3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Zach Ellis of South Loop Ventures, Toby Hamilton of Hamilton Health Box, and Ellen Ochoa of NASA. Photos courtesy

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes a podcast with the founder of a new venture firm, a former astronaut and recent award recipient, and a health care innovator with fresh funding.

Zach Ellis, founder and managing partner of South Loop Ventures

Zach Ellis explains on the Houston Innovators Podcast that South Loop Ventures plans to invest in promising companies from across the country and bring them into Houston's ecosystem to grow and scale. Photo via LinkedIn

Houston has a lot of the right ingredients for commercialization and scaling up companies, so when Zach Ellis moved to town to stand up a venture capital firm that made investments in diverse founders, he decided to go about it in an innovative way.

South Loop Ventures, which Ellis launched two years ago, invests in pre-seed and seed-stage startups across health care, climatetech, aerospace, sports, and fintech. While the first handful of investments, which have already been made, are into Houston-based companies, Ellis explains on the Houston Innovators Podcast that the firm plans to invest in promising companies from across the country and bring them into Houston's ecosystem to grow and scale.

"Any investor wants to feel like they are looking at the best possible investment opportunities in which to deploy capital," Ellis says on the show. "So that's reason No. 1 to cast your net as widely as possible.

"At the same time, you want to give any investment that you make greatest chances of success," he continues. "The biggest factor of success outside of the team and the capital you give them, is the customers that they can call upon. In bringing targeted companies to Houston or connecting them with Houston, you introduce the opportunity for them to achieve rapid scale and work with world-class partners very efficiently." Read more.


Toby R. Hamilton, founder and CEO of Hamilton Health Box

Dr. Toby Hamilton has secured $10 million to grow his company. Photo via tmc.edu

A Houston company that is working on a value-based model for primary care has fresh funding to support its mission.

Hamilton Health Box announced the completion of a $10 million series A funding round led by 1588 Ventures with participation from Memorial Hermann Health System, Impact Ventures by Johnson & Johnson Foundation, Texas Medical Center Venture Fund, and the Sullivan Brothers.

The company, founded in 2019 by Dr. Toby R. Hamilton, will use the funding to fuel its expansion into rural areas to help assist those living in Health Professional Shortage Areas, or HPSAs. Read more.

Ellen Ochoa, former astronaut and center director at the NASA's Johnson Space Center

Ellen Ochoa was recognized for her leadership at NASA Johnson and for being the first Hispanic woman in space. Photo via NASA

Two astronauts recently received Presidential Medals of Freedom from President Joe Biden for their leadership in space.

Ellen Ochoa, the former center director and astronaut at the NASA's Johnson Space Center in Houston, and Jane Rigby, senior project scientist for NASA’s James Webb Space Telescope, were honored at the White House on May 3.

Ochoa spent 30 years with NASA, which included being the 11th director of JSC, deputy center director of JSC, and director of Flight Crew Operations. She served on the nine-day STS-56 mission aboard the space shuttle Discovery in 1993, and became the first Hispanic woman in space. She flew four more times to space with STS-66, STS-96, STS-110, and more.

“I’m so grateful for all my amazing NASA colleagues who shared my career journey with me,” Ochoa says in a NASA news release. Read more.

Dr. Toby Hamilton has secured $10 million to grow his company. Photo via tmc.edu

Houston startup secures $10M to expand into rural communities

ready to grow

A Houston company that is working on a value-based model for primary care has fresh funding to support its mission.

Hamilton Health Box announced the completion of a $10 million series A funding round led by 1588 Ventures with participation from Memorial Hermann Health System, Impact Ventures by Johnson & Johnson Foundation, Texas Medical Center Venture Fund, and the Sullivan Brothers.

The company, founded in 2019 by Dr. Toby R. Hamilton, will use the funding to fuel its expansion into rural areas to help assist those living in Health Professional Shortage Areas, or HPSAs.

The company has pioneered a proprietary “small footprint primary care delivery model,” which is considered suitable for rural markets, employer worksites, office buildings, schools, and university campuses. The cost-effective microclinics are “prefabricated facilities” that are designed for primary care services, and employ a hybrid in-person and telemedicine care approach.

Hamilton began his career as a physician before founding Emerus Holdings, which is a micro-hospital system in the Houston area that later moved to private equity.

