Intuitive Machines engineer talks STEM, innovation, and second chances

Innovator Interview

Mario Romero is an engineer for Intuitive Machines and a former Navy SEAL. He credits his successes in STEM to second—and third—chances. Photo via LinkedIn

Mario Romero is an assembly, integration, and test engineer at the innovative Houston aerospace company Intuitive Machines. He previously served as a Navy SEAL and an EVA Flight Simulator Specialist at NASA.

Intuitive Machines landed its IM-2 mission on the moon last month, before calling an early end of mission. The company reported that its lunar lander was on its side, preventing it from completing the mission as planned.

Still, the IM-2 mission landed closer to the lunar South Pole than any previous lander, according to NASA. And the company still has plenty of innovative projects in the works.

The company secured about $2.5 million from NASA to study challenges related to carrying cargo on the company’s lunar lander and hauling cargo on the moon. The lander will be used for NASA’s Artemis missions to the moon and eventually to Mars.

“Someone has to do it; in fact, the more the merrier,” Romero says on being part of an innovative culture.

“Competition forces innovation, and if I can be selfish for a moment, I think it’s of particular importance for Intuitive Machines because my extremely capable team is more than worthy of having their place stamped in history. We, as a species, have to strive to become a multiplanetary species. Incidentally, part of the trickle-down effect of innovation often leads to spin-off technology that in some way benefits humanity here on Earth.”

Last year, Romero was awarded the key to the city from his hometown of Vineland, New Jersey, and made it a point in his speech to give kids a chance to succeed in the future.

“I am the product of many chances, secondary, tertiary, and more, given to me,” Romero says. “Many of these were admittedly entirely undeserving. I look back now and recognize that those teachers, judges, police, etc. might have all seen something in me that I couldn’t then see in myself. … This is precisely why I often emphasize giving kids multiple chances. Kids are kids, and you can never fully know how you’re inspiring them in the moment, nor how the chances that you give them will affect the trajectory of their lives.”

Texas is expected to represent nearly 10 percent of future STEM opportunities in the nation, and nine of the 20 biggest employers in Texas are STEM-related.

As STEM has become increasingly popular in high schools and at the university level, and the aerospace industry continues to innovate, it is possible that many young future innovators may take the same path a young Romero did.

“I think it’s natural that when new leaps are made in the STEM fields, and in the aerospace realm at large, the youth in general become galvanized by it,” Romero says.

“It’s exciting and reinvigorating to understand that humanity is on the cusp of the next great adventure. As fantastic and essential as this is, I want to emphasize the importance of the arts as well. It has an important place and an important role to play in our evolution, so I personally don’t limit youthful interest to STEM alone. There are fantastic works of art awaiting us, in all their variety, that will come as a result of the efforts and innovation.”

From Your Site Articles
Launched from South Texas, SpaceX's Starship survived for around 50 minutes before losing contact and landing in the Indian Ocean. Photo via SpaceX/Twitter

SpaceX's mega rocket launch from Texas base provides mixed results

50-minute flight

SpaceX came close to completing an hourlong test flight of its mega rocket on its third try Thursday, but the spacecraft was lost as it descended back to Earth.

The company said it lost contact with Starship as it neared its goal, a splashdown in the Indian Ocean. The first-stage booster also ended up in pieces, breaking apart much earlier in the flight over the Gulf of Mexico after launching from the southern tip of Texas near the Mexican border.

“The ship has been lost. So no splashdown today,” said SpaceX’s Dan Huot. “But again, it’s incredible to see how much further we got this time around.”

Two test flights last year both ended in explosions minutes after liftoff. By surviving for close to 50 minutes this time, Thursday's effort was considered a win by not only SpaceX's Elon Musk, but NASA as well as Starship soared higher and farther than ever before. The space agency is counting on Starship to land its astronauts on the moon in another few years.

The nearly 400-foot (121-meter) Starship, the biggest and most powerful rocket ever built, headed out over the Gulf of Mexico after liftoff Thursday morning, flying east. Spectators crowded the nearby beaches in South Padre Island and Mexico.

