Houston resilience tech innovator proves out platform amid Hurricane Beryl

HOUSTON INNOVATORS PODCAST EPISODE 245

Ali Mostafavi, founder of Resilitix.AI, joins the Houston Innovators Podcast to discuss how he pivoted to provide important data amid Hurricane Beryl. Photo via tamu.edu

Earlier this month, Ali Mostafavi got an unexpected chance to pilot his company's data-backed and artificial intelligence-powered platform — all while weathering one of Houston's most impactful storms.

Mostafavi, a civil and environmental engineering professor at Texas A&M University, founded Resilitix.AI two years ago, and with the help of his lab at A&M, has created a platform that brings publicly available data into AI algorithms to provide its partners near-real time information in storm settings.

As Hurricane Beryl came ashore with Houston on its path, Mostafavi says he had the opportunity to both test his technology and provide valuable information to his community during the storm.

"We were in the process of fine tuning some of our methods and algorithms behind our technology," Mostafavi says on the Houston Innovators Podcast. "When disasters happen, you go to activation mode. We put our technology development and R&D efforts on hold and try to test our technology in an operational setting."

The platform provides its partners — right now, those include local and state organizations and emergency response teams — information on evacuation reports, street flooding, and even damage sustained based on satellite imagery. Mostafavi says that during Beryl, users were wondering how citizens were faring amid rising temperatures and power outages. The Resilitix team quickly pivoted to apply algorithms to hospital data to see which neighborhoods were experiencing high volumes of patients.

"We had the ability to innovate on the spot," Mostafavi says, adding that his own lack of power and internet was an additional challenge for the company. "When an event happens, we start receiving requests and questions. ... We had to be agile and adapt our methods to be responsive. Then at the same time, because we haven't tested it, we have to verify that we are confident (in the information we provide)."

On the episode, Mostafavi shares how Hurricane Harvey — which occurred shortly after Mostafavi moved to Houston — inspired the foundation of Resilitix and how Houston is the ideal spot to grow the company.

"We are very excited that our company is Houston based," he says. "We should not be just ground zero of disasters. We have to also be ground zero for solutions as well. I believe Houston should be the hub for resilience tech innovation as it is for energy transition.

"I think energy transition, climatetech, energy tech, and disaster tech go hand in hand," Mostafavi continues. "I feel that we are in the right place."

Houston City Hall's basement got a major upgrade. Photo via HoustonTX.gov

Photos: City of Houston reveals $4.4M facilities upgrades to repair Hurricane Harvey damage

new and improved

Where some might see just a basement, Mayor Sylvester Turner sees an opportunity to tell a story of Houston's resiliency and dedication to sustainability.

When Hurricane Harvey hit Houston, it left 18 to 20 inches of floodwaters in the basement of Houston City Hall. The city received funding from FEMA to support the $4.4 million renovation project that commenced in 2020. After facing challenges — including a defaulted contractor — the city revealed the new space this week, which was completed by contractor Dunhill Construction.

"The City Hall Basement renovation is a testament to the resilient spirit of Houston," says Turner in the news release. "We encountered some challenges, but we've revitalized this space while preserving our history and embracing innovation. This space truly embodies our commitment to a sustainable future."

The new basement holds conference rooms, training facilities, and a wellness center that was donated by Cigna. The project was focused on implementing sustainability and efficiency and included replacing aging air handling units with more efficient technology, LED lighting equipped with sensors to avoid energy waste, and a sliding floodgate to prevent history from repeating itself should another storm hit Houston.

The project also incorporated 18 pieces of Houston-focused art by artists including Mark Chen, Syd Moen, Nancy Newberry, and David Reinfeld. The 49 Houston mayor portraits, which were rescued by a staffer during the storm, were conserved, reframed, and rehung.

The space will also be the home to Houston's first walk-in 311 center, per the release, and the 311’s Continuity of Operations Plan, or COOP, and will be a secondary location in case the main call center fails.

With the completion of the project, the city has a few more upgrades — including additional training facilities, the mayor's dining room, and kitchen — coming soon and set to be completed in November.

