What You're Reading

5 top trending innovation stories in Houston this week

From tech innovators to recently funded startups and growing software companies, here's what you're reading this week. Pexels

Editor's note: The most read stories on InnovationMap this week cover a myriad of things — from tech innovators and Houston innovation events to recently funded startups and growing software companies. Here are the stories that you're reading.

3 Houston tech innovators to know this week

These three innovators are using their technology to provide solutions across industries. Courtesy photos

Innovation isn't always about being the first to create a technology. Sometimes, innovation is seeing the potential an existing technology has to impact a different industry. That's what all three of this week's innovators to know have done across industries. And, they are are only just getting started. Read the full story here.

5 Houston startups beginning 2019 with new capital

These five companies are starting 2019 out with some cash, and here's what they plan on doing with it. Getty Images

Finding growing Houston startups is as easy as following the money, and a few local companies are starting 2019 strong with a recent round of funding closed. InnovationMap has rounded up a few recent raises to highlight heading into the new year. Read the full story here.

Updated: 10 can't-miss innovation events for January

From enlightening talks to anniversary celebrations, here's where you need to be in January. Getty Images

Houston's innovation community is starting 2019 strong with plenty of business professional events. This story first published a few weeks ago, but has been updated to include new events. Read the full story here.

Houston software company looks to grow its workforce internationally

This growing Houston company is providing industrial industries with smart analytics. Getty Images

A Houston-based analytics-focused company is gearing up for growth in 2019 and plans to staff up its headquarters and remote offices abroad.

Arundo Analytics Inc. brings industrial companies — which sometimes are slow to adopt brand-new technology — into the world of machine learning and advanced analytics to help boost revenue, cut costs and reduce risks. Read the full story here.

Growing Houston cyber security company plans to hire

Houston-based Security Gate has grown 1,000 percent each year. Getty Images

Cyber security is constantly evolving, and, while information hacks are always a concern, worst-case scenarios could even be life threatening.

Houston-based startup, Security Gate, is addressing all of types of cyber security threats, says Ted Gutierrez, an Army special forces vet and co-founder and CEO of the company. Read the full story here.

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Building Houston

 
 

This UH engineer is hoping to make his mark on cancer detection. Photo via UH.edu

Early stage cancer is hard to detect, mostly because traditional diagnostic imaging cannot detect tumors smaller than a certain size. One Houston innovator is looking to change that.

Wei-Chuan Shih, professor of electrical and computer engineering at the University of Houston's Cullen College of Engineering, recently published his findings in IEEE Sensors journal. According to a news release from UH, the cells around cancer tumors are small — ~30-150nm in diameter — and complex, and the precise detection of these exosome-carried biomarkers with molecular specificity has been elusive, until now.

"This work demonstrates, for the first time, that the strong synergy of arrayed radiative coupling and substrate undercut can enable high-performance biosensing in the visible light spectrum where high-quality, low-cost silicon detectors are readily available for point-of-care application," says Shih in the release. "The result is a remarkable sensitivity improvement, with a refractive index sensitivity increase from 207 nm/RIU to 578 nm/RIU."

Wei-Chuan Shih is a professor of electrical and computer engineering at the University of Houston's Cullen College of Engineering. Photo via UH.edu

What Shih has done is essentially restored the electric field around nanodisks, providing accessibility to an otherwise buried enhanced electric field. Nanodisks are antibody-functionalized artificial nanostructures which help capture exosomes with molecular specificity.

"We report radiatively coupled arrayed gold nanodisks on invisible substrate (AGNIS) as a label-free (no need for fluorescent labels), cost-effective, and high-performance platform for molecularly specific exosome biosensing. The AGNIS substrate has been fabricated by wafer-scale nanosphere lithography without the need for costly lithography," says Shih in the release.

This process speeds up screening of the surface proteins of exosomes for diagnostics and biomarker discovery. Current exosome profiling — which relies primarily on DNA sequencing technology, fluorescent techniques such as flow cytometry, or enzyme-linked immunosorbent assay (ELISA) — is labor-intensive and costly. Shih's goal is to amplify the signal by developing the label-free technique, lowering the cost and making diagnosis easier and equitable.

"By decorating the gold nanodisks surface with different antibodies (e.g., CD9, CD63, and CD81), label-free exosome profiling has shown increased expression of all three surface proteins in cancer-derived exosomes," said Shih. "The sensitivity for detecting exosomes is within 112-600 (exosomes/μL), which would be sufficient in many clinical applications."

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