Support Houston startups by shopping local this holiday season. Photos courtesy

'Tis the season for giving — and what if you could check off your holiday to-do list and simultaneously support some local startups? This year's Houston startup gift guide includes comfortable-yet-stylish heels, culinary treats, and more.

Need some more ideas? Browse last year's roundup of Houston startup-created gift ideas and check out the 2020 and 2019 startup gift guides as well for even more options.

For the family fashionista: All-day comfort shoes

Steffie Tomson founded a company to prioritize comfort — without sacrificing style — for women on the go. Photo via getawaysticks.com

Before starting her business, Houstonian Steffie Tomson ordered $2,000 worth of shoes and sliced them all in half with a bandsaw just to see what was inside. Tomson, a neuroscientist by trade and the founder and CEO of footwear startup Getaway Sticks, had an idea for a different kind of shoe — one that was redesigned to prioritize women’s comfort.

Earlier this year, Tomson shared the Getaway Sticks origin story with InnovationMap. The heels are available online for around $200 per pair.

For the resident chef: Fresh fish delivered

Sugar Land-based Fish Fixe floated their seafood delivery service on Shark Tank last year. Photo via Shark Tank

Houstonians Melissa Harrington and Emily Castro saw how beneficial incorporating fish into your diet can be — so they decided to launch an easier way to do it. They launched Fish Fixe in 2017 to deliver seafood with easy-to-access instructions on storage and thawing — plus cooking recipes that take around 20 minutes.

The duo appeared on the 13th season of Shark Tank last year. In 2020, as InnovationMap reported, the company saw a 400-percent increase in sales. They pitched asking for $200,000 in investment. Lori Greiner, the "queen of QVC," took the bait — and 25 percent equity.

Shoppers can stock up on various boxes from $109 to $219, or opt for a gift card for their loved one.

For the health nut: Sustainably-sourced nutrients

A Houston-based fund has deployed capital into a local nutritional supplement business. Photo via Instagram

Houston--based iwi creates nutritional supplements for the brain and the heart — and they are doing it in a sustainable setting: algae farms. These football field-sized farms operate on desert land using just salt water and sand and produce algae sustainably — all while absorbing CO2. Miguel Calatayud, CEO of the company, tells InnovationMap that the farms even area able to reuse 98 percent of the water involved in the process. Earlier this year, iwi received an investment from a local group in an $8 million deal.

The company has almost a dozen options online for around $30 per canister of supplements.

For your aging loved ones: Afterlife planning and memory keeping

The Postage — a Houston-based company that's streamlining afterlife planning — has rolled out a new app. Photo courtesy of The Postage

There's a lot that goes into legacy and afterlife planning, and a Houston startup has emerged to make the process a whole lot easier. The Postage helps its users generate their wills and organize information to leave behind, the company's founder, Emily Cisek, shares with InnovationMap. The platform also every user to leave messages, photos, and memories in a digital vault that will stand the test of time.

Giving the gift of legacy planning can be an option for anyone in your family — from the grandparents to the newlyweds.

For someone seeking luscious locks: Hair growth tracking kit

This startup is making sure every follicle of hair on your head is counted. Photo via myhaircounts.com

While it might seem odd to gift someone a hair loss tracking kit, this product from a Houston company has helped many men and women suffering from hair density challenges. MyHairCounts created a hair density imaging kit and app based on proprietary and patent-pending software. The kit includes a variety of items such as scalp imaging guides, a comb, and gel to help individuals photograph their hair follicles at specified angles. Users then upload these photographs into the app for analyses which are delivered within 48 hours. These analyses inform the user whether or not their hair regrowth treatment is effective.

The kit itself is just $40 and available online. Users can work with the company on a longer hair growth plan, too.

Bonus: What to bring to the table

Support Houston startups by bringing these goodies to your next festive shindig. Photos courtesy

Sometimes your presence is the present, and if you're headed to some holiday dinner parties, here are some innovative ideas for the potluck.