A few minutes later, the booster separated seamlessly from the spaceship, but broke apart 1,500 feet (462 meters) above the gulf, instead of plummeting into the water intact. By then, the spacecraft was well to the east and continuing upward, with no people or satellites on board.

Starship reached an altitude of about 145 miles (233 kilometers) as it coasted across the Atlantic and South Africa, before approaching the Indian Ocean. But 49 minutes into the flight — with just 15 minutes remaining — all contact was lost and the spacecraft presumably broke apart.

At that point, it was 40 miles (65 kilometers) high and traveling around 16,000 mph (25,700 kph).

SpaceX's Elon Musk had just congratulated his team a little earlier. “SpaceX has come a long way,” he said via X, formerly called Twitter. The rocket company was founded exactly 22 years ago Thursday.

NASA watched with keen interest: The space agency needs Starship to succeed in order to land astronauts on the moon in the next two or so years. This new crop of moonwalkers — the first since last century’s Apollo program — will descend to the lunar surface in a Starship after transferring from NASA's Orion capsule in lunar orbit.

NASA Administrator Bill Nelson quickly congratulated SpaceX on what he called a successful test flight as part of the space agency's Artemis moon-landing program.

The stainless steel, bullet-shaped spacecraft launched atop a first-stage booster known as the Super Heavy. Both the booster and the spacecraft are designed to be reusable, although they were never meant to be salvaged Thursday.

On Starship’s inaugural launch last April, several of the booster’s 33 methane-fueled engines failed and the booster did not separate from the spacecraft, causing the entire vehicle to explode and crash into the gulf four minutes after liftoff.

SpaceX managed to double the length of the flight during November’s trial run. While all 33 engines fired and the booster peeled away as planned, the flight ended in a pair of explosions, first the booster and then the spacecraft.

The Federal Aviation Administration reviewed all the corrections made to Starship, before signing off on Thursday’s launch. The FAA said after the flight that it would again investigate what happened. As during the second flight, all 33 booster engines performed well during ascent, according to SpaceX.

Initially, SpaceX plans to use the mammoth rockets to launch the company’s Starlink internet satellites, as well as other spacecraft. Test pilots would follow to orbit, before the company flies wealthy clients around the moon and back. Musk considers the moon a stepping stone to Mars, his ultimate quest.

NASA is insisting that an empty Starship land successfully on the moon, before future moonwalkers climb aboard. The space agency is targeting the end of 2026 for the first moon landing crew under the Artemis program, named after the mythological twin sister of Apollo.

After an August 29 scrub, the Artemis I mission is set to launch. Photo by Ben Smegelsky/NASA via NASA Flickr

Houston readies for historic return to moon with new NASA launch date

GO FOR LAUNCH

Houstonians who are eagerly anticipating America’s historic return to the moon now have a new date. Artemis I will now launch on Saturday, September 3, with a two-hour window beginning at 1:17 pm, NASA announced late Tuesday, August 30.

Viewers can tune into the livestream of the rocket and spacecraft at the launch pad on the NASA Kennedy YouTube channel. Additionally, live coverage of events can be found on NASA Television, the NASA app, and the agency’s website.

This comes after the initial August 29 launch was scrubbed. At that time, teams were not able to chill down the four RS-25 engines to necessary temperatures. Teams also caught and quickly managed a hydrogen leak on one of the rocket’s components.

NASA reports that teams are currently addressing and testing both issues in advance of the Saturday launch. Another important component for flight windows — weather — is currently favorable. Meteorologists with the U.S. Space Force Space Launch Delta 45 forecast favorable weather conditions for Saturday. Though some rain showers are expected, they are predicted to be sporadic during the launch window, per NASA.

As space fans are aware, Artemis I is the first flight test of NASA’s Orion spacecraft, Space Launch System rocket (dubbed SLS), and the ground systems at the agency’s Kennedy Space Center in Florida.