Houston Mayor Sylvester Turner celebrated the opening of the renovated City Hall basement that was damaged in Hurricane Harvey. 

Photo via houstontx.gov

Together, the city and HCC will train Houstonians in resiliency preparedness. Image via Getty Images

City of Houston announces partnership college on 5th anniversary of Hurricane Harvey

preparing the city of Houston

Last week, Houston Mayor Sylvester Turner looked back on the past five years since Hurricane Harvey and made a lofty goal to provide the community with resiliency training.

The city of Houston and Houston Community College signed a memorandum of understanding that will address the city's goal to train 500,000 citizens, employees, small businesses, volunteers, and first responders in new resiliency training programs starting this fall.

The agreement was signed last week at the "Embracing Resiliency Symposium" hosted by the Resilience Innovation Hub, Amegy Bank, and HCC in front of 175 business, civic, community, education, and government leaders attending.

“I am pleased to announce the City of Houston’s partnership with Houston Community College’s new Resilience Center of Excellence and the Operations Training Facility and all the many ways we will collectively pave the path for a stronger and more prepared citizens, workforce, and community and a more resilient future,” Mayor Turner says at the event.

“Five years back, as we faced the wrath and impacts of Hurricane Harvey, it was a moment of reckoning for us as a city. It spurred us to think more cohesively about response and recovery; and most importantly, it urged us to think about building forward from recovery, from response towards resilience," he continues.

Starting this fall, the Houston community will have access to the following seven resiliency courses:

  • Resiliency 101 + Community Emergency Response Training (CERT)
  • Disaster Case Management
  • Facilities and Infrastructure
  • Disaster Recovery
  • Drones, Data Science, and Internet of Things
  • Public Safety and Rescue
  • Medical Triage

An additional 30 courses and programs will follow in 2023.

“As Mayor Turner recently stated, the lessons learned from Hurricane Harvey and subsequent disasters have identified one common take-away: When we work together as a team, Greater Houston is always resilient,” HCC Chancellor Cesar Maldonado says at the event. “In light of this observation, we must remain vigilant so these disasters will not continue to harm our families, our neighborhoods, our companies, our facilities and the community-at-large."

Earlier this summer, HCC announced that it is developing the Resilience Center of Excellence to aid the city’s resilience campaign. At the heart of this project is the 65,000-square-foot, $30 million Resiliency Operations Center, which will be built on a five-acre site HCC’s Northeast campus. The complex is scheduled to open in 2024.

"The HCC Resiliency Center of Excellence and Operations Training Facility will contribute to addressing preparedness and long-term mitigation from future floods, storms, snow and ice, pandemics and other challenges that have cost the region in the loss of lives, community, operations, and economic competitiveness," Maldonado continues.

The roof of Carnegie Vanguard High School features an example of the Green Stormwater Infrastructure. Photo courtesy of the City of Houston

City of Houston launches pilot program to promote stormwater infrastructure growth

seeing green

The City of Houston has launched a pilot project that will speed up the permitting process for environmentally friendly stormwater projects.

The Green Stormwater Infrastructure Expedited Permitting Pilot Program, announced August 4, will approve at least 10 projects in the Houston area by August 2022. In conjunction with the Resilient Houston initiative, the city is targeting 100 green stormwater infrastructure projects by 2025.

The city is working on rules and regulations that will govern development of green stormwater infrastructure. Mayor Sylvester Turner rolled out a tax abatement program for green stormwater infrastructure projects last December.

According to a city news release, green stormwater infrastructure improves the performance of drainage systems and can make real estate projects more attractive to buyers, while delivering benefits such as heat reduction, improvement of air and water quality, and conservation of native habitats.

Green stormwater infrastructure helps reduce the downstream impact of development and mimics how rain behaves when it falls onto an undeveloped green landscape. Techniques that fit into this category include green roofs, rain gardens, rainwater harvesting, permeable pavement, and urban forests.

"In the aftermath of Hurricane Harvey, we have taken critical steps to address our flooding and drainage challenges. As Houston has rapidly developed, we have relied on traditional gray infrastructure systems to keep us safe. However, as we build forward, we must consider new and innovative approaches for achieving greater flood resilience in Houston," the city says in a 2019 report about green stormwater infrastructure.

