3 Houston innovators to know this week

Who's who

This week's innovators to know are all tech entrepreneurs with big ideas. Courtesy photos

From the science of love to confusing cryptocurrency, this week's Houston innovators to know are dabbling in some interesting industries to say the least.

Corey Allen, founder of Ecotone and treasurer of the Greater Houston LGBT Chamber

Corey Allen had entrepreneurialism in his blood — but it wasn't until he got involved with the Greater Houston LGBT Chamber that he got the courage to break out on his own. Courtesy of Corey Allen

This week's Pride Month feature is Corey Allen, who has an amazing storing into entrepreneurialism. He found confidence and encouragement from joining the LGBT chamber and started his own business. Now, he helps lead the organization as treasurer. Click here to read his Q&A with InnovationMap.

Brittany Barreto, CEO and co-founder of WeHaveChemistry

Brittany Barreto has expanded her DNA dating technology to a compatibility company named We Have Chemistry. Courtesy of WeHaveChemistry

As Brittany Barreto was working to use science to find singles love, she fielded many requests from couples who wanted in on the DNA compatibility tool she created. The requests kept coming in and now, Barreto has pivoted her dating app, Pheramor, to a new compatibility concept called WeHaveChemistry. Click here to read the full story.

Spencer Randall, principal and co-founder of CryptoEQ

Cryptocurrency doesn't have to be a big, confusing risk with this Houston startup's technology. Courtesy of CryptoEQ

Spencer Randall, through his new company CryptoEQ, wants to simplify ratings and analysis in cryptocurrency, which historically has been confusing and approachable to most. With the company's beta now live, Randall hopes that those not familiar with cryptocurrency will be able to use the platform as a learning tool. The platform takes information on trending cryptocurrency and boils it down into three columns — rating, technical analysis and trend analysis — in order for users to know when to buy or sell. Read the full story here.

Corey Allen had entrepreneurialism in his blood — but it wasn't until he got involved with the Greater Houston LGBT Chamber that he got the courage to break out on his own. Courtesy of Corey Allen

Houston entrepreneur explains how he's seen the city's LGBT and innovation communities evolve

Featured Innovator

Corey Allen grew up surrounded by entrepreneurship. His family owned several small businesses when he was growing up. But it took the support of his community to push him toward leadership.

From working in an accounting firm to dabbling in a few oil and gas companies, Allen's career trajectory changed when he joined the Greater Houston LGBT Chamber of Commerce. Within the organization, for which he serves as treasurer, he met other motivated entrepreneurs and was given the support needed to open his own business, Ecotone.

Allen spoke with InnovationMap about his career and the importance of the LGBTQ community in entrepreneurship.

InnovationMap: How does Houston differ from other cities in the U.S. in terms of technology and entrepreneurship? What makes Houston different?

Corey Allen: I think everybody does default to Austin, right? People believe that that's the only technology hub in Texas. Houston is new and different from other cities in terms of tech and entrepreneurship, right now especially. In creating three local startups, we experienced tremendous support from well-established groups like the Greater Houston Partnership, the city of Houston with the Mayor's entrepreneurship program, the Greater Houston Chamber of Commerce. But, you know, what I think what is really new especially for Texas, within in Houston, is the local coworking spaces that are globally recognized brands and the coding camps. I think that is what is creating the infrastructure and ecosystem that we've been talking about for the last five years at least. I think that compared to other cities in the U.S., I don't see that type of energy and that type of investment being created in Houston right now.

IM: You mentioned a little bit about being involved in the process of creating three local startups. What makes Houston the right place to be involved in the startup culture that’s cultivating right now?

CA: I think there's two things that come to mind. Houston really is home, and it's always been home for me. And it really is a big, small town. I came from a small town in Texas, about halfway between Houston and Dallas, and our family always navigated to Houston for fun, but also for business. It was really the foundation for my own family, and I think what we get out of Houston is that southern hospitality is a real thing. So, that's certainly the first thing. And the second is that Houston has the foundation for a prosperous ecosystem. Obviously, there's a lot of oil and gas and the Texas Medical Center is already globally recognized. The more that we continue to focus on venture capital and innovation, which is what is wanted and needed right now, Houston is creating our own new technology and entrepreneurship to capture everybody's attention.

IM: What are some of the ways the tech and innovation community support their LGBTQ colleagues throughout the month of June?

Yeah, I love this question. I think it goes without saying for the community to come out and support the LGBTQ community by joining the chamber of commerce. Also, attending our second annual Pride in Business, which is June 28. That's been an outstanding event for all of the businesses in the community to be involved in the LGBT community. In three years time, (the Greater Houston LGBT Chamber) has been growing exponentially to over 125 visible members. And we have corporate partnerships that really speak to the impact that is being made in the community and in Houston. We have corporate partners like Shell and United. And also celebrate and attend the Houston Pride Parade, which is on June 22.

IM: What advice do you have for up-and-coming lgbtq entrepreneurs?

CA: The learning is the action. I used to really be annoyed by the phrase "sell faster." I actually live that now. You can't fail until you act, and now I know that you can't compete until you fail.

IM: That's great advice right there. What does pride month mean to you?

CA: It's very personal, and it hits home. My partner and I are going to be celebrating 19 years together in September, and I think that pride means celebrating a history that we don't stop to think about everyday. We were at a chamber meeting recently, and a member was sharing her experience of walking in the second pride parade. And she said that it wasn't the same. Even the police at the time did not protect the community. And that's a big difference from today. And I think anybody that goes out to the pride parade this year, I want them to know they're safe. And you know, I think that that's what we have to be thankful for today is to know that we can love without constant fear. It really just reminds us that we're not going to let anyone take that away again.

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Portions of this interview have been edited.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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