The next phase of the Houston Spaceport will build out connectivity and workforce training. Rendering via Houston Airports

Since the Houston Spaceport secured the 10th FAA-Licensed commercial spaceport designation in 2015, the development's tenants have gone on to secure billions in NASA contracts. Now, the Houston Spaceport is on to its next phase of growth.

“Reflecting on its meteoric rise, the Spaceport has seen remarkable growth in a short span of time. From concepts on paper to the opening of Axiom Space, Collins Aerospace, and Intuitive Machines, the journey has been nothing short of extraordinary,” says Arturo Machuca, director of Ellington Airport and the Houston Spaceport, in a news release. “These anchor tenants, collectively holding about $5 billion in contracts with NASA and other notable aerospace companies, are not just shaping the future of space exploration but injecting vitality into Houston’s economy.”

The next phase of development, according to Houston Airports, will include:

  • The construction of a taxiway to connect Ellington Airport and the Spaceport
  • The construction of a roadway linking Phase 1 infrastructure to Highway 3
  • The expansion of the EDGE Center, in partnership with San Jacinto College

Rendering via Houston Airports

The Houston Spaceport's first phase completed in 2019. Over the past few years, tenants delivered on their own buildouts. Last year, Intuitive Machines moved into its new $40 million headquarters and Axiom Space opened its test facility. In 2022, Collins Aerospace cut the ribbon on its new 120,000 square-foot facility.

“The vision for the Houston Spaceport has always been ambitious,” says Jim Szczesniak, director of Aviation for Houston Airports. “Our vision is to create a hub for aviation and aerospace enterprises that will shape the future of commercial spaceflight.”

Educational partners have also revealed new spaces, including San Jacinto College's EDGE Center, which broke ground in July of 2019, finally celebrated its grand opening in 2021. Last year, Texas Southern University got the greenlight to operate an aeronautical training hub on a two-acre site at Ellington Airport.

“By providing the education and training needed to sustain jobs in the rapidly evolving space industry, the Spaceport is not only attracting companies but also nurturing the talent that will drive Houston's aerospace sector forward,” continues Szczesniak in the release.

Houston's primed to lead space innovation into the future — it's already happening here, as one panel at SXSW explains. Image via axiomspace.com

Houston experts at SXSW: Why now is the opportune time for space commercialization

Houston House

For all of the time they've been on earth, humans have looked up and wondered what was out there. Now more than ever, as a recent panel of experts discussed, humans are equipped to find out.

“We actually have, for the very first time, not just the ability to answer those questions, but to be able to go and live among the stars,” says Douglas Terrier, associate director for vision and strategy at NASA's Johnson Space Center. “It’s really a phenomenal thing to think that we are existing at this time.”

Terrier was joined by fellow panelists Matt Ondler, CTO of Axiom Space, and Tim Crain, CTO of Intuitive Machines, along with moderator Arturo Machuca, director of Houston Spaceport, to explore what has contributed to this unique moment in time for space commercialization. The panel, which was presented by Houston Spaceport and hosted by the Greater Houston Partnership, took place at Houston House at SXSW on Sunday, March 13.

An industry that was run exclusively by the government has evolved to include commercialization — and not just on a corporate level.

“We’re at this inflection point where access to space is easier — companies are emerging and it’s not just NASA and big companies like Boeing and Lockheed that can participate in space,” Ondler says.

This evolution was crucial to continue developing the technologies needed to advance the industry. Ondler's company Axiom Space is working on the first commercial space station for lower earth orbit, or LEO. This project will be 100 to 1,000 times less expensive than what it cost to build the International Space Station.

“We’re really leveraging so much history and so much of the government’s investment to build our commercial space station,” Ondler says.

The LEO economy is a trillion dollar economy — and one that has been overtaken by commercial companies, which is exactly what NASA needed to allow for it to refocus efforts to returning to the moon with its Artemis project.

