NASA revamps Artemis moon landing program by modeling it after Apollo

To the moon

Commander Reid Wiseman of the Artemis II mission. Photo courtesy of NASA

NASA is revamping its Artemis moon exploration program to make it more like the fast-paced Apollo program half a century ago, adding an extra practice flight before attempting a high-risk lunar landing with a crew in two years.

The overhaul in the flight lineup came just days after NASA’s new moon rocket returned to its hangar for more repairs, and a safety panel warned the space agency to scale back its overly ambitious goals for humanity’s first lunar landing since 1972.

Artemis II, a lunar fly-around by four astronauts, is off until at least April because of rocket problems.

The follow-up mission, Artemis III, had been targeting a landing near the moon’s south pole by another pair of astronauts in about three years. But with long gaps between flights and concern growing over the readiness of a lunar lander and moonwalking suits, NASA’s new administrator Jared Isaacman announced that mission would instead focus on launching a lunar lander into orbit around Earth in 2027 for docking practice by astronauts flying in an Orion capsule.

The new plan calls for a moon landing — potentially even two moon landings — by astronauts in 2028.

“Everybody agrees. This is the only way forward,” Isaacman said.

The hydrogen fuel leaks and helium flow problems that struck the Space Launch System rocket on the pad at NASA's Kennedy Space Center in February also plagued the first Artemis test flight without a crew in 2022.

Another three-year gap was looming between Artemis II and the moon landing by astronauts as originally envisioned, Isaacman said.

Isaacman stressed that “it should be incredibly obvious” that three years between flights is unacceptable. He'd like to get it down to one year or even less.

Isaacman, a tech billionaire who bought his own trips to orbit and performed the world’s first private spacewalk, took the helm at NASA in December.

During NASA’s storied Apollo program, he said, astronauts’ first flight to the moon was followed by two more missions before Neil Armstrong and Buzz Aldrin landed on the moon. What's more, he added, the Apollo moonshots followed one another in quick succession, just as the earlier Projects Mercury and Gemini had rapid flight rates, sometimes coming just a few months apart.

Twenty-four Apollo astronauts flew to the moon from 1968 through 1972, with 12 of them landing.

“No one at NASA forgot their history books. They knew how to do this," Isaacman said. “Now we're putting it in action.”

To pick up the pace and reduce risk, NASA will standardize its Space Launch System rockets moving forward, Isaacman said. These are the massive rockets that will launch astronauts to the moon aboard Orion capsules. At the same time, Elon Musk's SpaceX and Jeff Bezos' Blue Origin are speeding up their work on the landers needed to get the astronauts from lunar orbit down to the surface.

Isaacman said next year will see an Orion crew rendezvousing in orbit around Earth with SpaceX's Starship, Blue Origin's Blue Moon or both landers. It's similar to the methodical approach that worked so well during Apollo in the late 1960s, he noted. Apollo 8, astronauts' first flight to the moon, was followed by two more missions before Armstrong and Aldrin aimed for the lunar surface.

“We should be getting back to basics and doing what we know works,” he said.

The Aerospace Safety Advisory Panel recommended that NASA revise its objectives for Artemis III “given the demanding mission goals.” It’s urgent the space agency do that, the panel said, if the United States hopes to safely return astronauts to the moon. Isaacman said the revised Artemis flight plan addresses the panel's concerns and is supported by industry and the Trump administration.

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Mario Romero is an engineer for Intuitive Machines and a former Navy SEAL. He credits his successes in STEM to second—and third—chances. Photo via LinkedIn

Intuitive Machines engineer talks STEM, innovation, and second chances

Innovator Interview

Mario Romero is an assembly, integration, and test engineer at the innovative Houston aerospace company Intuitive Machines. He previously served as a Navy SEAL and an EVA Flight Simulator Specialist at NASA.

Intuitive Machines landed its IM-2 mission on the moon last month, before calling an early end of mission. The company reported that its lunar lander was on its side, preventing it from completing the mission as planned.

