The Houston Angel Network's investors heard from growing startups in their portfolio — along with a few prospects. Getty Images

The Houston Angel Network checked in with their investors and portfolio companies at their biannual Houston Angel Summit that gathered HAN members, local investors, and startup founders for a day full of educational opportunities, pitches, and fireside chats.

The event, which took place last week at Rice University's Liu Idea Lab for Innovation and Entrepreneurship, featured 11 startups – both new and more familiar to HAN members – pitching their growing companies in hopes of catching the interest of potential investors.

BioMedical Music Solutions

Austin-based BioMedical Music Solutions has a SaaS platform that uses artificial intelligence and music to accelerate rehabilitation at a lower cost. Founder Hope Young explained her years-proven therapy can work its magic in one-third of the time and one-tenth of the cost of traditional physical therapy sessions.

Optelos

Houston-based Optelos has a patented SaaS solution that can transform physical asset images, videos, and documents into what's known as a "Digital Inspection Twin" that can enabling knowledge workers utilizing our unified data management, reality modeling, and in-process artificial intelligence solution, to digitally visualize, analyze and manage their entire asset base.

Pocket Naloxone

Maryland-based Pocket Naloxone is attempting to solve the opioid crisis. The company has a portfolio of over-the-counter drug overdose reversal agents, including a naloxone OTC product.

AI Driller

Houston-based AI Driller is using mathematic algorithms to apply automation on rigs for drilling. The startup can also offer its clients real-time data and cuts out the opportunity for human error.

Cavu Biotherapies

Houston pet immunotherapy company, Cavu Biotherapies, has seen a tremendous amount of growth and is now a treatment partner at 43 clinic providers in 18 states and Canada. Founder Colleen O'Connor says she's seen a near 600 percent growth in revenue over the past year and treated 38 dog cancer patients in that timeframe.

CorInnova

Another Houston company, CorInnova, has created a device from a soft, flexible material that can be easily inserted through a 1-inch incision, and then be used for increase blood pumping in the heart by 50 percent.

Hive Genie

Houston-based Hive Genie is using technology to help beekeepers optimize their pollination operations and monitor hive operations remotely. Gone are the days, Hive Genie hopes, that beekeepers need to suit up to track and maintain their colonies physically.

Siera AI

Austin-based Siera AI is using its AI-enabled cloud IoT platform for logistics solutions and safety improvements in warehouse settings. A goal of the company's, according to its website, is to free humans from these types of dull, dangerous, dirty tasks.

Skycom

The sky's not even the limit for Austin-based Skycom and its airship technology that supplies low-cost cell towers in orbit. The technology can bring down the cost of mobile service providers and allow for growth into new markets.

Tevido

Another Austin company, Tevido uses a pigment cell graft process to use patients' own skin cells to restore normal skin color for patients with vitiligo and pale scars.

Tot Squad

Los Angeles-based Tot Squad emerged as a service-focused company for baby-related tasks and now has emerged as a digital marketplace connecting service providers online to parents and to-be parents for needs like stroller cleaning or carseat installation.

Four Houston companies showed the city what they're made of at TMCx's recent Demo Day. Courtesy of TMCx

Houston-based medical device companies pitch at TMCx Demo Day

Local legends

Earlier this month, 16 medical device companies wrapped up their time at the Texas Medical Center's accelerator program and pitched their companies to fellow health professionals, guests, and more. While each made important connections in the local ecosystem during the program, a quarter of the entrepreneurs had roots in Houston already.

Four of the 16 TMCx09 companies that are headquartered in Houston. They have built solutions within sepsis, surgery, and transplant spaces in health care. Here's a little more about the homegrown companies that pitched at the event.

CorInnova

Photo via corinnova.com

The standard practice for acute heart failure patients is very invasive, says William Altman, CEO of CorInnova.

"The problem with existing devices is that they have invasive blood contact," Altman says. "Problem with that is blood contact is bad. It can cause up to 15 percent rate of stroke, which could kill you, and after five to seven days it provides 10 percent rate of blood destruction and has a 47 percent rate of kidney disfunction."

