This week's roundup of Houston innovators includes Carlos Estrada of BioWell, Elizabeth Gore of Hello Alice, and Daniel Barvin of Coya Therapeutics. Photos courtesy

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes a podcast with the leader of a new bioindustrial accelerator, a fintech leader celebrating a big win, and an operations expert fighting for an ALS cure.

Carlos Estrada, head of Venture Acceleration at BioWell

Carlos Estrada, head of Venture Acceleration at BioWell, joins the Houston Innovators Podcast to share why Houston is already a great hub for bioindustrial innovation. Photo courtesy of BioWell

Bioindustrial technologies have a high potential for impacting sustainability — but they tend to need a little bit more help navigating the startup valley of death. That's where the BioWell comes in.

Carlos Estrada, head of Venture Acceleration at BioWell, says the idea for the accelerator was came to First Bight Ventures, a Houston-based biomanufacturing investment firm, as it began building its portfolio of promising companies.

"While we were looking at various companies, we found ourselves finding different needs that these startups have," Estrada says on the Houston Innovators Podcast. "That's how the opportunity for the BioWell came about." Read more.

Elizabeth Gore, co-founder and president of Hello Alice

It's a win for Hello Alice and Elizabeth Gore, co-founder and president (right). Photo courtesy Cayce Clifford/Hello Alice

A Houston fintech company is celebrating the dismissal of a lawsuit from former Trump Administration officials.

Last year, America First Legal sued Houston-based Hello Alice and its partner, Progressive Insurance, alleging that their program to award 10 $25,000 grants to Black-owned small businesses constitutes racial discrimination. AFL was founded by former Trump Administration adviser Stephen Miller and features a handful of other former White House officials on its board.

The case has been dismissed by a federal judge in Ohio, who said that the “Plaintiffs fail to allege any injury in fact that would support their standing to seek either retrospective or prospective relief," according to a news release from Hello Alice.

“This resolution marks a pivotal moment not only for our company but for the broader small business community in the United States,” Elizabeth Gore, co-founder and president of Hello Alice, says in the release. “Facing a labor shortage, heightened interest rates, and inflation, this country needs its small business owners, and they, in return, need the capital and resources that programs like Hello Alice provide." Read more.

Daniel Barvin, vice president of operations and patient advocacy at Coya Therapeutics

Daniel Barvin has a neurodegenerative disease in his near future. He joined Houston-based Coya Therapeutics to help fight for a cure to the aggressively deadly ALS. Photo courtesy

When genetic testing proved to Daniel Barvin that he, like his grandfather, aunt, uncle, and father before him, would most likely die of amyotrophic lateral sclerosis, more commonly known as ALS, and/or frontotemporal degeneration (FTD) in his 40s, he didn't slow him down.

in a guest column for InnovationMap, he writes "instead I chose to fight for every chance to change not only my life, but the lives of millions who are suffering or may one day suffer from neurodegenerative disease."

He joined Houston-based Coya Therapeutics in 2021 to support operations and patient advocacy at a company actively developing a therapeutic that can fight neurodegenerative diseases like ALS. Read more.

Following the round, Hello Alice is now valued at $130 million. Photo courtesy Cayce Clifford/Hello Alice

Houston tech platform raises series C round backed by Mastercard

money moves

Hello Alice, a fintech platform that supports 1.5 million small businesses across the country, has announced its series C round.

The amount raised was not disclosed, but Hello Alice reported that the fresh funding has brought the company's valuation to $130 million. Alexandria, Virginia-based QED Investors led the round, and investors included Mastercard, Backstage Capital, Guy Fieri, Golden Seeds, Harbert Growth Partners Fund, How Women Invest I, LP, Lovell Limited Partnership, Tyler “Ninja” and Jessica Blevins, and Tamera Mowry and Adam Housley, per a news release from the company.

