NASA technology is up for grabs and InnovationMap has a new podcast — here are some innovators to know this week. Courtesy photos

Another Monday means another weekly roundup of who's who in Houston innovation.

This week, we have our first Houston Innovators Podcast guest to feature, as well as a NASA expert who wants to loan you space technology.

Jon Nordby, managing director at MassChallenge Texas

Courtesy of MassChallenge

On our first episode of the new Houston Innovators Podcast, we discuss Houston accelerators with Jon Nordby, managing director for MassChallenge Texas. The first Houston program launched this year, and, as the organization looks toward its next cohort, the Houston innovation ecosystem is evolving in front of our eyes.

To read more about Nordby and MassChallenge, click here to read the story and listen to the podcast.

Sara Kelly, founder of Rigby

Courtesy of Rigby

Sara Kelly thinks you shouldn't have to get married or buy a house to have a nice dish set. She created Rigby, a Houston-based direct-to-consumer tableware company that is flipping the script on dishes.

"The reaction to the brand and the product has been great," says Kelly. "It's been so exciting for me to see that. At this point, we're focused on organic growth since we're so new."

Click here to read more about Rigby.

Steven Gonzalez, technology transfer strategist at NASA

Courtesy of NASA

Steven Gonzalez's job is to move NASA technology out into the world. The Johnson Space Center has hundreds of technology applications and IPs, and so much more can be done with those ideas here on earth. In a guest column for InnovationMap, Gonzalez writes of the NASA Johnson Space Center Technology Transfer and Commercialization Office, which will loan technology licenses to startups for free for three years.

"New technologies have been researched, developed, and proven on the ground — as well as above the earth on the International Space Station — in fields including medical, communications, agriculture, manufacturing, materials, structures, and much more," he writes. "At NASA's JSC, we are proud of the exceptional innovators who continue to develop technologies that advance the space program and technology for society on our home planet, and we love to share our knowledge."

Click here to read more about the program.

This isn't your grandmother's tableware company. Courtesy of Rigby

This female-founded Houston startup is shaking up tableware design

Dishing on dishes

A good tableware set comes into your life once in a lifetime — and usually that occasion is from a wedding registry. But a Houston entrepreneur wants to change that way of thinking.

Sara Kelly created her direct-to-consumer tableware brand called Rigby, which features handcrafted stoneware dishes, glassware, and a flatware line.

"With Rigby I want to encourage individuals in all life stages to feel at home with the present," says Kelly in a news release. "You shouldn't feel like you have to wait for a big lifetime event, like getting married or buying a house, to purchase tableware and other items that make your time at home more enjoyable."

Kelly, founder, tells InnovationMap that as a single professional she felt disconnected from the tableware industry, which she says is focused on wedding registries and unrealistic entertaining. After realizing that her friends felt the same way, Kelly saw an opportunity to start a business and the idea for Rigby was born in 2017. She launched the line just two years later in August.

"The reaction to the brand and the product has been great," says Kelly. "It's been so exciting for me to see that. At this point, we're focused on organic growth since we're so new."

The brand's pieces are crafted and hand-finished by professional craftspeople in Portugal. Kelly tells InnovationMap that she was inspired to source from the country following her travels in Europe where she purchased a few ceramic pieces. The company currently partners with three different factories across Portugal.

Drawn to the centuries-old heritage crafts of stoneware, glassware, and flatware production in Europe, Kelly tells InnovationMap that she knew that she wanted to partner with factories that incorporate a human touch into every step of the process.

Kelly, originally from the Southampton neighborhood in the Houston-area, moved back to the city six years ago. She tells InnovationMap that Houston's growing and supportive startup community was key to her decision to grow Ribgy into a national brand from the Lone Star state. Before launching Rigby, Kelly worked in product marketing for four years.

"Houston is a great market, and we're based here, so it's really important to me to have a presence in Houston," says Kelly. "Right now, I'm in the process of figuring out how the product can get in front of people here through pop-ups, and collaborations with other brands and influencers."

Rigby's stoneware includes mugs, dinner plates, salad plates, pasta bowls, and breakfast bowls, which are all available in off white, mint, charcoal-navy, and grey. Hand-blown glasses are available in a short and a tall design and each piece is unique. The 18/10 stainless steel flatware sets are available in polished stainless steel, satin black, satin gold, and satin copper finishes. Pricing for sets of four range from $48 to $64 for dishware, $56 to $64 for glassware, and $180 to $280 for flatware. Rigby's collection is available only online.

"I put a lot of thought into the design details of each piece and carefully considered how each piece feels in your hand," says Kelly. "The plates have an angled rim, which makes them easy to pick up and prevents food from spilling off the sides. The stoneware dishes feel substantial in your hand — not dainty or fragile — and stack on shelves nicely. Our flatware has a sleek, slightly rounded silhouette and feels comfortable when held. All of our items are dishwasher safe."

Kelly tells InnovationMap that Rigby's focus on craftsmanship and high quality products helps them stand out from their competitors. "We're also focused on people's real lives, so instead of the 'Instagram perfect' message, it's about how people live their lives everyday," says Kelly.

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”