Houston researchers are commercializing their human tissue-printing technology

3d-printed organs

Houston researchers are commercializing their organ 3D printing technology. Jordan Miller/Rice University

There may come a time when you or someone you love is in need of a new pair of lungs. Or perhaps it's a liver. It's not a scenario anyone dreams of, but thanks to Houston company Volumetric, you may never end up on a waiting list. Instead, that organ is made to order and 3D printed using a mix of medical plastics and human cells.

And this possibility isn't necessarily in the distant future. On the cover of the May 3 issue of the journal Science, is a contraption that looks a bit like a futuristic beehive. It's a working air sac complete with blood vessels, the beginnings of a technology that is perhaps only a decade from being implanted in humans. And it was crafted on a 3D printer in Jordan Miller's lab at Rice University.

Yes, there are shades of another Houston story — Denton Cooley's implantation of the first artificial heart — but Cooley only inserted the organ. Miller and his bioengineering graduate student Bagrat Grigoryan are primed to profit from their inventions.

In 2018, they started Volumetric Inc., a company that sells both the hydrogel solutions used for printing organs like theirs and the printers themselves. Touring Miller's lab in the Houston Medical Center is a visual timeline of his team's progress designing printers. The version being manufactured is a slick little number, small enough to fit under chemical exhaust hoods, but fitted with everything necessary to print living tissues. It's made and sold in cooperation with CellInk, a larger bioprinting company.

"Our technology is based on projection," Miller explains. Specifically, it's stereolithography, a type of 3D printing that produces the finished product layer-by-layer. Shining colored light of the right intensity turns the polymers into a solid gel.

But why start a company when Miller and Grigoryan are already busy with research?

"If we want to do translational research, commercialization is important," reasons Miller. "We need to build the market to get that technology into the world."

Miller explains that usually the inventor of a technology is the best one to bring it to market.

"When we were building this technology in the lab we saw the potential for commercialization," he recalls. "We do see that this technology is highly scalable. We do think it can have a positive impact on tissue models in a lab."

Those tissue models could one day make not just scientists, but also animal rights activists, very happy. With the technology that Volumetric is developing, scientists could eventually print human cells so well that animal models would be far less accurate in predicting the success that the product being tested would have on humans.

As academics, though, Miller and Grigoryan weren't sure how to start a company. Fortunately, there is the National Science Foundation (NSF) and its I-Corps program. The pair spent a couple of weeks doing a regional program that taught scientists how to commercialize their technology.

"They want to see funded research get out of the lab," Miller says, explaining that they moved on to the national I-Corps program while Miller was on sabbatical from teaching at Rice, allowing them to interview potential customers.

This gave them the confidence to launch last year. Grigoryan now works full-time at the Med Center incubator and accelerator, Johnson & Johnson's JLabs. He has a team of two other scientists on staff.

"It would have been a lot harder to get started if we didn't have a space like JLabs available," Miller says. It also helps, he adds, that JLabs takes no equity, only helping the fledgling brand to finalize its market and get hooked in with potential investors.

Volumetric has its demo units ready to go and expects to start shipping printers in late June, pending final certifications.

"We believe we have technology to make organ replacements for people," Miller says.

And someday soon, long waits for a new set of lungs and a life of antirejection drugs could be a thing of the past.


Rice University bioengineers (from left) Bagrat Grigoryan, Jordan Miller and Daniel Sazer and collaborators created a breakthrough bioprinting technique that could speed development of technology for 3D printing replacement organs and tissues. Photo by Jeff Fitlow/Rice University
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These Houston entrepreneurs and startups are searching for flooding solutions

Flood tech

The feeling is all too familiar for Houstonians. Tropical Storm Imelda hit Houston with devastating flood waters just two years after Hurricane Harvey did its damage.

With any obstacle or challenge, there is room for innovation. Over the past year, InnovationMap has covered various flood tech startups in Houston. Here are six innovations that can make a difference the next time a storm decides to take its toll on Houston.

Self-deploying flood protection for buildings

FloodFrame's technology can protect a home or commercial building from flood water damage. Photo via floodframe.com

A self-deploying flood damage prevention device caught Tasha Nielsen's eye on a trip to Denmark, and then launched the U.S. iteration of FloodFrame to bring the technology here.

