Four Rice University lab-stage innovations are receiving fresh funding to get them closer to commercialization. Photo courtesy of Rice University

Four Houston research projects are splitting hundreds of thousands of dollars in grant funding from Rice University.

After announcing the One Small Step Grant program in September to support Rice-developed, lab-stage innovations, the university has named its inaugural recipients. After receiving nearly 30 applicants, four research projects were selected to share $360,000 in grant funding.

“Being able to fund near-commercial projects represents a leap forward in our mission of supporting the cutting-edge work of our faculty and students and helping bring those to market,” Adrian Trömel, assistant vice president for strategy and investments, says in a news release. “Feedback from industry and investors show that they’re excited on how the One Small Step grants help derisk these technologies, getting them ready to launch. Watch this space for the next generation of leading deeptech companies.”

The selected projects include:

  • PerisBio, developed by Samira Aglhara Fotovat and Samantha Fleury from Rice Professor Omid Veiseh's Lab, focuses on novel, hydrogel-encapsulated engineered "cell factories" for the minimally invasive treatment of endometriosis. The project received a $100,000 award.
  • Solidec, founded by Ryan Duchanois and Yang Xia from Rice Professor Haotian Wang's Lab, is a room temperature, solid-state direct air capture technology. The project received a $100,000 award.
  • HornetX, led by Rice Professor Aditya Mohite's Lab, aims to produce highly stable green hydrogen using a perovskite-based photoelectrochemical cell with leading efficiency. The project received a $80,000 award.
  • Coflux, developed by Jeremy Daum and Alec Ajnsztajn from the labs of Rice Professors Rafael Verduzco and Pulickel Ajayan, focuses on covalent organic framework-based photocatalysts for instream remediation of PFAS (per- and polyfluoroalkyl substances) from water. The project received a $80,000 award.

The Office of Innovation created an investment advisory committee — made up of entrepreneurs, investors and corporate executives across industries — to select these recipients. The grant program was funded by the Office of Innovation, with support from Breakthrough Energy Fellows for climate and energy projects

“The inaugural winners of the One Small Step Grant represent the innovative spirit and dedication to excellence that defines our students and faculty," Rice Chief Innovation Officer Paul Cherukuri says. "We are proud to support these groundbreaking projects on their journey from lab to market."

Rice University is in the process of restructuring operations at the Ion. Photo courtesy of the Ion

Houston innovation hub restructures, pulls in more Rice resources

cha-cha-changes

Rice University is leaning in on the Ion by restructuring the innovation hub's team and increasing the university's presence at the hub.

Paul Cherukuri, vice president for innovation, tells InnovationMap that the changes being made at the Ion — Rice's Midtown innovation hub — are a reflection of Rice President Reginald DesRoches's vision for the hub and for the university as a leader of innovation.

"We're embracing the community even further by what we've done with this restructuring," Cherukuri says. "The restructuring is really a result of Reggie's vision of us wanting to move forward with helping the community to grow innovation across Houston, throughout Texas, if not the world."

He adds that the university is "putting resources from Rice Alliance and amping up what's happening at the Ion."

Earlier this month, Rice announced that Brad Burke, executive director of the Rice Alliance for Technology and Entrepreneurship, has been named associate vice president for industry and new ventures reporting to Cherukuri's Office of Innovation.

Cherukuri confirms that the Rice Alliance will take over programming at the Ion, and that he too will have an increased presence at the hub. The restructuring includes elimination of positions at the Ion; however, Rice declined to comment on matters of personnel.

"We have members of the Ion staff who are going to be integrated to the Rice Alliance," Cherukuri says. "The direction of this is really so that we can no longer stay behind the hedges and do more for the Houston community."

Cherukuri says the university has already made a concerted effort on this, and soon will deliver on the Rice Nexus, a hub within the Ion for showcasing and connecting Rice innovation. Additionally, Rice announced last month that it's partnering with Woodside Energy, which committed $12.5 million over the next five years to create the Woodside Rice Decarbonization Accelerator.