“We are thrilled to hit the milestone of 1.5 million small businesses utilizing Hello Alice to elevate the American dream. There are more entrepreneurs launching this year than in the history of our country, and we will continue to ensure they get the capital needed to grow,” Elizabeth Gore and Carolyn Rodz, co-founders of Hello Alice, say in a news release. “In closing our Series C, we welcome Mastercard to our family of investors and continue to be grateful to QED, How Women Invest, and our advocates such as Guy Fieri.”

The funding will go toward expanding capital offerings and AI-driven tools for its small business membership.

“Our team focuses on finding and investing in companies that are obsessed with reducing friction and providing superior financial services solutions to their customers,” QED Investors Co-Founder Frank Rotman says in the release. “Hello Alice has proven time and time again that they are on the leading edge of providing equitable access to capital and banking services to the small business ecosystem."

Hello Alice, which closed its series B in 2021 at $21 million, has collaborated with Mastercard prior to the series C, offering small business owners the Hello Alice Small Business Mastercard in 2022 and a free financial wellness tool, Business Health Score, last year. Mastercard also teamed up with other partners for the the Equitable Access Fund in 2023.

“With Hello Alice, we’re investing to provide support to small business owners as they look to access capital, helping to address one of the most cited business challenges they face,” Ginger Siegel, Mastercard's North America Small Business Lead, adds. “By working together to simplify access to the products and services they need when building and growing their business, we’re helping make a meaningful impact on the individuals who run their businesses, the customers they serve, and our communities and economy at large.”

While Hello Alice's founders' mission is to help small businesses, their own company was threatened by a lawsuit from America First Legal. The organization, founded by former Trump Administration adviser Stephen Miller and features a handful of other former White House officials on its board, is suing Hello Alice and its partner, Progressive Insurance. The lawsuit alleges that their program to award10 $25,000 grants to Black-owned small businesses constitutes racial discrimination. Gore calls the lawsuit frivolous in an interview on the Houston Innovators Podcast. The legal battle is ongoing.

Inspired by the lawsuit, Hello Alice launched the Elevate the American Dream, a grant program that's highlighting small businesses living out their American dreams. The first 14 grants have already been distributed, and Hello Alice plans to award more grants over the next several weeks, putting their grant funding at over $40 million.


The ultimate who's who of 2023 — these are our favorite Houston Innovators Podcast guests of last year. Photos courtesy

Editor's Picks: 7 favorite Houston Innovator Podcast episodes of 2023

year in review

Editor's note: In 2023, I recorded 50 episodes of the Houston Innovators Podcast — a weekly discussion with a Houston innovator, startup founder, investor, and more. I've rounded up seven podcast episodes that stood out for me looking back at the year of recordings. Scroll through to see whom I selected and stream their individual episodes, and tune into the last episode of the year where I explain why I enjoyed each conversation.



Episode 174 - Rolling out nationwide - Mike Francis and Carrie Horazeck of NanoTech

NanoTech's Chief Commercial Officer Carrie Horazeck and Co-Founder and CEO Mike Francis join the Houston Innovators Podcast to celebrate the nationwide launch of their roof coating product. Photo via LinkedIn

A Houston startup is celebrating its nationwide launch of its flagship product that coats roofs to reduce energy waste.

NanoTech's Nano Shield Cool Roof Coat is a unique product that can be added onto roofs to reduce energy waste on buildings. Co-founder and CEO Mike Francis and Chief Commercial Officer Carrie Horazeck joined the Houston Innovators Podcast to share more details about the product.

"It's just a coating that can go on top of existing structure — any type of commercial roof," Horazeck says on the show. "We have a pretty good amount of data from 2022 showcasing that we can reduce HVAC consumption within the building by about 30 to 40 percent.

"Our clients really see a immediate benefit in their energy bill, and, of course, if you reduce the HVAC consumption, that automatically translates to a decrease in your scope one emissions," she continues. Continue reading.


