New cancer-fighting nanodrug tops Houston innovation news to know

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The team developed Nano-273, which helps the immune system fight pancreatic and lung cancers. Photo courtesy UH

Editor's note: The new year brings big Houston innovation news, from pending retirements to new hires and a cancer-fighting nanodrug. Below are the five most-read InnovationMap stories published January 16-30, 2026:

1. Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

Wei Gao (center), a UH assistant professor of pharmacology, and her team have developed Nano-273, which helps the immune system fight pancreatic and lung cancers. Photo courtesy UH.

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within. Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum. Continue reading.

2. Rice Alliance and the Ion leader Brad Burke to retire this summer

Houston entrepreneurship and innovation leader Brad Burke is set to retire on June 30. Photo by Jeff Fitlow/Rice University

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university. Burke will remain at the Rice Alliance as an adviser until his retirement on June 30. Continue reading.

3. 5+ must-know application deadlines for Houston innovators

The University of Michigan's Intero Biosystems earned a top-place finish and the largest total investment from the 2025 Rice Business Plan Competition. Photo courtesy Rice University.

As 2026 ramps up, the Houston innovation scene is looking for the latest groups of innovative startups that'll make an impact. A number of accelerators and competitions have opened applications. See which might be a good fit for you or your venture, and take careful note of the deadlines. Continue reading.

4. Houston startups closed $1.75 billion in 2025 VC funding, says report

Local startups collected $1.75 billion in venture capital in 2025. Photo via Pexels.

Going against national trends, Houston-area startups raised 7 percent less venture capital last year than they did in 2024, according to the PitchBook-NVCA Venture Monitor report. The report shows local startups collected $1.75 billion in venture capital in 2025, down from $1.89 billion the previous year. Continue reading.

5. Baylor College of Medicine names Minnesota med school dean as new president, CEO

Baylor College of Medicine has named Dr. Jakub Tolar as its new president, CEO and executive dean. Photo courtesy of Mendel Lectures.

Dr. Jakub Tolar, dean of the University of Minnesota Medical School, is taking over as president, CEO and executive dean of Houston’s Baylor College of Medicine on July 1. Tolar—who’s also vice president for clinical affairs at the University of Minnesota and a university professor—will succeed Dr. Paul Klotman as head of BCM. Klotman is retiring June 30 after leading Texas’ top-ranked medical school since 2010. Continue reading.

Houston entrepreneurship and innovation leader Brad Burke is set to retire on June 30. Photo by Jeff Fitlow/Rice University

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

This year, two Houston innovation leaders will receive recognition as trailblazers at the 2024 Houston Innovation Awards. Photos courtesy

Houston Innovation Awards to honor 2 trailblazers with posthumous recognition

top leaders

Last month, the Houston innovation community suffered the loss of two business leaders who left a significant impact on the ecosystem. In November, both individuals' careers will be recognized with Trailblazer Legacy Awards.

Every year, the Houston Innovation Awards honors a Trailblazer Award recipient for their past and future dedication to startups in Houston, and this year InnovationMap is doing approaching the award differently in light of recent events. Paul Frison, founder of the Houston Technology Center, and Scott Gale, executive director of Halliburton Labs, will receive the award posthumously. Frison died on September 5, and Gale died on September 24. The award was decided on by the 2024 judges and InnovationMap.

“I am immensely proud to honor these two remarkable individuals with the Trailblazer Award this year. It is fitting, as they represent two generations of building Houston’s ecosystem," 2023 Trailblazer Award recipient Brad Burke, managing director of the Rice Alliance and the associate vice president for industry and new ventures within Rice University's Office of Innovation, tells InnovationMap.

"Paul Frison was a pioneering leader who helped establish the Houston Technology Center and fostered the city’s tech ecosystem during the initial technology boom around the year 2000. Scott Gale, through his work at Halliburton Labs over the past five years, has been instrumental in launching Houston’s energy transition ecosystem," he continues. "Both have played pivotal roles in championing technology innovators.”

