Houston ranked in the top 10 and Dallas-Fort Worth claimed the top spot on a recent tech hub report. Photo via Getty Images.

Houston already is the Energy Capital of the World, and now it’s gaining ground as a tech hub.

On Site Selection magazine’s 2026 North American Tech Hub Index, Houston jumped to No. 10 from No. 16 last year. The index relies on data from Site Selection as well as data from CBRE, CompTIA and TeleGeography to rank the continent’s tech hotspots. The index incorporates factors such as internet connectivity, tech talent and facility projects for tech companies.

In 2023, the Greater Houston Partnership noted the region had “begun to receive its due as a prominent emerging tech hub, joining the likes of San Francisco and Austin as a major player in the sector, and as a center of activity for the next generation of innovators and entrepreneurs.”

The Houston-area tech sector employs more than 230,000 people, according to the partnership, and generates an economic impact of $21.2 billion.

Elsewhere in Texas, two other metros fared well on the Site Selection index:

  • Dallas-Fort Worth nabbed the No. 1 spot, up from No. 2 last year.
  • Austin rose from No. 8 last year to No. 7 this year.

San Antonio slid from No. 18 in 2025 to No. 22 in 2026, however.

Two economic development officials in DFW chimed in about the region’s No. 1 ranking on the index:

  • “This ranking affirms what we’ve long seen on the ground — Dallas-Fort Worth is a top-tier technology and innovation center,” said Duane Dankesreiter, senior vice president of research and innovation at the Dallas Regional Chamber. “Our region’s scale, talent base, and diverse strengths … continue to set DFW apart as a national leader.”
  • “Being recognized as the top North American tech hub underscores the strength of the entire Dallas-Fort Worth region as a center of innovation and next-generation technology,” said Robert Allen, president and CEO of the Fort Worth Economic Development Partnership.

While not directly addressing Austin’s Site Selection ranking, Thom Singer, CEO of the Austin Technology Council, recently pondered whether Silicon Hills will grow “into the kind of community that other cities study for the right reasons.”

“Austin tech is not a club. It is not a scene. It is not a hashtag, a happy hour, or any one place or person,” Singer wrote on the council’s blog. “Austin tech is an economic engine and a global brand, built by thousands of people who decided to take a risk, build something, hire others, and be part of a community that is still young enough to reinvent itself.”

South of Austin, Port San Antonio is driving much of that region’s tech activity. Occupied by more than 80 employers, the 1,900-acre tech and innovation campus was home to 18,400 workers in 2024 and created a local economic impact of $7.9 billion, according to a study by Zenith Economics.

“Port San Antonio is a prime example of how innovation and infrastructure come together to strengthen [Texas’] economy, support thousands of good jobs, and keep Texas competitive on the global stage,” said Kelly Hancock, the acting state comptroller.

Check out these workshops, networking events, conferences, and other goings on in Houston this month. Photo via Getty Images

10+ can't-miss Houston business and innovation events in November

where to be

This month, Houstonians have yet another good batch of in-person and online innovation events, and you and your tech network need to know about them.

Here's a roundup of virtual events not to miss this month — like demo days, workshops, conventions, and more.

Note: This post might be updated to add more events.

November 3 — Enventure "Inspire" Seminar Series - With Dr. Alyssa Johnston

The "Inspire" Seminar Series was developed by Enventure to help students learn about the reality of working in the biotech and biomedical fields. This particular event will star Dr. Alyssa Johnston, PhD, AstraZeneca Medical Science Liaison. Currently, Alyssa is a MSL at AstraZeneca specializing in GI/GU/Head & Neck Oncology. She is the study lead for a gastric cancer clinical trial, tumor lead for several liver cancer trials, and also works on several IITs. She is the field medical trainer for the pan tumor team and works on sustainability projects including inclusion and diversity projects.

The event is on Wednesday, November 3, at 6 pm. It's free and happening online. Click here to register.

November 4 — The Greentown Labs Climatetech Summit 2021: Empowering the Technology of Tomorrow

The Greentown Labs Climatetech Summit is a deep dive focused on empowering the technology of tomorrow. Climatetech entrepreneurs are developing the solutions that are the core of global decarbonization, yet they need support, cooperation, and collaboration from investors, policymakers, and the growing climatetech workforce in order to scale their critical technologies. The energy transition is here, and the climatetech ecosystem needs your involvement to keep the momentum going.