Last year, Cherukuri joined the Houston Innovators Podcast to expound upon his vision for the Ion in his role as the inaugural vice president for innovation, which he was named to in 2022.


For the third year, Rice University has tapped 10 Rice Innovation Fellows working in engineering and materials science fields to support. Photo via rice.edu

10 Houston scientists named to fellowship for turning research into businesses

top of class

Rice University has announced its latest cohort of fellows who aim to translate research into real-world startups.

The 2024 cohort of Rice Innovation Fellows is the third of its kind since the university's Office of Innovation and The Liu Idea Lab for Innovation and Entrepreneurship (or Lilie) launched the program in 2022. The group includes 10 Ph.D. and postdoctoral students working in engineering and materials science fields.

The program provides personalized mentorship and up to $20,000 equity-free funding.

According to Lilie, the 10 members of the 2024 cohort are:

  • Barclay Jumet, a Ph.D. candidate in the department of mechanical engineering, working under Dan Preston and specializing in mechanics, thermal systems and wearable technologies. InnovationMap covered his recent technology here.
  • Tianshu Zhai, a Ph.D. student studying materials science specializing in hexagonal boron nitride-based thermal interface materials
  • Zachary Kingston, a postdoctoral research associate and lab manager for the Kavraki Lab in the Computer Science department at Rice, working under the direction of Dr. Lydia Kavraki, a pioneer in the field of robot motion planning. Kingston is developing a novel approach to high-performance, low-cost robot motion planning with Wil Thomason.
  • Soobin Cho, a Ph.D. student and co-founder of Duromem, which created the Dual-Role Electrically Conductive Membrane to improve existing water treatment systems
  • Sara Abouelniaj, a Ph.D. candidate in Material Science and Nanoengineering and founder of Graphene Grids LLC, which is exploring opportunities to diversify its range of grid types services offered
  • Alisha Menon, is founding a medical device startup that's developing wireless, AI-enabled patient monitoring devices for babies in the NICU. Her work is being done in collaboration with the Texas Medical Center and Rice, with support from NSF and the Southwest Pediatric Device Consortium.
  • Wil Thomason, a CRA Computing Innovation postdoctoral fellow in the Kavraki Lab at Rice University who is developing low-cost robot motion planning with Kingston
  • Jeremy Daum, a Ph.D. candidate at Rice in the Materials Science department working on a a novel production method to create photocatalysts
  • Jonathan Montes, a Ph.D. candidate in Bioengineering focused on combating neurodegenerative diseases with highly selective neuromodulation
  • Andrew (AJ) Walters, a Ph.D. student in Bioengineering working in the labs of Dr. Caleb Bashor (Rice) and Dr. Scott Olson (UTHealth Houston McGovern Medical School) who's building an accessible allogeneic cell therapy to treat inflammation disorders and potentially cancer. He was awarded a three-year NSF Graduate Research Fellowship in 2022.

Over the last three years, Innovation Fellows have brought in more than $6 million in funding for their ventures, according to Rice.

Last year, the cohort of 10 included doctoral and postdoctoral students working in fields from bioengineering and chemistry to civil and environmental engineering.

Late last year, Lilie also announced its new entrepreneurship council known as Lilie’s Leadership Council. The group is made up of 11 successful business leaders with ties to Houston from the likes of co-founder Frank Liu to former Houston Mayor Annise Parker and several other CEOs and board members of successful companies. The council members agreed to donate time and money to the university’s entrepreneurship programs.

Rice University has launched the One Small Step Grant program and has plans to establish the One Giant Leap VC fund. Photo courtesy of Rice University

Rice University launches research innovation grant program with VC fund in the works

coming soon

Over 60 years ago at Rice University, President John F. Kennedy recommitted the country to the Space Race. Now, decades later, the university is announcing its commitment to moonshot innovators.

