3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Zimri Hinshaw of BUCHA BIO, Kelly Klein of Easter Seals of Greater Houston, ad John Mooz of Hines. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from esports to biomaterials — recently making headlines in Houston innovation.

Zimri Hinshaw, CEO of BUCHA BIO

Zimri T. Hinshaw, CEO of BUCHA BIO, joins the Houston Innovators Podcast to discuss how he's planning to scale his biomaterials startup to reduce plastic waste. Photo courtesy of BUCHA BIO

After raising a seed round of funding, BUCHA BIO is gearing up to move into its new facility. The biomaterials company was founded in New York City in 2020, but CEO Zimri T. Hinshaw shares how he started looking for a new headquarters for the company — one that was more affordable, had a solid talent pool, and offered a better quality of life for employees. He narrowed it down from over 20 cities to two — San Diego and Houston — before ultimately deciding on the Bayou City.

Since officially relocating, Hinshaw says he's fully committed to the city's innovation ecosystem. BUCHA BIO has a presence at the University of Houston, Greentown Labs, and the East End Maker Hub — where the startup is building out a new space to fit the growing team.

"By the end of this month, our laboratories will be up and running, we'll have office space adjacent, as well as chemical storage," Hinshaw says on the Houston Innovators Podcast. Listen to the episode and read more.

Kelly Klein, development director of Easter Seals Greater Houston

A nonprofit organization has rolled out an esports platform and event to raise awareness and funding for those with disabilities. Photo via Easter Seals

For many video games is getaway from reality, but for those with disabilities — thanks to a nonprofit organization —gaming can mean a lot more. On Saturday Dec. 3 — International Day of Persons with Disabilities — from 1 to 9 pm, Easter Seals Greater Houston will be joining forces with ES Gaming for the inaugural Game4Access Streamathon.

Gaming helps enhance cognitive skills, motor skills, improve mental well-being, and can help reduce feelings of social isolation due to the interactive nature of playing with others.

“This is really a unique way for (people) to form a community without having to leave their house, and being part of an inclusive environment,” says Kelly Klein, development director of Easter Seals Greater Houston. ”The adaptive equipment and specialized technology just does so many miraculous things for people with disabilities on so many levels — not just gaming. With gaming, it is an entrance into a whole new world.” Read more.

John Mooz, senior managing director at Hines

Levit Green has announced its latest to-be tenant. Photo courtesy

Levit Green, a 53-acre mixed-use life science district next to the Texas Medical Center and expected to deliver this year, has leased approximately 10,000 square feet of commercial lab and office space to Sino Biological Inc. The Bejing-based company is an international reagent supplier and service provider. Houston-based real estate investor, development, and property manager Hines announced the new lease in partnership with 2ML Real Estate Interests and Harrison Street.

“Levit Green was meticulously designed to provide best-in-class life science space that can accommodate a multitude of uses. Welcoming Sino Biological is a testament to the market need for sophisticated, flexible space that allows diversified firms to perform a variety of research,” says John Mooz, senior managing director at Hines, in a press release. “Sino is an excellent addition to the district’s growing life science ecosystem, and we look forward to supporting their continued growth and success.” Read more.Read more.

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A nonprofit organization has rolled out an esports platform and event to raise awareness and funding for those with disabilities. Photo via Getty Images

Houston nonprofit facilitates gaming for a good cause

esports for charity

For many video games is getaway from reality, but for those with disabilities — thanks to a nonprofit organization —gaming can mean a lot more.

On Saturday Dec. 3 from 1 to 9 pm, Easter Seals Greater Houston will be joining forces with ES Gaming for the inaugural Game4Access Streamathon.

The streamathon will be held on International Day of Persons with Disabilities, and feature ESG Ambassador Gamers from the Houston area and nationally gaming, interacting with special celebrity guests, and opportunities for audience participation and shoutouts – all while supporting a good cause. The event will take place on popular streaming platform Twitch.

Gaming helps enhance cognitive skills, motor skills, improve mental well-being, and can help reduce feelings of social isolation due to the interactive nature of playing with others.

“This is really a unique way for (people) to form a community without having to leave their house, and being part of an inclusive environment,” says Kelly Klein, development director of Easter Seals Greater Houston. ”The adaptive equipment and specialized technology just does so many miraculous things for people with disabilities on so many levels — not just gaming. With gaming, it is an entrance into a whole new world.”

