Support Houston startups by shopping local this holiday season. Photos courtesy

'Tis the season for giving — and what if you could check off your holiday to-do list and simultaneously support some local startups? This year's Houston startup gift guide includes comfortable-yet-stylish heels, culinary treats, and more.

Need some more ideas? Browse last year's roundup of Houston startup-created gift ideas and check out the 2020 and 2019 startup gift guides as well for even more options.

For the family fashionista: All-day comfort shoes

Steffie Tomson founded a company to prioritize comfort — without sacrificing style — for women on the go. Photo via getawaysticks.com

Before starting her business, Houstonian Steffie Tomson ordered $2,000 worth of shoes and sliced them all in half with a bandsaw just to see what was inside. Tomson, a neuroscientist by trade and the founder and CEO of footwear startup Getaway Sticks, had an idea for a different kind of shoe — one that was redesigned to prioritize women’s comfort.

Earlier this year, Tomson shared the Getaway Sticks origin story with InnovationMap. The heels are available online for around $200 per pair.

For the resident chef: Fresh fish delivered

Sugar Land-based Fish Fixe floated their seafood delivery service on Shark Tank last year. Photo via Shark Tank

Houstonians Melissa Harrington and Emily Castro saw how beneficial incorporating fish into your diet can be — so they decided to launch an easier way to do it. They launched Fish Fixe in 2017 to deliver seafood with easy-to-access instructions on storage and thawing — plus cooking recipes that take around 20 minutes.

The duo appeared on the 13th season of Shark Tank last year. In 2020, as InnovationMap reported, the company saw a 400-percent increase in sales. They pitched asking for $200,000 in investment. Lori Greiner, the "queen of QVC," took the bait — and 25 percent equity.

Shoppers can stock up on various boxes from $109 to $219, or opt for a gift card for their loved one.

For the health nut: Sustainably-sourced nutrients

A Houston-based fund has deployed capital into a local nutritional supplement business. Photo via Instagram

Houston--based iwi creates nutritional supplements for the brain and the heart — and they are doing it in a sustainable setting: algae farms. These football field-sized farms operate on desert land using just salt water and sand and produce algae sustainably — all while absorbing CO2. Miguel Calatayud, CEO of the company, tells InnovationMap that the farms even area able to reuse 98 percent of the water involved in the process. Earlier this year, iwi received an investment from a local group in an $8 million deal.

The company has almost a dozen options online for around $30 per canister of supplements.

For your aging loved ones: Afterlife planning and memory keeping

The Postage — a Houston-based company that's streamlining afterlife planning — has rolled out a new app. Photo courtesy of The Postage

There's a lot that goes into legacy and afterlife planning, and a Houston startup has emerged to make the process a whole lot easier. The Postage helps its users generate their wills and organize information to leave behind, the company's founder, Emily Cisek, shares with InnovationMap. The platform also every user to leave messages, photos, and memories in a digital vault that will stand the test of time.

Giving the gift of legacy planning can be an option for anyone in your family — from the grandparents to the newlyweds.

For someone seeking luscious locks: Hair growth tracking kit

This startup is making sure every follicle of hair on your head is counted. Photo via myhaircounts.com

While it might seem odd to gift someone a hair loss tracking kit, this product from a Houston company has helped many men and women suffering from hair density challenges. MyHairCounts created a hair density imaging kit and app based on proprietary and patent-pending software. The kit includes a variety of items such as scalp imaging guides, a comb, and gel to help individuals photograph their hair follicles at specified angles. Users then upload these photographs into the app for analyses which are delivered within 48 hours. These analyses inform the user whether or not their hair regrowth treatment is effective.

The kit itself is just $40 and available online. Users can work with the company on a longer hair growth plan, too.

Bonus: What to bring to the table

Support Houston startups by bringing these goodies to your next festive shindig. Photos courtesy

Sometimes your presence is the present, and if you're headed to some holiday dinner parties, here are some innovative ideas for the potluck.

  • Houston-based Dream Harvest Farming Co., a vertical indoor farming company producing leafy greens and herbs and delivering them locally to grocery stores in Texas and nearby states. Pick up Dream Harvest products at a Whole Foods location, and read more about the company.
  • This year has been a big one for the growing Bread Man Baking Co., as the company expanded from its 5,000-square-foot kitchen and moved its operations into a new 40,000-square-foot facility on the northeast side of Houston. Pick up some of the company's products at Whole Foods or HEB. Read more about the company.
  • A new, “hyperpure” oxygen-enriched water brand has rolled out in Houston in single-serve and subscription options. Dubbed HOW — Hyperpure Oxygenated Water — the award-winning super-filtered water (via a 14-level filtration process that removes impurities down to the nano-level .0001 microns) is now available at 35 specialty retailers around town. Read more about the company.