Rice University's Office of Innovation established the One Small Step Grant — named for Neil Armstrong's first words spoken from Tranquility Base just several years after JFK's speech at Rice — last month. The program will provide funding to faculty working on "promising projects with commercial potential," according to the website.

The grant initiative will provide as many as five awards a year, each with funding of up to $100,000. Applications, which are open now, are accepted on a rolling basis, and the university's Rice Investment Committee will review submissions on a quarterly basis.

"The One Small Step Grant is a beacon of hope by providing support to enable critical experiments that pave the way for groundbreaking startups or licensing breakthrough tech," reads the website. "We seek projects within 12-18 months of forming a spin-out or embarking on a licensing event."

Paul Cherukuri, vice president of innovation at Rice University, shared the news of the grant program at an August 28 panel for the opening of Houston Methodist's Tech Hub at the Ion.

He says the initiative comes out of the need to financially support faculty-led, research-focused projects and to incentivize these faculty members to take their innovative ideas and commercialize them. Since he took on his role at Rice a year ago, he's observed the need for this type of funding.

"As soon as we announced this, in the same day, we had five professors fill out the form," Cherukuri says about the One Small Step Grant program.

The initiative has two parts to it, with the new grant program being the first to deliver. Next will be the One Giant Leap Fund, which Rice has not yet revealed details on.

Paul Cherukuri, vice president of innovation at Rice University, shared details about the new program at a recent event at the Ion. Photo via Rice.edu

In his new role, Adrian Trömel will oversee the creation of the Rice Nexus, an innovation hub within the Ion that aims to bridge the gap between the university and Houston's innovation ecosystem. Photo courtesy of Rice

University names Houston founder to leadership role to oversee new innovation hub

next up for the rice nexus

Rice University’s Office of Innovation has named Houston materials scientist-turned-entrepreneur Adrian Trömel as its new assistant vice president for strategy and investments.

Trömel founded non-invasive neurostimulation medical device company CNX Medical at the Texas Medical Innovation Institute in 2019 and most recently served as chief growth officer for Hamilton Health Box, which brings an on-site care team to company offices.

In his new role, Trömel will oversee the creation of the Rice Nexus, an innovation hub within the Ion that aims to bridge the gap between the university and Houston's innovation ecosystem. He will also lead the creation of a translational research grant fund and a university-affiliated venture fund for Rice-affiliated entrepreneurs, according to the release.

“Adrian brings a broad, multidisciplinary background to the team at the Office of Innovation,” Paul Cherukuri, chief innovation officer at Rice, says in a statement. “As a materials scientist and entrepreneur, his experience can be brought to bear to help faculty and students spin out new technologies and start new ventures.”

Trömel holds a bachelor’s and master’s in materials sciences from the École polytechnique fédérale de Lausanne (EPFL) and the Netherlands and an MBA from Rice. He is also an angel investor and a lead lecturer for Rice's New Enterprise MBA ELab.

In addition to his professional work, he serves as the foreign trade advisor to the Ministry of Economy of Luxembourg.

Rice has been building up its Office of Innovation in the last few years. In August 2022, the university named Cherukuri as the inaugural vice president for innovation. According to Rice President Reginald DesRoches, the Office of Innovation and the Cherukuri's position were created to ensure Rice is a leader within Houston and the global innovation ecosystem.

This past March, Cherukuri announced plans to develop the Rice Nexus.

"We've got so much technology in our labs that we've never shared with the world," he said at the time. "We're going to demonstrate that in the Ion."

Click here to listen to a full interview with Cherukuri about thought leadership in Houston, Rice University, and the challenges of advancing research and technology to address society's greatest needs on the Houston Innovators Podcast.

Ten individuals from Rice University have been named to the second cohort of the Innovation Fellowship program. Photos via Rice.edu

10 Houston researchers named to fellowship to advance innovation

owls taking flight

A program with a mission to translate research into innovative startups has named its 2023 cohort of fellows.

