associate professor of electrical and computer engineering who leads the Secure and Intelligent Micro-Systems Lab at Rice, will work on power and data pipeline development to enable the functional miniaturization of the Mesh Points.

“Current neurotechnologies are limited in scale, specificity and compatibility with human use,” Robinson said in a news release. “The Brain Mesh will be a precise, scalable system for brain-state monitoring and modulation across entire neural circuits designed explicitly for human translation. Our team brings together a key set of capabilities and the expertise to not only work through the technical and scientific challenges but also to steward this technology into clinical trials and beyond.”

The fourth Rice lab, led by assistant professor of electrical and computer engineering Jerzy Szablowski, will collaborate with researchers from three universities and two industry partners to develop closed-loop, self-regulating gene therapy for dysfunctional brain circuits. The team is backed by an award of approximately $2.3 million.

“Our goal is to develop a method for returning neural circuits involved in neuropsychiatric illnesses such as epilepsy, schizophrenia, dementia, etc. to normal function and maybe even make them more resilient,” Szablowski said in a news release.

Neurological disorders in the U.K. have a roughly $5.4 billion economic burden, and some estimates run as high as $800 billion annually in terms of economic disruptions in the U.S. These conditions are the leading cause of illness and disability with over one in three people impacted according to the World Health Organization.