HOW water comes to you via subscription. Photo by Alex Montoya

Houston restaurant veteran pops open award-winning and sustainable new bottled water

how nice

Houstonians who are picky about their bottled water but also environmentally minded now have a refreshing local option — one that even comes to them.

A new, “hyperpure” oxygen-enriched water brand has rolled out in Houston in single-serve and subscription options. Dubbed HOW — Hyperpure Oxygenated Water — the award-winning super-filtered water (via a 14-level filtration process that removes impurities down to the nano-level .0001 microns) is now available at 35 specialty retailers around town.

HOW secured gold medal awards in the coveted category of Best Tasting Purified Drinking Water in 2019 and 2021 at the annual Berkeley Springs International Water Tasting in Berkeley Springs, West Virginia. That contest is widely known in the industry as The Oscars of water tasting competitions.

The new water comes courtesy of local serial entrepreneur Bob Peebler, whose 40-plus year career in business has spawned multiple ventures, including the instantly recognizable health-conscious Ruggles Green restaurants.

Fresh air

Peebler’s water journey started six years ago when he met an inventor in Santa Barbara who was building a perfect water system that not only produced hyperpure water, but also an experimental system that raised the oxygen levels of the water up to five times beyond the oxygen content in tap and bottled water.

“This difference in the inventor’s system was how he used a patented system that injects 98 percent oxygen into a swirling vortex that creates nano bubbles that find their way to embed in the water,” Peebler tells CultureMap. “The bubbles are so small that when the body absorbs the water, it ends up raising the oxygen levels of the body’s tissues. After seeing lab measurements, I was convinced that this was different. The other intrigue is that in-solution oxygen creates a silky texture which makes the water a pleasure to drink.”

After coaxing the inventor to build a system at his home in Ojai, California, Peebler shared the water with his friends, who couldn’t get enough of it. The serial entrepreneur was inspired.

Precious metal

Hardly surprising that the Houstonian responsible for Ruggles Green and its healthy and planet-first approach (reusable containers, biodegradable utensils) would create an eco-friendly new product. Aside from the health benefits offered with HOW, Peebler wanted reusable and recyclable delivery systems. And that meant no plastic bottles, but rather, aluminum.

“No one is certain how microplastics affect our health, but I’m guessing it’s not a good thing, and I know it doesn’t help the taste,” says Peebler. “More importantly, there are 1 million plastic bottles purchased every minute, and roughly 70 percent of that mostly non-recyclable plastic waste ends up in our oceans, lakes, bayous and landfills. In contrast, the aluminum bottles that HOW uses are infinitely recyclable.”

A winning formula

Learning first-hand how wasteful the restaurant industry is, Peebler ensured his Ruggles Green operations recycled grease, composted waste, used diode lighting, and employed other environmentally friendly approaches. With that in mind, he’s ensured that his water tastes good, is good for the planet, and the bottles are reusable or easily recycled.

Currently available for home delivery (subscribe here), HOW can also be found at spots such as Midtown Market, Phoenicia Specialty Foods, Rice Epicurean Market, O Athletik, Total Nutrition, and all four Local Foods locations. Bottled in a specialty plant in Mineral Wells, Texas, HOW is slated to be released to Dallas-Fort Worth, Austin, and San Antonio.

It’s all part of Peebler’s ambition to provide a wealth of water that’s good for people and planet.

“If we deliver a superior tasting product that just happens to be better for both your health and our planet,” Peebler adds, “we believe that’s a winning combination that will resonate with consumers.”

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This article originally ran on CultureMap.

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Houston researchers report promising first in-human trial for implantable cancer therapy

cancer breakthrough

When it comes to cancer remedies, the treatment can be as challenging for the body as its cause. But what if immunotherapy could be localized? That’s precisely what a Houston team may soon make a reality.

Rice University researchers, in partnership with MD Anderson Cancer Center, recently published their findings from the first in-human trial of an implantable cancer-fighting treatment in the journal Clinical Cancer Research. The paper details testing of AVB-001, encapsulated cells engineered to release interleukin-2 (IL-2)—a naturally occurring signaling protein that boosts immunity—in the peritoneal cavities of 14 patients. The goal is to avoid the toxicity usually experienced with less targeted treatments, as well as find a solution to IL-2s’ abbreviated half-lives.