Still, the IM-2 mission landed closer to the lunar South Pole than any previous lander, according to NASA. And the company still has plenty of innovative projects in the works.

The company secured about $2.5 million from NASA to study challenges related to carrying cargo on the company’s lunar lander and hauling cargo on the moon. The lander will be used for NASA’s Artemis missions to the moon and eventually to Mars.

“Someone has to do it; in fact, the more the merrier,” Romero says on being part of an innovative culture.

“Competition forces innovation, and if I can be selfish for a moment, I think it’s of particular importance for Intuitive Machines because my extremely capable team is more than worthy of having their place stamped in history. We, as a species, have to strive to become a multiplanetary species. Incidentally, part of the trickle-down effect of innovation often leads to spin-off technology that in some way benefits humanity here on Earth.”

Last year, Romero was awarded the key to the city from his hometown of Vineland, New Jersey, and made it a point in his speech to give kids a chance to succeed in the future.

“I am the product of many chances, secondary, tertiary, and more, given to me,” Romero says. “Many of these were admittedly entirely undeserving. I look back now and recognize that those teachers, judges, police, etc. might have all seen something in me that I couldn’t then see in myself. … This is precisely why I often emphasize giving kids multiple chances. Kids are kids, and you can never fully know how you’re inspiring them in the moment, nor how the chances that you give them will affect the trajectory of their lives.”

Texas is expected to represent nearly 10 percent of future STEM opportunities in the nation, and nine of the 20 biggest employers in Texas are STEM-related.

As STEM has become increasingly popular in high schools and at the university level, and the aerospace industry continues to innovate, it is possible that many young future innovators may take the same path a young Romero did.

“I think it’s natural that when new leaps are made in the STEM fields, and in the aerospace realm at large, the youth in general become galvanized by it,” Romero says.

“It’s exciting and reinvigorating to understand that humanity is on the cusp of the next great adventure. As fantastic and essential as this is, I want to emphasize the importance of the arts as well. It has an important place and an important role to play in our evolution, so I personally don’t limit youthful interest to STEM alone. There are fantastic works of art awaiting us, in all their variety, that will come as a result of the efforts and innovation.”

Launched from South Texas, SpaceX's Starship survived for around 50 minutes before losing contact and landing in the Indian Ocean. Photo via SpaceX/Twitter

SpaceX's mega rocket launch from Texas base provides mixed results

50-minute flight

SpaceX came close to completing an hourlong test flight of its mega rocket on its third try Thursday, but the spacecraft was lost as it descended back to Earth.

The company said it lost contact with Starship as it neared its goal, a splashdown in the Indian Ocean. The first-stage booster also ended up in pieces, breaking apart much earlier in the flight over the Gulf of Mexico after launching from the southern tip of Texas near the Mexican border.

“The ship has been lost. So no splashdown today,” said SpaceX’s Dan Huot. “But again, it’s incredible to see how much further we got this time around.”

Two test flights last year both ended in explosions minutes after liftoff. By surviving for close to 50 minutes this time, Thursday's effort was considered a win by not only SpaceX's Elon Musk, but NASA as well as Starship soared higher and farther than ever before. The space agency is counting on Starship to land its astronauts on the moon in another few years.

The nearly 400-foot (121-meter) Starship, the biggest and most powerful rocket ever built, headed out over the Gulf of Mexico after liftoff Thursday morning, flying east. Spectators crowded the nearby beaches in South Padre Island and Mexico.

A few minutes later, the booster separated seamlessly from the spaceship, but broke apart 1,500 feet (462 meters) above the gulf, instead of plummeting into the water intact. By then, the spacecraft was well to the east and continuing upward, with no people or satellites on board.

Starship reached an altitude of about 145 miles (233 kilometers) as it coasted across the Atlantic and South Africa, before approaching the Indian Ocean. But 49 minutes into the flight — with just 15 minutes remaining — all contact was lost and the spacecraft presumably broke apart.