Easter Seals is the seventh-largest nonprofit and largest disability service organization in the United States, and helps 1.5 million people per year. ES Gaming was established to create a new standard for equity and inclusion among gamers, and hopes to add to its community building with more tournaments and charity streams. According to the organization, a gaming scholarship program is expected to launch sometime in 2023.

According to ES Gaming, 64 percent of people with disabilities play video games, and 60 percent of disabled gamers play casual games for more than 5 hours per week. Technology has been at the forefront of trying to bridge the developmental gaps with those with disabilities of all kinds.

“The advancements we’ve made over the last 25 years (in technology) ending with the iPad, and everything in between has really made it a level playing field not just for gaming, but for employment and everything,” Klein tells InnovationMap.

This tech giant is extending access to the internet for those who need it. Photo courtesy of Comcast

Comcast deploys $1M in Houston to shrink digital divide

access for all

Global Internet service provider, Comcast, is investing more than $1 million locally to help give families in the Houston region an opportunity to thrive in the digital age.

The funds are aimed to help students, adults and people with disabilities to ‘level up’ their computer, career development and tech education skills. The million-dollar investment will also support ongoing efforts to build awareness about low-cost or no-cost connectivity programs like Internet Essentials and the federal government’s Affordable Connectivity Program.

“The Internet is where life happens. It allows students to expand their educational aspirations and it empowers parents to explore better job openings so they can ultimately deliver a better quality of life for their families,” says Ralph Martinez, Comcast Houston’s regional senior vice president. “We are passionate about doing our part to close the digital divide and committed to helping establish a more equitable foundation for learning, working and succeeding.”

This effort is part of the company’s $1 billion, decade-long commitment to expand access to the internet across the world and open doors for the next generation of innovators, entrepreneurs, storytellers and creators.

In December 2021, Comcast donated funds to support local diversity-focused non-profit, SERJobs.

So far, Comcast has given grants to eight Houston area organizations. More announcements will be made later this year, according to the company’s press release.

  • United Way | Funding will be used to provide tech experts (Digital Navigators) to help people in need of digital skills training.
  • BakerRipley | Funding will support computer skills, software, email and internet safety training for low-income adults in the Houston area.
  • Comp-U-Dopt | Funding will support students participating in Early Adopters, STEAM Team and Learn2Earn, which brings technology education to area youth. Comp-U-Dopt will also use the funding to provide tech experts (Digital Navigators) to help people in need of digital skills training.
  • Easter Seals of Greater Houston | Funding will support the development of a curriculum for people with disabilities to help them successfully learn to use digital technology to gain and maintain employment
  • The Boys and Girls Club of Greater Houston | Funding will help high school students gain technical and leadership skills through the Workforce Readiness Program.
  • AAMA | Funding will be used to purchase technology and equipment to support students through the training program at the Work and Learn Center, with an emphasis on digital literacy and design.
  • Dress for Success | Funding will be used to provide Houston-area women with the resources needed to obtain long-term employment through access to job readiness training, digital skills workshops, computers and mobile labs.
  • AVANCE-Houston | Funding will support adult literacy program and continue to build pathways to economic mobility for families in the community.
The Easter Seals of Houston demonstrated new vision control technology from Comcast. Photo courtesy of Easter Seals

Houston nonprofit tests Comcast's new vision control technology for viewers with disabilities

tech for good

A local nonprofit organization has tapped into new technology from Comcast to benefit the community of people with visual disabilities and impairments.

In November 2014, the company announced the industry's first voice-enabled television user interface, a solution that allowed those who are blind or visually impaired to navigate the platform. In May 2015, Comcast announced the Xfinity remote with voice control. Later that same year, the company produced the first live entertainment show in U.S. broadcast history to be accessible to people with visual disabilities.

Continuing on this track of innovation, in June 2019, the company announced eye control for television. Any Xfinity user can now change the channel, set a recording, and search for a show using eye movement, working seamlessly with existing eye gaze hardware and software.

The Easter Seals Greater Houston demonstrated the new technology with their community, posted on the its YouTube page. The demonstration showcased the web-based remote for tablets and computers that pairs with an eye gaze system allowing viewers to control their smart TV.

"While eye gaze technology has existed for quite some time, last summer Comcast launched the Xfinity X1 eye control, which is a web-based TV remote for tablets and computers that pairs with an existing eye gaze system," says Cristen Reat, founder and program director of Easter Seals' BridgingApps. "This feature allows people with physical disabilities, such as Cerebral Palsy, ALS, and spinal cord injuries the ability to change the channel, set a recording and search for a favorite TV show with just their eyes."