“We’ve gotten over that first obstacle where we’ve commercialized operations of low earth orbit,” Terrier says. “That frees us up to look further.”

For decades, the aerospace industry has been responsible for churning out technologies that, in addition to their space application, can make a difference on earth as well.

“We spend a lot of money getting to space, but what it does is push forward all of these things we have to invent, and they find their ways into application in medicine, water purification, clean energy — all return tenfold value to our society," Terrier says on the panel.

Today, Terrier says the space economy is over $400 billion — and only a quarter of that is government investment. With this influx of companies working in space innovation, Houston has all it needs to be a leader in the field.

“Innovation and the ability to commercially engage in space requires a lot of ideas and new ways of looking of things,” Crain says, pointing out the area around the JSC and the spaceport. “The more opportunities we have for these ideas to come together and interchange, that is going to open up the capability to make commercialization successful.”

He continues saying the city is building a critical mass with space tech startups, talent within engineering and manufacturing, government support, and more.

“It’s more open now than it's ever been for both the city and for NASA to support companies who want to work in Houston,” Crain says. “When you put all those ingredients together the opportunities are really endless, and it’s the place to be.”

Airports, spaceports, and carports — these three Houston innovators represent the city's future. Courtesy photos

3 Houston innovators to know this week

Who's who

This week's Houston innovators to keep an eye on are working on technologies that are true testaments to the day and age we live in. From commercial space travel to a product that protects vehicles from floodwaters that are more and more frequent, these entrepreneurs are providing solutions to problems no one even dreamed of having a few decades ago.

Mark Bergsrud, co-founder and CEO of Grab

Courtesy of Grab

For over 20 years, Mark Bergsrud worked at the intersection of travel and technology — first at Continental Airlines, then at United Airlines following the merger, and now for himself as the co-founder of Grab, a Houston startup that's making grabbing a bite at the airport way easier.

Grab's technology digitizes and optimizes the airport dining experience — from ordering pickup remotely ahead of time to kiosks or table tablet ordering. The company, which has operations in 37 airports, just closed a multimillion-dollar Series A fundraising round to help continue its growth.

"We've called ourselves a startup for a long time, and now we think of ourselves as more of a scale-up company," Bergsrud says. "Now it's about having the money to scale faster."

Read more about the company by clicking here.

Rahel Abraham, founder of ClimaGuard

Courtesy of ClimaGuard

For inventors, you can usually pinpoint a particular "eureka" moment. For Rahel Abraham, it was seeing her 2008 Infiniti G35 completely totaled by the rain waters of Hurricane Harvey. She knew there had to be some way to protect cars and valuables from flooding, so she invented ClimaGuard's Temporary Protective Enclosure.

Abraham, who was selected for the 12-week DivInc accelerator program in Austin for her company, wants to make the product available to everyone.

"My goal is not to make it to where it's an exclusive product — available only to those who can afford it — but I want to be able to help those who it would make even more of an economic impact for," Abraham says.

Read more about the company by clicking here.

Arturo Machuca, general manager of Ellington Airport and the Houston Spaceport

Arturo Machuca

Courtesy of the Houston Airport System

Arturo Machuca is playing a waiting game. Various companies are developing commercial spaceflight and — whether that technology delivers in two years or 10 years, Machuca wants Houston to be ready. Ellington Airport and the Houston Spaceport are being developed throughout a multiphase, multimillion-dollar process, while also serving as an active airport.

"We use what we already have at Ellington Airport," Machuca tells InnovationMap. "We're serving aviation today until commercial spaceflight gets here."

Read the full interview by clicking here.

Commercial space technology is being developed at this moment, and Arturo Machuca wants to make sure the Houston Spaceport is ready for the technology when it's finished. Courtesy of the Houston Airport System

Houston Spaceport general manager wants to connect the city to the rest of the world

Featured innovator

In 2015, Houston became the 10th licensed spaceport in the United States. Now, four years later, it's Arturo Machuca's job as general manager of the Houston Spaceport and Ellington Airport to guide the institution from idea into reality.