Episode 181 - Gearing up for high-speed global travel - Sassie Duggleby of Venus Aerospace

Sarah "Sassie" Duggleby of Venus Aerospace joins the Houston Innovators Podcast this week. Photo courtesy of Venus

Sarah "Sassie" Duggleby is on a mission to get people home in time for dinner — whether they are traveling around the world or working for her business. That's why she founded Venus Aerospace, which is developing hypersonic space planes. It's also why she relocated the company from the West Coast to Houston.

"We knew we had to find a location where we could test our engine and still be home for dinner," Duggleby says on this week's episode of the Houston Innovators Podcast. "Our company vision is 'home for dinner.' We want to fly you across the globe and have you home for dinner. And, if you work for us, we want you home for dinner."

Venus's technology enables this revolutionary travel through its supersonic combustion engine — more akin to a rocket's engine than an airplane's — that allows for travel at a higher elevation, she explains on the show. Jet engines rely on air outside of the aircraft to combust, and rocket engines work with a system that supplies air internally. And, as Duggleby explains, the engine can go further with the same amount of fuel, so it's a more sustainable way of traveling too. Continue reading.


Episode 182 - Stopping neurodegenerative diseases in their tracks - Howard Berman of Coya Therapeutics

For Howard Berman, CEO and co-founder of Coya Therapeutics, commercializing his company is personal. Photo courtesy of Coya

When Howard Berman sought out renowned Houston Methodist researcher and neurologist Dr. Stanley Appel, he was looking for treatment for his father, who was suffering from dementia. He wasn't looking for a job, but Dr. Appel had other ideas and asked Berman to meet with him.

"I was interested in what I could do for my dad," Berman says on the Houston Innovators Podcast, explaining how he took the meeting with Dr. Appel, who then presented him with some of his research. "By slide five my jaw had hit the ground.

"He had shown that he could stop the progression in one of his early trials of ALS," Berman says.

Not too long after that meeting, Berman, who founded digital health platform imaware, joined Dr. Appel to lead commercialization of Coya Therapeutics, a biotech startup that raised over $20 million in venture funding before going public a few months ago. Continue reading.


Episode 187 - Bridging the gap to innovation - Ramanan Krishnamoorti of University of Houston

Ramanan Krishnamoorti, vice president of energy and innovation at the University of Houston, joins the Houston Innovators Podcast to talk about the university's dedication to helping the city become an innovative force. Photo via UH.edu

Ramanan Krishnamoorti has had a varied career in academia, from an engineering professor to nanotech research. While he never made the transition from researcher to entrepreneur, he managed to snag a CEO title at the university about a decade ago: Chief energy officer.

Since then his role has expanded to include advancing UH's innovation of all kinds — from health tech to the arts — as vice president of energy and innovation at UH. In his role, he oversees the UH Technology Bridge, a lab and coworking space for tenants just a short drive away from UH's main campus, as well as future plans, like a new central campus hub for innovation that's in its early stages of development.

"What we really need at the university today is to bring innovation — which tech transfer is a piece of — and connect that to real-world challenges to deliver what the world needs, which is talented folks delivering new innovative, entrepreneurial, or intrapreneurial programs," Krishnamoorti says on this week's episode of the Houston Innovators Podcast. Continue reading.

Episode 193 - Innovating in the East End - Erik Ibarra of Magnolia Fund and ORDRS

Erik Ibarra's latest venture is to give agency to residents in the neighborhood he grew up in. Photo courtesy

Innovation isn't always tinkering with tech or programming software, although serial entrepreneur Erik Ibarra knows that world well. Sometimes it's about rethinking how a community improves and develops without doing the residents a disservice.

That's why Ibarra started Magnolia Fund, a mission-driven investment fund dedicated to enriching the East End community and preserving the neighborhood's culture and history. Ibarra, who has lived in the area the majority of his life, says on the Houston Innovators Podcast, that he's looking to turn residents into investors.

"Our investors from the neighborhood, today they walk around and look at their house and say, 'I own that,' and that's great," Ibarra says. "In the future, our investors should be able to say that, and then point to a building and say, 'I own a portion of that building too. And I helped that small business over there.'" Continue reading.