“The first in a series of increasingly complex missions, Artemis I will be an uncrewed flight test that will provide a foundation to extend human presence to the Moon and beyond,” NASA notes in a news release. “The mission will demonstrate the performance of the SLS rocket and test Orion’s capabilities over the course of about six weeks as it travels about 40,000 miles beyond the Moon and back to Earth.”

Given the gravity of the launch, NASA planned considerable fanfare for the broadcast, including celebrity appearances by Jack Black, Chris Evans, and Keke Palmer, as well as a special performance of “The Star-Spangled Banner” by Josh Groban and Herbie Hancock. A planned musical performance featured “America the Beautiful” by The Philadelphia Orchestra and cellist Yo-Yo Ma, conducted by Yannick Nézet-Séguin.

Representatives from Johnson Space Center had not received an update on the Saturday broadcast program when contacted on Wednesday, August 31.

Houston and lunar missions have been inextricably tied since NASA’s first launches. In 1962, President John F. Kennedy boldly declared that America would go to the moon before the end of the decade in front of a packed Rice University football stadium.

On July 20, 1969 – a commitment to the late President Kennedy’s directive — Apollo 11 marked its arrival to the lunar surface with a statement heard around the globe from Commander Neil Armstrong, who would take mankind’s first steps on the surface: “Houston, Tranquility base here. The Eagle has landed.”

And the Bayou City has (somewhat tiredly) been the source of a ubiquitous sentence — that is actually a paraphrasing — uttered by Apollo 13 Commander Jim Lovell: “Houston, we’ve had a problem here.” The adjusted “Houston, we have a problem” declaration was later immortalized by Tom Hanks (as Lovell) in the blockbuster Apollo 13.

What will be the next iconic phrase sent back to Houston when NASA’s manned mission readies to land on Earth’s sole satellite? The countdown is on.

------

This article originally ran on CultureMap.

The Artemis I mission will launch NASA’s Space Launch System rocket with the Orion spacecraft from Kennedy Space Center in Florida on Monday. The uncrewed mission is planned to circle the moon. Photo via NASA

Here's how Houstonians can watch as NASA returns to the Moon

the countdown begins

UPDATE: NASA halted the Monday, August 29 Artemis I launch attempt at approximately 7:34 am Monday. According to a statement, the Space Launch System rocket and Orion spacecraft remain in a safe and stable configuration. Launch controllers were continuing to evaluate why a bleed test to get the RS-25 engines on the bottom of the core stage to the proper temperature range for liftoff was not successful, and ran out of time in the two-hour launch window. Engineers are continuing to gather additional data.

In less than a week, NASA and its commercial partners are returning humans to the Moon in the first mission of the Artemis Program. All eyes will be on the rocket as it launches Monday, August 29.

Artemis I — the mission's first flight test of the NASA’s Orion spacecraft, Space Launch System rocket — is an uncrewed mission that will launch from Kennedy Space Center in Florida before circling the moon. The SLS rocket is targeted to launch during a two-hour window that opens at 7:33 a.m. on Monday, August 29, from Launch Pad 39B at Kennedy.

Coverage of the launch has already started, and viewers can tune into the livestream of the rocket and spacecraft at the launch pad on the NASA Kennedy YouTube channel. Additionally, live coverage of events started airing on Monday on NASA Television, the NASA app, and the agency’s website. The launch countdown will begin Saturday, Aug. 27, at 9:23 a.m.

While launch is the main event, the broadcast will also include celebrity appearances by Jack Black, Chris Evans, and Keke Palmer, as well as a special performance of “The Star-Spangled Banner” by Josh Groban and Herbie Hancock. It also will feature a performance of “America the Beautiful” by The Philadelphia Orchestra and cellist Yo-Yo Ma, conducted by Yannick Nézet-Séguin.

"The first in a series of increasingly complex missions, Artemis I will be an uncrewed flight test that will provide a foundation to extend human presence to the Moon and beyond," NASA reports in a news release. "The mission will demonstrate the performance of the SLS rocket and test Orion’s capabilities over the course of about six weeks as it travels about 40,000 miles beyond the Moon and back to Earth."

