Who's who

3 Houston innovators to know this week

This week's set of innovators to know are making waves in industries across Houston. Courtesy photos

In this Monday roundup of Houston innovators, we traverse into the restaurant, health care, and higher education industries with a startup founder focused on using technology to improve the dining experience, a self-starter in health care, and a leader on the Rice University campus with a new office for his growing staff.

Brad Burke, managing director of the Rice Alliance for Technology and Entrepreneurship

Photo via alliance.rice.edu

The Rice Alliance for Technology and Entrepreneurship has moved into its new Gensler-designed, 3,000-square-foot Bill and Stephanie Sick Suite that is expected to be a game changer for the program.

"The Rice Alliance meets frequently with venture capitalists, entrepreneurs, students, mentors, and other members of the Houston entrepreneurial ecosystem," says Brad Burke, who leads the innovation arm of Rice University. "The new space is on the first floor of the Jones School and is much more accessible and visible to our guests and visitors." Click here to read more and see photos of the space.

Roberta Schwartz, executive vice president and chief innovation officer at Houston Methodist

Courtesy of Houston Methodist

Roberta Schwartz is an innovator by nature. On last week's episode of the Houston Innovators Podcast, she shared her story of overcoming breast cancer as a young woman. Seeking a support system and camaraderie, she co-founded the Young Survival Coalition.

"I was 27 when I was unexpectedly diagnosed with breast cancer — I have no family history, no cancer in the family. It certainly was a shock to my system," Schwartz says on this week's episode of the Houston Innovators Podcast. "Once I was diagnosed, and through some of the original surgery and care I had to do, I knew that I wanted to reach out and find a larger community of young women."

Now, she's leading Houston Methodist's Center for Innovation, another entity she saw a need for, then created. Click here to read the story and stream the podcast episode.

Ken Bridge, founder of Roovy Technologies

Photo courtesy of Roovy

People use their smartphones for everything these days. So, Houston restaurateur Ken Bridge thought, why couldn't they use them to optimize their dining experience? Bridge created Roovy Technologies, and the app uses point-of-sale technology to put the power of ordering, paying, and communicating with the kitchen and bar, right into the hands of customers.

"Roovy is a platform that allows the user to order and pay entirely from their phone," says Bridge. "We will soon be the first company to have all three categories of this type of app: dine-in, take out and delivery." Click here to read more about Roovy.

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Building Houston

 
 

From biomolecular research to oral cancer immunotherapy, here are three research projects to watch out for in Houston. Photo via Getty Images

Research, perhaps now more than ever, is crucial to expanding and growing innovation in Houston — and it's happening across the city right under our noses.

In InnovationMap's latest roundup of research news, a couple local scientists are honored by awards while another duo of specialists tackle a new project.

University of Houston professor recognized with award

Mehmet Orman of UH has been selected to receive an award for his research on persister cells. Photo via UH.edu

Mehmet Orman, assistant professor of chemical and biomolecular engineering at the University of Houston Cullen College of Engineering has been honored with a Faculty Early Career Development Award from the National Science Foundation. The award comes with a $500,000 grant to study persister cells — cells that go dormant and then become tolerant to extraordinary levels of antibiotics.

"Nearly all bacterial cultures contain a small population of persister cells," says Orman in a news release. "Persisters are thought to be responsible for recurring chronic infections such as those of the urinary tract and for creating drug-resistant mutants."

Previously, Orman developed the first methods to directly measure the metabolism of persister cells. He also developed cell sorting strategies to segregate persisters from highly heterogeneous bacterial cell populations, and, according to the release, he will be using his methods in the NSF research project.

Houston researchers collaborate on oral cancer innovation

Dr. Simon Young of UTHealth and Jeffrey Hartgerink of Rice University are working on a new use for an innovative gel they developed. Photo via Rice.edu

Two Houston researchers — chemist and bioengineer Jeffrey Hartgerink at Rice University and Dr. Simon Young at the University of Texas Health Science Center at Houston — have again teamed up to advance their previous development of a sophisticated hydrogel called STINGel. This time, they are using it to destroy oral cancer tumors.

SynerGel combines a pair of antitumor agents into a gel that can be injected directly into tumors. Once there, the gel controls the release of its cargo to not only trigger cells' immune response but also to remove other suppressive immune cells from the tumor's microenvironment. The duo reported on the technology in the American Chemical Society journal ACS Biomaterials Science & Engineering.

SynerGel, combines a pair of antitumor agents into a gel that can be injected directly into tumors, where they not only control the release of the drugs but also remove suppressive immune cells from the tumor's microenvironment.

"We are really excited about this new material," Hartgerink says in a news release. "SynerGel is formulated from a specially synthesized peptide which itself acts as an enzyme inhibitor, but it also assembles into a nanofibrous gel that can entrap and release other drugs in a controlled fashion.

In 2018, the pair published research on the use of a multidomain peptide gel — the original STINGel — to deliver ADU-S100, an immunotherapy drug from a class of "stimulator of interferon gene (STING) agonists."

The research is supported by the Oral and Maxillofacial Surgery Foundation, the National Institutes of Health, the Welch Foundation, the National Science Foundation and the Mexican National Council for Science and Technology.

Texas Heart Institute researcher honored by national organization

Dr. James Martin of Texas Heart Institute has been named a senior member of the National Academy of Inventors. Photo courtesy of THI

The National Academy of Inventors have named Houston-based Texas Heart Institute's Dr. James Martin, director of the Cardiomyocyte Renewal Lab, a senior member.

Martin is an internationally recognized developmental and regenerative biologist and his research is focused on understanding how signaling pathways are related to development and tissue regeneration.

"Dr. Martin has long been a steward of scientific advancement and has proven to be a tremendous asset to the Texas Heart Institute and to its Cardiomyocyte Renewal Lab through his efforts to translate fundamental biological discoveries in cardiac development and disease into novel treatment strategies for cardiac regeneration," says Dr. Darren Woodside, vice president for research at THI, in a news release. "Everyone at the Texas Heart Institute is thrilled for Dr. Martin, whose induction into the NAI as a Senior Member is well-deserved."

Martin has authored over 170 peer-reviewed papers in top journals he holds nine U.S. patents and applications, including one provisional application, all of which have been licensed to Yap Therapeutics, a company he co-founded.

The full list of incoming NAI Senior Members, which includes three professionals from the University of Houston, is available on the NAI website.

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