Rice University's Innovation Fellows program, which is run by the Liu Idea Lab for Innovation and Entrepreneurship and the Office of Innovation, has announced the 10 innovators that will be joining the program this year. The program, open to Rice faculty and doctoral and postdoctoral students, provides support — funding, mentorship, and more — to move innovation out of labs and into commercialization.

“The Rice Innovation Fellows program is a critical part of our efforts to support innovation and entrepreneurship,” Rice President Reginald DesRoches says in a news release. “These exceptional individuals represent some of the most innovative and promising research being conducted at Rice, and we’re thrilled to support them as they work to bring their ideas to the world.”

According to the release, the 10 members of the 2023 cohort are:

  • Martha Fowler, a doctoral student from the bioengineering lab of Omid Veiseh
  • Carson Cole, a doctoral student from the chemistry lab of Jeff Hartgerink
  • Fatima Ahsan, a doctoral student from the electrical and computer engineering lab of Behnaam Aazhang
  • Siraj Sidhik, a doctoral student from the materials science and nanoengineering lab of Aditya Mohite
  • Roman Zhuravel, a postdoctoral student from the physics and astronomy lab of Guido Pagano
  • Samira Aghlara-Fotovat, a doctoral student from the bioengineering lab of Veiseh
  • Clarke Wilkirson, a doctoral student from the mechanical engineering lab of Peter Lillehoj
  • Yuren Feng, a doctoral student from the civil and environmental engineering lab of Qilin Li
  • Yang Xia, a doctoral student from the chemical and molecular engineering lab of Haotian Wang
  • Thao Vy Nguyen, a doctoral student from the chemical engineering lab of Sibani Lisa Biswal

Each of Rice's Innovation Fellows will receive up to $20,000 in funding, as well as access to the university's network for mentorship and training.

“We're incredibly excited to welcome this exceptional group of researchers into the Innovation Fellows program,” says Yael Hochberg, head of the Rice Entrepreneurship Initiative and faculty director for Lilie, in the release. “We look forward to working with them as they bring their groundbreaking research to market and make a real impact on the world.”

Last year's inaugural cohort in raised more than $1 million in venture capital funding and over $3 million in additional nondilutive funding, as well as earning more than $500,000 in revenue.

Some of the 2022 cohort's accomplishments included Helix Earth Technologies winning the inaugural TEX-E Prize and Sygne Solutions securing second place and $200,000 at the 2023 Rice Business Plan Competition.

Paul Cherukuri, Rice’s vice president for innovation, who recently joined the Houston Innovators Podcast, explains how this is one avenue Rice has for getting innovation off campus and into industry.

“With commercialization of research at the forefront of what Rice University wants to do,” says Cherukuri, "the Innovation Fellows program is the first in a constellation of programs and resources developed by the Office of Innovation to help impactful new ventures overcome the hard tech ‘valley of death’ and transition from the campus to the community, so we can help create the next generation of game-changing company for Houston, Texas and the world,."

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Unique cell therapy developed in Houston doses inaugural patient

cancer-fighting innovation

Replay, a genome-writing company headquartered in San Diego, has announced that its first patient has been dosed with an engineered T-Cell Receptor Natural Killer (TCR-NK) cell therapy for relapsed or refractory multiple myeloma.

What does that have to do with Houston? Last year, Replay incorporated a first-in-class engineered TCR-NK cell therapy product company, Syena, using technology developed by Dr. Katy Rezvani at The University of Texas MD Anderson Cancer Center.

Rezvani, a professor of stem cell transplantation and cellular therapy, is the force behind MD Anderson’s Rezvani Lab, a group of 55 people, all focused on harnessing natural killer cells to combat cancer.

“Everybody thinks that the immune system is fighting viruses and infections, but I feel our immune system is capable of recognizing and killing abnormal cells or cells that are becoming cancerous and they're very powerful. This whole field of immunotherapy really refers to the power of the immune system,” Rezvani tells InnovationMap.