A full itinerary of events — including press conferences, virtual social opportunities, and more — is available online. Interested parties can also follow NASA’s Artemis blog for updates.

Auburn University's SwiftSku took first place in this year's virtually held Rice Business Plan Competition, but it was the second place company that went home with over half a million in cash and investment prizes. Photo via rice.edu

Over $1.4M in prizes awarded at Rice University's student startup competition

RBPC 2021

In its 21st year, the Rice Business Plan Competition hosted 54 student-founded startups from all over the world — its largest batch of companies to date — and doled out over $1.4 million in cash and investment prizes at the week-long virtual competition.

RBPC, which is put on by the Rice Alliance for Technology and Entrepreneurship, took place Tuesday, April 6, to Friday, April 9 this year. Just like 2020, RBPC was virtually held. The competition announced the 54 participating startups last month, and coordinated the annual elevator pitches, a semi-finals round, wildcard round and live final pitches. The contestants also received virtual networking and mentoring.

Earlier this week, Rice Alliance announced the seven student-led startups that then competed in the finals. From this pack, the judges awarded the top prizes. Here's how the finalists placed and what won:

  • SwiftSku from Auburn University, point of sales technology for convenience stores that allows for real time analytics, won first place and claimed the $350,000 grand prize from Goose Capital. The company also won the $50,000 Business Angel Minority Association Prize, the $500 Best Digital Elevator Pitch Prize from Mercury Fund, and the $500 Third Place Anbarci Family People's Choice prize, bringing the company's grand total in cash and investment prizes to $401,000. The company also won the CFO Consulting Prize, a $25,000 in-kind award.
  • AgZen from the Massachusetts Institute of Technology, a pesticide alternative spray and formulation technology company, won the second place $100,000 investment prize (awarded by Finger Interests, Anderson Family Fund, Greg Novak, and Tracy Druce). The startup also won a $300,000 Owl Investment Prize, the $100,000 Houston Angel Network Prize, the $500 Best Energy Elevator Pitch Prize from Mercury Fund, and the $1,500 Third Place Anbarci Family People's Choice prize, bringing the company's grand total in cash and investment prizes to $502,000. The company also won the $30,000 in-kind Polsinelli Energy Prize.
  • FibreCoat GmbH from RWTH Aachen University, a startup with patented spinning technology for the production of inexpensive high-performance composite fibers, won the third place $50,000 investment prize (also awarded by Finger Interests, Anderson Family Fund, Greg Novak, and Tracy Druce). The company also won the $100,000 TiE Houston Angels Prize and the $500 Best Hard Tech Elevator Pitch Prize from Mercury Fund, bringing the company's grand total in cash and investment prizes to $150,500.
  • Candelytics from Harvard University, a startup building the digital infrastructure for 3-D data, won the fourth place $5,000 prize.
  • OYA FEMTECH Apparel from UCLA, an athletic wear company that designs feminine health-focused clothing, won the fifth place $5,000 prize. The company also won the $5,000 Eagle Investors Prize, the $25,000 Urban Capital Network Prize, and the $1,000 Second Place Anbarci Family People's Choice prize, bringing the company's grand total in cash and investment prizes to $36,000.
  • LFAnt Medical from McGill University , an innovative and tech-backed STI testing company, won the sixth place $5,000 prize and the $20,000 Johnson and Johnson Innovation Prize, bringing the company's grand total in cash and investment prizes to $25,000.
  • SimpL from the University of Pittsburgh, an AI-backed fitness software company, won the seventh place $5,000 prize. The company also won the $25,000 Spirit of Entrepreneurship Prize from the Pearland Economic Development Corp., bringing the company's grand total in cash and investment prizes to $30,000.

Some of the competition's participating startups outside of the seven finalists won monetary and in-kind prizes. Here's a list of those.

