Houston-founded blockchain startup raises $15M series A to increase international impact

money moves

Topl's latest fundraising round includes participation from a Houston investor as well as international partners. Image via Getty Images

A blockchain technology company that was founded out of Rice University has closed its latest round of funding.

Founded in 2017, Topl is a blockchain-as-a-service company that's developing a purpose-built blockchain ecosystem to empower impact and sustainability within its userbase of businesses. The company's $15 million series A round was co-led by Houston-based Mercury, Republic Asia, and Malta-based Cryptology Asset Group.

“Topl’s blockchain was purpose built to power the next wave of supply chains and markets, that are more sustainable and inclusive,” says Chris Georgen, founder and managing director of Topl, in a news release. “Every decision we’ve made has been relentlessly focused on this problem and it’s exciting to see this approach yielding results with more than 30 different impact-forward use cases already live or approaching launch. Through this latest fundraise and with the strong network we’ve built, we’re looking to accelerate the growth of our ecosystem and setting a goal of at least 100 applications launched by next year.”

The company, which is now headquartered in Austin but still has a presence in Houston, has raised over $20 million in investment to date. Topl announced its $3 million seed round of funding — also led by Mercury — in 2020.

“Despite broader market dynamics across the Web3 sector, Topl’s strategic and early focus on users allowed the team to build an incredibly strong foundation that can weather cycles by providing an increasingly in-demand service to companies implementing various sustainable initiatives,” says Samantha Lewis, principal at Mercury, in the release. “We are excited to support Topl in this pivotal growth period.”

The round included two new international investors in Topl. Republic Asia is a newly launched arm of private investing platform Republic that is focused on fintech and web3 solutions. Houstonian Youngro Lee leads the division as executive vice president at Republic and head of Republic Asia and will join Topl's board to assist with international expansion.

“Sustainability and climate considerations are no longer mere luxuries, but an absolute necessity for companies to contribute to global finance and commerce,” Lee says in the release. “Topl will make it easier than ever for any organization around the world to harness the power of blockchain to track and monetize their positive environmental impact.”

Cryptology, with its European operations, also brings Topl key international presence.

"It's been an honor to see Topl progress from when it first entered Iconic Lab's accelerator program back in 2018 to where it is today," says Patrick Lowry, CEO of Cryptology, in the release. "Cryptology is hyper-focused on driving crypto adoption in an impact-focused, sustainable manner. We are proud to add Topl to our portfolio of companies and excitedly await Topl's network decentralization."

In addition to increasing its international impact, Topl will reportedly continue to build out its blockchain and technology. Per the release, Topl expects to launch a traceability platform for ethically and sustainably sourced products later this year.

Topl, which launched a grant program to fund Web3 startups and developers with inclusive and sustainable solutions, plans to announce its first 20 grant awards early next year. The grant recipients will also receive development, go-to-market, and fundraising support from Topl's team and network.

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Cart.com and Topl — two growing Houston startups — have made strategic appointments. Photos courtesy

2 Houston startups announce new execs to their leadership

short stories

A pair of Houston tech startups have recently announced new appointments to their leadership staff. An e-commerce company has a new chief people officer and a blockchain company named a new president to lead commercialization.

Meet Cart.com's new C-suite hire

Sara Patterson is a human resources veteran. Photo courtesy of Cart.com

Houston-based Cart.com, an end-to-end ecommerce services provider, appointed Sara Patterson as chief people officer. She will lead all aspects of the company's talent acquisition and employee experience of the fast-growing startup.

As the company grows its team and its ecommerce-as-a-service platform, it's Patterson job to forge a strong, unified culture and develop a compelling talent acquisition strategy to support continuing growth, according to a press release from Cart.com.

"Sara is one of the most accomplished and experienced HR leaders in the business. She has a real gift for talent management, and unrivaled expertise driving success for fast-growing companies across a wide range of industries," says Omair Tariq, CEO of Cart.com, in the release. "Her experience and dedication are exactly what we need as we forge a unified workforce to support our end-to-end ecommerce platform. After all, we aren't just growing our workforce at record speed. We're also building a unified culture and delivering incredible employee experiences to ensure that our entire team — from office workers to warehouse pickers — can stay laser-focused on our core goal of helping ecommerce brands to thrive."

She has three decades of experience in human resources, including serving as CPO of Lemonade, which included managing over 500 employees. She also worked as vice president of HR and head of talent management at Walmart eCommerce, which had more than 15,000 employees. She has also held senior leadership positions at Bonobos, Tribune Media, Conde Nast, Coach, and Gilt.