Traditional "gray" infrastructure, designed to move urban stormwater away from the built environment, includes curbs, gutters, drains, piping, and collection systems, according to the U.S. Environmental Protection Agency (EPA). Generally, gray infrastructure collects and moves stormwater from impervious surfaces, such as roadways, parking lots, and rooftops, and into a series of pipes that ultimately send untreated stormwater into local waterways.

In tandem with Houston's new permitting program, the city has created the Green Stormwater Infrastructure Awards and Recognition Program. The program salutes green development and redevelopment projects. It "is intended to recognize some of the most effective and exemplary of 'green' building in Houston and encourage more development projects to adopt resilient measures," according to the news release.

Projects considered for the awards program will be judged on factors such as:

  • Proximity to nearby communities.
  • Impact on nearby communities.
  • Efforts to conserve native plants.

Turner says the permitting and awards programs are part of an initiative aimed at "futureproofing our city" to ease harm caused by hurricanes and flooding.

"In Houston and in towns across the U.S., climate change is no longer knocking on our front door; it's broken into the house," Turner wrote in an opinion piece published in July by The Hill.

The innovations and Houston startups that came out of Hurricane Harvey are no coincidence. Richard Seline of ResilientH2O Partners explains how he's helping foster new hurricane and flood prevention technologies in the Bayou City. Photo courtesy of ResilientH20

New Houston hub calls for collaboration for flood and hurricane prevention innovation

Houston innovators podcast episode 43

When it comes to insurance, most people's interaction is pretty limited buying a plan, filing claims when need be, and paying the monthly bill. However, unbeknownst to most of their insured clients, insurance companies are investing in insuratech and new innovations within the natural disaster space.

Richard Seline, managing director of ResilientH20, along with the Insurance Information Institute and The Cannon, to launch the Gulf Coast & Southwest Resilience Innovation Hub to foster this type of technology and bring insuratech startups and the big insurance players to the table — something that's not often done.

"It's two different languages," Seline says on the Houston Innovators Podcast. "There's a whole language and a whole mindset within the insurance industry that is not real well known."

The hub, which is based in downtown Houston's Cannon Tower, has been hard at work hosting virtual pitch events and networking opportunities since it launched in June just as the 2020 hurricane season commenced. Seline explains the mission is threefold: allow for reverse pitching where insurance companies tell innovators what their challenges are in hopes of inspiring new technology, introducing insuratech companies to potential investors or clients, and fostering innovation for new natural disaster prevention innovations.

On the podcast, Seline discusses new endeavors he's working on within his organization and explains the role his feels the new hub has in Houston's innovation ecosystem. To him, the city must work collaboratively to move the needle on growth of its innovation ecosystem.

"The good news is there is a lot of great activity underway in Houston right now — no questions asked," Seline says. "What we are doing can be seen as complimentary and not competitive with anyone else."

From game-changing startups to watch out for to upcoming events and partnerships for the Gulf Coast & Southwest Resilience Innovation Hub, check out the podcast. You can listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.



From a water-absorbing tower to sensor-enabled rubber ducks, here are some flooding solution ideas coming out of Houston. Courtesy of Gensler's ByDesign

These Houston entrepreneurs and startups are searching for flooding solutions

Flood tech

The feeling is all too familiar for Houstonians. Tropical Storm Imelda hit Houston with devastating flood waters just two years after Hurricane Harvey did its damage.

With any obstacle or challenge, there is room for innovation. Over the past year, InnovationMap has covered various flood tech startups in Houston. Here are six innovations that can make a difference the next time a storm decides to take its toll on Houston.

Self-deploying flood protection for buildings

FloodFrame's technology can protect a home or commercial building from flood water damage. Photo via floodframe.com

A self-deploying flood damage prevention device caught Tasha Nielsen's eye on a trip to Denmark, and then launched the U.S. iteration of FloodFrame to bring the technology here.

