Houston voices

Houston research: Why you need a data management plan

Every situation is unique and deserves a one-of-the-kind data management plan, not a one-size-fits-all solution. Graphic byMiguel Tovar/University of Houston

Why do you need a data management plan? It mitigates error, increases research integrity and allows your research to be replicated – despite the “replication crisis” that the research enterprise has been wrestling with for some time.

Error

There are many horror stories of researchers losing their data. You can just plain lose your laptop or an external hard drive. Sometimes they are confiscated if you are traveling to another country — and you may not get them back. Some errors are more nuanced. For instance, a COVID-19 repository of contact-traced individuals was missing 16,000 results because Excel can’t exceed 1 million lines per spreadsheet.

Do you think a hard drive is the best repository? Keep in mind that 20 percent of hard drives fail within the first four years. Some researchers merely email their data back and forth and feel like it is “secure” in their inbox.

The human and machine error margins are wide. Continually backing up your results, while good practice, can’t ensure that you won’t lose invaluable research material.

Repositories

According to Reid Boehm, Ph.D., Research Data Management Librarian at the University of Houston Libraries, your best bet is to utilize research data repositories. “The systems and the administrators are focused on file integrity and preservation actions to mitigate loss and they often employ specific metadata fields and documentation with the content,” Boehm says of the repositories. “They usually provide a digital object identifier or other unique ID for a persistent record and access point to these data. It’s just so much less time and worry.”

Integrity

Losing data or being hacked can challenge data integrity. Data breaches do not only compromise research integrity, they can also be extremely expensive! According to Security Intelligence, the global average cost of a data breach in a 2019 study was $3.92 million. That is a 1.5 percent increase from the previous year’s study.

Sample size — how large or small a study was — is another example of how data integrity can affect a study. Retraction Watch removes approximately 1,500 articles annually from prestigious journals for “sloppy science.” One of the main reasons the papers end up being retracted is that the sample size was too small to be a representative group.

Replication

Another metric for measuring data integrity is whether or not the experiment can be replicated. The ability to recreate an experiment is paramount to the scientific enterprise. In a Nature article entitled, 1,500 scientists lift the lid on reproducibility, “73 percent said that they think that at least half of the papers can be trusted, with physicists and chemists generally showing the most confidence.”

However, according to Kelsey Piper at Vox, “an attempt to replicate studies from top journals Nature and Science found that 13 of the 21 results looked at could be reproduced.”

That's so meta

The archivist Jason Scott said, “Metadata is a love note to the future.” Learning how to keep data about data is a critical part of reproducing an experiment.

“While this will be always be determined by a combination of project specifics and disciplinary considerations, descriptive metadata should include as much information about the process as possible,” said Boehm. Details of workflows, any standard operating procedures and parameters of measurement, clear definitions of variables, code and software specifications and versions, and many other signifiers ensure the data will be of use to colleagues in the future.

In other words, making data accessible, useable and reproducible is of the utmost importance. You make reproducing experiments that much easier if you are doing a good job of capturing metadata in a consistent way.

The Big Idea

A data management plan includes storage, curation, archiving and dissemination of research data. Your university’s digital librarian is an invaluable resource. They can answer other tricky questions as well: such as, who does data belong to? And, when a post-doctoral student in your lab leaves the institution, can s/he take their data with them? Every situation is unique and deserves a one-of-the-kind data management plan, not a one-size-fits-all solution.

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This article originally appeared on the University of Houston's The Big Idea. Sarah Hill, the author of this piece, is the communications manager for the UH Division of Research.

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Building Houston

 
 

Proxima Clinical Research has announced an office expansion — and more Houston innovation news. Photo via Twitter

Houston's innovation ecosystem has had some big news this month, from new job titles for Houston innovators to expanding office space.

In this roundup of Houston startup and innovation news, a Houston organization expands its footprint in the TMC, Rice University opens applications for a cleantech accelerator, and more.

Organization expands footprint in Houston

Proxima CRO has announced its expansion within TMCi. Photo via Twitter

Proxima Clinical Research, a contract research organization headquartered in Houston, announced that it is expanding its office space in the Texas Medical Center Innovation Factory.

"Texas Medical Center is synonymous with innovation, and the TMC Innovation space has proven an ideal location for our CRO. It's an important part of our origin story and a big part of our success," says Kevin Coker, CEO and co-founder of Proxima CRO, in a news release.