FloodFrame works by using buoyancy. A lightweight cloth is wrapped around a tube is installed underground outside the perimeter of your home or business. One end of that cloth is attached to a box that is also installed underground. As flooding begins, an automatic system will release the lids to deploy the inflation of the tube that will protect the structure. When the flood comes in, the system will float on top of the flood — kind of like a pool noodle — and protect the structure from the water.

FloodFrame adds a level of security during flooding events and can be considered more cost-effective when compared to the high cost of renovating or rebuilding after flooding.

"Right now we are focused on residential but I think there's a huge potential for it to go commercial. A lot of commercial buildings are self insured, and commercial developers, industrial developers, this would be a drop in the bucket for the overall cost of the entire project," Nielsen tells InnovationMap. "For homeowners, it's kind of a bigger expense, but I think there is the potential for homebuilders to include it as an option in the entire package of a new house because when you put it in to a mortgage, it's only another like $0.50 a month."

A waterproof container for your car.

After the floods from Hurricane Harvey totaled her car, Rahel Abraham wanted to find a solution. ClimaGuard/Facebook

Floodwaters from Hurricane Harvey seriously damaged about 600,000 vehicles in the Houston area, which included Rahel Abraham's 2008 Infiniti G35. Now, Abraham's brainchild forms the backbone of her Houston-based startup, ClimaGuard LLC. The company's waterproof, temperature-resistant, portable Temporary Protective Enclosure (TPE) can entirely cover a compact car, sedan, or midsize SUV. It comes in three sizes; the cost ranges from $349 to $499.

To protect a vehicle, someone sets a TPE on the ground, a driveway, or another flat surface, then drives the vehicle onto the bottom part of the product, and connects the bottom and top parts with the zipper. Abraham likens it to a clamshell preserving a pearl.

"My goal is not to make it to where it's an exclusive product — available only to those who can afford it — but I want to be able to help those who it would make even more of an economic impact for," Abraham tells InnovationMap.

A network to find shelter.

Reda Hicks create GotSpot — a digital tool that helps connect people with commercial space with people who need it. Courtesy of GotSpot

It only took a natural disaster for Reda Hicks to make her startup idea into a reality.

"I had been thinking on what it would be like to help people find space to do business in and how businesses find a way to stay in business a long time," Hicks tells InnovationMap. "But, I was afraid of the tech."

Hicks, who has practiced law for almost 15 years, wanted to create a website that allows for people with commercial space — a commercial kitchen, conference room, spare desks, etc. — to list it. Then, space seekers — entrepreneurs, nonprofits, freelancers, etc. — can rent it. When Hurricane Harvey hit, Hicks was kicking herself for not acting on her idea sooner.

"It was really Harvey and having so many people desperate to find space for emergency purposes that made me realize there are so many contexts in which people need space right away for something specific," she says. "Certainly the primary user is the entrepreneur trying to grow their business, but there are so many other reasons why a community would need better access to the space it already has."

Now Hicks is growing GotSpot in hopes that short-term rental space and emergency housing can be smooth sailing no matter the circumstances. Recently, the company was named a finalist for MassChallenge Texas in Austin.

A water-absorbing tower. 

Fil Trat would be able to absorb water, filter it, and release it into the body of water when the time comes. Courtesy of Gensler's ByDesign

In the wake of Hurricane Harvey, many Houstonians began to think of solutions for the next time Mother Nature struck with her full-force of flooding. Gensler designers Chelsea Bryant, Jordan Gomez, Luisa Melendez, Barbara Novoa, Benjamin Nanson, Maria Qi, and Melinda Ubera created a solution as a part of Gensler's By Design program called Fil Trat. The tower can absorb, filter, and store flood waters until the bayou is ready for the water to be released — cleaner than it was before.

During Harvey, thousands of people were displaced, but Fil Trat has a solution for that too. The tower's floors would alternate between filtration floors and shelters, which could house up to 24 families per floor.

While the suggested Houston locale would be by Buffalo Bayou, the group suggests putting the tower in other coastal cities at risk of devastating flooding.

Sensor-enabled rubber ducks that can track weather developments.