Dr. Katy Rezvani is a professor of stem cell transplantation and cellular therapy and the force behind MD Anderson’s Rezvani Lab, which is focused on harnessing natural killer cells to combat cancer. Photo via mdanderson.org

At Rezvani Lab, scientists train immune cells to fight cancer. While cancer drugs like chemotherapy are still the norm, immunotherapy has gained ground, led by Houston research, including the work of Nobel laureate Jim Allison. The harnessed cells are taught to attack cancerous cells, while ignoring healthy ones, says Rezvani. “We’re turning them into heat-seeking missiles,” she explains.

However, there must be a beacon to signal to those “missiles” that there is something to attack. Much of the field has used chimeric antigen receptors (CARs) to achieve that. But they have limitations.

“CARs can only recognize beacons that sit on the surface of the tumor cells,” Rezvani says. “So basically, it's like the tumor cell has to have a hat on it.”

She says that this usually means that the targets that send off a signal are relatively limited, mostly blood cancers. Using T cell receptors (TCRs) may be able to open up the field to look beyond the “hat.” In other words, TCRs can peer inside cells and see what differentiates a tumor cell from healthy cells. With Replay, Rezvani Lab has developed a first-in-class and first-in-human approach of engineering natural killer cells to express the TCR.

There are six different FDA-approved products that use CAR-T cells, but Rezvani says that her TCR-NK-based technology, though still in its early phases, shows great promise.

“We could use it to target many different types of antigens, many different types of cancers, especially solid tumors," she explains. "These cell therapies have a lot of potential — we call them living drugs… It's not like chemotherapy where you have to keep giving different multiple cycles, these cells are very long lived.”

Rezvani, who started her career in London, says that Houston has been instrumental in the success of her lab.

“There are so many opportunities because we have access to some of the most brilliant minds in research,” Rezvani says. “We have some of the best clinicians in the world. We have patients who come to us who are willing to participate in our clinical trials — really put their trust in us — and are committed and want to participate in these clinical studies.”

The role of funding also plays a part. As Rezvani admitted, bringing a new technology to the market is expensive. The philanthropists who help support trials can’t be forgotten among Houston’s finest.

Whether or not Syena produces the first TCR-NK product on the market, Rezvani is enthusiastic and hopeful for the future of her patients.

“The field of immunotherapy is really expanding, the field of cell therapies is expanding, and there is so much promise,” she says. “The promise of AI, big data, all the engineering tools that we have available, the promise of CRISPR — all of that is going to bring what we've learned from biology, from basic science, together to help us make the cell therapies that are going to be safe and and also very effective for our patients.”

How corporations can implement meaningful innovation, according to this Houston expert

guest column

I vividly remember, it was a typical Tuesday at Houston Exponential, and I’m sipping maybe my third coffee of the morning when the phone rings.

On the line is yet another hopeful voice from a newly minted innovation group at a "big company." They lay out their vision: “We’ve got this new innovation group! It’s me — a tech enthusiast who’s been yelling into the corporate void about needing to shake things up for the last two decades — plus a data scientist who loves numbers more than people, and a procurement guy who… well, procures stuff. And here’s the kicker: they’ve handed us $60 million to put to work. But here’s the catch — this treasure needs to be turned into a groundbreaking innovation that will dazzle the C-Suite, in about six months.”

I chuckle then sigh, because I’ve heard this story not once or twice, but about a dozen times over. And unfortunately, each of those grand plans crashed faster than a shooting star burning out over the Texas night sky — brilliant, swift, and leaving us wondering what might have been. Why? Well, let’s dig into some observations from my time working with institutional innovators from around the world and uncover just why throwing money at innovation like confetti at a wedding isn’t the quick fix big companies hope it will be.

The big miss here is a deep understanding of and ability to articulate the challenges. Innovation isn’t a highway where you can just press the gas and speed straight to Mt. Scale. It’s more like a winding country road with breathtaking views, unexpected potholes, and the occasional bewildered chicken crossing your path. For institutional innovators — the brave souls charting the course through this ever-changing landscape — the journey is filled with excitement, challenges, and the promise of discovery.