CorInnova's technology features a device that can be easily inserted through a 1-inch incision, and then be used for increase blood pumping by 50 percent.

"Surgeons tell us this is less invasive than minimally invasive aortic valve replacement, which is a widely done surgery, so this promises widespread adoption for our technology as we get it approved," Altman says.

The human prototype is expected to be ready in two years, with the next year being focused on animal studies. CorInnova is raising $12 million to accomplish its goals.

Ictero Medical

Getty Images

An estimated 10 to 15 percent of the United States population will get a gallstone in their lifetime. Should one of those stones cause trouble or blockages, the only solution is to remove the gallbladder completely through surgery. However, Matthew Nojoomi, CEO and co-founder of Ictero Medical, has another idea.

Ictero Medical has created a minimally invasive treatment that uses cryoablation to defunctionize the gallbladder without having to remove it.

"The CholeSafe System not only treats the source of the disease, but it leverages existing clinical workflows that doctors use to access the gallbladder," says Nojoomi, adding that the process only uses mild station and pain control.

The company expects to get to humans in the next two years, and has launched a financing round.

PATH EX

path ex

Photo via tmc.com

Currently, sepsis is hard to identify in patience. Even if a patient is in a hospital, and that hospital knows the patient has sepsis, the individual still has a 38 percent chance of dying, says Sinead Miller, CEO of PATH EX.

"Right now the problems associated with sepsis are very clear," she says. "It's the leading cause of death in our ICUs, and it's also associated with the highest hospital cost and readmission rates."

PATH EX's technology allows medical professionals to better diagnose and treat sepsis. The PATH EX therapeutic device can be hooked up to a patient and flow his or her blood through the machine to capture bacteria, clean and recirculate the blood, and faster diagnose what sort of bacteria the patient has attracted. The device technology is similar to hemo hemodialysis, Miller explains.

The Houston company, which recently won big at the Ignite Healthcare Network's Fire Pitch Competition, was named an honoree within the Johnson and Johnson Breakthrough Medical Technologies Quickfire Challenge.

The company was recently received clearance from the Food and Drug Administration as a breakthrough device technology. PATH EX closed its $615,000 seed round — with plans for a series A next year — and has received $1 million in SBIR grant funding. The company was founded two years ago, and relocated to call Houston HQ this year.

Volumetric

Jordan Miller/Rice University

Volumetric is banking on their technology being among the inventions that will lead the medical industry into the future. The human tissue-printing technology company has created the 3D printer and the "ink" that can create whole organs for transplant.

"We can create complicated vascular architectures inside of soft water-based gels, in this case, mimicking the structure and function of human lung tissue," says Jordan Miller, CEO. "We can oxygenate red blood cells."

The company is commercializing its technology and has three streams of revenue, which as generated almost $1 million in revenue in Volumetric's second year. The company is also in the process of closing its seed round of fundraising.

Earlier this year, the startup, which works out of Rice University, was featured on the cover of Science magazine.

Here's what life science startups were named most promising at the recent Rice Alliance Texas Life Science Forum.. Getty Images

Rice Alliance names most promising life science companies at annual forum

Best of the best

Houston hosted an annual meeting of the minds that included thoughtful discussions, presentations, panels, and startup pitches within the life science industry.

The Texas Life Science Forum, organized and hosted by the Rice Alliance and BioHouston, took place on November 6 at Rice University's Bioscience Research Collaborative. Throughout the day, over 50 life science startups pitched to the audience. At the end of the forum, 10 startups — most of which are based in Houston — were recognized as being the most promising.

Here's what life science startups you should be keeping an eye out for.

Abilitech Medical

abilitech

Photo via abilitechmedical.com

A St. Paul, Minnisota-based medical device company, Abilitech Medical develops assistive technology to Multiple sclerosis, Muscular Dystrophy, Parkinson's and stroke patients. The first product, Alibitech Assist, will be cleared by the FDA in 2020, with other devices to follow in 2022 and 2023.

