Most of Houston's smartest ZIP codes surround the Texas Medical Center. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

The Houston area is bursting with brain power. Three ZIP codes in the region are home to the biggest share of Texans who've earned a master's, professional, or doctoral degree, according to a new list from UnitedStatesZipCodes.org. And that, according to one economic development executive, is a boon to Houston's workforce.

Houston's 77030 ZIP code, which houses the Texas Medical Center, sits atop the new ranking. There, more than half (51.7 percent) of adults 25 and over, or about 3,800 people, hold a postgraduate or professional degree. As a whole, 12 percent of adults in the Houston metro area have a postgraduate or professional degree, according to the Greater Houston Partnership.

The postgraduate category includes PhDs and MBAs, while the professional category includes JDs (law degrees) and MDs (medical degrees).

"When deciding where to live, neighborhoods full of residents with postgraduate degrees are … increasingly attractive," reads UnitedStatesZipCodes.org, which based its ranking on U.S. Census Bureau data. "Well-educated communities — full of leaders in technology, medicine, business, and more — can bring new industries and revenue."

Ranking second on the list of brainiest Texas ZIP codes is Houston's 77005, where 48.5 percent of adults (or about 8,600 people) hold a postgraduate or professional degree. This ZIP code, which neighbors the 77030 ZIP code, includes the Rice campus. Also, it's presumably home to a lot of highly educated Rice professors and Texas Medical Center doctors.

Directly to the west of the 77030 ZIP is Bellaire — 77401 — which appears at No. 3 in the ranking. In the 77401 ZIP code, 47.6 percent of adults (or nearly 6,300 people) have earned a postgraduate or professional degree; it, too, is likely packed with Rice University professors and Texas Medical Center doctors.

Susan Davenport, senior vice president of economic development at the Greater Houston Partnership, says the region's two top-tier schools — Rice and the University of Houston — along with the region's more than 40 other four-year and two-year schools contribute to Houston's collective brain trust. So do two nearby schools: the University of Texas at Austin and Texas A&M University in College Station.

"More broadly, we are an attractive market for educated professionals from across the country, especially compared to leading East or West Coast cities, because of our lower cost of living, affordable housing prices, and strong economy," Davenport says.

"This creates a virtuous cycle: Companies move to or expand in Houston because they want access to this talent," she adds, "and leading talent moves here because they want to work for these companies and institution."

Davenport says initiatives like the Innovation Corridor, the TMC3 research campus and The Ion entrepreneurship hub also help nurture a well-educated workforce.

"We anticipate these projects will attract even more of the world's brightest minds to our region," she says.

Three other Houston ZIP codes made the top 10 in Texas:

  • No. 5 — 77098 (39.2 percent). That percentage represents about 4,300 people. This ZIP code is just northwest of the Rice and Texas Medical Center campuses.
  • No. 6 — 77025 (39.15 percent). That percentage represents almost 8,200 people. This ZIP code is just southwest of the Rice and Texas Medical Center campuses.
  • No. 10 — 77024 (35.4 percent). That percentage represents about 9,400 people. This ZIP code is slightly east of the Energy Corridor.

"It is no surprise that top-flight, innovation-focused talent would flock to neighborhoods near downtown, Uptown and the world-renowned Texas Medical Center," Davenport says.

Other Texas ZIP codes in the top 10 for postgraduate or professional degrees are:

  • No. 4 — 78703, Austin (41.5 percent). This ZIP code, less than two miles west of the University of Texas campus, includes high-end neighborhoods such as Tarrytown and Old West Austin.
  • No. 7 — 75205, Dallas (37.7 percent). The Southern Methodist University campus sits on the east side of this ZIP code.
  • No. 8 — 78746, Austin (37.2 percent). This ZIP code encompasses parts of West Austin, as well as the wealthy suburbs of Rollingwood and West Lake Hills.
  • No. 9 — 78731, Austin (37.1 percent). This ZIP code incorporates part of Central Austin and a large swath of Northwest Austin.

Federal data shows the unemployment rates for people with master's, professional, and doctoral degrees are lower than for other groups, such as people whose bachelor's or associate's degrees are their most advanced degrees. In addition, people with a postgraduate or professional degree typically earn more money.

"Graduates with the right knowledge and skills have the ability to demand higher salaries, as they are equipped to make significant contributions to the revenue and growth of the companies they work for," the Digital Marketing Institute says.
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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.