“Traditional IL-2 therapy has shown potent antitumor activity, but its clinical use has been limited by severe side effects and delivery challenges,” Omid Veiseh, director of the Rice Biotech Launch Pad, professor of bioengineering at Rice and a senior author on the study, said in a press release. “This platform allows us to localize and sustain cytokine exposure directly where tumors reside while minimizing systemic toxicity.”

Serous ovarian carcinoma is especially well-suited to the use of AVB-001 because it tends to spread throughout the abdomen. After a minimally invasive laparoscopic procedure, patients implanted with the cells were noted to tolerate the treatment well. Half of the enrolled patients’ cancer was stabilized, with several among them reporting extended signs of benefit. No maximum tolerated dose was reached and there were no life-threatening events tied to the study.

If that sounds like less-than-earth-shaking results, this is only the beginning. The capsules were implanted for about one week because IL-2 activity drops off after that. The researchers now know that further testing should include either higher levels, repeated doses, or a combination thereof, in order to create stronger advances.

The team has already made early headway on this next step. Preclinical studies in nonhuman primates were not only tolerated well, but without added toxicity, the apes had consistent pharmacological effects.

“This is a foundational step,” Veiseh explained. “We now have evidence that the platform is safe, biologically active and potentially scalable. The next phase is optimizing dosing and exploring combination therapies to unlock its full clinical potential.”

The combination would also include a checkpoint inhibitor, which might improve AVB-001’s tumor-fighting power. “What is exciting is that we are not just delivering a drug, we are programming a microenvironment,” added Dr. Amir Jazaeri, professor of gynecologic oncology at MD Anderson, member of the Rice Biotech Launch Pad’s clinical advisory board and a senior author on the study. “This opens the door to combination strategies that could amplify immune responses in ways that have not been feasible before.”

Houston startup raises $6M to scale home-based healthcare platform

fresh funding

As healthcare systems race to expand care beyond hospitals and into the home, investors are placing bigger bets on the infrastructure needed to make that shift possible.

This month, Rosarium Health announced it has raised $6 million in seed funding led by Kalos Ventures, with participation from ResilienceVC, Rock Health Capital, Symphonic Capital, Black Tech Nations Ventures and others.

The investment will help the Houston-based startup continue to build its platform, which features a national network of 800-plus clinicians and 3,000-plus contractors to coordinate home accessibility upgrades and modifications for seniors and people living with disabilities.

For founder and CEO Cameron Carter, the company’s mission grew out of firsthand caregiving experiences.

“From my own personal caregiving experiences, I realized that the benefits exist on paper, but not in reality,” Carter said in a news release. “Families are being left to figure out the paperwork and installations all on their own, which shouldn’t be how this works.”

While Medicare Advantage and Medicaid plans have expanded coverage for home-based services and accessibility modifications, the logistics behind delivering those services often remain fragmented.

Rosarium’s platform coordinates the entire process, from clinical assessments and referrals to contractor management, documentation, reimbursement and installation.

“A clinician can document that a home isn’t safe and a plan can approve a benefit, but there’s no one that’s responsible for making sure the work actually gets done,” Carter says. “We built the missing piece.”

The company was founded in 2021 as Rose Health and was a 2023 participant in the Texas Medical Center’s Accelerator for HealthTech program. It has scaled quickly, building a network of more than 800 clinicians and 3,000 contractors across 34 states.

Rosarium is currently in-network for 1.2 million Medicare and Medicaid lives, with projected coverage expected to reach nearly 4 million by the end of the year, according to the release.

“We’re excited to back Cameron because he and the team at Rosarium are building the infrastructure healthcare needs right now to make the home a safe and comfortable place of care,” Kate Ballinger, investor at Kalos Ventures, added in the release.

As part of the recent investment, Ballinger will join Rosarium’s board of directors.

With eyes on the future, Rosarium plans to grow its partnerships with Medicaid and Medicare Advantage plans, including CalViva and Community Health Plan of Imperial Valley, strengthening its presence in California while expanding access to underserved communities.

Additionally, Carter predicts that home-based healthcare will be part of a broader transformation happening across the industry.

“There’s a growing recognition that health outcomes are shaped by what happens in the home,” he said in the release. “The future of healthcare isn’t just treating people after something goes wrong. It’s creating environments that help prevent those problems in the first place.”