AgilVax

agilvax

Photo via agilvax.com

Based in Albuquerque, New Mexico, AgilVax is a biopharmaceutical company that works with chemotherapy, checkpoint and KRAS inhibitors to fight various cancers. The company's AX09 is an immunotherapeutic that is headed for human clinical trials in 2020. Another product, M5, is a monoclonal antibody currently in preclinical trials.

Altoida

altoida

Photo via altoida.com

Altoida, based in Houston, has created a medical device that uses artificial intelligence and augmented reality to collect functional and cognitive data in patients to determine their risk Mild Cognitive Impairment from Alzheimer's Disease. The Altoida Neuro Motor Index has been cleared by the FDA and CE and detects cognitive decline with a 94 percent diagnostic accuracy six to 10 years ahead of the onset of symptoms.

ColubrisMX

Photo via Pexels

Houston-based ColubrisMX makes surgical robots specializing in minimally invasive and endoluminal surgeries. The company's team of engineers and surgeons works adjacent to the Texas Medical Center.

Cord Blood Plus

stem cell

Photo via Getty Images

Cord Blood Plus, based in Galveston, is working to commercialize its human umbilical cord blood stem cell technology. The company's primary mission is to use its research and treatment on breast cancer patients undergoing chemotherapy in order to prevent infections, speed up recovery, and shorten hospital stays.

CorInnova

CorInnova

Photo via CorInnova.com

Another Houston company, CorInnova is a medical device company that has developed a cardiac assist device to treat heart failure without many of the consequences from standard treatment. The device is able to self expand and gently compress the heart in sync with the heartbeat.

Mesogen

mesogen

Photo via Mesogen.com

Mesogen, which is based in The Woodlands, is in the business of using a patient's own cells to grow a human kidney for transplant. The tissue engineering technology allows for the creation of a kidney in less than a year with less risk of transplant rejection and a better quality of life over dialysis treatment.

Saranas

Courtesy of Saranas

Houston-based Saranas has created its Early Bird device to more quickly and more accurately detect bleeding in the human body. The company, which underwent successful clinical trials last year, recently received FDA clearance and launched the device in the United States.

Stream Biomedical

stream biomedical

Photo via streambiomedical.com

Stream Biomedical Inc. is tapping into a therapeutic protein that has proven to be neuroprotective and neuroreparative. The Houston company is aiming to apply the treatment in acute stroke cases and later for traumatic brain injury, Alzheimer's, and dementia cases.

VenoStent

Photo via venostent.com

Houston-based VenoStent has created a device that allows a successful stent implementation on the first try. VenoStent's SelfWrap is made from a shape-memory polymer that uses body heat to mold the stent into the vein-artery junction.

The next TMCx cohort begins August 5. Courtesy of TMC

TMCx announces its next medical device cohort with 5 startups hailing from Houston

Health tech

The Texas Medical Center's startup accelerator, TMCx, has added 19 companies from all around the world to join its medical device family.

The TMC Innovation Institute team narrowed down 140 applications to 40 for the second round of the process, which includes face-to-face interviews, according to a release. After those, 18 companies were selected to join the TMCx09 class, which focuses on medical devices. The last cohort, which specialized in digital health, concluded on June 6.

Out of the 18 companies, five are from Houston. Four other startups hail from other corners of the United States, while 10 international companies also made the cohort. The program commences on August 5, and will run for four months before concluding in a demo day event in November.

Here are the medical device startup companies joining the TMCx09 cohort.

See update at the bottom of this story.

Vascular devices

  • Neurescue (Copenhagen, Denmark) — Neurescue has developed a computer-aided aortic occlusion catheter to help save the lives of patients in the emergency care setting.
  • Venari Medical (Galway, Ireland) — Venari Medical is developing BioVena — a medical device that treats varicose veins and venous leg ulcers with a minimally invasive approach intended to reduce pain.
  • Obsidio (Solana Beach, California) — Obsidio is developing a universal gel embolic material to shrink lesions or to treat internal bleeds, aneurysms and vascular malformations.

