3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Rachel Moctron of ClassPass, Sid Upadhyay of WizeHire, and Ashley Small of Medley Inc. Courtesy photos

Editor's note: In the week's roundup of Houston innovators to know, I'm introducing you to three innovators across industries recently making headlines — from fitness tech and software to PR and communications.

Rachel Moncton, vice president of Global Marketing at ClassPass

Rachel Moncton shares why ClassPass tapped Houston as a prime place to expand. Photo courtesy of ClassPass

ClassPass recently announced its entrance into the Houston market, and at the helm of the company's new local presence is Rachel Moncton. In a guest article for InnovationMap, she shares why ClassPass was so interested in Houston. The search actually started four years ago, but the tech company finally landed in Houston for its fourth location.

"In 2017, the ClassPass team spent nine months conducting an intensive nationwide search for a city that matched our mission and values," Moncton writes. "As a brand focused on supporting an active lifestyle, we wanted a city that offered a connection to the outdoors. One of the most important driving factors in our search was finding a city where we could attract incredible talent to our team. Though we settled on Missoula, Houston was high on the list." Click here to read more.

Sid Upadhyay, co-founder and CEO of WizeHire

A Houston startup has closed a $7.5 million round of funding with mostly local investment. Photo courtesy of WizeHire

Sid Upadhyay's startup has something to celebrate. The software company founded in Houston closed a $7.5 million series A round of funding led by two Houston-area venture capital firms — Amplo and Mercury Fund. According to a news release, WizeHire will use the funds to scale their business, which is centered around providing personalized hiring resources to small businesses.

"We're a small business helping small businesses with a team of people looking out for you," says Upadhyay. "Hiring is complex and personal. Our customers see what we do not just as software; they see us as a trusted advisor." Click here to read more.

Ashley Small, founder and CEO of Medley Inc.

From events to online shopping — here are four tech trends to look out for this year according to Ashley Small. Photo courtesy of Medley

For Ashley Small, founder and CEO of Medley Inc., innovation and inclusion go hand in hand. Business leaders need diverse voices at the table to drive new ideas and innovation.

"Innovation is actually impossible without diversity," Small says on the most recent episode of the Houston Innovators Podcast. "A part of this is also being really open minded to the fact that you are going to hear ideas that sound and look different. Be open to that, because that is 100 percent the point."

Small discusses more about how she's honoring Black History Month with her team and the evolution the PR and media industries have seen over the past decade on the episode. Click here to stream the episode and read more.

Ashley Small, founder and CEO of Medley Inc., joins the Houston Innovators Podcast this week to discuss COVID-19's affect on her business and fostering diversity at startups. Photo courtesy of Medley Inc.

Houston founder calls for business leaders to 'make room for diverse voices'

HOUSTON INNOVATORS PODCAST EPISODE 70

Last year was one of quick pivots and tech solutions for Ashley Small and her company's clients. Small — the CEO and founder of Medley Inc., a Houston-based branding and public relations firm — works with both for-profit and nonprofit entities to tell their stories, and of course 2020 had its challenges in doing so. But they weren't anything Small, her team, and technology couldn't overcome.

Small founded Medley over 12 years ago, and for the past three of those years, her team has been completely virtual. She shares on the Houston Innovators podcast that this give her team a headstart on being able to find and quickly adopt quick tech solutions — but last year's shutdown also meant navigating this for all her clients.

"The biggest obstacle we had to overcome was figuring out what the best technology was for each client," Small says. "Where the learning curve has been is understanding all the available resources out there and understanding how offline experiences can help audiences connect online."

Founded in Houston, Medley has grown to the Los Angeles and Chicago markets over the years — and Small says that was intentional. An Oklahoma native, Small fell in love with Houston's diversity when she attended Texas Southern University, and sought out other diverse markets to expand her business. And, as a Black female founder, she fosters an inclusive community at her company — and wants to remind her fellow business owners how imperative it is to running an innovative company.

"Innovation is actually impossible without diversity," Small says, adding that when you bring different people to the table, you get new ways of thinking. "A part of this is also being really open minded to the fact that you are going to hear ideas that sound and look different. Be open to that, because that is 100 percent the point."

Small knows early-stage companies aren't always able to hire a bunch of people from diverse backgrounds right from the start, but there are other ways to surround yourself with diverse ideas.

"Make room for diverse voices -- and you may have to be a bit creative," Small says.

Medley's team also realizes that not every startup can afford to bring on an in-house or third-party PR team, but the company has a few options for startups, such as a three-month retainer to start as well as a series of workshops available online for as low as $19.

Small discusses more about how she's honoring Black History Month with her team and the evolution the PR and media industries have seen over the past decade on the episode. Listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


This week's roundup of Houston innovators includes Nicole Rogers of Validere, Allie Danziger of Ampersand, and Ashley Small of Medley Inc. Courtesy photos

3 female Houston innovators to know this week

who's who

Editor's note: In the week's roundup of Houston innovators to know, I'm introducing you to three female innovators across industries — from energy tech to business entrepreneurship.

Nicole Rogers, senior vice president at Validere

Nicole Rogers, senior vice president at Validere, joins the Houston Innovators Podcast to discuss how her company has grown exponentially over the past year. Photo courtesy of Validere

Nicole Rogers joined Canadian startup Validere during the summer last year — right smack dab in the middle of a pandemic. But despite COVID-19 and the drop in oil prices, the energy company grew exponentially — in clientbase, in venture capital support, and in employee count.

