HOUSTON INNOVATORS PODCAST EPISODE 11

Houston Methodist executive to lead the hospital into the future of health care

Roberta Schwartz is leading the innovation efforts at Houston Methodist. Courtesy of Houston Methodist

It may come as no surprise to anyone who's met Roberta Schwartz that she's a self starter. Schwartz, who is the executive vice president and chief innovation officer for Houston Methodist, was among the group that organized to create what is now the Center for Innovation within the hospital system.

But one of her earlier moments of innovation leadership came when she was diagnosed with cancer at a young age. She co-founded the Young Survival Coalition to help connect young breast cancer patients like herself.

"I was 27 when I was unexpectedly diagnosed with breast cancer — I have no family history, no cancer in the family. It certainly was a shock to my system," Schwartz says on this week's episode of the Houston Innovators Podcast. "Once I was diagnosed, and through some of the original surgery and care I had to do, I knew that I wanted to reach out and find a larger community of young women."

Now, in her role at Houston Methodist, Schwartz hopes to help cultivate new avenues of innovation within health care — from wearable technology and virtual reality to a human resources chatbot and a patient messaging platform.

Schwartz discusses these new technologies — as well as a new tech hub the hospital system is working on to demonstrate the future of health care — in the episode. Stream the episode below and subscribe wherever you get your podcasts.


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A research team housed out of the newly launched Rice Biotech Launch Pad received funding to scale tech that could slash cancer deaths in half. Photo via Rice University

A research funding agency has deployed capital into a team at Rice University that's working to develop a technology that could cut cancer-related deaths in half.

Rice researchers received $45 million from the National Institutes of Health's Advanced Research Projects Agency for Health, or ARPA-H, to scale up development of a sense-and-respond implant technology. Rice bioengineer Omid Veiseh leads the team developing the technology as principal investigator.

“Instead of tethering patients to hospital beds, IV bags and external monitors, we’ll use a minimally invasive procedure to implant a small device that continuously monitors their cancer and adjusts their immunotherapy dose in real time,” he says in a news release. “This kind of ‘closed-loop therapy’ has been used for managing diabetes, where you have a glucose monitor that continuously talks to an insulin pump. But for cancer immunotherapy, it’s revolutionary.”

Joining Veiseh on the 19-person research project named THOR, which stands for “targeted hybrid oncotherapeutic regulation,” is Amir Jazaeri, co-PI and professor of gynecologic oncology at the University of Texas MD Anderson Cancer Center. The device they are developing is called HAMMR, or hybrid advanced molecular manufacturing regulator.

“Cancer cells are continually evolving and adapting to therapy. However, currently available diagnostic tools, including radiologic tests, blood assays and biopsies, provide very infrequent and limited snapshots of this dynamic process," Jazaeri adds. "As a result, today’s therapies treat cancer as if it were a static disease. We believe THOR could transform the status quo by providing real-time data from the tumor environment that can in turn guide more effective and tumor-informed novel therapies.”

With a national team of engineers, physicians, and experts across synthetic biology, materials science, immunology, oncology, and more, the team will receive its funding through the Rice Biotech Launch Pad, a newly launched initiative led by Veiseh that exists to help life-saving medical innovation scale quickly.

"Rice is proud to be the recipient of the second major funding award from the ARPA-H, a new funding agency established last year to support research that catalyzes health breakthroughs," Rice President Reginald DesRoches says. "The research Rice bioengineer Omid Veiseh is doing in leading this team is truly groundbreaking and could potentially save hundreds of thousands of lives each year. This is the type of research that makes a significant impact on the world.”

The initial focus of the technology will be on ovarian cancer, and this funding agreement includes a first-phase clinical trial of HAMMR for the treatment of recurrent ovarian cancer that's expected to take place in the fourth year of THOR’s multi-year project.

“The technology is broadly applicable for peritoneal cancers that affect the pancreas, liver, lungs and other organs,” Veiseh says. “The first clinical trial will focus on refractory recurrent ovarian cancer, and the benefit of that is that we have an ongoing trial for ovarian cancer with our encapsulated cytokine ‘drug factory’ technology. We'll be able to build on that experience. We have already demonstrated a unique model to go from concept to clinical trial within five years, and HAMMR is the next iteration of that approach.”

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