Novel therapies

  • PATH EX (Houston) — PATH EX is developing an extracorporeal blood cleansing device designed to selectively remove pathogens, including multi-drug resistant bacteria, and endotoxins from circulating blood to diagnose and treat sepsis.
  • Innosphere (Hafia, Israel) — Innosphere is a medical device company developing brain stimulation solutions for treating cognitive disorders, with a focus on ADHD.

Rehab

  • AbiliTech (St. Paul, Minnesota) — AbiliTech is restoring independence to patients with upper limb neuromuscular conditions by offering a wearable assistive device that allows the user to perform independent activities of daily living.
  • Komodo OpenLab (Toronto, Ontario, Canada) — Komodo OpenLab has developed Tecla, an assistive device giving individuals with physical disabilities the ability to communicate, control, and connect with the world.

Surgery

  • CNX Medical (Houston) — CNX Medical is developing a transcutaneous neurostimulator that is placed in the ear and helps reduce inflammation after abdominal surgery, with a focus on post-operative ileus.
  • CorInnova (Houston) — CorInnova has developed a soft robotic non-blood contacting biventricular cardiac assist device for the treatment of heart failure that would eliminate the many adverse events associated with current technologies.
  • Ictero Medical (Houston) — Ictero Medical is developing a minimally invasive ablation solution to treat high-risk patients with gallstone disease and offer patients the benefits of surgery without the risk. The company was among the big winners at the Texas A&M New Ventures Competition.

Diagnostics

  • Artidis (Basel, Switzerland) — InArtidis has developed a nanomechanical biomarker technology using precise tissue measurement in combination with data analytics to personalize cancer diagnosis.
  • Inveox (Munich, Germany) — Inveox automates the pre-analytical process in cancer diagnosis to improve patient safety and lab efficiency.
  • Cambridge Respiratory Innovations Ltd. (Cambridge, United Kingdom) — CRiL has developed, N-Tidal, a device that analyzes CO2 end-tidal breathing to improve respiration monitoring.

Toward home health

  • Kegg (San Francisco) — Kegg is on a mission to simplify every woman's journey towards taking charge of her fertility with a user-friendly monitoring device.
  • TestCard (London) — TestCard is a flat pack urine test kit that functions in combination with a mobile phone application, turning a phone's camera into a clinical grade scanner.
  • Patch'd (New South Wales, Australia, and San Francisco) — Patch'd uses deep learning and wearable devices to predict the onset of sepsis in the at-home patient.

Transplant

  • Volumetric (Houston) — Volumetric's 3D bioprinting platform creates materials with living cells with applications in biomaterials, cancer research, and eventually human organ replacements. The company's technology started out of Rice University.
  • Tevosol (Edmonton, Alberta, Canada) — Tevasol is developing organ transplant transportation solutions. Their portable warm perfusion machines will help surgeons transplant more organs today and solve organ shortage tomorrow.

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Diagnostic Photonics withdrew from the program after the article published.

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Overheard: Master P shares his entrepreneurial advice at Houston Tech Rodeo kickoff

eavesdropping in Houston

Percy Miller developed his music career as Master P, but it's far from his only entrepreneurial endeavor. At Houston Exponential's kick-off event for the 2021 Houston Tech Rodeo, Miller took the virtual stage with Zack O'Malley Greenburg, a journalist and author.

In the discussion, Miller shared his experience in his many fields of entrepreneurship, including music, fashion, consumer packaged goods, and more. He focused on trusting your own hard work, surrounding yourself with a good support system, and embracing failure — something he's done throughout his career.

"I don't look at it as a loss. I look at it as a lesson. Every 'L' is a lesson," he says. "Every time I had a business fail, I learned something from it and it opened up a door into a future."

To hit the highlights from the fireside chat with Master P, check out some overheard moments below. To stream the full broadcast, click here.