FloodFrame works by using buoyancy. A lightweight cloth is wrapped around a tube is installed underground outside the perimeter of your home or business. One end of that cloth is attached to a box that is also installed underground. As flooding begins, an automatic system will release the lids to deploy the inflation of the tube that will protect the structure. When the flood comes in, the system will float on top of the flood — kind of like a pool noodle — and protect the structure from the water.

FloodFrame adds a level of security during flooding events and can be considered more cost-effective when compared to the high cost of renovating or rebuilding after flooding.

"Right now we are focused on residential but I think there's a huge potential for it to go commercial. A lot of commercial buildings are self insured, and commercial developers, industrial developers, this would be a drop in the bucket for the overall cost of the entire project," Nielsen tells InnovationMap. "For homeowners, it's kind of a bigger expense, but I think there is the potential for homebuilders to include it as an option in the entire package of a new house because when you put it in to a mortgage, it's only another like $0.50 a month."

A waterproof container for your car.

After the floods from Hurricane Harvey totaled her car, Rahel Abraham wanted to find a solution. ClimaGuard/Facebook

Floodwaters from Hurricane Harvey seriously damaged about 600,000 vehicles in the Houston area, which included Rahel Abraham's 2008 Infiniti G35. Now, Abraham's brainchild forms the backbone of her Houston-based startup, ClimaGuard LLC. The company's waterproof, temperature-resistant, portable Temporary Protective Enclosure (TPE) can entirely cover a compact car, sedan, or midsize SUV. It comes in three sizes; the cost ranges from $349 to $499.

To protect a vehicle, someone sets a TPE on the ground, a driveway, or another flat surface, then drives the vehicle onto the bottom part of the product, and connects the bottom and top parts with the zipper. Abraham likens it to a clamshell preserving a pearl.

"My goal is not to make it to where it's an exclusive product — available only to those who can afford it — but I want to be able to help those who it would make even more of an economic impact for," Abraham tells InnovationMap.

A network to find shelter.

Reda Hicks create GotSpot — a digital tool that helps connect people with commercial space with people who need it. Courtesy of GotSpot

It only took a natural disaster for Reda Hicks to make her startup idea into a reality.

"I had been thinking on what it would be like to help people find space to do business in and how businesses find a way to stay in business a long time," Hicks tells InnovationMap. "But, I was afraid of the tech."

Hicks, who has practiced law for almost 15 years, wanted to create a website that allows for people with commercial space — a commercial kitchen, conference room, spare desks, etc. — to list it. Then, space seekers — entrepreneurs, nonprofits, freelancers, etc. — can rent it. When Hurricane Harvey hit, Hicks was kicking herself for not acting on her idea sooner.

"It was really Harvey and having so many people desperate to find space for emergency purposes that made me realize there are so many contexts in which people need space right away for something specific," she says. "Certainly the primary user is the entrepreneur trying to grow their business, but there are so many other reasons why a community would need better access to the space it already has."

Now Hicks is growing GotSpot in hopes that short-term rental space and emergency housing can be smooth sailing no matter the circumstances. Recently, the company was named a finalist for MassChallenge Texas in Austin.

A water-absorbing tower. 

Fil Trat would be able to absorb water, filter it, and release it into the body of water when the time comes. Courtesy of Gensler's ByDesign

In the wake of Hurricane Harvey, many Houstonians began to think of solutions for the next time Mother Nature struck with her full-force of flooding. Gensler designers Chelsea Bryant, Jordan Gomez, Luisa Melendez, Barbara Novoa, Benjamin Nanson, Maria Qi, and Melinda Ubera created a solution as a part of Gensler's By Design program called Fil Trat. The tower can absorb, filter, and store flood waters until the bayou is ready for the water to be released — cleaner than it was before.

During Harvey, thousands of people were displaced, but Fil Trat has a solution for that too. The tower's floors would alternate between filtration floors and shelters, which could house up to 24 families per floor.

While the suggested Houston locale would be by Buffalo Bayou, the group suggests putting the tower in other coastal cities at risk of devastating flooding.

Sensor-enabled rubber ducks that can track weather developments.