At that point, it was 40 miles (65 kilometers) high and traveling around 16,000 mph (25,700 kph).

SpaceX's Elon Musk had just congratulated his team a little earlier. “SpaceX has come a long way,” he said via X, formerly called Twitter. The rocket company was founded exactly 22 years ago Thursday.

NASA watched with keen interest: The space agency needs Starship to succeed in order to land astronauts on the moon in the next two or so years. This new crop of moonwalkers — the first since last century’s Apollo program — will descend to the lunar surface in a Starship after transferring from NASA's Orion capsule in lunar orbit.

NASA Administrator Bill Nelson quickly congratulated SpaceX on what he called a successful test flight as part of the space agency's Artemis moon-landing program.

The stainless steel, bullet-shaped spacecraft launched atop a first-stage booster known as the Super Heavy. Both the booster and the spacecraft are designed to be reusable, although they were never meant to be salvaged Thursday.

On Starship’s inaugural launch last April, several of the booster’s 33 methane-fueled engines failed and the booster did not separate from the spacecraft, causing the entire vehicle to explode and crash into the gulf four minutes after liftoff.

SpaceX managed to double the length of the flight during November’s trial run. While all 33 engines fired and the booster peeled away as planned, the flight ended in a pair of explosions, first the booster and then the spacecraft.

The Federal Aviation Administration reviewed all the corrections made to Starship, before signing off on Thursday’s launch. The FAA said after the flight that it would again investigate what happened. As during the second flight, all 33 booster engines performed well during ascent, according to SpaceX.

Initially, SpaceX plans to use the mammoth rockets to launch the company’s Starlink internet satellites, as well as other spacecraft. Test pilots would follow to orbit, before the company flies wealthy clients around the moon and back. Musk considers the moon a stepping stone to Mars, his ultimate quest.

NASA is insisting that an empty Starship land successfully on the moon, before future moonwalkers climb aboard. The space agency is targeting the end of 2026 for the first moon landing crew under the Artemis program, named after the mythological twin sister of Apollo.

After an August 29 scrub, the Artemis I mission is set to launch. Photo by Ben Smegelsky/NASA via NASA Flickr

Houston readies for historic return to moon with new NASA launch date

GO FOR LAUNCH

Houstonians who are eagerly anticipating America’s historic return to the moon now have a new date. Artemis I will now launch on Saturday, September 3, with a two-hour window beginning at 1:17 pm, NASA announced late Tuesday, August 30.

Viewers can tune into the livestream of the rocket and spacecraft at the launch pad on the NASA Kennedy YouTube channel. Additionally, live coverage of events can be found on NASA Television, the NASA app, and the agency’s website.

This comes after the initial August 29 launch was scrubbed. At that time, teams were not able to chill down the four RS-25 engines to necessary temperatures. Teams also caught and quickly managed a hydrogen leak on one of the rocket’s components.

NASA reports that teams are currently addressing and testing both issues in advance of the Saturday launch. Another important component for flight windows — weather — is currently favorable. Meteorologists with the U.S. Space Force Space Launch Delta 45 forecast favorable weather conditions for Saturday. Though some rain showers are expected, they are predicted to be sporadic during the launch window, per NASA.

As space fans are aware, Artemis I is the first flight test of NASA’s Orion spacecraft, Space Launch System rocket (dubbed SLS), and the ground systems at the agency’s Kennedy Space Center in Florida.

“The first in a series of increasingly complex missions, Artemis I will be an uncrewed flight test that will provide a foundation to extend human presence to the Moon and beyond,” NASA notes in a news release. “The mission will demonstrate the performance of the SLS rocket and test Orion’s capabilities over the course of about six weeks as it travels about 40,000 miles beyond the Moon and back to Earth.”