Sensor-enabled rubber ducks might be the solution to keeping track of major weather events. Courtesy of Project Owl

Nearly two years after Hurricane Harvey battered the Houston area, a flock of electronic "rubber ducks" flew above homes in Katy in a broader endeavor to keep first responders and victims connected during natural disasters.

Developers and backers of Project Owl, an Internet of Things (IoT) hardware and software combination, conducted a pilot test of this innovation June 1 — the first day of this year's hurricane season. In the Katy test, 36 "ducks" took flight.

"So, our technology can be deployed to help communities that have been destroyed after natural disasters by providing quickly accessible communications network to coordinate and organize a response," Bryan Knouse, co-founder and CEO of Project Owl, tells InnovationMap.

The DuckLink network comprises hubs resembling rubber ducks, which can float in flooded areas if needed. It takes only five of these hubs to cover one square mile. This network sends speech-based communications using conversational systems (like Alexa and Facebook Messenger) to a central application. The app, the Owl software incident management system, relies on predictive analytics and various data sources to build a dashboard for first responders.

Restored native wetland coastal prairies.

Memorial Park Conservancy is gearing up to unveil one if its first projects within its 10-year master plan redevelopment. Photo courtesy of MPC

Before it was the fourth largest city in America, Houston was a prairie. That type of ecosystem — thick with prairie grass — is very absorbing when it comes to rain water. Cassidy Brown Johnson, a Rice University lecturer and president of the Coastal Prairie Partnership, has been taking every opportunity to raise awareness on the importance of prairie restoration.

"It's really surprising to people that the trees and all this lushness is actually all artificial," Johnson says. "We know that this ecosystem evolved with the cyclical flooding events that happened here."

This movement to bring back Houston's ancient ecosystem is a new focus on a few prairie conservationist groups — and even the Harris County Flood Control. This has been going on for a while, but recent flooding events have opened the eyes of people now looking for reliable solutions to flooding problems.

"After Hurricane Harvey, people started realizing that this might be one of the solutions we could actually investigate and see if it can help us," Johnson says. "A green space is going to absorb way more water than a parking lot."

Memorial Park Conservancy's its master plan redevelopment project includes a lot of prairie restoration plans is expected to deliver by 2028.

The project is a collaborative effort between MPC, Uptown Houston TIRZ, and Houston Parks and Recreation Department to redevelop the 1,500-acre park. An ongoing part of the transformation will be stormwater management upgrades. MPC has budgeted $3 million to this asset of the renovation. While a part of the plan is tributaries for run-off water, bringing back prairie and wetlands will do a great deal to help abate stormwater.

"We're taking ball fields, parking lots, and roads and converting them back to what was here — native wetland coastal prairie," MPC president and CEO Shellye Arnold tells InnovationMap. "This serves important stormwater purposes."

5 most popular innovation stories in Houston this week

What's trending

Editor's note: This week's top stories include an innovation news roundup, a new TMC accelerator program, what startups can learn from successful Houston exits, and more.

3 Houston innovators to know this week

Accenture and Plug and Play Tech Center made strategic hires in Houston. Plus, a local expert shares how important electronics recycling is. Courtesy photos

The movers and shakers of the Houston innovation world did a lot of extra moving and shaking last week. This week's Houston innovators to know include two new hires within the ecosystem. Continue reading.

New coworking space to open, Houston to host Accenture's health tech awards, and more innovation news

Spaces plans to open a new location in Houston this month, Chevron Technology Ventures invests in autonomous vehicle tech, and more Houston innovation news. Courtesy of Spaces

A lot is happening in the Houston innovation ecosystem — so much that you may have missed a few key news items. Let's hit the highlights, shall we?

Applications are open for major health tech awards program that is coming to town, a Houston corporate venture fund doles out cash to self-driving cars, new coworking space to deliver, a diversity-focused partnership launches, and more Houston innovation news. Continue reading.

TMC introduces new cancer therapeutics accelerator program following $5 million grant

A new accelerator program will aim to advance cancer therapeutics technology. Photo courtesy of TMC

The Texas Medical Center is taking a step forward in cancer prevention and treatment thanks to a multimillion-dollar grant from a Texas organization.