Sensor-enabled rubber ducks might be the solution to keeping track of major weather events. Courtesy of Project Owl

Nearly two years after Hurricane Harvey battered the Houston area, a flock of electronic "rubber ducks" flew above homes in Katy in a broader endeavor to keep first responders and victims connected during natural disasters.

Developers and backers of Project Owl, an Internet of Things (IoT) hardware and software combination, conducted a pilot test of this innovation June 1 — the first day of this year's hurricane season. In the Katy test, 36 "ducks" took flight.

"So, our technology can be deployed to help communities that have been destroyed after natural disasters by providing quickly accessible communications network to coordinate and organize a response," Bryan Knouse, co-founder and CEO of Project Owl, tells InnovationMap.

The DuckLink network comprises hubs resembling rubber ducks, which can float in flooded areas if needed. It takes only five of these hubs to cover one square mile. This network sends speech-based communications using conversational systems (like Alexa and Facebook Messenger) to a central application. The app, the Owl software incident management system, relies on predictive analytics and various data sources to build a dashboard for first responders.

Restored native wetland coastal prairies.

Memorial Park Conservancy is gearing up to unveil one if its first projects within its 10-year master plan redevelopment. Photo courtesy of MPC

Before it was the fourth largest city in America, Houston was a prairie. That type of ecosystem — thick with prairie grass — is very absorbing when it comes to rain water. Cassidy Brown Johnson, a Rice University lecturer and president of the Coastal Prairie Partnership, has been taking every opportunity to raise awareness on the importance of prairie restoration.

"It's really surprising to people that the trees and all this lushness is actually all artificial," Johnson says. "We know that this ecosystem evolved with the cyclical flooding events that happened here."

This movement to bring back Houston's ancient ecosystem is a new focus on a few prairie conservationist groups — and even the Harris County Flood Control. This has been going on for a while, but recent flooding events have opened the eyes of people now looking for reliable solutions to flooding problems.

"After Hurricane Harvey, people started realizing that this might be one of the solutions we could actually investigate and see if it can help us," Johnson says. "A green space is going to absorb way more water than a parking lot."

Memorial Park Conservancy's master plan redevelopment project, which is being supported by the Kinder Foundation, includes a lot of prairie restoration plans is expected to deliver by 2028.

The project is a collaborative effort between MPC, Uptown Houston TIRZ, and Houston Parks, Kinder Foundation, and Recreation Department to redevelop the 1,500-acre park. An ongoing part of the transformation will be stormwater management upgrades. MPC has budgeted $3 million to this asset of the renovation. While a part of the plan is tributaries for run-off water, bringing back prairie and wetlands will do a great deal to help abate stormwater.

"We're taking ball fields, parking lots, and roads and converting them back to what was here — native wetland coastal prairie," MPC president and CEO Shellye Arnold tells InnovationMap. "This serves important stormwater purposes."

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Houston e-commerce giant Cart.com launches government-focused subsidiary

government branch

Houston e-commerce and logistics unicorn Cart.com has launched a new subsidiary.

Cart Government Solutions (CGS), which was announced earlier this week, will provide supply chain and logistics services and software for the federal and state government sectors. The new subsidiary will be headquartered in Washington, D.C., and operate out of about 6 million square feet of secure warehouse space across 14 U.S. facilities, according to a news release from Cart.com. It will support both domestic and overseas logistics.

Industry veteran Gregg Zegras will lead the new entity as president. Zegras previously served as Cart.com's chief revenue officer, according to LinkedIn. Before that, he served as president of Connecticut-based Pitney Bowes Global eCommerce, a digital shipping solutions company.

Remington Tonar, Cart.com's co-founder, will serve as CGS's chief innovation officer.

“Government agencies face procurement and logistics challenges that many commercial platforms simply weren’t built to solve,” Zegras said in the news release. “Cart Government Solutions exists to change that. We’re combining the speed and innovation of a technology company with the compliance rigor, security, and operational depth that federal and state customers require, and we’re doing it with a team that has spent careers working alongside and inside these agencies.”