Given the gravity of the launch, NASA planned considerable fanfare for the broadcast, including celebrity appearances by Jack Black, Chris Evans, and Keke Palmer, as well as a special performance of “The Star-Spangled Banner” by Josh Groban and Herbie Hancock. A planned musical performance featured “America the Beautiful” by The Philadelphia Orchestra and cellist Yo-Yo Ma, conducted by Yannick Nézet-Séguin.

Representatives from Johnson Space Center had not received an update on the Saturday broadcast program when contacted on Wednesday, August 31.

Houston and lunar missions have been inextricably tied since NASA’s first launches. In 1962, President John F. Kennedy boldly declared that America would go to the moon before the end of the decade in front of a packed Rice University football stadium.

On July 20, 1969 – a commitment to the late President Kennedy’s directive — Apollo 11 marked its arrival to the lunar surface with a statement heard around the globe from Commander Neil Armstrong, who would take mankind’s first steps on the surface: “Houston, Tranquility base here. The Eagle has landed.”

And the Bayou City has (somewhat tiredly) been the source of a ubiquitous sentence — that is actually a paraphrasing — uttered by Apollo 13 Commander Jim Lovell: “Houston, we’ve had a problem here.” The adjusted “Houston, we have a problem” declaration was later immortalized by Tom Hanks (as Lovell) in the blockbuster Apollo 13.

What will be the next iconic phrase sent back to Houston when NASA’s manned mission readies to land on Earth’s sole satellite? The countdown is on.

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This article originally ran on CultureMap.

The Artemis I mission will launch NASA’s Space Launch System rocket with the Orion spacecraft from Kennedy Space Center in Florida on Monday. The uncrewed mission is planned to circle the moon. Photo via NASA

Here's how Houstonians can watch as NASA returns to the Moon

the countdown begins

UPDATE: NASA halted the Monday, August 29 Artemis I launch attempt at approximately 7:34 am Monday. According to a statement, the Space Launch System rocket and Orion spacecraft remain in a safe and stable configuration. Launch controllers were continuing to evaluate why a bleed test to get the RS-25 engines on the bottom of the core stage to the proper temperature range for liftoff was not successful, and ran out of time in the two-hour launch window. Engineers are continuing to gather additional data.

In less than a week, NASA and its commercial partners are returning humans to the Moon in the first mission of the Artemis Program. All eyes will be on the rocket as it launches Monday, August 29.

Artemis I — the mission's first flight test of the NASA’s Orion spacecraft, Space Launch System rocket — is an uncrewed mission that will launch from Kennedy Space Center in Florida before circling the moon. The SLS rocket is targeted to launch during a two-hour window that opens at 7:33 a.m. on Monday, August 29, from Launch Pad 39B at Kennedy.

Coverage of the launch has already started, and viewers can tune into the livestream of the rocket and spacecraft at the launch pad on the NASA Kennedy YouTube channel. Additionally, live coverage of events started airing on Monday on NASA Television, the NASA app, and the agency’s website. The launch countdown will begin Saturday, Aug. 27, at 9:23 a.m.

While launch is the main event, the broadcast will also include celebrity appearances by Jack Black, Chris Evans, and Keke Palmer, as well as a special performance of “The Star-Spangled Banner” by Josh Groban and Herbie Hancock. It also will feature a performance of “America the Beautiful” by The Philadelphia Orchestra and cellist Yo-Yo Ma, conducted by Yannick Nézet-Séguin.

"The first in a series of increasingly complex missions, Artemis I will be an uncrewed flight test that will provide a foundation to extend human presence to the Moon and beyond," NASA reports in a news release. "The mission will demonstrate the performance of the SLS rocket and test Orion’s capabilities over the course of about six weeks as it travels about 40,000 miles beyond the Moon and back to Earth."

A full itinerary of events — including press conferences, virtual social opportunities, and more — is available online. Interested parties can also follow NASA’s Artemis blog for updates.