A long-time Houston businessman, Frison founded HTC in 1999 and served as its CEO and president. The organization evolved into Houston Exponential several years ago. Frison remained active within Houston innovation until 2020. Prior to HTC, he served in various executive roles at American Hospital Supply, LifeMark, ComputerCraft, and LifeCell, spending the last 50 of his years in Houston. Born in Glendale, California, he served in the Unites States Coast Guard.

"Houston's vibrant technology entrepreneurship ecosystem is the product of Paul Frison's commitment to innovation, integrity, and growth for our community," says Walter Ulrich, former president and CEO of HTC. "He is the father of Houston's tech ecosystem, CEO of one of Houston's first tech Unicorns, founder of the Houston Technology Center ranked as a top ten technology incubator by Forbes, philanthropist, veteran, and family man."

Gale helped to launch Halliburton Labs in 2020. Prior to that role, he lead global strategy initiatives for Halliburton. A Brigham Young University graduate, he received his MBA from Rice University in 2019, where he co-founded the Jones Student Association for Executives. After his graduation, he served on the the Rice Business Alumni Association Board and the Energy Advisory Board for the Rice Alliance Clean Energy Accelerator. He was also a voice actor and the co-host of two podcasts: Rice University's Owl Have You Know Podcast, which shares experiences of Rice's business community, and the Curiosity podcast, which explored optimism and curiosity with guests and co-host Brad Rossacci.

"We established the Trailblazer Award to recognize the city's innovation leaders, and Scott and Paul both more than deserve to be recognized for their contributions to Houston," Natalie Harms, editor of InnovationMap, says. "My hope is that this year's Trailblazer Legacy Awards pay tribute to their lasting impacts."

The awards will be presented at the November 14 event.

Here's who's calling the shots for the 2024 Houston Innovation Awards. Photos courtesy

2024 Houston Innovation Awards names esteemed judges for annual program

meet the decision makers

Ten Houstonians are in the hot seat for deciding the best companies and individuals in Houston's innovation ecosystem.

InnovationMap has announced its 2024 Houston Innovation Awards judging panel, which includes startup founders, nonprofit leaders, investors, corporate innovators, and more. In addition to the 10 judges, InnovationMap Editor Natalie Harms will serve as the editorial representative on the judging panel.

The selected judges will evaluate applications from the nearly 300 nominations that were submitted this year. The judges will be using their expertise to evaluate the nominees' applications, which are due to InnovationMap this week.

Read about this year's judges below, and don't forget to secure your tickets to the November 14 event to see who the panel selects as the winners for the annual celebration of Houston innovation.

Angela Wilkins, chief data officer at Starling Medical

Houston data scientist joins medical device startup amid AI evolution in the sectorAngela Wilkins joins the Houston Innovators Podcast to discuss the intersection of data and health care. Photo courtesy

Angela Wilkins has had a decade-long career in data science in business and academia and now oversees data science for Houston health tech company Starling Medical. She founded Mercury Data Science, which became OmniScience, and previously ran Rice University's Ken Kennedy Institute as executive director.

Brad Burke, associate vice president for industry and new ventures at Rice University's Office of Innovation and executive director of the Rice Alliance

The 2023 recipient of the Trailblazer Award, Brad Burke returns to the Houston Innovation Awards as a judge. For over 20 years, he's led the Rice Alliance for Technology and Entrepreneurship, and recently took on a new leadership role within the university's growing Office of Innovation.

Calicia Johnson, senior product manager at Xbox and co-lead for Black at Xbox at Microsoft

Calicia Johnson is a leader within Microsoft's Houston office, especially when it comes to representing and encouraging diversity. She was named the winner of the 2023 DEI Champion award at the Houston Innovation Awards. Prior to Xbox, she worked for nearly 10 years in oil and gas with the bulk of that time at Chevron.

Emily Cisek, CEO and founder of The Postage

Last year, Emily Cisek's company, The Postage, a secure life planning and small business succession platform, was a finalist in three Houston Innovation Awards categories, winning the award for Female-Founded Business. She returns as a judge as her company continues to grow.