"People are the key to success for any growing company, and I'm thrilled to be joining one of the fastest-growing and most transformative companies in the ecommerce space," Patterson says in the release. "Cart.com's leaders have made it clear that they see a strong culture as the key to lasting success, and I couldn't agree more. I'm delighted to be joining such a talented team, and supporting their continuing mission to unlock scalable growth for ecommerce brands."

Here's who will lead commercialization for Topl

Tim Marx has transitioned from adviser to employee at Topl. Photo courtesy of Topl

Tim Marx has joined Topl as president, the company recently announced. Marx will lead Topl's commercialization efforts and scaling. He previously supported the blockchain company as adviser.

A Fulbright Scholar, Stanford MBA, and former Boston Consulting Group partner and managing director, Marx has consulted on the ground in more than 20 countries, including those of Latin America, Europe, and Asia. He will continue to support Baird Capital as a venture partner, which he has since 2018.

"My overall thesis for getting involved in Topl is that I finally saw a really solid business use case versus a classic solution looking for a problem to solve," Marx says.

To learn more about him, read his recent Topl team member blog.

These two innovators have linked up for a new ESG offering. Photos courtesy

2 Houston blockchain companies connect on ESG initiative

team work

Two Houston-based startups specializing in blockchain technology have announced a collaborative within the Environmental, Social and Governance, or ESG, space.

Data Gumbo and Topl have partnered up to offer companies a private-public blockchain solution for ESG reporting. The collaborative solution, according to a news release, allows for public-facing, accurate, and immutable ESG progress reports that are accessible to outside audiences and stakeholders, including public analysts, investors, governments, and more.

"As companies today face mounting pressure to report timely and accurate ESG data, including performance and progress, they need the right tools to collect, standardize and automate reporting while preserving security for sensitive data," says Andrew Bruce, CEO and founder of Data Gumbo, in the release. "For the first time, this partnership offers companies total control of their accurate ESG data, allowing them to publish and report metrics in whatever manner best suits them satisfying investors', regulator agencies' and other stakeholders' desires."

The tool will gather business operation and transaction data and compare it to defined standards. This enables the complete review and certification of ESG metrics by auditors using GumboNet ESG. Once the environmental impact is determined, the company can easily share data recorded on Topl's public-facing blockchain.

"Companies can now comprehensively collect ESG data and report to private entities and public audiences," says Kim Raath, founder and CEO of Topl. "This partnership combines the power of our two complementary solutions to support a new level of transparency for companies that desire to showcase their fully verifiable progress on crucial ESG metrics."

Both companies have been players within the ESG space. Data Gumbo launched GumboNet ESG, a sustainability measurement solution that can pull together a company's operational data to ESG standards reporting, in March. Topl's blockchain-as-a-service offering rolled out just a few weeks later.

The five finalists in the Female-Founded Business category for the inaugural InnovationMap Awards share the challenges they overcame as female founders. Photos courtesy

Houston founders share the challenges they've had to overcome as women in tech

innovationmap awards

Even in 2021, women face discrimination in the workplace — whether it's running their own businesses or climbing the corporate ladder.

The five female finalists of the Female-Founded Business category for the InnovationMap Awards presented by Techwave were asked to share their challenges overcame as female founders. Here's what they had to say. Click here to register for the livestream.

Raising capital

Carolyn Rodz, founder of Hello Alice, says raising capital was her biggest challenge.

"We overcame it through insane networking and persistence," she continues. "Each round got easier as we proved that we knew how to grow this business and build a fiercely loyal owner community.

Katharine Forth, co-founder of Zibrio, agrees that raising early funding was her biggest challenge.

"To overcome it, I was very creative with the limited funds to generate the progress we created until we reached a threshold that was more comfortable for investors," she explains.

Being the only woman in the room

"This is a hurdle in and of itself, but it brings lots of other little behavioral hurdles too," says Kim Raath, CEO and co-founder of Topl. "Because men and women are socialized so differently, women often have to adapt to or accommodate for male-pattern behaviors."

Raath continues, saying how men tend to up-sell what they are doing, while women undersell. Additionally, she says, men are more likely to make statements while women suggest their ideas.

"It takes a lot of courage to fight for yourself and your ideas in a room full of men," Raath says. "You can't expect others to do it for you. Even further, those of us that are in the room have a duty to speak up, not just for our own sake, but for other voices that are still excluded. Being a woman in the tech space means learning how to accommodate, navigate, and hold your ground."