In my first hand experience mentoring over 500 startups and corporations, I’ve seen that the magic of innovation doesn’t come from a deep-pocketed budget but from a deep understanding of the problems we aim to solve. If you can view challenges through a kaleidoscope of perspectives, not just through the monochrome lens of one industry, you find the alternate routes that, while not exactly shortcuts, do keep you from turning down dark alleys and dead ends. A key observation here is that solutions to hard problems often lie in adjacent industries.

For example, consider how biomimicry has led to inventions like Velcro, inspired by burrs' ability to stick to animal fur, or how bullet trains in Japan were designed to mimic the kingfisher's beak for better aerodynamics. These are just a few examples of how solutions to complex problems often reside right in front of us or in the industry next door. Right here in Houston, Pumps & Pipes is a glowing example of how experts from Energy, Life Science and Space converge on similar problem sets with wildly different perspectives and applications.

Imagine if the engineers at NASA sat down for tacos with teachers from the local high school, or if doctors brainstormed with video game designers over a game of pickleball. Sounds fun, right? But it’s also where the magic happens. When we step out of our industry bubbles, we find that the solutions to our biggest problems often come from the most unexpected places.

So how do we begin to find these solutions? It all starts with a clear and clearly articulated challenge statement.

A crucial factor in encouraging organizations to look beyond traditional industry boundaries is to foster a deep understanding of problem-solution fit (you can read more about Problem - Solution fit in my last article here) and that means a deep understanding of the Problem. By guiding problem holders to dig deep into the nuances of the problems they aim to address, we expand their perspective. Once a comprehensive grasp of the problems are established, new pathways for solutions organically emerge. To do this you must broaden the collective thinking to the point where solutions from other industries become not just viable but often the most effective approach. My favorite quote on this subject is that “people don’t need a ¼ inch drill bit, they need a ¼ inch hole, and really they don’t need a ¼ hole, they need to hang a picture and when framed in that context, a command strip is more effective at solving the problem.”

So how do we do this? It’s easy, just continuously ask "why" or “why does this matter to your customer” to peel back the layers of the initial problem statements to reveal underlying causes or first principles. Ok this is actually much harder than it sounds but when organizations are guided through exercises to distill their challenges into first principles and more universal problem statements, a transformation occurs, resulting in several benefits:

  1. Expanding Solution Horizons: By elevating the problem discussion beyond industry-specific issues, the range of potential solutions widens remarkably.
  2. Universal Problem Statements: Restating the issues into more universal terms unlocks innovative approaches and solutions previously unseen.
  3. Enhanced Solution Fit and Success Probability: This reframing leads to solutions that are not only more fitting but also stand a higher chance of successfully being adopted and integrated and thus resolving the underlying issues.
  4. Increased Buy-In: These solutions are and are perceived as more novel and thus receive increased buy-in across the organization when moving towards adoption.

The critical lesson here is the power of abstracting the problem. By pulling back from the immediate and specific issues and reinterpreting them into broader, more universally applicable challenges, we can tap into a richer vein of solutions. This approach not only broadens the scope of potential innovations but also increases the alignment and effectiveness of the solutions we pursue.

The art of crafting challenge statements that are both broad enough to inspire innovative thinking and specific enough to be actionable is crucial. These statements serve as beacons, guiding both internal and external innovation efforts towards solutions that are not bound by conventional industry norms. By framing challenges in a way that invites diverse perspectives, organizations unlock innovative solutions that transcend traditional boundaries, fostering a more expansive and inclusive approach to problem-solving.

Turning lofty ambitions into tangible results begins with understanding that innovation isn’t just about flashy gadgets or the latest buzzwords. It’s about solving real problems for real people. This means rolling up our sleeves, listening intently, and sometimes realizing that the solution isn’t a high-tech wonder but perhaps something as simple and elegant as a command strip instead of a hole in the wall.

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Jon Nordby is managing partner at Anthropy Partners, a Houston-based investment firm, and professor of entrepreneurship at the University of Houston.