  • Houston-based Dream Harvest Farming Co., a vertical indoor farming company producing leafy greens and herbs and delivering them locally to grocery stores in Texas and nearby states. Pick up Dream Harvest products at a Whole Foods location, and read more about the company.
  • This year has been a big one for the growing Bread Man Baking Co., as the company expanded from its 5,000-square-foot kitchen and moved its operations into a new 40,000-square-foot facility on the northeast side of Houston. Pick up some of the company's products at Whole Foods or HEB. Read more about the company.
  • A new, “hyperpure” oxygen-enriched water brand has rolled out in Houston in single-serve and subscription options. Dubbed HOW — Hyperpure Oxygenated Water — the award-winning super-filtered water (via a 14-level filtration process that removes impurities down to the nano-level .0001 microns) is now available at 35 specialty retailers around town. Read more about the company.

HOW water comes to you via subscription. Photo by Alex Montoya

Houston restaurant veteran pops open award-winning and sustainable new bottled water

how nice

Houstonians who are picky about their bottled water but also environmentally minded now have a refreshing local option — one that even comes to them.

A new, “hyperpure” oxygen-enriched water brand has rolled out in Houston in single-serve and subscription options. Dubbed HOW — Hyperpure Oxygenated Water — the award-winning super-filtered water (via a 14-level filtration process that removes impurities down to the nano-level .0001 microns) is now available at 35 specialty retailers around town.

HOW secured gold medal awards in the coveted category of Best Tasting Purified Drinking Water in 2019 and 2021 at the annual Berkeley Springs International Water Tasting in Berkeley Springs, West Virginia. That contest is widely known in the industry as The Oscars of water tasting competitions.

The new water comes courtesy of local serial entrepreneur Bob Peebler, whose 40-plus year career in business has spawned multiple ventures, including the instantly recognizable health-conscious Ruggles Green restaurants.

Fresh air

Peebler’s water journey started six years ago when he met an inventor in Santa Barbara who was building a perfect water system that not only produced hyperpure water, but also an experimental system that raised the oxygen levels of the water up to five times beyond the oxygen content in tap and bottled water.

“This difference in the inventor’s system was how he used a patented system that injects 98 percent oxygen into a swirling vortex that creates nano bubbles that find their way to embed in the water,” Peebler tells CultureMap. “The bubbles are so small that when the body absorbs the water, it ends up raising the oxygen levels of the body’s tissues. After seeing lab measurements, I was convinced that this was different. The other intrigue is that in-solution oxygen creates a silky texture which makes the water a pleasure to drink.”

After coaxing the inventor to build a system at his home in Ojai, California, Peebler shared the water with his friends, who couldn’t get enough of it. The serial entrepreneur was inspired.

Precious metal

Hardly surprising that the Houstonian responsible for Ruggles Green and its healthy and planet-first approach (reusable containers, biodegradable utensils) would create an eco-friendly new product. Aside from the health benefits offered with HOW, Peebler wanted reusable and recyclable delivery systems. And that meant no plastic bottles, but rather, aluminum.

“No one is certain how microplastics affect our health, but I’m guessing it’s not a good thing, and I know it doesn’t help the taste,” says Peebler. “More importantly, there are 1 million plastic bottles purchased every minute, and roughly 70 percent of that mostly non-recyclable plastic waste ends up in our oceans, lakes, bayous and landfills. In contrast, the aluminum bottles that HOW uses are infinitely recyclable.”

A winning formula

Learning first-hand how wasteful the restaurant industry is, Peebler ensured his Ruggles Green operations recycled grease, composted waste, used diode lighting, and employed other environmentally friendly approaches. With that in mind, he’s ensured that his water tastes good, is good for the planet, and the bottles are reusable or easily recycled.

Currently available for home delivery (subscribe here), HOW can also be found at spots such as Midtown Market, Phoenicia Specialty Foods, Rice Epicurean Market, O Athletik, Total Nutrition, and all four Local Foods locations. Bottled in a specialty plant in Mineral Wells, Texas, HOW is slated to be released to Dallas-Fort Worth, Austin, and San Antonio.

It’s all part of Peebler’s ambition to provide a wealth of water that’s good for people and planet.

“If we deliver a superior tasting product that just happens to be better for both your health and our planet,” Peebler adds, “we believe that’s a winning combination that will resonate with consumers.”

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This article originally ran on CultureMap.

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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.