Support Houston startups by shopping local this holiday season. Photos courtesy

'Tis the season for giving — and what if you could check off your holiday to-do list and simultaneously support some local startups? This year's Houston startup gift guide includes comfortable-yet-stylish heels, culinary treats, and more.

Need some more ideas? Browse last year's roundup of Houston startup-created gift ideas and check out the 2020 and 2019 startup gift guides as well for even more options.

For the family fashionista: All-day comfort shoes

Steffie Tomson founded a company to prioritize comfort — without sacrificing style — for women on the go. Photo via getawaysticks.com

Before starting her business, Houstonian Steffie Tomson ordered $2,000 worth of shoes and sliced them all in half with a bandsaw just to see what was inside. Tomson, a neuroscientist by trade and the founder and CEO of footwear startup Getaway Sticks, had an idea for a different kind of shoe — one that was redesigned to prioritize women’s comfort.

Earlier this year, Tomson shared the Getaway Sticks origin story with InnovationMap. The heels are available online for around $200 per pair.

For the resident chef: Fresh fish delivered

Sugar Land-based Fish Fixe floated their seafood delivery service on Shark Tank last year. Photo via Shark Tank

Houstonians Melissa Harrington and Emily Castro saw how beneficial incorporating fish into your diet can be — so they decided to launch an easier way to do it. They launched Fish Fixe in 2017 to deliver seafood with easy-to-access instructions on storage and thawing — plus cooking recipes that take around 20 minutes.

The duo appeared on the 13th season of Shark Tank last year. In 2020, as InnovationMap reported, the company saw a 400-percent increase in sales. They pitched asking for $200,000 in investment. Lori Greiner, the "queen of QVC," took the bait — and 25 percent equity.

Shoppers can stock up on various boxes from $109 to $219, or opt for a gift card for their loved one.

For the health nut: Sustainably-sourced nutrients

A Houston-based fund has deployed capital into a local nutritional supplement business. Photo via Instagram

Houston--based iwi creates nutritional supplements for the brain and the heart — and they are doing it in a sustainable setting: algae farms. These football field-sized farms operate on desert land using just salt water and sand and produce algae sustainably — all while absorbing CO2. Miguel Calatayud, CEO of the company, tells InnovationMap that the farms even area able to reuse 98 percent of the water involved in the process. Earlier this year, iwi received an investment from a local group in an $8 million deal.

The company has almost a dozen options online for around $30 per canister of supplements.

For your aging loved ones: Afterlife planning and memory keeping

The Postage — a Houston-based company that's streamlining afterlife planning — has rolled out a new app. Photo courtesy of The Postage

There's a lot that goes into legacy and afterlife planning, and a Houston startup has emerged to make the process a whole lot easier. The Postage helps its users generate their wills and organize information to leave behind, the company's founder, Emily Cisek, shares with InnovationMap. The platform also every user to leave messages, photos, and memories in a digital vault that will stand the test of time.

Giving the gift of legacy planning can be an option for anyone in your family — from the grandparents to the newlyweds.

For someone seeking luscious locks: Hair growth tracking kit

This startup is making sure every follicle of hair on your head is counted. Photo via myhaircounts.com

While it might seem odd to gift someone a hair loss tracking kit, this product from a Houston company has helped many men and women suffering from hair density challenges. MyHairCounts created a hair density imaging kit and app based on proprietary and patent-pending software. The kit includes a variety of items such as scalp imaging guides, a comb, and gel to help individuals photograph their hair follicles at specified angles. Users then upload these photographs into the app for analyses which are delivered within 48 hours. These analyses inform the user whether or not their hair regrowth treatment is effective.

The kit itself is just $40 and available online. Users can work with the company on a longer hair growth plan, too.

Bonus: What to bring to the table

Support Houston startups by bringing these goodies to your next festive shindig. Photos courtesy

Sometimes your presence is the present, and if you're headed to some holiday dinner parties, here are some innovative ideas for the potluck.