Grace Rodriguez, CEO and executive director of Impact Hub Houston

Grace Rodriguez was a judge for the inaugural Houston Innovation Awards in 2021, and she returns to judge the awards in accordance to her mission of helping "do gooders do greater." In addition to leading Impact Hub Houston, she is a board member of the City of Houston Office of Business Opportunity and is on the Board of Directors for Downtown Houston.

Joey Sanchez, founder of Cup of Joey

As the 2024 Ecosystem Builder award recipient, Joey Sanchez has worked for years leading Houston innovation, including as senior director of ecosystems at the Ion Houston and director of corporate engagement at Houston Exponential. He's now growing his startup, Cup of Joey, a weekly coffee meetup organization, across Houston.

Jon Nordby, managing partner at investment firm Anthropy Partners and founder of EconWerx

For years, Jon Nordby has been a champion of Houston innovation in his previous leadership roles at Houston Exponential, MassChallenge, and the Greater Houston Partnership. A former Houston Innovation Awards judge from 2021, he now works hands on with startups and organizations looking to grow an innovation ecosystem.

Margarita Kelrikh, counsel at Pillsbury

As counsel in Pillsbury's Houston office, Margarita Kelrikh has supported the firm's growing startup clients since her appointment earlier this year. Prior to joining the firm, she held in-house counsel positions at a few companies, including WeWork. She received her bachelor's degree at the University of Chicago and her law degree at Columbia School of Law.

Pedro Silva, co-founder of Milkify

Pedro Silva co-founded Milkify, a freeze-drying breastmilk service, with his wife, Berkley Luck, and the company has appeared on Shark Tank and won last year's BIPOC-Founded Business Award.

Wade Pinder, founder of Product Houston

As the 2023 Mentor of the Year winner, Wade Pinder has mentored countless Houston startups and has decades of experience in product development — most recently through his own company, Product Houston.

Editorial judge: Natalie Harms, editor of InnovationMap

For the fourth year, Natalie Harms will represent InnovationMap on the annual awards judging panel as the founding editor of InnovationMap the host of the Houston Innovators Podcast.

She reports on innovation and technology for InnovationMap and on energy transition for EnergyCapitalHTX — and their impact on the city of Houston. A Houston native, she's worked as a business journalist for almost a decade and has a degree in journalism from the University of Houston and a certificate in publishing from New York University.

Paul Frison, the founder of the Houston Technology Center, has died. Photo via dignitymemorial.com

Houston Technology Center founder dies, leaves legacy of innovation

saying goodbye

The Houston innovation ecosystem is mourning the loss of one of its early leaders, Paul Frison, who died on September 5. He was 87.

A long-time Houston businessman, Frison founded the Houston Technology Center in 1999 and served as its CEO and president. The organization evolved into Houston Exponential several years ago. Frison remained active within Houston innovation until 2020.

“Paul Frison was a visionary and energetic leader who always presented a positive outlook on what the Houston technology entrepreneurship community could become," Brad Burke, associate vice president for industry and new ventures at Rice University's Office of Innovation, remembers. "He was one of the pioneers in the community who established the Houston Technology Center as one of the early leaders of the Houston ecosystem. I admired how he helped launch the ecosystem and created the platform for many others to build upon.”

Prior to HTC, he served in various executive roles at American Hospital Supply, LifeMark, ComputerCraft, and LifeCell, spending the last 50 of his years in Houston. Born in Glendale, California, he served in the Unites States Coast Guard.

Blair Garrou, co-founder and managing director of Mercury Fund, says Frison was his first boss and mentor in the tech and entrepreneurship sector.

“When people look back to how the Houston tech community was founded, it starts with Paul Frison," Garrou says. "Paul had run multiple companies and I was lucky to have him as CEO when I worked for him at the Houston Technology Center. He quickly became a mentor, and over time, a good friend and confidant. I have Paul to thank for launching my career in tech and venture capital.

"My favorite quote of Paul’s was, 'Do not confuse effort with results,'” Garrou continues. "Despite his results-driven work ethic – which was legendary — Paul was also deeply-rooted in family and faith, and has been a role model for me over my entire professional life.”