Last month, the Cancer Prevention and Research Institute of Texas announced 71 new statewide grants that totaled $136 million. TMC was the recipient of a $5 million grant that is being used to develop a new accelerator geared at designing new cancer therapeutics treatments. Continue reading.

Here's what startups can learn from Houston exits

At Houston Exponential's second annual HX Capital Summit, four Houston entrepreneurs turned investors discussed their lessons learned. Getty Images

One way to evaluate a city's innovation ecosystem is by the number of successful exits they've had. From startups being acquired by big companies to bringing in a private equity partner, exits can put a city on the map.

Houston has quite a few exits under its belt, and some of those entrepreneurs have stayed in town to fund future success stories. At Houston Exponential's second annual HX Capital Summit, four entrepreneurs discussed their exits, providing key lessons learned for entrepreneurs. Continue reading.

3 startup lessons you can learn from this Texas Olympian turned entrepreneur

Whether it's in the gym or the boardroom, the ability to pick yourself up after a failure is key to success, as this former Olympian learned. Getty Images

I've hit rock bottom more times than I can count. As a gymnast, I overcame injuries that would have ended many other athletes' careers — only to watch my Olympic dreams slip out of reach. As a businessman, I built a successful startup — and then lost it all.

The main thing I've learned? Setbacks can be productive if you're willing to learn from them. Today, as I lead a successful company, I constantly inform my decision-making with the lessons I learned as an athlete and entrepreneur.

Three of those lessons can help everyone — both in the gym and in the boardroom. Continue reading.

Houston startup creates device to keep loved ones in touch with each other

Caring is sharing

When Charley Donaldson's mother-in-law was battling cancer, he and his wife had great support from their friends and family. But they also knew there were a lot of people who cared about them who didn't know what to say or do during such a challenging time.

"It's like, you want to show people that you care about them, but you don't want to interrupt their day, or you don't want to be a burden to them if they aren't up to company," Donaldson says about the common reactions he heard from others – and often felt himself when he had friends going through similar struggles. "There had to be a way to share the idea of, 'Hey, I'm thinking about you.'"

It took three years of rattling around that idea before CaringBand came to life. The light-up bracelet is Bluetooth enabled, and connects to a mobile app. A person gives the bracelet to a loved one, who then pairs it with his or her smartphone. App users can send and receive pre-set messages of encouragement to and from other app users.

Those wearing a CaringBand bracelet get alerted by a blinking light or vibration that lets them know someone is thinking about them. The wearer then reads these encouraging messages on the CaringBand app when convenient and with no need to respond.

"When we pilot tested it, we were super excited to find out what we thought was validated," says Donaldson. "People really loved knowing that others were keeping them in their thoughts, and those who sent messages liked that they didn't have to worry about saying or doing the wrong thing."

Donaldson says he wanted The CaringBand to be as easy as possible for people to use, and also ensure that it was a solid support system. When someone is going through medical treatments, he knows that can be exhausting, and he also realizes that friends and family want to be able to do something, anything, to express their love and support.

"If you're a normal, compassionate person, you want to show you care about someone," he says. "This lets you do that in your own way."

And while it might sound like The CaringBand is designed to make the senders of messages feel better about offering a good thought for someone, Donaldson says those going through treatments have really loved seeing their bracelets light to up to tell them they're on someone's mind. That small show of support has made a big difference, they told Donaldson in surveys.

"She is sitting on the couch having so much fun reading her messages," says one user in a testimonial. "The smile on her face is priceless." "People tell you they think of you and pray for you all the time," read another. "The bracelet gives you a reminder that they really are."

"We made it super easy," he says. "It's a hardware to software solution and we wanted to erase as many friction points as possible in its creation. This is two touches of a smart phone."

Currently, the CaringBand app is live and functional. The bracelet is still in developmental stages, and Donaldson says the team is working with individuals and groups such as the Tyler Robinson Foundation to further test it. The bracelet should be a go for full distribution and sale by the first quarter of 2020.

"Obviously, this doesn't replace driving over to see someone or having a cup of coffee with a friend," says Donaldson. "But it is a great supplemental tool to show your love and care when you might not know what else to do."

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