Auburn University's SwiftSku took first place in this year's virtually held Rice Business Plan Competition, but it was the second place company that went home with over half a million in cash and investment prizes. Photo via rice.edu

Over $1.4M in prizes awarded at Rice University's student startup competition

RBPC 2021

In its 21st year, the Rice Business Plan Competition hosted 54 student-founded startups from all over the world — its largest batch of companies to date — and doled out over $1.4 million in cash and investment prizes at the week-long virtual competition.

RBPC, which is put on by the Rice Alliance for Technology and Entrepreneurship, took place Tuesday, April 6, to Friday, April 9 this year. Just like 2020, RBPC was virtually held. The competition announced the 54 participating startups last month, and coordinated the annual elevator pitches, a semi-finals round, wildcard round and live final pitches. The contestants also received virtual networking and mentoring.

Earlier this week, Rice Alliance announced the seven student-led startups that then competed in the finals. From this pack, the judges awarded the top prizes. Here's how the finalists placed and what won:

  • SwiftSku from Auburn University, point of sales technology for convenience stores that allows for real time analytics, won first place and claimed the $350,000 grand prize from Goose Capital. The company also won the $50,000 Business Angel Minority Association Prize, the $500 Best Digital Elevator Pitch Prize from Mercury Fund, and the $500 Third Place Anbarci Family People's Choice prize, bringing the company's grand total in cash and investment prizes to $401,000. The company also won the CFO Consulting Prize, a $25,000 in-kind award.
  • AgZen from the Massachusetts Institute of Technology, a pesticide alternative spray and formulation technology company, won the second place $100,000 investment prize (awarded by Finger Interests, Anderson Family Fund, Greg Novak, and Tracy Druce). The startup also won a $300,000 Owl Investment Prize, the $100,000 Houston Angel Network Prize, the $500 Best Energy Elevator Pitch Prize from Mercury Fund, and the $1,500 Third Place Anbarci Family People's Choice prize, bringing the company's grand total in cash and investment prizes to $502,000. The company also won the $30,000 in-kind Polsinelli Energy Prize.
  • FibreCoat GmbH from RWTH Aachen University, a startup with patented spinning technology for the production of inexpensive high-performance composite fibers, won the third place $50,000 investment prize (also awarded by Finger Interests, Anderson Family Fund, Greg Novak, and Tracy Druce). The company also won the $100,000 TiE Houston Angels Prize and the $500 Best Hard Tech Elevator Pitch Prize from Mercury Fund, bringing the company's grand total in cash and investment prizes to $150,500.
  • Candelytics from Harvard University, a startup building the digital infrastructure for 3-D data, won the fourth place $5,000 prize.
  • OYA FEMTECH Apparel from UCLA, an athletic wear company that designs feminine health-focused clothing, won the fifth place $5,000 prize. The company also won the $5,000 Eagle Investors Prize, the $25,000 Urban Capital Network Prize, and the $1,000 Second Place Anbarci Family People's Choice prize, bringing the company's grand total in cash and investment prizes to $36,000.
  • LFAnt Medical from McGill University , an innovative and tech-backed STI testing company, won the sixth place $5,000 prize and the $20,000 Johnson and Johnson Innovation Prize, bringing the company's grand total in cash and investment prizes to $25,000.
  • SimpL from the University of Pittsburgh, an AI-backed fitness software company, won the seventh place $5,000 prize. The company also won the $25,000 Spirit of Entrepreneurship Prize from the Pearland Economic Development Corp., bringing the company's grand total in cash and investment prizes to $30,000.

Some of the competition's participating startups outside of the seven finalists won monetary and in-kind prizes. Here's a list of those.