Episode 198 - The undeniable impact of AI - Anshumali Shrivastava of ThirdAI CorpEpisode 198 - The undeniable impact of AI - Anshumali Shrivastava of ThirdAI Corp

Anshumali Shrivastava joins the Houston Innovators Podcast to share the revolutionary work ThirdAI is doing for artificial intelligence. Photo via rice.edu

Anshumali Shrivastava's career has evolved alongside the rise of artificial intelligence. Now, he believes his company represents the future of the industry's widespread implementation.

Shrivastava, who's also a professor at Rice University, founded ThirdAI, pronounced "third eye," in 2021 to democratize artificial intelligence through software innovations. As Shrivastava explains on the Houston Innovators Podcast, AI processes have historically been run on larger, less accessible computing hardware. ThirdAI's tools are able to run on a regular central processing unit, or CPU, rather than the more powerful graphics processing unit, or GPU.

"We focus on the problems that people are facing in the current AI ecosystem," Shrivastava says on the podcast. "Right now, if you are to build some of the large-language models and (linear programming) models, you need a lot of computing power, dedicated engineers to move it, and, even if you are using fully managed services, it's costly and there are a lot of privacy implications because you have to move data around." Continue reading.


Episode 212 - The 'frivolous' lawsuit over DEI funding - Carolyn Rodz and Elizabeth Gore of Hello Alice

Hello Alice Co-Founders Carolyn Rodz and Elizabeth Gore join the Houston Innovators Podcast to discuss the lawsuit they're facing. Photo courtesy Cayce Clifford/Hello Alice

For years, Hello Alice has been helping small businesses across the country get equitable access to funding and support. Now, the Houston tech company is facing its own obstacle: An affirmative action lawsuit.

"I don't think in a million years that we ever expected anything like this," Elizabeth Gore, co-founder and president of Hello Alice, says on the Houston Innovators Podcast. "There's surprise, then there's fear, and then there's anger. But now on the other side of it, we're emboldened, confident, and more passionate than ever."

America First Legal's lawsuit against Hello Alice and its partner, Progressive Insurance, alleges that their program to award10 $25,000 grants to Black-owned small businesses constitutes racial discrimination. AFL was founded by former Trump Administration adviser Stephen Miller and features a handful of other former White House officials on its board. Continue reading.

This week's roundup of Houston innovators includes Carolyn Rodz and Elizabeth Gore of Hello Alice and Kelly McCormick of UH. Photos courtesy

3 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries recently making headlines in Houston innovation.

Carolyn Rodz and Elizabeth Gore, co-founders of Hello Alice

Hello Alice Co-Founders Carolyn Rodz and Elizabeth Gore join the Houston Innovators Podcast to discuss the lawsuit they're facing. Photo courtesy Cayce Clifford/Hello Alice

For years, Hello Alice has been helping small businesses across the country get equitable access to funding and support. Now, the Houston tech company is facing its own obstacle: An affirmative action lawsuit.

"I don't think in a million years that we ever expected anything like this," Elizabeth Gore, co-founder and president of Hello Alice, says on the Houston Innovators Podcast. "There's surprise, then there's fear, and then there's anger. But now on the other side of it, we're emboldened, confident, and more passionate than ever."

America First Legal's lawsuit against Hello Alice and its partner, Progressive Insurance, alleges that their program to award10 $25,000 grants to Black-owned small businesses constitutes racial discrimination. AFL was founded by former Trump Administration adviser Stephen Miller and features a handful of other former White House officials on its board. Read more.

Kelly McCormick, professor at University of Houston's C.T. Bauer College of Business

UH Professor Kelly McCormick is shaking things up with a new class — on Taylor Swift. Photo via UH.edu

This spring, University of Houston business students can enroll in “The Entrepreneurial Genius of Taylor Swift,” the new class is part of the curriculum at coming to the C. T. Bauer College of Business at the University of Houston. Swfities who’re super “ready for it,” however, can get a jump on enrollment now.