According to the company, CGS will focus on meeting compliance and security requirements in the public sector. Some of the services the new entity will offer include:

  • Inventory management
  • Cold-chain and specialty storage for pharmaceuticals, medical devices and regulated goods
  • Enterprise-grade supply chain software
  • Government-compliant webstores and online ordering portals
  • Cybersecurity operations

Cart.com has been serving the public sector since 2022, when the company began distributing COVID-19 health supplies nationwide, according to the news release. Through that pandemic-era contract, the company reports it moved more than 725 million units, with an average of under two days per shipment.

Cart.com was founded in Houston in 2020, though it briefly moved its headquarters to Austin. The company reached unicorn status with its $60 million Series C raise in 2023. It most recently raised $180 million in growth capital from private equity firm Springcoast Partners in March, which put the startup over the $1 billion in fundraising mark in just six years.

At the time, Cart.com said it planned to scale its logistics network, expand AI capabilities and develop workflow automation tools.

Houston-based KBR Inc. also recently launched a government services spinoff. Read more here.

2 Houston universities named best colleges of 2027 by Princeton Review

A-Plus Ratings

Back-to-school season is has returned in full force, and that means it's time for college rankings. Two Houston universities in particular are being hailed as the top of the class for 2027.

The high caliber schools — Rice University and University of Houston — earned new acclaim in The Princeton Review's ranking of the "Best 392 Colleges" for 2027.

The Princeton Review's 35th annual "Best Colleges" rankings are determined by a survey of 172,000 current college students that gave "candid feedback" about their schools and their experiences. The flagship guide does not rank the schools overall, but it does rank them across 50 different categories, including best-run colleges, best quality of life, happiest students, best athletic facilities, among others.

In all, 14 Texas institutions were highlighted in the overall list of the 392 best colleges.

Schools don't pay to be included in the guide, but The Princeton Review clarified that schools could pay for a "featured" designation. No Houston university paid to be featured in this year's guide. Trinity University in San Antonio and Southwestern University, a private school in the Austin suburb Georgetown, were the only two Texas schools that paid to be "featured."

Rice and UH have been on a winning streak in separate reports of the best universities worldwide, best graduate schools, and best online degree programs.

In addition to being included in the overall list, Rice was highlighted as one of the Best Value Colleges, Colleges That Create Futures, and it earned high marks in Princeton Review's Mental Health Honor Roll 2026. The home of the Rice Owls also starred in the regional Best Southwest list that contained 41 universities across Arizona, Colorado, New Mexico, Oklahoma, and Texas.

"Rice University stands out as a leading research university where academic diversity and a wide array of interdisciplinary institutes and centers make it easy for students to explore multiple areas of interest," the school's profile says. "At Rice, 'knowledge isn’t siloed — students are constantly crossing disciplines and interests in ways that feel natural rather than exceptional.'"

Rice earned the following rankings on 14 other lists:

  • No. 1 – Lots of Race/Class Interaction
  • No. 3 – Best College Newspaper
  • No. 9 – Friendliest Students
  • No. 11 – Best Quality of Life
  • No. 13 – Great Financial Aid
  • No. 14 – Top 50 Best Value Private Colleges
  • No. 17 – Their Students Love These Colleges
  • No. 18 – Top 20 Best Value Private Colleges Without Aid
  • No. 18 – Best Student Support and Counseling Services
  • No. 19 – Best College Dorms
  • No. 21 – Students Study the Most
  • No. 24 – Best Campus Food
  • No. 24 – Best College Radio Station
  • No. 24 – Best-Run colleges
The University of Houston also appeared in the Best Southwest, Best Value Colleges, and Colleges That Create Futures lists, and it was named a top Green College, which examined schools that "share superb sustainability practices, a strong foundation in sustainability education, and a healthy quality of life for students on campus

UH earned five more accolades:

  • No. 1 – Top 50 Undergraduate Schools for Entrepreneurship Studies
  • No. 1 – Top Undergraduate Schools for Entrepreneurship Studies in the Southwest
  • No. 8 – Most Politically Moderate Students
  • No. 15 – Financial Aid Not So Great
  • No. 42 – Top 50 Best Value Public Colleges
In the school's profile, students say they had an overall positive experience thanks to UH's excellent academic offerings and dedicated faculty members.