  • Mercury Fund's Elevator Pitch Prizes also included:
    • Best Life Science $500 Prize to Blue Comet Medical Solutions from Northwestern University
    • Best Consumer $500 Prize to EasyFlo from the University of New Mexico
    • Best Overall $1,000 prize to Anthro Energy from Stanford University
  • The Palo Alto Software Outstanding LivePlan Pitch $3,000 Prize went to LiRA Inc. from the University of North Carolina at Chapel Hill
  • The OFW Law FDA Regulatory Strategy Prize, a $20,000 in-kind award went to Paldara Inc. from Oklahoma State University.
  • The Silver Fox Mentoring Prize, which included $20,000 in kind prizes to three winners selected Ai-Ris from Texas A&M University, BruxAway from the University of Texas, and Karkinex from Rice University as recipients.
  • The first, second, and third place winners also each received the legal service prize from Baker Botts for a total of $20,000 in-kind award.
  • The Courageous Women Entrepreneurship Prize from nCourage — a $50,000 investment prize — went to Shelly Xu Design from Harvard University.
  • The SWPDC Pediatric Device Prize — usually a $50,000 investment divided its prize to two winners to receive $25,000 each
    • Blue Comet Medical Solutions from Northwestern University
    • Neurava from Purdue University
  • TMC Innovation Healthcare Prize awarded a $100,000 investment prize and admission into its accelerator to ArchGuard from Duke University
  • The Artemis Fund awarded its $100,000 investment prize to Kit Switch from Stanford University
The awards program concluded with a plan to host the 22nd annual awards in 2022 in person.

If you missed the virtual programming, each event was hosted live on YouTube and the videos are now available on the Rice Alliance's page.

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Austin company to bring AI-powered school to The Woodlands

AI education

Austin-based Alpha School, which operates AI-powered private schools, is opening its first Houston-area location in The Woodlands.

The 8,000-square-foot school, scheduled to be ready for the 2026-27 academic year, initially will serve students in kindergarten through eighth grade. Alpha says the school will offer “open workshop spaces and innovative classrooms that support personalized instruction, core academics, leadership development, and real-world life skills.”

Alpha sets aside two hours each school day for the AI-driven, self-paced study of core subjects like math, reading and science. The rest of each school day consists of life-skills workshops focusing on topics such as leadership and financial literacy.

Alpha’s school in The Woodlands has begun accepting applications for the 2026-27 school year. Annual tuition costs $40,000.

“The Woodlands is one of the most dynamic, forward-thinking communities in Texas, and Alpha is proud to bring

an innovative educational model that complements its strong academic foundation,” says Rachel Goodlad, head

of expansion for Alpha.

Founded in 2014, Alpha School combines adaptive technology-driven instruction with immersive life-skills workshops. Its model emphasizes mastery-based learning in core subjects alongside development of communication, critical thinking, financial literacy and leadership skills. It operates more than 15 schools across the country.

Elsewhere in Texas, Alpha operates schools in Austin, Brownsville, Fort Worth and Plano. Alpha also operates 12 Texas Sports Academy campuses in Texas, including locations in Houston, Pearland and Richmond, along with a NextGen Academy esports school in Austin, a school for gifted students in Georgetown, and lower-cost Nova Academy campuses in Austin and Bastrop.

Alpha has fans and critics. While supporters tout students’ high achievement rates, detractors complain about the high tuition and the AI-influenced depersonalization of education.

“Students and our country need to be in relationship with other human beings,” Randi Weingarten, president of the American Federation of Teachers, a teachers union, tells The New York Times. “When you have a school that is strictly AI, it is violating that core precept of the human endeavor and of education.”

Alpha co-founder MacKenzie Price, a podcaster and social media influencer, doesn’t share Weingarten’s views.

“Parents and teachers: We need to embrace this change,” Price wrote after President Trump signed an executive order promoting AI in schools.

The Times notes that Alpha doesn’t employ AI as a tutor or a supplement. Rather, the newspaper says, AI is “the school’s primary educational driver to move students through academic content.”

Houston space tech co. lands $175M and more innovation news to know

Trending News

Editor's note: The top Houston innovation news for the month includes major fundraising rounds for two Houston scaleups and local inductees into the National Academy of Inventors. Here are the five most-read InnovationMap headlines from March 1-15, 2026:

1. Intuitive Machines secures $175M equity investment to fuel growth

Intuitive Machines has landed a $175 million investment as it looks secure satellite deals and develop space-based data centers. Photo courtesy Intuitive Machines.