  • Houston-based Dream Harvest Farming Co., a vertical indoor farming company producing leafy greens and herbs and delivering them locally to grocery stores in Texas and nearby states. Pick up Dream Harvest products at a Whole Foods location, and read more about the company.
  • This year has been a big one for the growing Bread Man Baking Co., as the company expanded from its 5,000-square-foot kitchen and moved its operations into a new 40,000-square-foot facility on the northeast side of Houston. Pick up some of the company's products at Whole Foods or HEB. Read more about the company.
  • A new, “hyperpure” oxygen-enriched water brand has rolled out in Houston in single-serve and subscription options. Dubbed HOW — Hyperpure Oxygenated Water — the award-winning super-filtered water (via a 14-level filtration process that removes impurities down to the nano-level .0001 microns) is now available at 35 specialty retailers around town. Read more about the company.

HOW water comes to you via subscription. Photo by Alex Montoya

Houston restaurant veteran pops open award-winning and sustainable new bottled water

how nice

Houstonians who are picky about their bottled water but also environmentally minded now have a refreshing local option — one that even comes to them.

A new, “hyperpure” oxygen-enriched water brand has rolled out in Houston in single-serve and subscription options. Dubbed HOW — Hyperpure Oxygenated Water — the award-winning super-filtered water (via a 14-level filtration process that removes impurities down to the nano-level .0001 microns) is now available at 35 specialty retailers around town.

HOW secured gold medal awards in the coveted category of Best Tasting Purified Drinking Water in 2019 and 2021 at the annual Berkeley Springs International Water Tasting in Berkeley Springs, West Virginia. That contest is widely known in the industry as The Oscars of water tasting competitions.

The new water comes courtesy of local serial entrepreneur Bob Peebler, whose 40-plus year career in business has spawned multiple ventures, including the instantly recognizable health-conscious Ruggles Green restaurants.

Fresh air

Peebler’s water journey started six years ago when he met an inventor in Santa Barbara who was building a perfect water system that not only produced hyperpure water, but also an experimental system that raised the oxygen levels of the water up to five times beyond the oxygen content in tap and bottled water.

“This difference in the inventor’s system was how he used a patented system that injects 98 percent oxygen into a swirling vortex that creates nano bubbles that find their way to embed in the water,” Peebler tells CultureMap. “The bubbles are so small that when the body absorbs the water, it ends up raising the oxygen levels of the body’s tissues. After seeing lab measurements, I was convinced that this was different. The other intrigue is that in-solution oxygen creates a silky texture which makes the water a pleasure to drink.”

After coaxing the inventor to build a system at his home in Ojai, California, Peebler shared the water with his friends, who couldn’t get enough of it. The serial entrepreneur was inspired.

Precious metal

Hardly surprising that the Houstonian responsible for Ruggles Green and its healthy and planet-first approach (reusable containers, biodegradable utensils) would create an eco-friendly new product. Aside from the health benefits offered with HOW, Peebler wanted reusable and recyclable delivery systems. And that meant no plastic bottles, but rather, aluminum.

“No one is certain how microplastics affect our health, but I’m guessing it’s not a good thing, and I know it doesn’t help the taste,” says Peebler. “More importantly, there are 1 million plastic bottles purchased every minute, and roughly 70 percent of that mostly non-recyclable plastic waste ends up in our oceans, lakes, bayous and landfills. In contrast, the aluminum bottles that HOW uses are infinitely recyclable.”

A winning formula

Learning first-hand how wasteful the restaurant industry is, Peebler ensured his Ruggles Green operations recycled grease, composted waste, used diode lighting, and employed other environmentally friendly approaches. With that in mind, he’s ensured that his water tastes good, is good for the planet, and the bottles are reusable or easily recycled.

Currently available for home delivery (subscribe here), HOW can also be found at spots such as Midtown Market, Phoenicia Specialty Foods, Rice Epicurean Market, O Athletik, Total Nutrition, and all four Local Foods locations. Bottled in a specialty plant in Mineral Wells, Texas, HOW is slated to be released to Dallas-Fort Worth, Austin, and San Antonio.

It’s all part of Peebler’s ambition to provide a wealth of water that’s good for people and planet.

“If we deliver a superior tasting product that just happens to be better for both your health and our planet,” Peebler adds, “we believe that’s a winning combination that will resonate with consumers.”

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This article originally ran on CultureMap.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."