“A music career only lasts 3 to 5 years at the most. … I started diversifying my portfolio and I looked at the tech side and said, ’This is where you got to be at.’”

Miller says he was out in the Bay Area in the '90s and early '00s, and he saw first hand the tech scene developing in Silicon Valley. He even released an album in 2005 called Ghetto Bill, a reference to Bill Gates.

“I have failed a lot — don’t be afraid to fail. Get out and take that chance on yourself.”

Miller's music career mirrors, in some ways, the dynamic path of a startup. He received a $10,000 investment from his grandparents and used it to launch his career.

"I created an empire with $10,000," he says.

But It wasn't always easy, and Miller remembers the hustle, selling his music from the trunk of his car, and his many failures.

“You have to be committed to what you do — and you have to love it. It never was about money. When you’re passionate about something, you have a purpose. You’ll get there. If you do it for money, you’ll probably never be successful.”

Passion is a key ingredient in the recipe for success, Miller explains. It drives accomplishment and, "if you get it that easy, you'll probably lose it even quicker," he continues.

“I have an entrepreneurial spirit — I have to learn everything about what I’m doing.”

When it came to developing his music career, Miller says he wore every different hat in the process because he knew he would work the hardest.

"For me, if I can be the talent and the person who runs the company, I feel like there's no limit," Miller says. "I knew I could depend on myself."

“Show me your friends, and I can show you your future.”

Miller started his own record label, No Limit Records, and it was here he cultivated an environment of artists who didn't just want to perform, get pampered, and hang out at the club.

"People at No Limit — it was like a university," he says. "Everybody was coming to study to not only learn how to be an artist but also learn entrepreneurship and financial literacy."

“Most people wanted that advanced check, that money upfront. But my thing was I wanted the control in the end. When you come from a poor culture, you look at things differently. At least I did.”

Miller says he learned this at a young age, that if you hold the power, you make the decisions. "I want better for my kids and the only way I am going to do that is by creating longevity where I own the largest percent of the company," he says.

“It’s all about economic empowerment — we’re stronger together.”

Miller says he's focused on product and taking over the grocery stores, as well as driving economic empowerment for other BIPOC-founded companies and putting money back into the community.

"I want to focus on other minority-owned companies and brands get their products on the shelves,' he says.

Experts: Houston can win in the energy transition — here's how

Guest column

President Joe Biden recently announced his 2030 goal for the United States to achieve a 50 percent reduction in greenhouse gas emissions from its 2005 levels. This announcement comes on the heels of the American Jobs Plan, a $2 trillion infrastructure and climate-response program which offers a host of energy- and climate change-related initiatives, including a plan to speed up the conversion of the country to carbon-free electricity generation by 2035.

To reach these goals, companies of all industries are looking to implement clean energy investments and practices and do so quickly. Perhaps more than any major city in America, Houston faces fundamental questions about its economy and its future in the global Energy Transition. Some 4,600 energy companies, including more than a dozen Fortune 500 companies, serve as the foundation of the city's economy.

While many of these are working in the renewables space, the vast majority are rooted in fossil fuels. Many in Houston have long been anticipating this move towards renewables, but the new executive position on emissions has brought renewed pressure on Houston to take action and put investments behind securing its position as the Energy Capital of the World.

Houston's energy transition status

There has been an uptick in Energy Transition activity in Houston over the past several years. Currently, Houston boasts at least 100 solar energy-related companies and 30 wind energy-related companies. Environmental Entrepreneurs ranked Houston seventh among the top 50 U.S. metro areas for clean energy employment in the fourth quarter of 2019, with 1.9 percent of all clean energy jobs in the U.S. In 2019, Houston had 56,155 clean energy jobs, up nearly 4 percent from 2018, according to E2. However, by comparison, there are roughly 250,000 fossil fuel jobs in the area. (S&P Global)


Many traditional oil and gas companies have embraced this change, pivoting to more sustainable and resilient energy solutions. Companies working in tangentially related industries, like finance, infrastructure and services, are beginning to understand their role in the Energy Transition as well.

