Houston health tech accelerator launches nonprofit to spark, support female leaders in the industry

igniting change

Ignite has announced a new foundation to further its reach in supporting women in health care. Photo via ignitehealthcare.org

For the past few years, a Houston organization has supported nearly 100 female-founded health tech startups with programming, crucial connections, and more. Now, with a newly launched nonprofit arm, the organization is taking it to the next level to bolster women in health care.

Ignite Healthcare Network, which was founded in 2017 by longtime Houston health care professional Ayse McCracken, has created Ignite Health Foundation, a nonprofit foundation, to go beyond startups and technology to support women in health care across the board with networking and events, in-person and virtual programming, professional development, and more.

"The Foundation is a vehicle for major fundraising grants and foundations allowing Ignite to scale the work we do to discover exceptional women leaders and innovators, connect them with an expert community and help them achieve their career goals," McCracken says in a news release.

"This initiative not only amplifies our commitment to inspiring innovation in an untapped resource, female leaders and entrepreneurs but also sets the stage for groundbreaking advancements in healthcare," she adds.

The foundation will accept donations from those who look to level the playing field for women in health care leadership and to support innovative endeavours from female founders. The financial support will go toward all of Ignite's programming

"Join us on the journey and invest in women shaping the future of healthcare to create an inclusive and healthier world," says Sara Speer Selber, chair of Friends of Ignite Health Foundation, in the release.

Last month, Ignite hosted its annual Fire Pitch Competition at the Ion, crowning the award recipients and doling out cash prizes. This year, eight finalists of the 19-company cohort presented at the competition for judges and an audience, and three companies secured top spots and prizes.

In a recent interview with InnovationMap, McCracken spoke to how she's always looking for ways to grow her impact with Ignite.

"Having an impact in the health care industry and finding solutions is important to me," McCracken says of her passion for Ignite on a recent episode of the Houston Innovators Podcast. "The second aspect of that is there are so many women in health care, and yet you don't see them in leadership roles."

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Ayse McCracken joins the Houston Innovators Podcast to discuss women in health care and Ignite Madness. Photo courtesy of Ignite

Houston innovator is putting female health tech entrepreneurs on center stage

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When COVID-19 hit, Ayse McCracken realized that women in health care were going to be disproportionately affected by the pandemic and social isolation. As the founder and board chair of Ignite Healthcare Network, a nonprofit dedicated to connecting and promoting female health tech entrepreneurs, McCracken jumped to provide a virtual way to connect her members.

"With COVID, it has only escalated the importance of our work, so we've elevated our voices through our webinar series," McCracken says on this week's Houston Innovators Podcast.

The webinars featured prominent women in health care discussing leaderships, the effect of the pandemic, and more. Now, Ignite has introduced an entirely new virtual event series focused on startups and, something slightly unexpected: basketball. Ignite Madness begins tomorrow, October 22, and will feature 35 startups. The startups will be narrowed down to seven finalists, who will then pitch at the finals next Thursday, October 29. Click here to register.

"We wanted to do something that was kind of fun and engaging for people while showcasing great entrepreneurs. We didn't want it to just be a pitch event," McCracken says. "When you look at basketball, the similarities were very interesting."

Women make up a significant portion of the fan base for basketball, McCracken says she discovered, and she had the idea of featuring female coaches into the pitch competition. Seven college basketball coaches will be involved in the event as mentors, sharing their own stories.

McCracken says she was strategic when organizing the pitch competition and made sure the competing companies were representative of both the industry's innovation and of diversity. The startups from 13 states across the United States and six other countries — 43 percent of the founders pitching are women of color.

"When we say women, we mean women of all colors and ethnicities," McCracken says. "We have made sure that our leadership team is diverse and inclusive. Everything we do, you'll see women in a very inclusive way."

While you'll have to watch the pitches yourself, McCracken says, the startups are focusing on novel medical devices, cancer detection, and nanotech-based treatment selection platforms, mental health platforms, telehealth solutions, digital solutions for women's health issues like fertility, and so much more.

McCracken shares more about what viewers can expect from the event as well as the important role women in health care play and the evolution of the industry in Houston on the podcast. You can listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


Ignite Healthcare Network has hosted a pitch compeition for a few years now, but this is the first year for its mini-accelerator program. Courtesy of Ignite

Houston nonprofit launches accelerator program to give women-led startup a leg up within health care

The future is female

Within health care, female consumers make 80 percent of the buying power while women hold 65 percent of the workforce's jobs, according to a recent study. However, when you look at the C-suites in the industry, those percentages fall drastically, says Ayse McCracken.

"For as many women as there are involved in health care, it's not reflected in leadership," says McCracken, founder of Ignite Healthcare Network. "That's what brought us together."

Just 30 percent of health care C-suites are women — and only 13 percent have female CEOs, per the report by Oliver Wyman. Houston-based nonprofit Ignite is an organization comprised of over 150 of these rare female health care execs and focused on clearing a path for future female leaders in the industry.

McCracken founded the network in 2016, and her team established a "Shark Tank-style" pitch competition. After three years of the annual event seeing successes, Ignite is introducing its inaugural mini-accelerator program.

"As we saw this innovation economy and startup space begin to evolve in the city, it seemed that our contribution to this was that we could help incubate and find companies that had high likelihood of success," says McCracken.

Ignite and its partners identified 13 female-led companies from all around the world were selected from over 80 applications and now will go through a 10-week program called the Customer-Partner Program. Each company is paired with a partner and potential customer — from Memorial Hermann and Texas Children's Hospital to Humana and Gallagher.

Here are the participating female-led startups:

  • iTreatMD from San Francisco
  • BabyNoggin (by Qidza) from San Francisco
  • Ria Health from San Francisco
  • Savonix from San Francisco
  • MotiSpark from Los Angeles
  • UpHold Health from Chicago
  • Sound Scouts from Sydney, Australia
  • Augment Therapy from Cleveland, Ohio
  • Oncora Medical Philadelphia
  • Materna Medical from Mountain View, California
  • Path Ex Inc Houston
  • PyrAmes Inc. from Cupertino, California
  • Spoke Health Denver

The Fire Pitch Competition will take place on October 17 at the Texas Medical Center's Innovation Institute. Hundreds of thousands of dollars in prizes is on the line for the 13 companies.

"This year's event is already receiving increased recognition from investors," says Ignite board member and event co-chair, Cheryl Stavins, in a release. "In addition to the top three finalists sharing awards that include entry into the TMCx Digital Health Accelerator, over $125,000 in professional services, and cash prizes of $10,000, Fire Pitch participants will be eligible for investment prizes."

The Texas Halo Fund will be awarding its $100,000 investment prize, called the Corona Award, along with a $50,000 prize from TMC Innovation Institute.

Beyond the new program, McCracken says she wants to expand Ignite's reach and capabilities for its members and startups — including new investment opportunities.

"I think what we're doing now is reaching out beyond Houston and looking at how we can continue to grow the opportunity to have an impact and help women-led companies and women in organizations," she says.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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