He is preceded in death by his wife, Barbara, and his grandson, Christian David Elders. He is survived by his daughters Maryanne Elders and Jill Cortez and their families, including grandchildren Matthew Elders, Laney Elders, Max Cortez, Jake Cortez, and Sofie Cortez.

A celebration of life will be held for Frison on September 16 at 1 pm at Second Baptist Church, with a reception following in the Deacon’s Parlor. More details are available online. In lieu of flowers, Frison's wishes were for for donations to Second Baptist Church to be made in his honor.

Introducing: Houston Energy and Climate Startup Week, a collaborative initiative that will showcase Houston's ecosystem of energy tech innovators. Photo via Getty Images

Houston organizations team up to bring inaugural climate startup week

mark your calendars

Three organizations are teaming up to put on a week of programming and events focused on energy and climate startups.

Greentown Labs, Halliburton Labs, and the Rice Alliance for Technology and Entrepreneurship have announced Houston Energy and Climate Startup Week 2024 taking place September 9 to 13.

“These organizations will execute events that will serve as a launching pad for an Energy and Climate Startup Week in Houston, showcasing the city as a national hub for the energy future,” Brad Burke, executive director of the Rice Alliance, says in the release. “We welcome the community to bring other energy and climate events to the week, which we’ll cross-promote as the dates approach.”

The week will assemble investors, industry leaders, and startups from across the energy industry and from around the world to showcase Houston's growing sustainable, low-carbon energy future.

The initiative is in collaboration with the Houston Energy Transition Initiative, or HETI, an initiative of the Greater Houston Partnership, as well as Activate, Digital Wildcatters, Renewable Energy Alliance Houston, and TEX-E.

“As the energy capital and one of the most diverse cities in the world, Houston stands as a center point for these solutions. The region is welcoming, diverse and has the know-how to play a critical role in building an energy abundant, low-carbon future," Jane Stricker, executive director of HETI and senior vice president at GHP, says in the release. "We welcome all who want to be part of the solution to join for this exciting, inaugural week of events.”

Attendees can expect tech and startup showcases, panels, pitches, discussions, and networking events to be hosted across Houston and at the Ion, Rice's innovation hub in Midtown. More details on the events will be added to the Ion's website as they become available.

“We look forward to the opportunity to highlight talented founders and connect them with investors, industry practitioners and university resources to help accelerate energy innovation,” Dale Winger, managing director of Halliburton Labs, says in the release. “The collaboration to launch Energy and Climate Startup Week reflects how Houston works together to scale solutions."

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Axiom Space tops $525M in oversubscribed round, announces Swiss subsidiary

funding boost

Axiom Space tacked on an additional $175 million to a previously announced capital raise, bringing the oversubscribed round to a total of more than $525 million.

Axiom shared in February that it had secured $350 million in a financing round led by Type One Ventures and Qatar Investment Authority. In the latest release from the company, Axiom reports that Japan-based MUFG Bank Ltd. joined the round as a new investor, in addition to continued participation from existing backers.

The funding will go toward developing the company's commercial space station, known as Axiom Station, and the production of its Axiom Extravehicular Mobility Unit (AxEMU) under its NASA spacesuit contract.

“Investor interest in this round outpaced what we set out to raise, which speaks to the moment we’re in,” Jonathan Cirtain, CEO and president of Axiom Space, said in the news release. “Our partners see what is possible in low-Earth orbit, and they see who is positioned to lead it.”

Axiom announced last month that it planned to open a Japanese subsidiary July 1. Earlier this week, it also shared plans to establish Axiom Space Switzerland, a wholly owned subsidiary based in Lucerne that is also expected to begin operations this summer.

The Switzerland subsidiary aims to establish Axiom's presence in Europe and help it partner with the European Space Agency and other space organizations and companies on the continent.

“Europe is a founding leader in the creation of the commercial space economy, and Switzerland is uniquely positioned to convene the government agencies, research institutions, and industrial entities that will shape its next decade,” Cirtain added in a separate release. “Axiom Space Switzerland facilitates the scaling of development and deployment of the infrastructure that will succeed the International Space Station.”

