This week's innovators to know represents a homecoming, an accelerator launch, and a call for tech education. Courtesy photos

This week's innovators to know span across industries — from sports tech to education, but they are all fighting for something here in Houston. Here's what they are focused on bringing to the Houston innovation ecosystem.

Mike T. Brown, founder of Win-Win

Courtesy of Win-Win

Mike T. Brown decided to move his Silicon Valley sports tech platform that gamifies charitable donations to his hometown of Houston. Win-Win, which launched in 2016 and since raised $1.2 million in funding, is ready to scale and launch full-scale during the 2019 NFL season.

"I couldn't be more excited about returning to Houston to become a part of the city's tech revolution," says Brown in the release. "After visiting The Cannon, I immediately felt the energy and have witnessed their commitment to pushing Houston's tech startup movement. I can't wait to get fully plugged into the city's ecosystem, to start hiring local talent and raising money from local investors." Read more about Brown and Win-Win here.

Yvette Casares Willis, director of strategic partnerships for MassChallenge Texas

Courtesy of MassChallenge Texas

Yvette Casares Willis has been working to put Houston on the map for MassChallenge Texas, and her work is finally coming to fruition. The organization opened applications for its inaugural cohort last week. As excited as she is to work with the cohort, Willis is looking forward to what it means for the program to arrive in Houston and help to connect the dots across the city's innovation ecosystem.

"I'm excited about what Houston has to offer," says Willis, who is the director of partnerships for the organization. "We have everything we could possibly provide in this ecosystem to be amazing, as long as we all work together. If we can all collaborate and if we all have the same mission, we can really make a difference in Houston." Read more about Willis and MassChallenge Texas here.

TeKedra Pierre, internship coordinator at The Village School

Courtesy of The Village School

Tekedra Pierre's job is to help students be aware of real-life needs in the workforce through internship programs. And what's extremely clear to Pierre is the need for more professionals in tech — specifically the cybersecurity space. She wrote a piece for InnovationMap on the subject.

"Employers struggle to keep employees up to speed on the latest technologies and skill sets needed to succeed and thrive in the rapidly changing and evolving business landscape," she writes. "To remain competitive, Houston businesses must attract qualified workers to fill these positions that range from cybersecurity to industrial technology, engineering and medicine. And the earlier we can reach them, the better." Read Pierre's piece here.

Win-Win, a gamified donation platform, is moving to Houston this summer. Photo via Facebook

Silicon Valley-founded sports tech startup relocates to Houston

Homecoming

It's a homecoming of sorts for Mike T. Brown, a professional athlete turned entrepreneur, who is moving his Silicon Valley-founded startup to his hometown of Houston. Win-Win is a tech-enabled platform where fans can donate to their favorite athletes' causes through a gamified donation platform.

The company launched in 2016 and since raised $1.2 million in funding. Win-Win is ready to scale, according to a press release, and launch full-scale during the 2019 NFL season. Currently, the company is accepting investors on a crowdfunding site.

Brown will move his team into The Cannon this summer and enter The Cannon's Venture Studio.

"I couldn't be more excited about returning to Houston to become a part of the city's tech revolution," says Brown in the release. "After visiting The Cannon, I immediately felt the energy and have witnessed their commitment to pushing Houston's tech startup movement. I can't wait to get fully plugged into the city's ecosystem, to start hiring local talent and raising money from local investors."

Brown spent four years in the NFL, and was at one point a linebacker for the Indianapolis Colts. He hung up his helmet in 2013, taught himself to code, and moved to Silicon Valley. He worked as a mid-market growth lead for a $32 million venture-backed startup called Kiip. Growing up in Houston, Brown attended Alief Taylor High School before playing football at Duke University, getting a degree in public policy.

Win-Win is moving to the city at a time when sports startups are thriving, says Lawson Gow, founder and CEO of The Cannon. Gow is the son of InnovationMap's parent company's CEO. The Cannon is also home to sports tech startup sEATz.

"Houston has long needed better entrepreneurial resources to stop our startups from leaving for greener pastures, and we are excited to be part of the local entrepreneurial growth over the last couple of years, helping to provide a landing spot for a young, growing company like Win-Win," says Gow in the release. "On top of that, Houston is extremely well-positioned to be the home for sports-tech startups, and Mike moving back can be a great catalyst towards continuing to establish our city as a sports-tech hub."

Win-Win is joining fellow sports tech startup sEATz at The Cannon.Courtesy of The Cannon

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.