The expansion will include around 7,500-square feet of additional office space.

"The resources found across TMC's campuses allow for companies such as Proxima Clinical Research to achieve clinical and business milestones that will continue to shape the future of life sciences both regionally and globally. We are excited for Proxima to expand their footprint at TMC Innovation Factory as they further services for their MedTech customers," says Tom Luby, director of TMC Innovation, in the release.

$20M grant fuels hardtech program's expansion

Activate is planting its roots in Houston with a plan to have its first set of fellows next year. Photo via Activate.org

A hardtech-focused nonprofit officially announced its Houston expansion this week. Activate, which InnovationMap reported was setting up its fifth program here last month, received a $20M commitment by the National Science Foundation to fuel its entrance into the Bayou City.

“Houston’s diversity offers great promise in expanding access for the next generation of science entrepreneurs and as a center of innovation for advanced energy," says NSF SBIR/STTR program director Ben Schrag in a news release.

The organization was founded in Berkeley, California, in 2015 to bridge the gap between the federal and public sectors to deploy capital and resources into the innovators creating transformative products. The nonprofit expanded its programs to Boston and New York before launching a virtual fellowship program — Activate Anywhere, which is for scientists 50 or more miles outside one of the three hubs.

“We are delighted to be opening our newest Activate community in Houston,” says Activate Anywhere managing director Hannah Murnen, speaking at the annual Advanced Research Projects Agency-Energy Innovation Summit. “Houston is a city where innovation thrives, with an abundance of talent, capital, and infrastructure—the perfect setting for the Activate Fellowship.”

Activate is still looking its Houston’s first managing director is actively underway and will select fellows for Activate Houston in 2024.

TMC names new entrepreneur in residence

Zaffer Syed has assumed a new role at TMC. Photo via TMC.org

Houston health tech innovator has announced that he has joined the Texas Medical Center's Innovation Factory as entrepreneur in residence for medtech. Zaffer Syed assumed the new role this month, according to his LinkedIn, and he's been an adviser for the organization since 2017.

Syed has held a few leadership roles at Saranas Inc., a medical device company founded in Houston to detect internal bleeding following medical procedures. He now serves as adviser for the company.

"As CEO of Saranas, he led the recapitalization of the company that led to the FDA De Novo classification and commercial launch of a novel real-time internal bleed monitoring system for endovascular procedures," reads the TMC website. "Zaffer oversaw clinical development, regulatory affairs and strategic marketing at OrthoAccel Technologies, a private dental device startup focused on accelerating tooth movement in patients undergoing orthodontic treatment.

"Prior to working in startup ventures, Zaffer spent the first 13 years of his career in various operational roles at St. Jude Medical and Boston Scientific to support the development and commercialization of Class III implantable devices for cardiovascular and neuromodulation applications."

TMC is currently looking for an entrepreneur in residence for its TMCi Accelerator for Cancer Therapeutics program.

Applications open for clean energy startup program

Calling all clean energy startups. Photo courtesy of The Ion

The Clean Energy Accelerator, an energy transition accelerator housed at the Ion and run by the Rice Alliance for Technology and Entrepreneurship, has opened applications for Class 3. The deadline to apply is April 14.

The accelerator, which helps early-stage ventures reach technical and commercial milestones through hybrid programming and mentorship, will host its Class 3 cohort from July 25 to Sept. 22.

“Accelerating the transition to a net-zero future is a key goal at Rice University. Through accelerating the commercial potential of our own research as well as supporting the further adoption of global technologies right here in Houston, the Rice Alliance Clean Energy Accelerator is proof of that commitment,” says Paul Cherukuri, vice president of innovation at Rice, in a news release. “The Rice Alliance has all the critical components early-stage energy ventures need for success: a corporate innovation network, energy investor network, access to mentors and a well-developed curriculum. This accelerator program is a unique opportunity for energy startups to successfully launch and build their ventures and get access to the Houston energy ecosystem.”

According to Rice, the 29 alumni companies from Class 1 and 2 have gone on to secure grants, partnerships, and investments, including more than $75 million in funding. Companies can apply here, learn more about the accelerator here or attend the virtual information session April 3 by registering here.

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