Being treated equally

For Samantha Snabes, co-founder of re:3D, her biggest challenge was being treated the same as her male co-founder.

"I've learned that I need to be more confident and to be proud of the differences in my leadership or communication style," she explains.

Being mistaken for the secretary

Shoshi Kaganovsky, founder of RingOn, says electronics is a very male dominated arena.

"Every time I approach a man — whether to interview him for a job or to partner up on another level — they think I'm the CEO's secretary," she says.

"When male investors talk to me they often times think I don't understand what I'm doing or that they need to dumb it down for me," continues Kaganovsky, who speaks five languages and has six degrees. "Second conversations are completely different usually."

Want to work for one of the top startups in Houston? These ones are hiring. Photo by Tima Miroshnichenko from Pexels

Here's which of the InnovationMap Awards finalists are hiring

growing biz

After scouring Houston for the best of the Houston innovation ecosystem and evaluating dozens of companies, InnovationMap has announced the finalists in its inaugural awards. But which of these companies are growing their teams?

Turns out, almost all of them have open positions — some planning to double their teams over the next year. In fact, the 28 companies that make up our cohort of finalists are looking for over 250 new employees — some have these positions open now and others are seeking these new team members over the next 12 months.

Let's look at how many new hires these top startups are looking for.

Biggest gains

The InnovationMap Awards finalist with the loftiest hiring goal is Liongard, which is a finalist in the People's Choice: Startup of the Year category. Liongard — a platform that helps IT companies automatically discover, document, and audit their customers' IT systems — is looking to fill 70 positions over the next year. The company, founded in 2015, has just over 100 employees now.

The startup finalist with the second highest hiring goals is Nanotech, a material science company with a mission to fireproof the world and reduce energy consumption. Nanotech is looking to hire over 40 new employees in the next 12 months, which would almost triple its current staff of 15. Founded in 2019 by Mike Francis, the company is a finalist in both the Energy Transition and People's Choice categories.

Another People's Choice finalist, GoCo, and its all-in-one employee management platform, is currently looking to grow its team by adding 20 new employees to its staff of 53. The company was founded in 2015 and has since raised over $12 million in VC funding.

Also looking to grow their team by 20 new hires is Hello Alice — a small business owner's passport through entrepreneurship that helps with networking, raising capital, and accessing growth tools. The company, co-founded by Carolyn Rodz, is up for an award in the BIPOC-Founded, Female-Founded, and People's Choice categories.

GoExpedi, whose founder and CEO Timothy Neal is a finalist in the Top Founder Under 40 category, currently has 17 positions open at the moment and is looking to add those new hires into its team of over 150 employees. The e-commerce, supply chain, and analytics company is streamlining procurement for industrial and energy MRO (maintenance, repair and operations).

While Female-Founded Business finalist RingOn — a wearable GPS tracker that is also a panic button that's designed for school kids and with an impact-driven mission of ending child trafficking — is only currently looking for six new hires, the company is expecting to hiring another 15 new employees next year. Right now, the company's employee count is at three.

Steady growth

A few of the awards finalists are sporting hiring goals in the seven to 12 new staffers range. Space Tech finalist NANCO Aero, which is developing package- and person-carrying air vehicles, is hiring a dozen new employees — a big goal considering the company currently has just four employees.

Enercross LLC, automation software for the energy industry, is a finalist in the Energy Transition category and is looking to add 11 new people to its team of 42. Meanwhile Sports Tech finalist sEATz — a mobile ordering and delivery platform for food, drinks, and merchandise at large events — is looking to about double its team of 10 over the few months.

Health Tech finalist Medical Informatics Corp. is the creator of Sickbay, which features web-based applications that transform data into actionable information to help care teams make better, faster decisions. The company has seven open positions to grow its team of 36.

Seeking selectively

The following InnovationMap Awards finalists are looking to grow their teams with between two and six new hires:

  • Allotrope Medical — creator of StimSite, a device that improves surgical safety and efficiency in millions of operations performed every year.
  • CaseCTRL — using artificial intelligence and automation to streamline surgical scheduling.
  • Cemvita Factory — engineering microbes that eat CO2 and produce valuable chemicals.
  • Cheers Health — creating products that are designed to support your liver and help you feel better after consuming alcohol.
  • Cognitive Space — providing a scalable satellite constellation management solution to the space industry.
  • Data Gumbo — creator of an interconnected industrial smart contract network secured and powered by blockchain.
  • DonateStock — simplifying the process of donating stock and helping nonprofits solicit, process, and manage stock donations.
  • FitLift — a wearable device and mobile platform that tracks motion and gives real-time feedback on lifting technique, allowing trainers, and athletes to drive results.
  • LAMIK Beauty — a tech-enabled clean color cosmetics company focusing on women of all diverse backgrounds
  • Molecule Software — creator of a leading cloud-native energy trading software.
  • re:3D Inc. — producer of large, affordable industrial 3D printers, and services that can print with new or recycled filament, pellets, or flake.
  • Saranas — creator of the Early Bird, the first and only FDA-approved bleed detection system for endovascular procedures.
  • Starling Medical — using AI and telehealth enabled medical devices to enable millions with bladder dysfunctions to be able to urinate safely and conveniently again.
  • Topl — impact monetization engine that enables digital and sustainable transformation across value chains and empowers the monetization of impact verified on the Topl Blockchain.
  • Zibrio Inc. — a fall prevention solution that empowers both clinicians and patients for better outcomes.

Find out which of these employers take home the win at the September 8 event at The Cannon - West Houston. Honorees, sponsors, judges, and their guests will celebrate in person, and the rest of the innovation community is invited to tune in to the livestream. Click here to RSVP.

Sponsorships are still available! If you are interested in partnering with InnovationMap as a sponsor of this event, send an email to awards@innovationmap.com.

And the finalists for the inaugural InnovationMap Awards are... Graphic via Gow Media

InnovationMap names 28 Houston startup finalists for inaugural awards

who will take home the win?

Who are Houston's rising stars across energy transition, sports tech, health, and more? InnovationMap set out on a quest to discover that for its inaugural awards. Ahead of the September 8 event, we're revealing the finalists across all categories.

Eight judges evaluated over 100 applications across eight categories for the 2021 InnovationMap Awards presented by Techwave. This year's judges included: Juliana Garaizar, head of the Houston incubator and vice president of innovation at Greentown Labs; Alex Gras, managing director at The Cannon; Rajasekhar Gummadapu, co-founder and CEO of Techwave; Natalie Harms, editor of InnovationMap; Serafina Lalany, interim president at Houston Exponential; Jon Nordby, managing director at MassChallenge; Emily Reiser, senior manager of innovation community engagement at the Texas Medical Center; and Grace Rodriguez, CEO and executive director of Impact Hub Houston.

The winners will be announced and celebrated — along with this year's previously announced Trailblazer Award recipient, Barbara Burger of Chevron Technology Ventures — at the September 8 event at The Cannon - West Houston. Honorees, sponsors, judges, and their guests will celebrate in person, and the rest of the innovation community is invited to tune in to the livestream. Click here to RSVP.

Sponsorships are still available! If you are interested in partnering with InnovationMap as a sponsor of this event, send an email to awards@innovationmap.com.

Without further adieu, here are this year's finalists:

BIPOC-Founded Business Finalists

The finalists for the BIPOC-Founded Business Award category, honoring innovative tech companies founded or co-founded by BIPOC representation, are:

  • Allotrope Medical — creator of StimSite, a device that improves surgical safety and efficiency in millions of operations performed every year.
  • Hello Alice — a small business owner's passport through entrepreneurship that helps with networking, raising capital, and accessing growth tools.
  • LAMIK Beauty — a tech-enabled clean color cosmetics company focusing on women of all diverse backgrounds
  • Molecule Software — creator of a leading cloud-native energy trading software.

Female-Founded Business Finalists

The finalists for the Female-Founded Business Award category presented by Veritex Community Bank, honoring innovative tech companies founded or co-founded by women, include:

  • DonateStock — simplifying the process of donating stock and helping nonprofits solicit, process, and manage stock donations.
  • Hello Alice — a small business owner's passport through entrepreneurship that helps with networking, raising capital, and accessing growth tools.
  • re:3D Inc. — producer of large, affordable industrial 3D printers, and services that can print with new or recycled filament, pellets, or flake.
  • RingOn — wearable GPS tracker that is also a panic button that's designed for school kids and with an impact-driven mission of ending child trafficking.
  • Topl — impact monetization engine that enables digital and sustainable transformation across value chains and empowers the monetization of impact verified on the Topl Blockchain.
  • Zibrio Inc. — a fall prevention solution that empowers both clinicians and patients for better outcomes.