The recently acquired funding will help expedite the high-touch care model to 98 million Americans in HPSAs, which was a goal for when the company was established during the Covid-19 pandemic. HHB has made partnerships with Federally Qualified Health Centers (FQHCs) to provide primary care services both at existing FQHC centers and through new sites in rural areas.

"Hamilton Health Box that was designed to deliver the lowest possible price of primary and preventative care," Hamilton said in a previous interview with Innovation Map. "We built that to be able to take that care to the jobsite and meet the customer where they are at."
This week's roundup of Houston innovators includes Dr. Toby Hamilton of Hamilton Health Box, Meredith Wheeler and Maggie Segrich of Sesh Coworking, and Simone Biles of Cerebral. Courtesy photos

4 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from health to coworking — recently making headlines in Houston innovation.

Dr. Toby Hamilton, founder and CEO of Hamilton Health Box

Dr. Toby Hamilton is a leader in Houston's health care innovation ecosystem, and he joins the Houston Innovators Podcast to discuss his latest endeavor, which is rethinking primary and preventative care. Photo via tmc.edu

Dr. Toby Hamilton has seen Houston establish itself as a leader in health innovation, and he's been a part of that journey too. He started his career as a physician before founding Emerus Holdings, a micro-hospital system in the Houston area which later exited to private equity. He also founded a nonprofit focused on connecting hospital innovation leaders called the Healthcare Innovators Professional Society and led the Texas Medical Center's Biodesign program for two years.

Over the years, he says he's seen the potential develop for Houston to hold a significant role in health care innovation across the world — it's just going to take all hands on deck.

"As a community, if we can get behind that vision and be the place that tests, develops, and creates opportunities, Houston has the potential to be unlike anything in the world," he says on the Houston Innovators Podcast. Click here to listen and read more.

Meredith Wheeler and Maggie Segrich, founders of Sesh Coworking

Co-founders Maggie Segrich (right) opened Sesh with Meredith Wheeler in 2020. Photo courtesy of Sesh

One of Houston's coworking companies is moving on up. Sesh Coworking is moving into a new space that's 10 times as large as its original location — and it's an optimal location too, say Meredith Wheeler and Maggie Segrich, founders of Sesh Coworking.

"Being able to grow our community at our beautiful original location in Montrose through the pandemic is a testament to the grit and resilience of Houstonians. We are so honored and grateful to be a part of their journey,” says Segrich. “We are excited that our new location in Midtown, near the Innovation District, will provide more Houstonians with the workspace and support they need."

The two-story space is expected to open in two phases. Tenants will first move into the space's second floor in January while the first floor, the larger of the two floors, completes construction and is expected in March. Click here to read more.

Simone Biles, chief impact officer at Cerebral

Houston's favorite gymnast is the chief impact officer on a California-based tech company that's raised $462M. Photo via getcerebral.com

The greatest gymnast of all time has a new title to her many gymnastics accomplishments. Simone Biles recently joined mental health startup Cerebral as chief impact officer, and the company is backed by SoftBank and has a valuation of $4.8 billion.

Biles has been vocal about her passion for mental health. Cerebral was an official sponsor of Biles’ Gold Over America Tour, which took place from September to November, and is an official sponsor of the 2022 Simone Biles International Invitational, a gymnastics competition that will be held January 27-30 at Houston’s George R. Brown Convention Center. The Spring-based World Champions Centre, Biles’ home gym, stages the invitational.

“Mental health is just as important as physical health, but for far too long the stigma of mental health has prevented too many people from seeking help,” Biles says in a Cerebral news release. “I have my own challenges with mental health, and therapy has been very empowering for me as I try to be the best person that I can be. I believe everyone should have access to mental health resources, and Cerebral gives me the ability to personalize my mental health care experience.” Click here to read more.

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Tesla poised to bring ‘megafactory’ to Houston area with 1,500 jobs

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Tesla is expected to bring a “megafactory” and 1,500 manufacturing jobs to the Houston area.

According to various news reports this week, Tesla intends to spend $200 million on a facility in Brookshire, Texas. The Waller County Commissioners Court approved tax abatements on March 5 for the new plant.

“We are super excited about this opportunity—1,500 advanced manufacturing jobs in the county and in the city," Waller County Precinct 4 Commissioner Justin Beckendorff said during Wednesday’s Commissioners Court meeting.

Tesla will lease two buildings in Brookshire's Empire West Business Park. According to documents from Waller County, Tesla will add $44 million in facility improvements. In addition, it will install $150 million worth of manufacturing equipment.