Houston-based space infrastructure and services company Intuitive Machines has secured a $175 million equity investment from unidentified institutional investors. The investors received shares of Class A stock in exchange for their funding. Publicly held Intuitive Machines (Nasdaq: LUNR) says it plans to use the capital to help build revenue and invest in technology, including communications and data-processing networks. Continue reading.

2. Houston e-commerce giant Cart.com raises $180M, surpasses $1B in funding

Cart.com has raised $180 million to scale its logistics network, expand AI capabilities and develop workflow automation tools. Photo courtesy of Cart.com

Houston-based commerce and logistics platform Cart.com has raised $180 million in growth capital from private equity firm Springcoast Partners, pushing the startup past the $1 billion funding mark since its founding in 2020. Cart.com says it will use the capital to scale its logistics network, expand AI capabilities and develop workflow automation tools. Continue reading.

3. Houston leads Texas with 7 new National Academy of Inventors senior members

The University of Houston has more faculty named to this year’s senior member class of the National Academy of Inventors than any other Texas institution. Photos courtesy UH.

The University of Houston is now home to seven new senior members of the National Academy of Inventors. According to UH, its seven new members represent the largest group from any single Texas institution this year, bringing the university's total senior member count to 46. Continue reading.

4. Booming Houston suburb launches innovation grant to attract startups

The City of Sugar Land is putting money on the table to support startups that relocate jobs to southwest Houston. Photo via Getty Images.

Think you’ve got a burgeoning startup? Consider moving it to southwest Houston. The City of Sugar Land announced the Sugar Land Starts Innovation Fund to support companies that move jobs to the area. Continue reading.

5. 6+ can't-miss Houston business and innovation events in March

From CERAWeek to H-Town Roundup, here's what not to miss this month and how to register. Photo courtesy of CERAWeek

March brings the return of some of Houston’s signature innovation events, plus insightful talks and celebrations in honor of Women's History Month. Here’s what not to miss and how to register. Continue reading.

Houston researcher secures $1.7M to develop drug for aggressive form of breast cancer

cancer research

A University of Houston researcher has joined a $3.2 million effort to develop a new drug designed to attack a cancer-driving protein commonly found in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is one of the most difficult-to-treat forms of cancer and accounts for 10 percent to 15 percent of all breast cancer cases. The disease gets its name because tumors associated with it test negative for estrogen receptors, progesterone receptors and excess HER2 protein, making it difficult to target. Due to this, TNBC is often treated with general chemotherapy, which can come with negative side effects and drug resistance, according to UH.

UH College of Pharmacy research associate professor Wei Wang is developing a drug that can target the disease more specifically. The drug will target MDM2, a protein often overproduced in TNBC that also contributes to faster tumor growth.

Wang is working on a team led by Wei Li, director of the University of Tennessee Health Science Center College of Pharmacy’s Drug Discovery Center. She has received $1.7 million to support the research.

Wang and UH professor of pharmacology and toxicology Ruiwen Zhang have discovered a compound that can break down MDM2. In early laboratory models, the compound has shown the ability to shrink tumors.

Wang and Zhang will focus on understanding how the treatment works and monitoring its effectiveness in models that closely mirror human disease.

“We will study how the drug targets MDM2 and evaluate the most promising drug candidates to determine effective dosing, understand how the drug behaves in the body, compare it with existing treatments and assess early safety,” Wang said in a news release.

Li’s team at the University of Tennessee will be working on the chemistry and drug design end of the project.

“This work could lead to an entirely new class of therapies for triple-negative breast cancer,” Li added in the release. “We’re hopeful that by directly removing the MDM2 protein from cancer cells, we can help more patients respond to treatment regardless of their tumor type.”

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