Reat tells InnovationMap that most people who have significant physical disabilities are also nonverbal or have nonstandard speech, making a voice remote not a possibility.

"Now, with this new feature, they can do things without relying on a caregiver," says Reat.

The Comcast website states that X1 eye control is free and uses a web page remote control that works seamlessly with existing eye gaze hardware and software, Sip-and-Puff switches, and other existing assistive technologies. To use eye control, Xfinity customers can visit xfin.tv/access and use their Xfinity login credentials to pair the web-based remote with their set-top-box. Then, each time the customer gazes at a button, the web-based remote will send the corresponding command to the television.

"The response from clients we have demonstrated this with has been ecstatic," says Reat. "Something as simple as being able to change the channel independently, without relying on another person's help, can be life-changing."

Reat tells InnovationMap that Comcast and Easter Seals have collaborated in the past.

"We've been great partners, especially over the past few years," says Reat. "Because of that partnership, they reached out to us when they wanted to create awareness about this new feature."

"Changing the channel on a TV is something most of us take for granted but until now, it was a near-impossible task for millions of viewers," says Tom Wlodkowski, vice president of accessibility at Comcast in the product launch news release. "When you make a product more inclusive you create a better experience for everyone and we're hoping our new X1 feature makes a real difference in the lives of our customers."

BridgingApps, a program backed by Easter Seals of Greater Houston, uses technology like iPads to help provide services for children and adults with disabilities — as well as for veterans — and their families. Courtesy of BridgingApps

Houston nonprofit optimizes technology for special needs treatment and diagnoses

Using tech for good

When the first iPad was released in April of 2010, tech accessibility changed in more ways than mobile checkouts or on-the-go streaming.

The interface of the device is built around the multi-touch screen, which became a game changing component in special needs therapy and sparked the founding of BridgingApps, a program part of Easter Seals Greater Houston.

The program provides access to educational and therapeutic tools to parents, teachers, and therapists to use these mobile devices and apps to target and improve cognitive and physical development in children and adults with disabilities.

"I am the parent of a child with multiple disabilities; my son was born with Down syndrome," says Cristen Reat, co-founder and program director at BridgingApps.

Reat tells InnovationMap that she helped start a support group in a therapy clinic where many parents were interested about why mobile devices and apps were so engaging to their children.

"We were just amazed about how our children with different types of disabilities were engaged with the devices, were able to communicate with the devices, and were making big strides in their therapy," says Reat.

BridgingApps was founded by Reat and Sami Rahman in 2010, both seeking to help their children grow. The program became a part of Easter Seals of Greater Houston in 2011. The website currently boasts over 3,000 apps which users can sort through by category, age, price, skill, grade level, mobile device, and more. The apps are also able to benefit and treat veterans and their families.

"I was amazed at how quickly my son was able to do things independently with these touch screens that he was not able to do with traditional computers," Reat tells InnovationMap.

The Easter Seals Greater Houston organization was recently awarded a $15,000 grant from the Comcast Foundation as part of the Comcast NBCUniversal Assistive Technology Grant Fund, expand the available equipment used in the community technology labs with new equipment such as the TobiiDynavox EyeMobile Mini Classic Eye Gaze system that includes new software called Look To Learn and SnapCore First, and the AbleNet Latitude Mounting Arm that holds an iPad, Kindle, or other tablet and mounts to beds, wheelchairs, and tabletops.

The nonprofit offers three assistive technology services labs across the Houston area, in Bellaire, the Woodlands, and Stafford. According to the website, each lab has open lab days that the public can access without an appointment to explore a variety of assistive technology, including adapted toys and switches, specialized software and computer equipment, communication devices, and mobile devices and apps. Workshops and trainings are also available.

"The whole idea of BridgingApps is a shortcut, so that you don't have to Google search every day," says Reat. "It's basically the Yelp of special needs apps where you can type in a diagnosis, a skill, something you're looking for, and you'll come up with a video, instructions, and summary that helps people figure out what can help them today."

The organization was also awarded a $75,000 grant by Blue Cross and Blue Shield of Texas, which, according to a news release, will help the nonprofit serve 50 individuals that are veterans and or current military as well as their family members through services such as digital trainings through app reviews and videos, face-to-face counseling and counseling via tele-health, especially for those without transportation or living in rural areas.

BridgingApps currently has a team of two full-time and seven part-time employees. The nonprofit hosts an annual fundraiser each Spring called Walk With Me. The next walk is scheduled for April 25 at the Houston Zoo.
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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

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