As part of the deal, Tesla will invest in property improvements that involve a 600,000-square-foot, $31 million manufacturing facility that will house $2 million worth of equipment and include improvements to the venue.

The facility will produce Tesla megapacks, which are powerful batteries to provide energy storage and support, according to the company. A megapack can store enough energy to power about 3,600 homes for one hour.

Tesla can receive a 60 percent tax abatement for 10 years. According to the tax abatement agreement, Tesla has to employ at least 1,500 people by 2028 in order to be eligible for the tax break.

In addition to the employment clause, Tesla also will be required to have a minimum of $75 million in taxable inventory by January 1, 2026, which will increase to $300 million after three years.

9 innovation & networking events for Houstonians to attend at SXSW 2025

A Houstonian's Guide to SXSW

South by Southwest, Austin's signature hybrid music, film and interactive festival, returns to the Texas capital this month, running March 7 through 15.

In the business and innovation sector, the festival fuses together SXSW Edu for educators at the beginning of the week and SXSW Interactive, which is one of the largest gatherings in the world of innovators, technologists, artists, startups, investors and policy-makers. SXSW is a powerful international magnet for creators and the people who serve them.

I started coming to Austin for SXSW in 1999, a few years after the Interactive portion (nicknamed "Spring Break for Nerds") launched and when the entire conference of 6,000 attendees fit into the Austin Convention Center. Back then, you could rub shoulders with famous bloggers who challenged established tech journalists in the hallways, multimedia artists handing out bootleg CD-ROMS, and hard-core geeks setting web standards and laws related to technology that we enjoy today.

SXSW, like Austin itself, has grown up quite a bit in the last two decades and has fended off the common Austin refrain of "It was better X years ago," as everything has become more commercial, less "authentic" and more expensive. SXSW officially sells tickets or badges for $2295.00 at the Platinum level (with cheaper options as well) providing access to stand in lines with hundreds of your friends for the most popular keynotes and panels.

One critical tradition of SXSW and part of the relentless motivation to "Keep Austin Weird" is the dozens of unofficial side events that pop up during the event all across the city. These unofficial events and activations typically provide networking opportunities fueled by the draw of internet-famous speakers, free food, and free alcohol. As SXSW has grown exponentially, it still seems to retain its charm and quirkiness as not quite a music festival, like Bonnaroo or Lollapalooza, nor a film festival like Sundance or Tribeca, and certainly not a traditional tech conference like CES. I like to think of it as a Carnival with many things to do and see but without a specific agenda or outcome. Since COVID and the financial market retraction, these parties and happy hours have become a lot more restrained, but they still exist if you know where to look.

This article is designed to guide you through the highlights, both official and unofficial, of SXSW with a focus on professional business development with a strong bent toward networking with tech startups. Here's what not to miss.

Friday, March 7

Equitech Texas Welcome Breakfast
9–11 a.m.
Inn Cahoots, 1221 E 6th St.
A breakfast gathering of people involved with Impact Investing and Equity Tech, led by Laurie Felker Jones

Startup Superconnector featuring Practice Pitch
11 a.m.–4 p.m.
Funded House, 315 Lavaca St.
This is a "Pop Up Pitch" event designed to help startups with their investor pitches by putting them in the same room with investors and professional service providers.

Startup Crawl at SXSW 2025
5 p.m. for Backstage VIP
6–9 p.m.
Capital Factory, 701 Brazos St., Suite 1600

Startup Crawl is arguably the most important unofficial event during SXSW where hundreds of startups showcase their offerings in a huge trade show, party format.

Saturday, March 8

The Red ThreadX
607 W. Third Street, 29th Floor
Curated content, strategic connections and actionable insights for military and defense-oriented businesses

SXSW 2025: Dolphin Tank
8–10:30 a.m.
FQ Lounge: Waller Creek Boathouse, 74 Trinity St.
In partnership with Amazon and The Female Quotient, this event is dedicated to championing women entrepreneurs.

Sunday, March 9

2025 TXST SXSW Lab: The Bobcat Den
1:30–8:00 p.m.
The Bobcat Den @ SXSW, Q-Branch 200 E. Sixth St., Suite 310
PROMO CODE: MICHAELBESTVIP
The TXST SXSW Lab: The Bobcat Den is a dynamic, all-day event that showcases Texas State University’s cutting-edge research, industry collaborations, and student innovation.