"Students confirm that 'the research and other academic opportunities... are very accessible to students who seek it out,'" the profile says. "This includes taking advantage of UH’s vast alumni network (more than 325,000 and counting), not to mention its location in the corporate center of Houston, where 'the opportunities that are provided are immense.'"

The 12 other public and private universities in Texas included in The Princeton Review's 2027 guide are:

  • The University of Texas at Austin
  • Southwestern University, Georgetown
  • Baylor University, Waco
  • Texas A&M University - College Station
  • Trinity University, San Antonio
  • Texas State University, San Marcos
  • Angelo State University, San Angelo
  • Texas Christian University, Fort Worth
  • University of Dallas, Irving
  • Southern Methodist University, Dallas
  • The University of Texas at Dallas, Richardson
  • Austin College, Sherman
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A version of this story originally appeared on CultureMap.com.

Houston named the No.1 emerging city for biopharma in inaugural report

Biopharma Leader

Houston is ranked No.1 on the first-ever Next 10 U.S. Biopharma Clusters report published by Genetic Engineering & Biotechnology News (GEN).

The report, which ranks the best emerging hubs for life science activities, considered patents, NIH funding, lab space, venture capital investments, and the number of jobs in regions in cities, states and “clusters” across the U.S. GEN touts Houston as the top city for the biopharma industry due to a surge in funding, job creation, medical innovations and startup success.

Here’s how Houston ranked in the report’s different categories;

  • No. 1 for NIH funding with 2,262 awards totaling more than $1.25 billion
  • No. 2 for emerging regions for jobs, with 28,000 jobs
  • No. 2 for lab space, with roughly 8 million square feet in the market
  • No. 6 for patents, with 2,760 patent families

According to BioHouston chairman Jeff Wade, Houston secured half a billion dollars in venture capital funding in 2025 and 2026 to date.

The report called out major biopharm news out of Houston in the last few months, including Bristol Myers Squibb selecting Houston for its $1 billion, 600,000-square-foot manufacturing site and Eli Lily selecting Houston for its $6.5 billion, 236-acre manufacturing site. Both facilities will be located within Generation Park, a 4,300-acre, master-planned commercial district near Lake Houston.

Houston startups like CrossBridge Bio and Duracyte were also mentioned in the report. CrossBridge, which develops antibody-drug conjugates for cancer, was acquired by Eli Lily in April for $300 million. Duracyte, a “living pharmacy” company, was launched out of Rice University’s biotech venture studio RBL LLC this spring and is backed by up to a $45 million Advanced Research Projects Agency for Health (ARPA-H) award.

The startup is working to commercialize its Hybrid Advanced Molecular Manufacturing Regulator (HAMMR) technology, a rechargeable, implantable device that can sense biological signals, monitor tumor environments and adjust therapeutic output in real time.

“There’s a lot of great talent, but the unique advantage that we have is we are able to benefit from a lot of unique clinical infrastructure and clinician insights,” Omid Veiseh, Duracyte co-founder and managing partner of RBL LLC, told GEN. “There are a lot of clinicians here who are eager to partner on investigator-initiated trials.”

The report also touted Houston’s Texas Medical Center, home to the University of Texas MD Anderson Cancer Center and Baylor College of Medicine, and international partnerships like the recently expanded TMC Korea BioBridge.

Other cities to make the list include:

  • No. 2 Minneapolis-St. Paul
  • No. 3 Denver-Boulder
  • No. 4 St. Louis
  • No. 5 Dallas-Fort Worth

States to make the list include:

  • No. 1 Ohio (including Cincinnati, Cleveland, and Columbus)
  • No. 2 Indiana (including Indianapolis)
  • No. 3 Florida (including Jacksonville and Miami-Fort Lauderdale)
  • No. 4 Georgia (including Atlanta and Augusta)
  • No. 5 Wisconsin (including Madison and Kenosha)

Regional state clusters to watch include:

  • Phoenix
  • Pittsburgh
  • Greater Richmond, Virginia
  • South Carolina
  • Utah

See the full report here.