Texas cashes in among 10 best U.S. state economies in 2026 report

State Economics

A new study gauging the success or decline in economic performance in every state has revealed Texas' economy remains stable in 2026 after it dropped out of the top five to No. 8 last year.

Texas boasts the No. 8 best state economy in the U.S. this year, according to WalletHub's annual "Best & Worst State Economies" report. The personal finance website's analysts ranked all 50 states and the District of Columbia across 28 relevant metrics to measure each state's economic activity and health status, and its "innovation potential."

Notably, Texas leads the nation for the most exports per capita in the U.S. in a five-way tie with Louisiana, Kentucky, North Dakota, and Indiana. Across the study's three main categories, Texas ranked highly for its economic activity (No. 7) and economic health (No. 11), and the state's "innovation potential" rank is the 24th best in the nation.

This is how WalletHub ranked Texas' economic performance, where No. 1 is considered the best and No. 25 is considered average:

No. 6 – Change in non-farm payrolls
No. 8 – Change in GDP
No. 8 – Startup activity
No. 11 – Annual median household income
No. 18 – Government surplus/deficit per capita
No. 21 – Percentage of jobs in high-tech industries
No. 30 – Unemployment rate

WalletHub previously ranked Texas one of the top three states to start a business in 2026, with Houston earning its own entrepreneurial acclaim in separate rankings of the best big cities for new businesses and for starting a career.

"U.S. economic growth depends heavily on the performance of individual states, and some contribute more than others," the report's author wrote. "For example, California, Texas, New York and Florida have economies so large that if they were countries, they would rank in the top 20 in the world."

The five states with the worst state economies in 2026 are Rhode Island (No. 47), Maine (No. 48), Louisana (No. 49), Kentucky (No. 50), and West Virginia (No. 51).

The top 10 best state economies for 2026 are:

No. 1 – Massachusetts
No. 2 – Washington
No. 3 – Utah
No. 4 – California
No. 5 – Delaware
No. 6 – North Carolina
No. 7 – New York
No. 8 – Texas
No. 9 – Colorado
No. 10 – Florida

---

This article originally appeared on CultureMap.com.

Houston lab explores how AI bots can help the elderly

AI for aging

The University of Houston’s Empathetic Lifespan AI & Robotics for Aging (ELARA) Lab is currently conducting research into how AI bots may be able to help the elderly live more social and independent lives through several ongoing initiatives.

The lab officially launched last month as part of the Gerald D. Hines College of Architecture & Design under the leadership of Assistant Professor Chorong Park. Part of the lab’s mission is tackling ongoing problems with aging, such as dealing with disabilities and social isolation. Researchers’ current work is focused on designing a new AI companion bot specifically tailored to the needs of older people.

“We need to take all the needs of older adults seriously,” Park said in a news release. “They won't use the robot if they don't feel at ease or if they feel they are being constantly watched.”

The field testing of new AI bots in this population hopes to overcome several traditional obstacles in technology use among the elderly. A study by Park shows that many older people have a fear of overt surveillance when using advanced AI. There is also ageism to consider. Most new technologies are designed with younger and employed buyers in mind, not retirees who may need help remembering daily tasks or accessing important information.

“The more older adults are excluded from technology development, the worse those technology gaps will become,” Park said. “AI and the majority of technologies are created for younger people, so my research method integrates older adults directly into the design process.”

ELARA recently collaborated with the Mamie George Community Center in Richmond, Texas, to track seniors’ response to desktop AI bots like Emo and Cupboo. Researchers also had participants use air-dry modeling clay to create their ideal robotic companion.

While the eventual AI bot may be able to help the elderly feel less isolated and more supported, there are concerns to consider. A study published in the Asian Journal of Psychology charted the development of delusional thinking in a 72-year-old woman who became convinced the empathic-response bot was in love with her. The rise of “AI psychosis” has the potential to exacerbate mental health problems, particularly in socially isolated people, which a quarter of Americans over the age of 65 are.

ELARA’s research is focused on creating “pet-like” AI models with enhanced trust cues. If it can overcome the dangers of socially isolated people relying on AI for companionship, it could be a big step forward for independent aging.

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