Monday, March 10

Founded in Texas - For Women Founders
9 a.m.–12:30 p.m.
Brown Advisory, 200 W. Sixth St., Suite 1700
Project W, The Artemis Fund, HearstLab and Brown Advisory have joined forces to bring you Founded in Texas, an investor feedback session designed to support Texas-based women who are founders of B2B and B2B2C technology companies.

Inaugural Texas House
11:00 a.m. on Monday, March 10, until 11:59 p.m. on Tuesday March 11
315 Lavaca St.
More than ever, Texans are leading at the frontiers of technology, entrepreneurship, and culture. See the full agenda

Tuesday, March 11

Super Connectors Meet Up
4–5 p.m.
Hilton Austin Downtown, 500 E. Fourth St.,Room 412
*Badge-only event
"Superconnectors," tor those who seem hyper-connected to large networks of people, are naturally drawn to SXSW. They thrive in a creative and innovative environment, affording them countless opportunities to meet interesting people. Meet some here.

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This information and more can be found at Marc Nathan's VIP Insider’s Guide to SXSW.


Houston space tech co.'s lunar lander touches down on moon — condition unknown

Lunar Landing

A privately owned lunar lander touched down on the moon Thursday, but as the minutes dragged on, flight controllers could not confirm its condition or whether it was even upright near the south pole.

The last time Intuitive Machines landed a spacecraft on the moon, a year ago, it ended up sideways.

The company's newest Athena lander dropped out of lunar orbit as planned, carrying an ice drill, a drone and two rovers for NASA and others. The hourlong descent appeared to go well, but it took a while for Mission Control to confirm touchdown.

“We're on the surface,” reported mission director and co-founder Tim Crain. A few minutes later, he repeated, "It looks like we're down ... We are working to evaluate exactly what our orientation is on the surface.”

Launched last week, Athena was communicating with controllers more than 230,000 miles away and generating solar power, officials said. But nearly a half-hour after touchdown, Crain and his team still were unable to confirm if everything was all right with the 15-foot lander. NASA and Intuitive Machines abruptly ended their live webcast, promising more updates at a news conference later in the afternoon.

“OK team, keep working the problem," Crain urged.

Intuitive Machines last year put the U.S. back on the moon despite its lander tipping on its side.

Another U.S. company Firefly Aerospace on Sunday became the first to achieve complete success with its commercial lunar lander. A vacuum already has collected lunar dirt for analysis and a dust shield has shaken off the abrasive particles that cling to everything.

Intuitive Machines was aiming this time for a mountain plateau just 100 miles from the south pole, much closer than before.

This week's back-to-back moon landings are part of NASA’s commercial lunar delivery program meant to get the space agency’s experiments to the gray, dusty surface and jumpstart business. The commercial landers are also seen as scouts for the astronauts who will follow later this decade under NASA's Artemis program, the successor to Apollo.

NASA officials said before the landing that they knew going in that some of the low-cost missions would fail. But with more private missions to the moon, that increased the number of experiments getting there.

NASA spent tens of millions of dollars on the ice drill and two other instruments riding on Athena, and paid an additional $62 million for the lift. Most of the experiments were from private companies, including the two rovers. The rocket-powered drone came from Intuitive Machines — it's meant to hop into a permanently shadowed crater near the landing site in search of frozen water.

Intuitive Machines' Trent Martin said before the flight that Athena needed to land upright in order for the drone and rovers to deploy.

To lower costs even more, Intuitive Machines shared its SpaceX rocket launch with three spacecraft that went their separate ways. Two of them — NASA’s Lunar Trailblazer and AstroForge’s asteroid-chasing Odin — are in jeopardy.

NASA said this week that Lunar Trailblazer is spinning without radio contact and won’t reach its intended orbit around the moon for science observations. Odin is also silent, with its planned asteroid flyby unlikely.

As for Athena, Intuitive Machines made dozens of repairs and upgrades following the company’s sideways touchdown by its first lander. It still managed to operate briefly, ending America’s moon-landing drought of more than 50 years.

Until then, the U.S. had not landed on the moon since Apollo 17 in 1972. No one else has sent astronauts to the moon, the overriding goal of NASA’s Artemis program. And only four other countries have successfully landed robotic spacecraft on the moon: Russia, China, India and Japan.

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