  • Mercury Fund's Elevator Pitch Prizes also included:
    • Best Life Science $500 Prize to Blue Comet Medical Solutions from Northwestern University
    • Best Consumer $500 Prize to EasyFlo from the University of New Mexico
    • Best Overall $1,000 prize to Anthro Energy from Stanford University
  • The Palo Alto Software Outstanding LivePlan Pitch $3,000 Prize went to LiRA Inc. from the University of North Carolina at Chapel Hill
  • The OFW Law FDA Regulatory Strategy Prize, a $20,000 in-kind award went to Paldara Inc. from Oklahoma State University.
  • The Silver Fox Mentoring Prize, which included $20,000 in kind prizes to three winners selected Ai-Ris from Texas A&M University, BruxAway from the University of Texas, and Karkinex from Rice University as recipients.
  • The first, second, and third place winners also each received the legal service prize from Baker Botts for a total of $20,000 in-kind award.
  • The Courageous Women Entrepreneurship Prize from nCourage — a $50,000 investment prize — went to Shelly Xu Design from Harvard University.
  • The SWPDC Pediatric Device Prize — usually a $50,000 investment divided its prize to two winners to receive $25,000 each
    • Blue Comet Medical Solutions from Northwestern University
    • Neurava from Purdue University
  • TMC Innovation Healthcare Prize awarded a $100,000 investment prize and admission into its accelerator to ArchGuard from Duke University
  • The Artemis Fund awarded its $100,000 investment prize to Kit Switch from Stanford University
The awards program concluded with a plan to host the 22nd annual awards in 2022 in person.

If you missed the virtual programming, each event was hosted live on YouTube and the videos are now available on the Rice Alliance's page.

A Houston-based company that's on a mission to the moon has a new control center. Photo via Jesus Motto/Savills

Houston-area space tech startup gets upgraded control center

new space

A space tech startup based in Clear Lake, just outside of Houston, has a new office that's going to help them take their technology out of this world.

Intuitive Machines, an engineering firm specializing in automation and aerospace, has upgraded its Houston-area control center. The company has moved into a 22,300-square-foot space on the sixth floor of a building located at 3700 Bay Area Road. The lease was executed last fall. London-based Savills had a Houston team to represent the tenant and oversee project management of the buildout.

"I was proud to work on the build-out for Intuitive Machines during such an exciting time in its history," says Savills associate director, David Finklea, in a news release. "As Intuitive is a leader in the aerospace space field, we created an environment that is far from the industry standard and complements its innovative endeavors. The design is bright and contemporary, with a relaxing and airy feel that imitates the illusion of being in space."

Currently, Intuitive Machines is working on NASA's Artemis Program and has been granted $77 million from the organization to launch a flight to the moon next year. In light of this project, Intuitive Machines needed a larger, optimized space to support its growing team.

Finklea and Derrell Curry, executive vice president at Savills, teamed up with architecture firm CDI Douglass Pye Inc. on the project that took elements from the company's former first-floor office and created a new design aesthetic that "evoked the neutral colors of the lunar landscape," according to the release.

"Despite the current COVID-19 pandemic and delays caused as a result, we were able to complete the space within six months through close coordination with Intuitive Machines, CDI Douglass Pye, and the landlord," Finklea says in the release. "Everyone came together to ensure the new headquarters was delivered promptly for Intuitive Machines to prepare for its historic mission that further solidifies the future of privatized space travel."

The unique control center is circular, which optimizes collaboration, and equipped with a large curved monitor. The office is also hooked up to emergency backup power — something the team needs as it continues on its mission to the moon.

"I couldn't be more pleased with Derrell and David and the team they put together to create our new headquarters. Everyone demonstrated a high level of professionalism and attention to detail that produced a workplace that truly represents Intuitive Machines as an innovative lunar space systems company," says Steve Altemus, president and CEO of Intuitive Machines, in the release. "Thank you to Savills, CDI Douglass Pye, and Byrd Construction for delivering an exceptional space that allows us to conduct our mission to the moon from our new control center right here in Houston!"

Intuitive Machines moved into a new space. Photo via Jesus Motto/Savills

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Property Showcase

Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

View All Listings