Ellington Airport and the Houston Spaceport are co-located just 15 miles outside of downtown Houston and just north of the Johnson Space Center. While major players in commercial space exploration develop the technology for space travel, Machuca and his team at the Houston Airport Systems are working to build Houston's Spaceport to be ready for that technology when it arrives.

Machuca spoke with InnovationMap for the final installment of this month's space-focused interviews in honor of the 50th anniversary of the Apollo 11 landing.

InnovationMap: Tell me a little bit about your career to date. 

Arturo Machuca: I am a very fortunate man in that I have had the chance to be involved in this project that's so relevant to the city of Houston. My background has been in aviation for 38 years. I've worked 21 years in commercial aviation. I've also worked in air service development, working with airlines to add new routes to and from Houston. I've worked in corporate aviation as well.

Now past 10 years since July 2009 been with the Houston Airport System. I was first based at the George Bush Intercontinental Airport, then in 2012 I was fortunate enough to work with director Mario Diaz on the inception of the spaceport plans. In 2015, we became the 10th commercial spaceport in the nation.

It's been so much fun. It's so good to come to work where you get to say, "I'm having fun with this."

IM: With the Houston Spaceport being only the 10th licensed in the United States, has it been challenging laying the groundwork?

AM: There has been some challenges in that we are adapting our infrastructure to serve as the commercial space, including very in depth due diligence. But at the same time, it's been easy because of the fact that we are distinguished amongst other spaceports. We are the only truly urban spaceport in the world, which makes it easier from my perspective. Plus, we are the home to Johnson Space Center and a number of space companies based here. While challenging, it's been very good to have those things on our side.

IM: What’s the big picture goal of the Houston Spaceport?

AM: Our goal will be to one day connect Houston to the world by commercial spaceflight. Companies like Virgin Galactic are developing their technology for point-to-point transportation, or space flight. We have no control over that — it's up to them. In the meantime, we continue to take advantage of existing structure and turning it into the spaceport. We use what we already have at Ellington Airport. We're serving aviation today until commercial spaceflight gets here.

IM: The Spaceport just broke ground on Phase I of the transformation. What are the priorities for that initiative?

AM: We have nearly 1,000 acres of land that we can develop. Our vision is to create a cluster of aerospace and aviation companies that allow for us to get to space in a quicker fashion. We have chosen four major areas of development to focus on phase one of the spaceport: drones, micro satellites, aviation and commercial spaceflight, and data and analytics. We're building the neighborhood, if you will, so that companies can come and set up on our land.

We've been working with universities, and about a month ago we just announced the Edge workforce training center where San Jacinto College will train students to support the industry.

IM: The spaceport has quite a few educational partners. Why has that been such a core component to the project?

AM: About 2.5 years ago we were working with a proposal to work with Blue Origin — a company owned by Jeff Bezos, the owner of Amazon. Blue Origin was looking for a location to build their rocket engine, and we thought the Houston Spaceport was the perfect place. The process took a little over a year, and I am proud to say that we made it to the final two cities. We were competing with Huntsville, Alabama, which is known as Rocket City. We didn't win, but when we went back and asked for feedback, they said that Huntsville offered a tremendous amount of educational support. We clearly realized that it's important to have that direct connection.

IM: What’s Houston’s future role in space?

AM: I think that Houston is poised for success because of the existing components we already have in place, like the Johnson Space Center. The city of Houston is working very closely with the JSC to make sure we remain mission relevant.

Pushing into commercial space flight, I believe that Houston is poised for a tremendous future. We are learning to better coordinate with the players on the government side and the private industry. I envision Houston becoming even a stronger player in the next 50 years because of the development and the growth of assets. I can see us serving as a city where we take passengers from one end of the world to the others using commercial space flight.

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Portions of this interview have been edited.

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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.