"One of the things we found that was to our advantage throughout the pandemic was a lot of folks in oil were having a career identity crisis. Oil really struggles with employment elasticity," Rogers says. "A lot of the colleagues we were talking to were just fatigued with the ups and downs going on in the past decade."

Rogers, who's based in the company's Houston office, shares more about Validere's growth and opportunities in the new year — plus what she thinks Houston needs to do to maintain its status of energy capital of the world in the episode. Click here to read more and to stream the podcast.

Allie Danziger, founder of Ampersand

Houston entrepreneur, Allie Danziger, wanted to create a program for young professionals looking to gain experience in unprecedented times. Photo courtesy of Ampersand

Allie Danziger has two small children, but she started thinking about if her kids were college age, would she want them to enroll in a virtual college experience or hold off for a time where they could have a more traditional experience. Realizing she probably wasn't alone, she thought about how she could create an alternative for high school grads — in this time of the pandemic but also in a time where college degrees aren't the best option for job security.

"I really believe that it scales way beyond this pandemic," says Danziger. In her research, she saw a lack of career-focused gap curriculums and resources available. "There are no programs that help you determine what the right path for you is—to really do that self-exploration and then apply it to your career path," she explains. Click here to read more.

Ashley Small, founder and CEO of Medley Inc.

From events to online shopping — here are four tech trends to look out for this year according to Ashley Small. Photo courtesy of Medley

It's a new year and the perfect time to reflect on where society is at from a technological standpoint. In light of the pandemic and an overarching trend of tapping into tech to provide solutions to COVID-19-related challenges, 2021 will likely see more of these trends.

"As a business owner, it's clear to me that many of these shifts will persist long after the pandemic has ended," writes Ashley Small, founder and CEO of Medley Inc., in a guest column for InnovationMap.

From subscriptions to online shopping, Small highlighted the types of tech in the digital realm that deserve our special attention in 2021. Click here to read more.

From events to online shopping — here are four tech trends to look out for this year. Photo courtesy of Medley

Houston expert: 4 tech trends to look out for in 2021

guest column

The events of 2020 dramatically changed the way marketing agencies — like mine, Medley Inc. — do business. As we enter 2021, many executives are reflecting on how many of these changes will be sustained in the coming year.

From subscriptions to online shopping, the digital realm deserves our special attention in 2021. Due to the COVID-19 pandemic, Medley, like many agencies, has pivoted to produce virtual events, run more targeted ads on all platforms, and become even more cloud-based and systemized.

As a business owner, it's clear to me that many of these shifts will persist long after the pandemic has ended. Here are four of the greatest changes I have observed and how they will continue to affect the way we do business in 2021.

1. Events will be hybrids on and offline

From the American Academy of Pediatrics to IBM, the 2020 pandemic forced businesses and organizations to fully digitize in-person conferences and events. With the coronavirus vaccine only just now being rolled out, it's likely that we won't be able to bring these events fully offline anytime soon.

While some organizations will probably host offline versions of their events, they may boast smaller attendance than usual or utilize a hybrid on- and offline strategy to account for the health and safety of their attendees. Thankfully, 2020 proved that there are fresh, innovative ways to engage participants in a virtual experience. Plan ahead to continue this innovation in 2021.

2. A platform to look out for

Clubhouse is the latest virtual platform, developed to eliminate the fatigue of online video events while still offering a new way to connect with others — including celebrities, thought leaders, and like-minded peers. What makes Clubhouse unique is that it's a hybrid between a never ending conference and a podcast, letting you tune into speakers and engage in lively discussions at your leisure.

Many experts are speculating that Clubhouse may be the next big social media platform, and for good reason: there's something there for everyone. Personally, I love some of the daily affirmation events happening on the platform. Niche apps like Quilt, which is geared exclusively toward women -- have also emerged, attesting to the growing power of socially distanced connections.

3. Subscription services and content fees will continue

Virtually eliminating offline revenue streams meant that many content platforms had to get creative about how they would continue to be profitable during the coronavirus pandemic. Already, we're seeing more news sites add paywalls and subscription services (or increase pricing on existing services) — a trend that likely won't change anytime soon.

Online video streaming is no exception to the rule. For example, Netflix recently announced a fee increase for 2021. Climbing content fees are likely a result of increased competition in the online streaming space, which has changed the way we consume traditional TV and movies.

As opposed to cable services, which pose a single monthly subscription fee for access to a variety of channels, the shows and films we love are contracted to single streaming platforms. Businesses like Netflix recognize that with this shift, we are increasingly willing to shell out a premium in order to continue consuming the content we love.

4. We will see more options with online shopping

As you may have noticed, Instagram now has a feature called Instagram Shopping. The department store giant Wal-Mart also partnered with influencers and Tik-Tok for Christmas to sell products in time for the holidays. Increased availability of online shopping is a natural evolution of a pandemic that makes it risky to leave our houses to go to the store. However, it's also a reflection of our society's growing need for convenience and instant gratification during the shopping experience.

In 2021, I anticipate that these options will only continue to grow. Expect products to appear at every turn on social media, whether you're scrolling your feed or watching an influencer live. As a result, we'll all need to be prepared to practice restraint each time we see items tailored to our interests.

At Medley, we're leaning into data-driven strategy and imagining the client experiences we've grown to love in a virtual world indefinitely. Regardless of what the future brings, we now know that there's a more convenient way to reach our consumers, connect and indulge a bit too.

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Ashley Small is the founder and CEO of Houston-based Medley Inc., a digital marketing and PR firm.

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Houston foundation grants $27M to support Texas chemistry research

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Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.

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