The challenge

While the Bayou City's proximity to the bay and natural oil supply may have set the scene for Houston's Energy Capital Status, the same geographic advantages do not exist in this new renewable space. As many have already begun to realize – Houston companies must make a concerted and timely effort to expend their focus to include renewables.

Greater Houston Partnership recently launched a new initiative aimed at accelerating Houston's activity around energy transition, while existing committees will continue efforts to bring energy tech and renewable energy companies to Houston. This initiative will bolster Houston's smart city efforts, explore the policy dimensions of carbon capture, use, and storage, and advocate for legislation that helps ensure the Texas Gulf Coast is positioned as a leader in that technology.

The Partnership estimates the city has seen $3.7 billion dollars of cleantech venture funding in recent years. Still, the infrastructure and services sector of the Energy Transition is vastly underinvested in, especially when compared to the tens of billions in the more traditional sector.

The opportunity

Houston, and the energy markets specifically, have always been great at raising capital and deploying it. The energy companies and capital needed to support them will continue to be in Houston as the energy markets transition to renewable sources in addition to fossil fuels.

The job opportunities in Houston and new energy are going to be significant. Texas is well suited to fit these needs as the technical skillset from fossil fuels to renewables is highly transferable. Given the technical expertise needed to manage energy—whether it's oil, gas or renewables—Houston and Texas will always have the universities here that feed the technical skills needed in energy.

Houston has always done a great job at attracting energy companies and related businesses to move their headquarters here or open and office in the area. Additionally, offering proper training opportunities for both oil and gas and renewable energy jobs has a proven track record of spurring growth and attracting talent to our area.

All of this, combined with a concerted effort from investors willing to double down on the sectors of solar, storage, electric vehicles and energy management sectors are critical. With swifter growth for jobs in the renewable space and incentivization of the next generation of energy companies, Houston can forge a clear path towards the "New Energy Capital of the World."

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Eric Danziger and Jordan Frugé are managing directors at Houston-based Riverbend Energy Group.

3 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — sports tech, energy, and more — recently making headlines in Houston innovation.

Lawson Gow, founder of The Cannon

Lawson Gow is bullish on Houston becoming a sports tech hub. Photo courtesy of The Cannon

Is Houston the next hub for sports tech innovation? Lawson Gow thinks so.

"Sports tech is a thing we can win at. There's no global hub for sports tech — so Houston can do that," Gow says. "We've always had that in our heads as a direction we want the city to head down, so it just makes it so opportunistic to create a space for that kind of innovation at work for the city."

The founder of Houston coworking company, The Cannon, announced last week plans for a sports tech hub in partnership with Braun Enterprises and Gow Media (InnovationMap's parent company). Click here to read more.

Kate Evinger, director of gBETA Houston

Kate Evinger joins the Houston Innovators Podcast to discuss the latest from gBETA Houston. Photo courtesy of gBETA

Most accelerators are focused on growing startups in a specific way toward a specific goal. For gBETA Houston, that goal is toward a new round of funding or another accelerator, says Kate Evinger, director of gBETA Houston on last week's episode of the Houston Innovators Podcast.

"We look at early-stage companies, so those that are pre-seed or seed-stage that are looking for mentorship or support," Evinger says on this week's episode of the Houston Innovators Podcast, "and we help get to that next step whether that's to raise an upcoming round or if they are looking to get into an equity-based accelerator program."

Evinger shares more details on the ongoing cohort on the episode. Click here to read more and stream the show.

Michael Lee, CEO of Octopus Energy US

A $2.23 million deal means a growing presence Texas for Octopus Energy. Photo via LinkedIn

A United Kingdom-founded energy company has expanded yet again in the Texas market. Octopus Energy announced the acquisition of Houston-based Brilliant Energy last week, and it's a huge opportunity for the company says Octopus Energy's United States CEO Michael Lee.

"This is a major moment for us, as we work to bring our 100% renewable energy supply and outstanding technology to more Texans and their homes," he says. Click here to read more.