This Houston ZIP code declared the smartest in Texas

brain power

Most of Houston's smartest ZIP codes surround the Texas Medical Center. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

The Houston area is bursting with brain power. Three ZIP codes in the region are home to the biggest share of Texans who've earned a master's, professional, or doctoral degree, according to a new list from UnitedStatesZipCodes.org. And that, according to one economic development executive, is a boon to Houston's workforce.

Houston's 77030 ZIP code, which houses the Texas Medical Center, sits atop the new ranking. There, more than half (51.7 percent) of adults 25 and over, or about 3,800 people, hold a postgraduate or professional degree. As a whole, 12 percent of adults in the Houston metro area have a postgraduate or professional degree, according to the Greater Houston Partnership.

The postgraduate category includes PhDs and MBAs, while the professional category includes JDs (law degrees) and MDs (medical degrees).

"When deciding where to live, neighborhoods full of residents with postgraduate degrees are … increasingly attractive," reads UnitedStatesZipCodes.org, which based its ranking on U.S. Census Bureau data. "Well-educated communities — full of leaders in technology, medicine, business, and more — can bring new industries and revenue."

Ranking second on the list of brainiest Texas ZIP codes is Houston's 77005, where 48.5 percent of adults (or about 8,600 people) hold a postgraduate or professional degree. This ZIP code, which neighbors the 77030 ZIP code, includes the Rice campus. Also, it's presumably home to a lot of highly educated Rice professors and Texas Medical Center doctors.

Directly to the west of the 77030 ZIP is Bellaire — 77401 — which appears at No. 3 in the ranking. In the 77401 ZIP code, 47.6 percent of adults (or nearly 6,300 people) have earned a postgraduate or professional degree; it, too, is likely packed with Rice University professors and Texas Medical Center doctors.

Susan Davenport, senior vice president of economic development at the Greater Houston Partnership, says the region's two top-tier schools — Rice and the University of Houston — along with the region's more than 40 other four-year and two-year schools contribute to Houston's collective brain trust. So do two nearby schools: the University of Texas at Austin and Texas A&M University in College Station.

"More broadly, we are an attractive market for educated professionals from across the country, especially compared to leading East or West Coast cities, because of our lower cost of living, affordable housing prices, and strong economy," Davenport says.

"This creates a virtuous cycle: Companies move to or expand in Houston because they want access to this talent," she adds, "and leading talent moves here because they want to work for these companies and institution."

Davenport says initiatives like the Innovation Corridor, the TMC3 research campus and The Ion entrepreneurship hub also help nurture a well-educated workforce.

"We anticipate these projects will attract even more of the world's brightest minds to our region," she says.

Three other Houston ZIP codes made the top 10 in Texas:

  • No. 5 — 77098 (39.2 percent). That percentage represents about 4,300 people. This ZIP code is just northwest of the Rice and Texas Medical Center campuses.
  • No. 6 — 77025 (39.15 percent). That percentage represents almost 8,200 people. This ZIP code is just southwest of the Rice and Texas Medical Center campuses.
  • No. 10 — 77024 (35.4 percent). That percentage represents about 9,400 people. This ZIP code is slightly east of the Energy Corridor.

"It is no surprise that top-flight, innovation-focused talent would flock to neighborhoods near downtown, Uptown and the world-renowned Texas Medical Center," Davenport says.

Other Texas ZIP codes in the top 10 for postgraduate or professional degrees are:

  • No. 4 — 78703, Austin (41.5 percent). This ZIP code, less than two miles west of the University of Texas campus, includes high-end neighborhoods such as Tarrytown and Old West Austin.
  • No. 7 — 75205, Dallas (37.7 percent). The Southern Methodist University campus sits on the east side of this ZIP code.
  • No. 8 — 78746, Austin (37.2 percent). This ZIP code encompasses parts of West Austin, as well as the wealthy suburbs of Rollingwood and West Lake Hills.
  • No. 9 — 78731, Austin (37.1 percent). This ZIP code incorporates part of Central Austin and a large swath of Northwest Austin.

Federal data shows the unemployment rates for people with master's, professional, and doctoral degrees are lower than for other groups, such as people whose bachelor's or associate's degrees are their most advanced degrees. In addition, people with a postgraduate or professional degree typically earn more money.

"Graduates with the right knowledge and skills have the ability to demand higher salaries, as they are equipped to make significant contributions to the revenue and growth of the companies they work for," the Digital Marketing Institute says.
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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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