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Houston cancer-fighting biotech company introduces its 4th ongoing clinical trial

Houston-based Moleculin Biotech now has four different oncology treatment currently in trials. Getty Images

A Houston-based biotech company has wrapped up enrollment for its most recent clinical trial of its cancer-fighting drug.

Moleculin Biotech Inc. (Nasdaq: MBRX) has launched its fourth ongoing trial — this time focusing on Cutaneous T-Cell Lymphoma, or CTCL, treatment. The company's other three trials include treatment for glioblastoma, an aggressive brain cancer, pancreatic cancer, one of the most virulent killers in oncology, and acute myeloid leukemia, or AML.

To treat these various types of cancers, Moleculin has a several drugs it's in preclinical or clinical trials testing — most biotech companies have only one they focus on. WP1220 is the drug that will be used in this trial for topical CTCL treatment of the cancer's resulting skin lesions.

"We believe there continues to be an unmet need for an improved topical therapy for Stage I-III CTCL skin lesions," says Walter Klemp, Moleculin's chairman and CEO, in a news release, "especially one that may avoid significant unwanted side effects."

WP1220 is what's known as a p-STAT3 inhibitor. STAT3 is a transcription factor that encourages tumor development. Moleculin's technology directly attacks the tumor, but also quiets T Cells, which allows the body's own immune system to fight the cancer itself. Essentially, it works both as chemotherapy and immunotherapy.

"This proof of concept, if successful, could be an important first demonstration of a therapeutic effect in humans from such a p-STAT3 inhibitor," Klemp continues. "We are pleased with how quickly this trial reached full recruitment and we are hopeful to be able to announce results from this trial yet this year."

Klemp founded the company in 2007, and Moleculin went public in 2016. Now, with the company's four clinical trials, Moleculin is even closer to saving lives with its products.

"Notwithstanding the relatively rare nature of CTCL, we believe showing activity with one of our STAT3 inhibitors, within our WP1066 family of molecules, could be an indicator of both the value of p-STAT3 as a target and the potential for our drugs in other cancers where STAT3 is highly activated," Klemp says in the release.

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Building Houston

 
 

CERAWeek attendees identified the four energy tech companies to watch. Photo via Getty Images

Wondering what energy tech companies you should keep an eye on? Wonder no more.

As a part of 2021 CERAWeek by IHS Markit, the Rice Alliance for Technology and Entrepreneurship hosted a virtual pitch competition today featuring 20 companies in four sessions. Each entrepreneur had four minutes to pitch, and then a few more to take questions from industry experts.

"Of the companies here today, we've intentionally selected a diverse group," says Brad Burke, managing director of the Rice Alliance at the start of the event. "They range from companies looking for their seed funding to companies that have raised $20 million or more."

The following companies pitched at the event: Acoustic Wells, ALLY ENERGY, Bluefield Technologies, Cemvita Factory, Connectus Global, Damorphe, Ovopod Ltd., DrillDocs, GreenFire Energy, inerG, Locus Bio-Energy Solutions, Nesh, Pythias Analytics, REVOLUTION Turbine Technologies, Revterra, ROCSOLE, Senslytics, Subsea Micropiles, Syzygy Plasmonics, Transitional Energy, and Universal Subsea.

At the end of each session, attendees voted via Zoom poll on which startup had the most potential. According to the event attendees, the most promising energy tech companies are:

REVOLUTION Turbine Technologies

Asheville, North Carolina-based REVOLUTION Turbine Technologies is working to "put a green spin on power." The company's micro-Expansion Turbine System produces green power for digital oilfield and pipeline initiatives through the recovery of excess natural gas pressure.

"RTT's technology provides a scalable, clean energy source to reliably power digital oilfield and pipeline initiatives at a significantly low operating cost," says Christopher Bean, founder and CEO, in his presentation. "Never has it been more important to make production and pipeline operations greener, safer, and efficient."

Connectus Global

Connectus Global, based in Calgary, provides custom technology solutions that can increase productivity, profits, and competitiveness. Connectus' Real-Time Location System, or RTLS, uses Ultra-Wide Band for communication and triangulation while hosting a Radio Frequency Identification Device, which come in the form of badges, tags, and receivers.

"In our first year, we received $800,000 in revenue and are on track to hit our numbers — $3.6 million — at the end of this fiscal year," says Mike Anderson, CEO of the company, in his presentation." We have a global white labeling agreement with Honeywell and we make up about 75 percent of their digitized workforce management portfolio."

The company's U.S. office is located in Houston.

DrillDocs

Houston-based DrillDocs has created an automated drilling cuttings characterization service, called CleanSight, that supports an operator's understanding of their wellbore's state of stability and cleanness in real time.

"We're taking computer vision to the drilling rig," says Calvin Holt, CEO and co-founder at DrillDocs, in his presentation. "Now for the first time, drilling and geomechanics teams will have unique, real-time data to ascertain the well's condition."

Revterra

Revterra, a Houston-based company and inaugural Greentown Houston member company, is creating a flywheel energy storage system for long-duration grid-scale applications.

"For those of us in Texas, the power outages we experienced a couple weeks ago are a stark reminder that the stability and the resiliency of our electric grid should be a top priority as we transition to low-emission power sources," says Ben Jawdat, founder and CEO at Revterra, in his presentation. "Energy storage is a critical element in both grid stability and enabling our transition to sustainable energy."

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