“You definitely don’t have to be a hardcore fan — a Swiftie — to learn and appreciate the entrepreneurial genius that has made Taylor Swift an international phenomenon,” notes Kelly McCormick, the Professor of Practice leading the course, citing Swift’s expertise in marketing, fan engagement, community building, and brand strategies.Read more.

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

California-based healthcare co. expands to Houston with new bioskills lab

med skills

Axis Research & Technologies, a California-based healthcare innovation solutions and medical research company, has expanded into the Houston area via a new 10,800-square-foot bioskills lab in Shenandoah last month.

The facility includes a main lab that’s configurable into a single space with over 20 stations, two more lab suites for specialized bioskills training, a conference room for presentations and a large multipurpose area.

Medical professionals can simulate a fully functional operating room in the lab for training and education. It also has the capability of handling cadaver specimens.

The company says the new facility aims to serve surgeons, medical device companies, hospitals and research institutions.

Axis was attracted to Houston thanks to the Texas Medical Center and other world-class medical groups, according to a release from the company. The facility in Shenandoah will be near medical facilities in The Woodlands.

“We are thrilled to expand into the Houston market,” Jill Goodwin, COO of Axis, said in a news release. “This new facility was driven by demand from our clients who have expressed a need for a high-quality bioskills lab in Houston. We repeatedly heard this feedback at the most recent American Academy of Orthopaedic Surgeons (AAOS) conference, which reinforced our decision to bring Axis to the region.”

Axis hosted its first lab event at its Houston-area venue on Feb. 22. The facility is currently accepting bookings for medical trainings, research collaborations and use of its bioskills lab.

“Our goal is to create an environment where groundbreaking medical advancements can take place,” Goodwin added in a news release. “Houston is home to one of the largest medical communities in the country, making it a perfect fit for our expansion.”

Axis' other bioskills labs are located in Nasvhille; Irvine, California; and Columbia, Maryland.

Texas institute grants $12M to bring leading cancer researchers to Houston

cha-ching

Rice University has recruited a prominent Swedish cancer researcher thanks to a $6 million grant from the Cancer Prevention and Research Institute of Texas.

It’s among $68 million in research grants recently awarded by the state agency, and six recruitment grants totaling $16 million to bring leading cancer researchers to Texas.

A news release from the Cancer Prevention and Research Institute of Texas (CPRIT) describes Pernilla Wittung-Stafshede of the Chalmers University of Technology in Gothenburg, Sweden, as “an accomplished and highly gifted biophysical scientist tackling complicated biological questions regarding the role of metals and metal dysregulation in various diseases. She pioneered a new research field around the role of metal ions in the folding and function of metalloproteins.”

Metalloproteins account for nearly half of all proteins in biology, according to the National Institutes of Health. They “catalyze some of the most difficult and yet important functions in [nature], such as photosynthesis and water oxidation,” the federal agency says.

Wittung-Stafshede, a professor of chemical biology and life sciences at Chalmers, is a former professor at Rice.

Aside from the money for Wittung-Stafshede, Houston recruitment grants also went to:

  • University of Texas M.D. Anderson Cancer Center: $2 million to recruit Rosalie Griffin of the Mayo Clinic
  • Baylor College of Medicine: $2 million to recruit Dr. Nipun Verma of the Yale University School of Medicine
  • Baylor College of Medicine: $2 million to recruit Xin “Daniel” Gao of Harvard University and the Massachusetts Institute of Technology

In Houston, cancer research grants were given to:

  • Baylor College of Medicine: $7.8 million
  • M.D. Anderson Cancer Center: $20.7 million
  • Rice University: $ 1 million
  • University of Houston: $1.2 million
  • University of Texas Health Science Center at Houston: $4.5 million

“The awards … represent the depth and diversity of CPRIT funding for cancer research in Texas,” says Kristen Doyle, CEO of CPRIT. “These grants develop new approaches to preventing, diagnosing, treating, and surviving cancer for all Texans.”

See the full list of awards here.