The event is all day Thursday, November 4. It's free and happening online, or $100 to attend in person at Greentown Houston. Click here to register.

November 8 — Climathon 2021 Awards

Drum roll... and the winning projects of the 2021 Houston Climathon Awards are... going to be revealed soon! Learn More About the Climathon: https://climathonhouston.org

The event is on Monday, November 8, at noon. It's free and happening online. Click here to register.

November 8 — The Cannon + Chevron Open House

Join The Cannon and Chevron for some snacks and learn how Chevron leverages relationships with the start up community to deliver higher returns and lower carbon. Members of Chevron Technology Ventures and the IT function will be available to provide some background on our presence at The Cannon and exchange ideas on partnering opportunities.

The event is on Monday, November 8, at noon. It's free and happening at The Cannon (1300 Brittmoore Rd). Click here to register.

November 9 — BEAMW Networking Launch Event

Business Ecosystem Alliance for Minorities & Women (BEAMW) is a newly launched alliance seeking to reduce barriers women and minority small business owners face. This Networking Launch Event will be the first of a series of networking events designed to bring small business owners, different business support organizations, investors, bankers, and collaborators together to gain valuable information and make key connections.

The event is on Tuesday, November 9, at 6 pm. It's free and happening at The Downtown Launchpad (1801 Main St). Click here to register.

November 10 — Go to Market Strategies with RHIS Group

The Cannon has partnered with the RHIS Group to expand available resources. Join the session on Go to Market Strategies to understand different pillars of strategy, organizational capability, challenges and common perceptions, and strategy development.

The event is on Wednesday, November 10, at 10:30 am. It's free and happening at The Cannon (1300 Brittmoore Rd). Click here to register.

November 10 — Investing in the Energy Transition: ESG and Regulatory Impacts

A key aspect of the energy transition is how industry accounts for long-term strategy and competitive positioning in a constantly evolving landscape. With a sharp focus on regulatory and ESG legal implications, this panel discussion examines how companies will address the marketplace changes – not only with its stakeholders, but within the foundation of their products and procedures as they define value creation toward constituents in the court of global opinion.

The event is on Tuesday, November 16, at 10 am. It's free and happening online. Click here to register.

November 11 — The Listies Gala

Come one, come all to a night celebrating Houston innovation at the Houston Museum of Natural Science. Think "Met Gala meets Houston innovation" and an evening of multicultural Houston food, immersive experiences, and of course HouTech. The host of the evening is Houston's Poet Laureate, Outspoken Bean, who will bring more Houston energy to the Lisites for everyone to enjoy.

The event is on Thursday, November 11, at 7 pm at the Houston Museum of Natural Science. Tickets are $75. Click here to register.

November 16 —  Investing in the Energy Transition: The World of External Investment Finance

As global industry continues to embark on an unparalleled pivot toward sustainable energy, crucial questions have risen regarding the financial risks and rewards of such an intrepid move. What is the role of venture capital? Private equity? Institutional investors? Infrastructure funds? Is moving away from traditional fossil fuels sustainable, and are there adequate channels of investments to fund? In what should be an insightful dialogue on our present position and what must be addressed along the way, this panel poses these queries – and more – toward financial experts to determine industry and societal cost of the energy transition. The goal? To explore the mismatch of opportunity and investment as well as the full range of buy-in – literally and figuratively – that the world must achieve to successfully adapt to the new landscape. Moderated by Ahmad Atwan, CEO of VC Fuel.

The event is on Tuesday, November 16, at 10 am. It's free and happening online. Click here to register.

November 16 — What happens when you talk to an investor?

Steve Jennis of Founder's Compass responds to questions submitted by members of The Cannon Community related to the fundraising process. This online session will be followed by an AMA session for any other questions, clarifications, or points provoked by his answers.

The event is on Tuesday, November 16, at 10 am. It's free and happening online. Click here to register.

November 17 — Illuminate Houston

The Greater Houston Partnership's Young Professionals and Entrepreneurs group, HYPE, invites you to Illuminate Houston - an event series highlighting businesses and thought leaders challenging the way we think about the future. Join for the final Illuminate Houston of 2021 featuring Juliana Garaizar, Head of Houston Incubator and VP, Innovation, Greentown Labs. Don't miss this dynamic conversation where this climatetech startup leader shares insights on Houston's growing innovation ecosystem and leading the way in the global energy transition.

The event is on Wednesday, November 17, at noon. It's $25 for non-members and happening online. Click here to register.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."