Health Care Business Finalists

The finalists for the Health Care Business Award category presented by Gray Reed, which honors health care businesses with an innovative solution within life sciences, include:

  • Allotrope Medical — creator of StimSite, a device that improves surgical safety and efficiency in millions of operations performed every year.
  • Medical Informatics Corp. — creator of Sickbay, which features web-based applications that transform data into actionable information to help care teams make better, faster decisions.
  • Saranas — creator of the Early Bird, the first and only FDA-approved bleed detection system for endovascular procedures.
  • Starling Medical — using AI and telehealth enabled medical devices to enable millions with bladder dysfunctions to be able to urinate safely and conveniently again.

Energy Transition Business Finalists

The finalists for the Energy Transition Business category, which honors energy business with innovative solutions within renewables, climatetech, clean energy, and beyond, are:

  • Cemvita Factory — engineering microbes that eat CO2 and produce valuable chemicals.
  • Data Gumbo — creator of an interconnected industrial smart contract network secured and powered by blockchain.
  • Enercross LLC — automation software for the energy industry.
  • Nanotech — a material science company with a mission to fireproof the world and reduce energy consumption.
  • re:3D Inc. — producer of large, affordable industrial 3D printers, and services that can print with new or recycled filament, pellets, or flake.
  • Renewell Energy — converting idle oil and gas wells into flexible energy storage.

Sports Tech Business Finalists

The finalists for the Sports Tech Business category, which is honoring a sports tech business with an innovative solution within sports are:

  • FitLift — a wearable device and mobile platform that tracks motion and gives real-time feedback on lifting technique, allowing trainers, and athletes to drive results.
  • Mainline — an esports tournament management system, tournament organizer, and event production company.
  • sEATz — a mobile ordering and delivery platform for food, drinks, and merchandise at large events.

Space Tech Business Finalists

The finalists for the Space Tech Business category, which is honoring an aerospace business with an innovative solution within space exploration. are:

  • Cemvita Factory — engineering microbes that eat CO2 and produce valuable chemicals.
  • Cognitive Space — providing a scalable satellite constellation management solution to the space industry.
  • NANCO Aero — developing package- and person-carrying air vehicles.

Top Founder Under 40 Finalists

The finalists for the Top Founder Under 40 category, which honors an innovative founder younger than 40 by Sept. 8, 2021, are:

  • Pamela Singh of CaseCTRL — using artificial intelligence and automation to streamline surgical scheduling.
  • Timothy Neal of GoExpedi — an e-commerce, supply chain, and analytics company that is streamlining procurement for industrial and energy MRO (maintenance, repair and operations).
  • Kim Roxie of LAMIK Beauty — a tech-enabled clean color cosmetics company focusing on women of all diverse backgrounds.
  • Emma Fauss of Medical Informatics Corp. — creator of Sickbay, which features web-based applications that transform data into actionable information to help care teams make better, faster decisions.
  • Emily Cisek of The Postage — a legacy planning platform using tech to make afterlife decision making easier.

People’s Choice: Startup of the Year Finalists

The finalists for the People's Choice: Startup of the Year category, which will each present a 60-second live elevator pitch at the event on September 8, are:

    • Cheers Health — creating products that are designed to support your liver and help you feel better after consuming alcohol.
    • GoCo — all-in-one employee management platform.
    • Hello Alice — a small business owner's passport through entrepreneurship that helps with networking, raising capital, and accessing growth tools.
    • Liongard — a platform that helps Information Technology companies automatically discover, document, and audit their customers' IT systems.
    • Nanotech — a material science company with a mission to fireproof the world and reduce energy consumption.
    • re:3D Inc. — producer of large, affordable industrial 3D printers, and services that can print with new or recycled filament, pellets, or flake.
    • Topl — impact monetization engine that enables digital and sustainable transformation across value chains and empowers the monetization of impact verified on the Topl Blockchain.

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    Texas tops ranking of best state for investors in new report

    by the numbers

    Texas ranks third on a new list of the best states for investors and startups.

    Investment platform BrokerChooser weighed five factors to come up with its ranking:

    • 2024 Google search volume for terms related to investing
    • Number of investors
    • Number of businesses receiving investments in 2024
    • Total amount of capital invested in businesses in 2024
    • Percentage change in amount of investment from 2019 to 2024

    Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

    Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

    “There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

    According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

    During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

    Autonomous truck company rolls out driverless Houston-Dallas route

    up and running

    Houston is helping drive the evolution of self-driving freight trucks.

    In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

    Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

    “Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

    Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

    Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

    The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

    “Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

    The company plans to expand its service to El Paso and Phoenix by the end of 2025.

    “These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

    In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

    In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

    “The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

    Houston cell therapy company launches second-phase clinical trial

    fighting cancer

    A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

    Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

    The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

    “This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

    The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

    In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

    The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

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